DE69233053D1 - Steroid-sulfatase hemmende Verbindungen - Google Patents

Steroid-sulfatase hemmende Verbindungen

Info

Publication number
DE69233053D1
DE69233053D1 DE69233053T DE69233053T DE69233053D1 DE 69233053 D1 DE69233053 D1 DE 69233053D1 DE 69233053 T DE69233053 T DE 69233053T DE 69233053 T DE69233053 T DE 69233053T DE 69233053 D1 DE69233053 D1 DE 69233053D1
Authority
DE
Germany
Prior art keywords
sub
compound
steroid
inhibiting compounds
enzyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69233053T
Other languages
English (en)
Other versions
DE69233053T2 (de
Inventor
Michael John Reed
Barry Victor Lloyd Potter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sterix Ltd
Original Assignee
Sterix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterix Ltd filed Critical Sterix Ltd
Application granted granted Critical
Publication of DE69233053D1 publication Critical patent/DE69233053D1/de
Publication of DE69233053T2 publication Critical patent/DE69233053T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Surgical Instruments (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69233053T 1991-08-29 1992-08-28 Steroid-sulfatase hemmende Verbindungen Expired - Fee Related DE69233053T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919118478A GB9118478D0 (en) 1991-08-29 1991-08-29 Steroid sulphatase inhibitors

Publications (2)

Publication Number Publication Date
DE69233053D1 true DE69233053D1 (de) 2003-06-12
DE69233053T2 DE69233053T2 (de) 2003-11-20

Family

ID=10700604

Family Applications (5)

Application Number Title Priority Date Filing Date
DE69233020T Expired - Fee Related DE69233020T2 (de) 1991-08-29 1992-08-28 Pharmazeutische Mischungen, enthaltend Sulphamatderivate als steroidsulfatasehemmende Verbindungen
DE69233053T Expired - Fee Related DE69233053T2 (de) 1991-08-29 1992-08-28 Steroid-sulfatase hemmende Verbindungen
DE69233149T Expired - Fee Related DE69233149T2 (de) 1991-08-29 1992-08-28 Verwendung einer Sulfamat-Ester enthaltenden Sterolverbindung zur Herstellung eines Arzneimittels zur Kontrolle der Östrogenproduktion
DE69231280T Expired - Lifetime DE69231280T2 (de) 1991-08-29 1992-08-28 Verwendung von Sulphamatederivaten als STEROID-SULFATASE HEMMENDE VERBINDUNGEN
DE69233431T Expired - Lifetime DE69233431T2 (de) 1991-08-29 1992-08-28 Östransulfamatderivate als Steroidsulfataseinhibitoren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69233020T Expired - Fee Related DE69233020T2 (de) 1991-08-29 1992-08-28 Pharmazeutische Mischungen, enthaltend Sulphamatderivate als steroidsulfatasehemmende Verbindungen

Family Applications After (3)

Application Number Title Priority Date Filing Date
DE69233149T Expired - Fee Related DE69233149T2 (de) 1991-08-29 1992-08-28 Verwendung einer Sulfamat-Ester enthaltenden Sterolverbindung zur Herstellung eines Arzneimittels zur Kontrolle der Östrogenproduktion
DE69231280T Expired - Lifetime DE69231280T2 (de) 1991-08-29 1992-08-28 Verwendung von Sulphamatederivaten als STEROID-SULFATASE HEMMENDE VERBINDUNGEN
DE69233431T Expired - Lifetime DE69233431T2 (de) 1991-08-29 1992-08-28 Östransulfamatderivate als Steroidsulfataseinhibitoren

Country Status (26)

Country Link
US (3) US5616574A (de)
EP (6) EP1099706B1 (de)
JP (6) JP3219408B2 (de)
KR (4) KR100258396B1 (de)
AT (5) ATE194843T1 (de)
AU (2) AU689043B2 (de)
BR (1) BR9206434A (de)
CA (4) CA2305749A1 (de)
CY (4) CY2253B1 (de)
CZ (1) CZ295939B6 (de)
DE (5) DE69233020T2 (de)
DK (4) DK0921130T3 (de)
ES (4) ES2193475T3 (de)
FI (5) FI940903A (de)
GB (1) GB9118478D0 (de)
GE (6) GEP20022766B (de)
GR (1) GR3034579T3 (de)
HK (3) HK1020672A1 (de)
HU (1) HUT66097A (de)
LV (1) LV12618B (de)
NO (6) NO307301B1 (de)
RU (4) RU2001125673A (de)
SG (7) SG88783A1 (de)
SK (4) SK282189B6 (de)
UA (4) UA41875C2 (de)
WO (1) WO1993005064A1 (de)

