DK0982032T3 - Anvendelse af en sulfamatesterholdig sterolforbindelse til fremstilling af et lægemiddel til kontrol af østrogenproduktion - Google Patents

Anvendelse af en sulfamatesterholdig sterolforbindelse til fremstilling af et lægemiddel til kontrol af østrogenproduktion

Info

Publication number
DK0982032T3
DK0982032T3 DK99203449T DK99203449T DK0982032T3 DK 0982032 T3 DK0982032 T3 DK 0982032T3 DK 99203449 T DK99203449 T DK 99203449T DK 99203449 T DK99203449 T DK 99203449T DK 0982032 T3 DK0982032 T3 DK 0982032T3
Authority
DK
Denmark
Prior art keywords
sub
compound
drug
manufacture
ester containing
Prior art date
Application number
DK99203449T
Other languages
English (en)
Inventor
Michael John Reed
Barry Victor Lloyd Potter
Original Assignee
Sterix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterix Ltd filed Critical Sterix Ltd
Application granted granted Critical
Publication of DK0982032T3 publication Critical patent/DK0982032T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
DK99203449T 1991-08-29 1992-08-28 Anvendelse af en sulfamatesterholdig sterolforbindelse til fremstilling af et lægemiddel til kontrol af østrogenproduktion DK0982032T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919118478A GB9118478D0 (en) 1991-08-29 1991-08-29 Steroid sulphatase inhibitors
PCT/GB1992/001587 WO1993005064A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors

Publications (1)

Publication Number Publication Date
DK0982032T3 true DK0982032T3 (da) 2003-11-03

Family

ID=10700604

Family Applications (4)

Application Number Title Priority Date Filing Date
DK98204337T DK0928609T3 (da) 1991-08-29 1992-08-28 Farmaceutiske præparater indeholdende sulfamatderivater som steroidsulfatase-inhibitorer
DK99203449T DK0982032T3 (da) 1991-08-29 1992-08-28 Anvendelse af en sulfamatesterholdig sterolforbindelse til fremstilling af et lægemiddel til kontrol af østrogenproduktion
DK92918285T DK0641355T3 (da) 1991-08-29 1992-08-28 Anvendelse af sulfamatderivater som steroid-sulfatase-inhibitorer
DK98204340T DK0921130T3 (da) 1991-08-29 1992-08-28 Steroid-sulfatase-inhibitorer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK98204337T DK0928609T3 (da) 1991-08-29 1992-08-28 Farmaceutiske præparater indeholdende sulfamatderivater som steroidsulfatase-inhibitorer

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK92918285T DK0641355T3 (da) 1991-08-29 1992-08-28 Anvendelse af sulfamatderivater som steroid-sulfatase-inhibitorer
DK98204340T DK0921130T3 (da) 1991-08-29 1992-08-28 Steroid-sulfatase-inhibitorer

Country Status (26)

