LV12618B - USE OF SULPHAMAT DERIVATIVES FOR STEROIDE SULPHATE INHIBITORS - Google Patents

USE OF SULPHAMAT DERIVATIVES FOR STEROIDE SULPHATE INHIBITORS Download PDF

Info

Publication number
LV12618B
LV12618B LVP-00-131A LV000131A LV12618B LV 12618 B LV12618 B LV 12618B LV 000131 A LV000131 A LV 000131A LV 12618 B LV12618 B LV 12618B
Authority
LV
Latvia
Prior art keywords
oestrone
compound
sulphamate
group
use according
Prior art date
Application number
LVP-00-131A
Other languages
English (en)
Latvian (lv)
Other versions
LV12618A (en
Inventor
Michael John Reed
Barry Victor Lloyd Potter
Original Assignee
Sterix Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterix Limited filed Critical Sterix Limited
Publication of LV12618A publication Critical patent/LV12618A/xx
Publication of LV12618B publication Critical patent/LV12618B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Medicinal Preparation (AREA)
  • Surgical Instruments (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
LVP-00-131A 1991-08-29 2000-10-03 USE OF SULPHAMAT DERIVATIVES FOR STEROIDE SULPHATE INHIBITORS LV12618B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919118478A GB9118478D0 (en) 1991-08-29 1991-08-29 Steroid sulphatase inhibitors

Publications (2)

Publication Number Publication Date
LV12618A LV12618A (en) 2001-02-20
LV12618B true LV12618B (en) 2001-07-20

Family

ID=10700604

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-00-131A LV12618B (en) 1991-08-29 2000-10-03 USE OF SULPHAMAT DERIVATIVES FOR STEROIDE SULPHATE INHIBITORS

Country Status (26)

Country Link
US (3) US5616574A (no)
EP (6) EP0641355B1 (no)
JP (6) JP3219408B2 (no)
KR (4) KR100258396B1 (no)
AT (5) ATE246706T1 (no)
AU (2) AU689043B2 (no)
BR (1) BR9206434A (no)
CA (4) CA2305749A1 (no)
CY (4) CY2253B1 (no)
CZ (1) CZ295939B6 (no)
DE (5) DE69233149T2 (no)
DK (4) DK0641355T3 (no)
ES (4) ES2196483T3 (no)
FI (5) FI940903A (no)
GB (1) GB9118478D0 (no)
GE (6) GEP20022803B (no)
GR (1) GR3034579T3 (no)
HK (3) HK1019753A1 (no)
HU (1) HUT66097A (no)
LV (1) LV12618B (no)
NO (6) NO307301B1 (no)
RU (4) RU2001125673A (no)
SG (7) SG103820A1 (no)
SK (4) SK282186B6 (no)
UA (4) UA41875C2 (no)
WO (1) WO1993005064A1 (no)