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GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
GB9604709D0 (en) * 1996-03-05 1996-05-01 Imperial College A compound
US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
US6011024A (en) * 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
GB9625334D0 (en) * 1996-12-05 1997-01-22 Imperial College Compound
GB9603325D0 (en) * 1996-02-16 1996-04-17 Imperial College A compound
US6903084B2 (en) * 1991-08-29 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
WO1995026717A1 (en) * 1994-04-05 1995-10-12 Celltech Therapeutics Limited Use of estrone derivatives as steroid sulphatase inhibitors
DE4447714C2 (de) * 1994-08-09 1998-02-05 Jenapharm Gmbh Verwendung von Estra-1,3,5(10)-trien-Derivaten zur Hormonsubstitutions-Therapie
DE4429397C2 (de) * 1994-08-09 2003-11-20 Jenapharm Gmbh Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
GB9422777D0 (en) * 1994-11-11 1995-01-04 Imperial College Assay
US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
US5705495A (en) * 1995-10-19 1998-01-06 Jenapharm Gmbh & Co. Kg. Sulfamate derivatives of 1,3,5(10)-estratriene derivatives, methods for their production and pharmaceuticals containing these compounds
US6921776B1 (en) 1996-02-16 2005-07-26 Sterix Limited Compound
US6506792B1 (en) 1997-03-04 2003-01-14 Sterix Limited Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using
ATE286038T1 (de) * 1996-03-05 2005-01-15 Sterix Ltd Verbindungen mit sulfonsäure-amidgruppe
KR20000035979A (ko) * 1996-09-12 2000-06-26 야마구찌 다까시 3-치환-ｄ-호모-1,3,5(10)-에스트라트리엔 유도체
US6642220B1 (en) 1996-12-05 2003-11-04 Sterix Limited Compounds that inhibit oestrone sulphatase; compositions thereof; and methods employing the same
US20040127473A1 (en) * 1996-12-05 2004-07-01 Reed Michael John Compound
WO1999064013A1 (en) * 1998-06-10 1999-12-16 Sterix Limited Pharmaceutical composition with tumor necrosis factor a and 2-methoxyestrone-3-o-sulphamate for inhibition of estrone sulphatase
US5763432A (en) * 1997-01-29 1998-06-09 Sri International Steriod inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use
DE19712488A1 (de) 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben
GB9708716D0 (en) * 1997-04-29 1997-06-18 Imperial College Chronic heart failure
US6376687B1 (en) 1997-07-18 2002-04-23 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
US5880115A (en) * 1997-07-18 1999-03-09 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
US6288050B1 (en) 1997-07-18 2001-09-11 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
GB2331988B (en) 1997-12-04 2003-04-16 Imperial College Polycyclic sulphamate inhibitors or oestrone sulphatase
GB2331987B (en) * 1997-12-04 2002-11-27 Imperial College Polycyclic sulphamate inhibitors of oestrone sulphatase
US6046186A (en) * 1997-12-24 2000-04-04 Sri International Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
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US6248780B1 (en) 1998-10-01 2001-06-19 Duquesne University Of The Holy Ghost Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
WO2000053620A1 (fr) * 1999-03-10 2000-09-14 Nippon Organon K. K. Nouveaux derives d'oestradiol
JP2000309599A (ja) 1999-04-13 2000-11-07 Kyowa Hakko Kogyo Co Ltd エストラ−１，３，５（１０），１６−テトラエン誘導体
US7078395B1 (en) 1999-06-16 2006-07-18 Sterix Limited Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling
IL145995A0 (en) 1999-04-30 2002-07-25 Sterix Ltd Use
AU2005225148B2 (en) * 1999-04-30 2008-04-03 Sterix Limited Use
GB9913536D0 (en) * 1999-06-10 1999-08-11 Sterix Ltd Use
US6583130B1 (en) 1999-09-13 2003-06-24 Schering Ag C13-substituted estra-1,3,5,(10)-trien-3-yl sulfamates, methods of preparing same, and pharmaceutical compositions containing these compounds
DK1237902T3 (da) * 1999-12-13 2006-03-06 Sterix Ltd Halogenerede sulphamat-, fosfonat-, thiofosfonat-, sulfonat- og sulfonamidforbindelser som hæmmere af steroid sulfatase
US7335650B2 (en) 2000-01-14 2008-02-26 Sterix Limited Composition
EP1284272A4 (de) * 2000-04-24 2003-09-10 Kyowa Hakko Kogyo Kk Östra-1,3,5(10)-trienderivate
DE10027887A1 (de) * 2000-05-31 2001-12-13 Jenapharm Gmbh Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
GB0020498D0 (en) * 2000-08-18 2000-10-11 Sterix Ltd Compound
EP1406634A1 (de) 2001-07-13 2004-04-14 Schering Aktiengesellschaft Kombination von drospirenon und estrogensulphamate-derivaten als hormon-replacement-therapie
EP1554572B1 (de) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
US8026229B2 (en) 2001-08-13 2011-09-27 Sterix Limited Antitumor-active 2-alkoxyestradiol sulfamates
DE10139494A1 (de) * 2001-08-13 2003-03-06 Jenapharm Gmbh Antitumor wirksame 2-Alkoxyestradiolsulfamate
WO2003033518A1 (en) * 2001-10-18 2003-04-24 Sterix Limited Steroidal compounds for inhibiting steroid sulphatase
CA2463227C (en) 2001-10-18 2010-08-10 Sterix Limited Steroidal compounds for inhibiting steroid sulphotase
US20040254241A1 (en) * 2002-08-28 2004-12-16 Yoji Ino Aryl sulfamate derivatives
AU2003272964A1 (en) * 2002-10-09 2004-05-04 Kyowa Hakko Kogyo Co., Ltd. Remedy for hormone-dependent cancer
DE10307104A1 (de) * 2003-02-19 2004-09-23 Schering Ag Antitumor wirksame 2-substituierte Estra-1,3,5(10)-trien-3-yl sulfamate
DE10307103A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate
DE10307105A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte 18a-Homoestra-1,3,5(10)-trien-3-yl sulfamate
DK1644350T3 (da) * 2003-05-16 2009-11-23 Theramex Sullfamatbenzothiophenderivater som steroidsulfataseinhibitorer
CA2526540C (en) 2003-05-21 2012-04-10 Aska Pharmaceutical Co., Ltd. Cyclicamino-phenyl sulfamate derivatives
US7534780B2 (en) 2004-05-21 2009-05-19 Bayer Schering Pharma Aktiengesellschaft Estradiol prodrugs
GB0412492D0 (en) 2004-06-04 2004-07-07 Sterix Ltd Compound
EP3827747A1 (de) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharmainformatiksystem
US8030298B2 (en) 2005-05-26 2011-10-04 Abbott Products Gmbh 17β-HSD1 and STS inhibitors
GB0511190D0 (en) * 2005-06-01 2005-07-06 Sterix Ltd Use
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
GB0624105D0 (en) * 2006-12-01 2007-01-10 Sterix Ltd Use
GB0706072D0 (en) 2007-03-28 2007-05-09 Sterix Ltd Compound
JP5543920B2 (ja) 2007-09-17 2014-07-09 プレグレム エスアー 閉経前の女性におけるエストロゲン依存症状の治療
EP2149371A1 (de) * 2008-07-28 2010-02-03 PregLem S.A. Verwendung von Steroid-Sulfatase-Hemmern zur Behandlung von Frühgeburtsleiden
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GB0914767D0 (en) 2009-08-24 2009-09-30 Sterix Ltd Compound
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GB9118465D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
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US5880115A (en) * 1997-07-18 1999-03-09 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same