Country Link
US (3) US5616574A (da)
EP (6) EP1522543A1 (da)
JP (6) JP3219408B2 (da)
KR (4) KR100258396B1 (da)
AT (5) ATE239753T1 (da)
AU (2) AU689043B2 (da)
BR (1) BR9206434A (da)
CA (4) CA2305749A1 (da)
CY (4) CY2253B1 (da)
CZ (1) CZ295939B6 (da)
DE (5) DE69233149T2 (da)
DK (4) DK0928609T3 (da)
ES (4) ES2148178T3 (da)
FI (5) FI940903A (da)
GB (1) GB9118478D0 (da)
GE (6) GEP20063773B (da)
GR (1) GR3034579T3 (da)
HK (3) HK1020672A1 (da)
HU (1) HUT66097A (da)
LV (1) LV12618B (da)
NO (6) NO307301B1 (da)
RU (4) RU2207134C2 (da)
SG (7) SG106116A1 (da)
SK (4) SK282189B6 (da)
UA (4) UA41875C2 (da)
WO (1) WO1993005064A1 (da)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
GB9603325D0 (en) * 1996-02-16 1996-04-17 Imperial College A compound
US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
GB9625334D0 (en) * 1996-12-05 1997-01-22 Imperial College Compound
WO1997032872A1 (en) * 1996-03-05 1997-09-12 Imperial College Of Science Technology And Medicine Compounds with a sulfamate group
GB9604709D0 (en) * 1996-03-05 1996-05-01 Imperial College A compound
US6011024A (en) * 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
US6903084B2 (en) 1991-08-29 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
ES2201101T3 (es) * 1994-04-05 2004-03-16 Celltech Therapeutics Limited Uso de inhibidores de sulfatasas de esteroides.
DE4429397C2 (de) * 1994-08-09 2003-11-20 Jenapharm Gmbh Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE4447715C2 (de) * 1994-08-09 1998-02-05 Jenapharm Gmbh Verwendung von Estra-1,3,5(10)-trien-Derivaten zur hormonalen Behandlung von Prostatakarzinomen
GB9422777D0 (en) * 1994-11-11 1995-01-04 Imperial College Assay
US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
US5705495A (en) * 1995-10-19 1998-01-06 Jenapharm Gmbh & Co. Kg. Sulfamate derivatives of 1,3,5(10)-estratriene derivatives, methods for their production and pharmaceuticals containing these compounds
US6506792B1 (en) 1997-03-04 2003-01-14 Sterix Limited Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using
US6921776B1 (en) 1996-02-16 2005-07-26 Sterix Limited Compound
WO1998011124A1 (fr) * 1996-09-12 1998-03-19 Teikoku Hormone Mfg. Co., Ltd. Derives d'oestrariene a trisubstitution-d-homo-1,3,5,(10)
US6642220B1 (en) 1996-12-05 2003-11-04 Sterix Limited Compounds that inhibit oestrone sulphatase; compositions thereof; and methods employing the same
US20040127473A1 (en) * 1996-12-05 2004-07-01 Reed Michael John Compound
US5763432A (en) * 1997-01-29 1998-06-09 Sri International Steriod inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use
DE19712488A1 (de) 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben
GB9708716D0 (en) * 1997-04-29 1997-06-18 Imperial College Chronic heart failure
US6288050B1 (en) * 1997-07-18 2001-09-11 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
US6376687B1 (en) 1997-07-18 2002-04-23 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