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US6011024A (en) 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
GB9603325D0 (en) 1996-02-16 1996-04-17 Imperial College A compound
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
WO1997032872A1 (en) * 1996-03-05 1997-09-12 Imperial College Of Science Technology And Medicine Compounds with a sulfamate group
GB9625334D0 (en) * 1996-12-05 1997-01-22 Imperial College Compound
US6903084B2 (en) 1991-08-29 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
US6013642A (en) * 1994-04-05 2000-01-11 Foulkes; Roland Use of estrone derivatives as steroid sulphatase inhibitors
DE4429397C2 (de) * 1994-08-09 2003-11-20 Jenapharm Gmbh Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE4429398C2 (de) * 1994-08-09 1997-09-11 Jenapharm Gmbh Verwendung von Estra-1,3,5(10)-trien-Derivaten zur hormonalen Kontrazeption
GB9422777D0 (en) * 1994-11-11 1995-01-04 Imperial College Assay
US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
US5705495A (en) * 1995-10-19 1998-01-06 Jenapharm Gmbh & Co. Kg. Sulfamate derivatives of 1,3,5(10)-estratriene derivatives, methods for their production and pharmaceuticals containing these compounds
US6506792B1 (en) 1997-03-04 2003-01-14 Sterix Limited Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using
US6921776B1 (en) 1996-02-16 2005-07-26 Sterix Limited Compound
CA2266051A1 (en) * 1996-09-12 1998-03-19 Teikoku Hormone Mfg. Co., Ltd. 3-substituted-d-homo-1,3,5,(10)-estratriene derivatives
US20040127473A1 (en) * 1996-12-05 2004-07-01 Reed Michael John Compound
US6642220B1 (en) 1996-12-05 2003-11-04 Sterix Limited Compounds that inhibit oestrone sulphatase; compositions thereof; and methods employing the same
US5763432A (en) * 1997-01-29 1998-06-09 Sri International Steriod inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use
DE19712488A1 (de) 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben
GB9708716D0 (en) * 1997-04-29 1997-06-18 Imperial College Chronic heart failure
US6288050B1 (en) * 1997-07-18 2001-09-11 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
US5880115A (en) * 1997-07-18 1999-03-09 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
US6376687B1 (en) 1997-07-18 2002-04-23 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
GB2331987B (en) * 1997-12-04 2002-11-27 Imperial College Polycyclic sulphamate inhibitors of oestrone sulphatase
GB2331988B (en) 1997-12-04 2003-04-16 Imperial College Polycyclic sulphamate inhibitors or oestrone sulphatase
US6046186A (en) * 1997-12-24 2000-04-04 Sri International Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
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EP1079859B1 (en) 1998-05-22 2010-07-14 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
ATE401896T1 (de) * 1998-06-10 2008-08-15 Sterix Ltd Pharmazeutische zusammensetzungen mit tumor nekrose faktor und 2-methoxyestron-3-o-sulphamat als estrone sulphatasehemmern
US6248780B1 (en) 1998-10-01 2001-06-19 Duquesne University Of The Holy Ghost Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
WO2000053620A1 (fr) * 1999-03-10 2000-09-14 Nippon Organon K. K. Nouveaux derives d'oestradiol
JP2000309599A (ja) 1999-04-13 2000-11-07 Kyowa Hakko Kogyo Co Ltd エストラ−１，３，５（１０），１６−テトラエン誘導体
AU783910B2 (en) * 1999-04-30 2005-12-22 Sterix Limited Use of estrone derivatives as antitumour agents
US7078395B1 (en) 1999-06-16 2006-07-18 Sterix Limited Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling
AU2005225148B2 (en) * 1999-04-30 2008-04-03 Sterix Limited Use
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WO2001044268A1 (en) * 1999-12-13 2001-06-21 Sterix Limited Halogenated sulphamate-, phosphonate-, thiophosphonate-, sulphonate- and sulphonamide- compounds as inhibitors of steroid sulphatase
US7335650B2 (en) * 2000-01-14 2008-02-26 Sterix Limited Composition
US6953785B2 (en) * 2000-04-24 2005-10-11 Kyowa Hakko Kogyo Co., Ltd. Estra-1,3,5(10)-triene derivatives
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GB0020498D0 (en) * 2000-08-18 2000-10-11 Sterix Ltd Compound
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US20030129186A1 (en) 2001-07-25 2003-07-10 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US8026229B2 (en) 2001-08-13 2011-09-27 Sterix Limited Antitumor-active 2-alkoxyestradiol sulfamates
DE10139494A1 (de) * 2001-08-13 2003-03-06 Jenapharm Gmbh Antitumor wirksame 2-Alkoxyestradiolsulfamate
DE60229009D1 (de) * 2001-10-18 2008-10-30 Sterix Ltd Steroidale Verbindungen zur Hemmung von steroid Sulfotase
ATE319734T1 (de) * 2001-10-18 2006-03-15 Sterix Ltd Steroidale verbindungen zur inhibierung von steroidsulfatasen
US20040254241A1 (en) * 2002-08-28 2004-12-16 Yoji Ino Aryl sulfamate derivatives
WO2004035089A1 (ja) * 2002-10-09 2004-04-29 Kyowa Hakko Kogyo Co., Ltd. ホルモン依存性癌の治療剤
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Also Published As