Also Published As

Publication number Publication date
NO995075L (no) 1994-04-29
GEP20022803B (en) 2002-09-25
DK0928609T3 (da) 2003-07-21
EP0982032A3 (de) 2002-03-20
DE69233020T2 (de) 2003-11-06
DE69231280T2 (de) 2000-11-30
GEP20022766B (en) 2002-08-26
NO940635L (de) 1994-04-29
SG106116A1 (en) 2004-09-30
DE69233020D1 (de) 2003-05-22
UA41875C2 (uk) 2001-10-15
ATE194843T1 (de) 2000-08-15
ES2148178T3 (es) 2000-10-16
RU2001125673A (ru) 2003-06-27
AU1007799A (en) 1999-03-04
SK282188B6 (sk) 2001-12-03
ATE239753T1 (de) 2003-05-15
RU94019334A (ru) 1996-10-20
UA70958C2 (uk) 2004-11-15
RU2210574C2 (ru) 2003-08-20
ATE278704T1 (de) 2004-10-15
SK24694A3 (en) 1994-11-09
NO995076L (no) 1994-04-29
AU2490592A (en) 1993-04-05
CY2394B1 (en) 2004-09-10
JP3581802B2 (ja) 2004-10-27
UA70957C2 (uk) 2004-11-15
NO307301B1 (no) 2000-03-13
LV12618A (en) 2001-02-20
NO20025725L (no) 1994-04-29
EP1522543A1 (de) 2005-04-13
NO308774B1 (no) 2000-10-30
ATE237333T1 (de) 2003-05-15
NO995075D0 (no) 1999-10-18
US6159960A (en) 2000-12-12
FI940903A (fi) 1994-04-20
EP0928609A2 (de) 1999-07-14
DE69233149T2 (de) 2004-06-24
DK0982032T3 (da) 2003-11-03
SK282187B6 (sk) 2001-12-03
JP3581820B2 (ja) 2004-10-27
RU2182152C2 (ru) 2002-05-10
DE69233053T2 (de) 2003-11-20
CZ295939B6 (cs) 2005-12-14
FI20002261A (fi) 2000-10-13
JP3219408B2 (ja) 2001-10-15
NO20025725D0 (no) 2002-11-28
CA2305758A1 (en) 1993-03-18
RU2207134C2 (ru) 2003-06-27
ES2196483T3 (es) 2003-12-16
JPH07501515A (ja) 1995-02-16
GR3034579T3 (en) 2001-01-31
FI20002259A (fi) 2000-10-13
UA70956C2 (uk) 2004-11-15
SG88782A1 (en) 2002-05-21
SG103820A1 (en) 2004-05-26
NO940635D0 (no) 1994-02-24
GEP20033094B (en) 2003-10-27
CY2397B1 (en) 2004-09-10
EP0928609A3 (de) 2001-11-07
DE69233431T2 (de) 2006-02-23
NO2595A (no) 1994-04-29
NO20002595D0 (no) 2000-05-19
EP1099706A2 (de) 2001-05-16
HK1025051A1 (en) 2000-11-03
JP2000038341A (ja) 2000-02-08
AU668882B2 (en) 1996-05-23
NO308903B1 (no) 2000-11-13
ES2204059T3 (es) 2004-04-16
KR100321019B1 (ko) 2002-03-20
CY2253B1 (en) 2003-07-04
JP2000355542A (ja) 2000-12-26
EP0641355A1 (de) 1995-03-08
HK1019753A1 (en) 2000-02-25
CA2305749A1 (en) 1993-03-18
EP1099706A3 (de) 2002-09-04
SG103374A1 (en) 2004-04-29
GEP20063773B (en) 2006-03-27
FI940903A0 (fi) 1994-02-25
NO20044458L (no) 1994-04-29
NO314287B1 (no) 2003-03-03
LV12618B (en) 2001-07-20
AU689043B2 (en) 1998-03-19
KR100322650B1 (ko) 2002-03-20
WO1993005064A1 (en) 1993-03-18
NO995076D0 (no) 1999-10-18
US5616574A (en) 1997-04-01
JP2000355598A (ja) 2000-12-26
BR9206434A (pt) 1994-09-27
HU9400583D0 (en) 1994-05-30
SK282189B6 (sk) 2001-12-03
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AU5837396A (en) 1996-09-05

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