US5880115A (en) * 1997-07-18 1999-03-09 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
GB2331987B (en) * 1997-12-04 2002-11-27 Imperial College Polycyclic sulphamate inhibitors of oestrone sulphatase
GB2331988B (en) 1997-12-04 2003-04-16 Imperial College Polycyclic sulphamate inhibitors or oestrone sulphatase
US6046186A (en) * 1997-12-24 2000-04-04 Sri International Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
GB9807779D0 (en) 1998-04-09 1998-06-10 Ciba Geigy Ag Organic compounds
CA2330611A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
AU765386B2 (en) * 1998-06-10 2003-09-18 Sterix Limited Pharmaceutical composition with tumor necrosis factor a and 2-methoxyestrone-3-(o)-sulphamate for inhibition of estrone sulphatase
US6248780B1 (en) 1998-10-01 2001-06-19 Duquesne University Of The Holy Ghost Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
WO2000053620A1 (fr) * 1999-03-10 2000-09-14 Nippon Organon K. K. Nouveaux derives d'oestradiol
JP2000309599A (ja) 1999-04-13 2000-11-07 Kyowa Hakko Kogyo Co Ltd エストラ−１，３，５（１０），１６−テトラエン誘導体
US7078395B1 (en) 1999-06-16 2006-07-18 Sterix Limited Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling
AU2005225148B2 (en) * 1999-04-30 2008-04-03 Sterix Limited Use
IL145995A0 (en) * 1999-04-30 2002-07-25 Sterix Ltd Use
GB9913536D0 (en) * 1999-06-10 1999-08-11 Sterix Ltd Use
US6583130B1 (en) 1999-09-13 2003-06-24 Schering Ag C13-substituted estra-1,3,5,(10)-trien-3-yl sulfamates, methods of preparing same, and pharmaceutical compositions containing these compounds
AU2190601A (en) * 1999-12-13 2001-06-25 Sterix Limited Halogenated sulphamate-, phosphonate-, thiophosphonate-, sulphonate- and sulphonamide- compounds as inhibitors of steroid sulphatase
US7335650B2 (en) 2000-01-14 2008-02-26 Sterix Limited Composition
US6953785B2 (en) * 2000-04-24 2005-10-11 Kyowa Hakko Kogyo Co., Ltd. Estra-1,3,5(10)-triene derivatives
DE10027887A1 (de) * 2000-05-31 2001-12-13 Jenapharm Gmbh Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
GB0020498D0 (en) 2000-08-18 2000-10-11 Sterix Ltd Compound
WO2003006027A1 (en) 2001-07-13 2003-01-23 Schering Aktiengesellschaft Combination of drospirenone and an estrogen sulphamate for hrt
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
US8026229B2 (en) 2001-08-13 2011-09-27 Sterix Limited Antitumor-active 2-alkoxyestradiol sulfamates
DE10139494A1 (de) * 2001-08-13 2003-03-06 Jenapharm Gmbh Antitumor wirksame 2-Alkoxyestradiolsulfamate
CA2463227C (en) * 2001-10-18 2010-08-10 Sterix Limited Steroidal compounds for inhibiting steroid sulphotase
WO2003033518A1 (en) * 2001-10-18 2003-04-24 Sterix Limited Steroidal compounds for inhibiting steroid sulphatase
US20040254241A1 (en) * 2002-08-28 2004-12-16 Yoji Ino Aryl sulfamate derivatives
JPWO2004035089A1 (ja) * 2002-10-09 2006-02-09 協和醗酵工業株式会社 ホルモン依存性癌の治療剤
DE10307103A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate
DE10307104A1 (de) * 2003-02-19 2004-09-23 Schering Ag Antitumor wirksame 2-substituierte Estra-1,3,5(10)-trien-3-yl sulfamate