Publication number Publication date
NO308774B1 (no) 2000-10-30
JP2000355598A (ja) 2000-12-26
ES2196483T3 (es) 2003-12-16
RU2182152C2 (ru) 2002-05-10
GR3034579T3 (en) 2001-01-31
DE69233149D1 (de) 2003-09-11
EP0928609B1 (en) 2003-04-16
NO20044458L (no) 1994-04-29
SK282186B6 (sk) 2001-12-03
FI20050991A (fi) 2005-10-03
DE69233020D1 (de) 2003-05-22
NO995076L (no) 1994-04-29
SK282189B6 (sk) 2001-12-03
SG115508A1 (en) 2005-10-28
AU689043B2 (en) 1998-03-19
FI940903A0 (fi) 1994-02-25
AU668882B2 (en) 1996-05-23
SG106116A1 (en) 2004-09-30
DE69233053T2 (de) 2003-11-20
NO314287B1 (no) 2003-03-03
AU5837396A (en) 1996-09-05
CA2305767A1 (en) 1993-03-18
SG103374A1 (en) 2004-04-29
SG88783A1 (en) 2002-05-21
NO940635L (no) 1994-04-29
DE69233053D1 (de) 2003-06-12
ES2193475T3 (es) 2003-11-01
HUT66097A (en) 1994-09-28
EP0982032A3 (en) 2002-03-20
DK0921130T3 (da) 2003-07-21
RU2001125673A (ru) 2003-06-27
US6159960A (en) 2000-12-12
ATE194843T1 (de) 2000-08-15
DE69231280T2 (de) 2000-11-30
UA70956C2 (uk) 2004-11-15
EP1099706B1 (en) 2004-10-06
NO940635D0 (no) 1994-02-24
GEP20033094B (en) 2003-10-27
KR100321018B1 (ko) 2002-03-20
NO995076D0 (no) 1999-10-18
SG88782A1 (en) 2002-05-21
CZ295939B6 (cs) 2005-12-14
EP0982032B1 (en) 2003-08-06
RU2207134C2 (ru) 2003-06-27
UA70957C2 (uk) 2004-11-15
JP2000038341A (ja) 2000-02-08
NO20002595D0 (no) 2000-05-19
GB9118478D0 (en) 1991-10-16
RU2210574C2 (ru) 2003-08-20
KR100258396B1 (ko) 2000-08-01
NO308903B1 (no) 2000-11-13
JP2003176297A (ja) 2003-06-24
CA2305758A1 (en) 1993-03-18
DE69231280D1 (de) 2000-08-24
NO995075L (no) 1994-04-29
JP2000355542A (ja) 2000-12-26
ATE278704T1 (de) 2004-10-15
EP1099706A2 (en) 2001-05-16
CA2114630A1 (en) 1993-03-18
HK1020672A1 (en) 2000-05-19
GEP20063773B (en) 2006-03-27
EP0921130B1 (en) 2003-05-07
DK0982032T3 (da) 2003-11-03
EP0641355A1 (en) 1995-03-08
CA2114630C (en) 2003-09-30
GEP20022803B (en) 2002-09-25
CY2398B1 (en) 2004-09-10
AU1007799A (en) 1999-03-04
FI20002261A (fi) 2000-10-13
EP0921130A2 (en) 1999-06-09
GEP20022637B (en) 2002-02-25
ES2148178T3 (es) 2000-10-16
SK282188B6 (sk) 2001-12-03
HK1025051A1 (en) 2000-11-03
DE69233020T2 (de) 2003-11-06
DE69233431T2 (de) 2006-02-23
JP3581802B2 (ja) 2004-10-27
JP3581820B2 (ja) 2004-10-27
AU2490592A (en) 1993-04-05
CY2394B1 (en) 2004-09-10
NO2595A (no) 1994-04-29
FI20002259A (fi) 2000-10-13
KR100322650B1 (ko) 2002-03-20
HU9400583D0 (en) 1994-05-30
CY2397B1 (en) 2004-09-10
EP0921130A3 (en) 2001-09-05
NO307301B1 (no) 2000-03-13
ES2204059T3 (es) 2004-04-16
SG103820A1 (en) 2004-05-26
CY2253B1 (en) 2003-07-04
ATE237333T1 (de) 2003-05-15
LV12618A (en) 2001-02-20
EP0641355B1 (en) 2000-07-19
ATE239753T1 (de) 2003-05-15
CZ44094A3 (en) 1995-01-18
NO318009B1 (no) 2005-01-17
ATE246706T1 (de) 2003-08-15
EP1522543A1 (en) 2005-04-13
WO1993005064A1 (en) 1993-03-18
NO995075D0 (no) 1999-10-18
DE69233149T2 (de) 2004-06-24
DE69233431D1 (de) 2004-11-11
DK0641355T3 (da) 2000-10-09
KR100321019B1 (ko) 2002-03-20
BR9206434A (pt) 1994-09-27
HK1019753A1 (en) 2000-02-25
GEP20022802B (en) 2002-09-25
DK0928609T3 (da) 2003-07-21
AU717116B2 (en) 2000-03-16
JPH07501515A (ja) 1995-02-16
NO20025725L (no) 1994-04-29
EP0982032A2 (en) 2000-03-01
CA2305749A1 (en) 1993-03-18
UA41875C2 (uk) 2001-10-15
GEP20022766B (en) 2002-08-26
JP2002255993A (ja) 2002-09-11
JP3219408B2 (ja) 2001-10-15
FI940903A (fi) 1994-04-20
US5616574A (en) 1997-04-01
FI20002260A (fi) 2000-10-13
EP0928609A2 (en) 1999-07-14
EP1099706A3 (en) 2002-09-04
SG73391A1 (en) 2006-08-30
SK282187B6 (sk) 2001-12-03
JP3581821B2 (ja) 2004-10-27
EP0928609A3 (en) 2001-11-07
RU94019334A (ru) 1996-10-20
UA70958C2 (uk) 2004-11-15
SK24694A3 (en) 1994-11-09
NO20025725D0 (no) 2002-11-28
US5830886A (en) 1998-11-03

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