DE10307105A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte 18a-Homoestra-1,3,5(10)-trien-3-yl sulfamate
ES2329241T3 (es) * 2003-05-16 2009-11-24 Laboratoire Theramex Derivados de sufamato de benzotiofeno como inhibidores de sulfatasa esteroidea.
JP4674161B2 (ja) * 2003-05-21 2011-04-20 あすか製薬株式会社 環状アミノフェニルスルファメート誘導体
US7534780B2 (en) 2004-05-21 2009-05-19 Bayer Schering Pharma Aktiengesellschaft Estradiol prodrugs
GB0412492D0 (en) 2004-06-04 2004-07-07 Sterix Ltd Compound
SI1889198T1 (sl) 2005-04-28 2015-02-27 Proteus Digital Health, Inc. Farma-informacijski sistem
US8030298B2 (en) 2005-05-26 2011-10-04 Abbott Products Gmbh 17β-HSD1 and STS inhibitors
GB0511190D0 (en) * 2005-06-01 2005-07-06 Sterix Ltd Use
WO2007035716A2 (en) 2005-09-16 2007-03-29 Raptor Pharmaceutical Inc. Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
GB0624105D0 (en) * 2006-12-01 2007-01-10 Sterix Ltd Use
GB0706072D0 (en) 2007-03-28 2007-05-09 Sterix Ltd Compound
BRPI0817045A2 (pt) 2007-09-17 2015-03-24 Preglem Sa Tratamento de condições estrogênio-dependentes em mulheres pré-menopáusicas
EP2149371A1 (en) * 2008-07-28 2010-02-03 PregLem S.A. Use of steroid sulfatase inhibitors for the treatment of preterm labor
WO2010095940A2 (en) 2009-02-20 2010-08-26 To-Bbb Holding B.V. Glutathione-based drug delivery system
NZ596876A (en) 2009-05-06 2014-01-31 Lab Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
GB0914767D0 (en) 2009-08-24 2009-09-30 Sterix Ltd Compound
CN110974840A (zh) * 2019-12-27 2020-04-10 天津市肿瘤医院 一种类固醇硫酸酯酶抑制剂及其药物用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE114806C (da) *
DE1593846A1 (de) * 1967-01-28 1971-02-25 Hoechst Ag Verfahren zur Herstellung von Sulfamidsaeure-arylestern
US3647738A (en) * 1970-11-03 1972-03-07 Union Carbide Corp Alpha-olefin polymer compositions
GB1398026A (en) * 1972-11-10 1975-06-18 Jenapharm Veb Steroid esters
DE2418217A1 (de) * 1974-04-13 1975-11-06 Hoechst Ag Sulfamidsaeureester und verfahren zu ihrer herstellung
DD114806A1 (da) * 1974-10-11 1975-08-20
US4937237A (en) * 1988-12-23 1990-06-26 Smithkline Beckman Corporation Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase
PT94305B (pt) * 1989-06-12 1997-02-28 Robins Co Inc A H Processo para a preparacao de compostos tendo um ou mais radicais aminossulfoniloxi uteis como produtos farmaceuticos
GB9003939D0 (en) * 1990-02-21 1990-04-18 Imperial College Sulphatase inhibitors
GB9603325D0 (en) * 1996-02-16 1996-04-17 Imperial College A compound
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
GB9625334D0 (en) * 1996-12-05 1997-01-22 Imperial College Compound
WO1997032872A1 (en) * 1996-03-05 1997-09-12 Imperial College Of Science Technology And Medicine Compounds with a sulfamate group
GB9118465D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
US5880115A (en) * 1997-07-18 1999-03-09 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same

Also Published As

Publication number Publication date
KR100321018B1 (ko) 2002-03-20
SK282189B6 (sk) 2001-12-03
SG73391A1 (en) 2006-08-30
US5830886A (en) 1998-11-03
EP0641355A1 (en) 1995-03-08
LV12618B (en) 2001-07-20
FI20002261A (fi) 2000-10-13
EP0928609A3 (en) 2001-11-07
NO20025725D0 (no) 2002-11-28
EP1099706A3 (en) 2002-09-04
KR100321019B1 (ko) 2002-03-20
DK0921130T3 (da) 2003-07-21
EP1099706B1 (en) 2004-10-06
FI20050991A (fi) 2005-10-03
EP1522543A1 (en) 2005-04-13
ES2148178T3 (es) 2000-10-16
US5616574A (en) 1997-04-01
NO2595A (no) 1994-04-29
NO995075D0 (no) 1999-10-18
FI940903A0 (fi) 1994-02-25
CA2305749A1 (en) 1993-03-18
SK282188B6 (sk) 2001-12-03
SG103374A1 (en) 2004-04-29
US6159960A (en) 2000-12-12
FI940903A (fi) 1994-04-20
CZ44094A3 (en) 1995-01-18
DK0928609T3 (da) 2003-07-21
JP3581802B2 (ja) 2004-10-27
GEP20063773B (en) 2006-03-27
CY2397B1 (en) 2004-09-10
UA70956C2 (uk) 2004-11-15
HK1025051A1 (en) 2000-11-03
CY2398B1 (en) 2004-09-10
DE69233431D1 (de) 2004-11-11
DK0641355T3 (da) 2000-10-09
JP2002255993A (ja) 2002-09-11
JP2000355598A (ja) 2000-12-26
CY2253B1 (en) 2003-07-04
DE69233020D1 (de) 2003-05-22
NO20044458L (no) 1994-04-29
HK1019753A1 (en) 2000-02-25
NO307301B1 (no) 2000-03-13
RU94019334A (ru) 1996-10-20
UA70958C2 (uk) 2004-11-15
NO314287B1 (no) 2003-03-03
NO308903B1 (no) 2000-11-13
ATE278704T1 (de) 2004-10-15
ATE239753T1 (de) 2003-05-15
ES2196483T3 (es) 2003-12-16
NO318009B1 (no) 2005-01-17
SK282186B6 (sk) 2001-12-03
HK1020672A1 (en) 2000-05-19
NO995076L (no) 1994-04-29
CA2114630A1 (en) 1993-03-18
DE69233053T2 (de) 2003-11-20
ATE237333T1 (de) 2003-05-15
AU1007799A (en) 1999-03-04
ATE194843T1 (de) 2000-08-15
GEP20022766B (en) 2002-08-26
GEP20022637B (en) 2002-02-25
ATE246706T1 (de) 2003-08-15
HUT66097A (en) 1994-09-28
AU5837396A (en) 1996-09-05
WO1993005064A1 (en) 1993-03-18
SK282187B6 (sk) 2001-12-03
EP0982032B1 (en) 2003-08-06
EP0641355B1 (en) 2000-07-19
DE69231280D1 (de) 2000-08-24
JP2003176297A (ja) 2003-06-24
JPH07501515A (ja) 1995-02-16
RU2210574C2 (ru) 2003-08-20
EP0982032A2 (en) 2000-03-01
DE69233149D1 (de) 2003-09-11
RU2001125673A (ru) 2003-06-27
GEP20022802B (en) 2002-09-25
DE69233149T2 (de) 2004-06-24
KR100322650B1 (ko) 2002-03-20
SG103820A1 (en) 2004-05-26
JP3219408B2 (ja) 2001-10-15
SG88783A1 (en) 2002-05-21
EP0921130A2 (en) 1999-06-09
LV12618A (en) 2001-02-20
CZ295939B6 (cs) 2005-12-14
RU2182152C2 (ru) 2002-05-10
ES2193475T3 (es) 2003-11-01
CA2114630C (en) 2003-09-30
GB9118478D0 (en) 1991-10-16
DE69231280T2 (de) 2000-11-30
EP0982032A3 (en) 2002-03-20
NO308774B1 (no) 2000-10-30
JP3581820B2 (ja) 2004-10-27
EP0928609B1 (en) 2003-04-16
SG88782A1 (en) 2002-05-21
NO995076D0 (no) 1999-10-18
RU2207134C2 (ru) 2003-06-27
EP0921130B1 (en) 2003-05-07
NO940635D0 (no) 1994-02-24
SG106116A1 (en) 2004-09-30
GEP20022803B (en) 2002-09-25
SG115508A1 (en) 2005-10-28
DE69233431T2 (de) 2006-02-23
GR3034579T3 (en) 2001-01-31
JP3581821B2 (ja) 2004-10-27
KR100258396B1 (ko) 2000-08-01
EP0921130A3 (en) 2001-09-05
NO20002595D0 (no) 2000-05-19
CA2305767A1 (en) 1993-03-18
JP2000355542A (ja) 2000-12-26
BR9206434A (pt) 1994-09-27
FI20002260A (fi) 2000-10-13
NO940635L (da) 1994-04-29
FI20002259A (fi) 2000-10-13
AU668882B2 (en) 1996-05-23
CA2305758A1 (en) 1993-03-18
EP1099706A2 (en) 2001-05-16
GEP20033094B (en) 2003-10-27
DE69233020T2 (de) 2003-11-06
NO20025725L (no) 1994-04-29
HU9400583D0 (en) 1994-05-30
AU2490592A (en) 1993-04-05
CY2394B1 (en) 2004-09-10
JP2000038341A (ja) 2000-02-08
EP0928609A2 (en) 1999-07-14
AU717116B2 (en) 2000-03-16
DE69233053D1 (de) 2003-06-12
UA41875C2 (uk) 2001-10-15
UA70957C2 (uk) 2004-11-15
ES2204059T3 (es) 2004-04-16
SK24694A3 (en) 1994-11-09
AU689043B2 (en) 1998-03-19
NO995075L (no) 1994-04-29

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DK0982032T3 (da) Anvendelse af en sulfamatesterholdig sterolforbindelse til fremstilling af et lægemiddel til kontrol af østrogenproduktion