ES2148178T3 - Uso de derivados de sulfamato como inhibidores de esteroide-sulfatasa. - Google Patents

Uso de derivados de sulfamato como inhibidores de esteroide-sulfatasa.

Info

Publication number
ES2148178T3
ES2148178T3 ES92918285T ES92918285T ES2148178T3 ES 2148178 T3 ES2148178 T3 ES 2148178T3 ES 92918285 T ES92918285 T ES 92918285T ES 92918285 T ES92918285 T ES 92918285T ES 2148178 T3 ES2148178 T3 ES 2148178T3
Authority
ES
Spain
Prior art keywords
steroid
sulfatase inhibitors
inhibitors
estrogeno
sulfamato
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92918285T
Other languages
English (en)
Inventor
Michael John Reed
Barry Victor Lloyd Potter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sterix Ltd
Original Assignee
Sterix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterix Ltd filed Critical Sterix Ltd
Application granted granted Critical
Publication of ES2148178T3 publication Critical patent/ES2148178T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Surgical Instruments (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE PRESENTAN NUEVOS INHIBIDORES DE SULFATASA ESTEROIDAL ASI COMO COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN PARA SU USO EN EL TRATAMIENTO DE TUMORES ESTROGENO DEPENDIENTES, ESPECIALMENTE CANCER DE PECHO. LOS NUEVOS INHIBIDORES DE SULFATASA ESTEROIDAL SON ESTERES DE SULFAMATO DE FORMULA (I), DONDE R1 Y R2 CADA UNO ES H, ALQUILO, CICLOALQUILO O ARILO, O JUNTOS REPRESENTAN UN GRUPO ALQUILENO QUE CONTIENE OPCIONALMENTE UN HETEROATOMO, POR EJEMPLO -O SIDUO DE UN ALCOHOL POLICICLICO, PREFERENTEMENTE UN ESTEROL, MAS PREFERENTEMENTE UN 3-ESTEROL. LOS COMPUESTOS PREFERIDOS SON ESTROGENO-3-SULFAMATO Y N,N-DIMETIL ESTROGENO-3-SULFAMATO.
ES92918285T 1991-08-29 1992-08-28 Uso de derivados de sulfamato como inhibidores de esteroide-sulfatasa. Expired - Lifetime ES2148178T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919118478A GB9118478D0 (en) 1991-08-29 1991-08-29 Steroid sulphatase inhibitors

Publications (1)

Publication Number Publication Date
ES2148178T3 true ES2148178T3 (es) 2000-10-16

Family

ID=10700604

Family Applications (4)

Application Number Title Priority Date Filing Date
ES98204337T Expired - Lifetime ES2193475T3 (es) 1991-08-29 1992-08-28 Composiciones farmaceuticas que contienen derivados de sulfamato como inhibidores de la sulfatasa esteroidea.
ES92918285T Expired - Lifetime ES2148178T3 (es) 1991-08-29 1992-08-28 Uso de derivados de sulfamato como inhibidores de esteroide-sulfatasa.
ES98204340T Expired - Lifetime ES2196483T3 (es) 1991-08-29 1992-08-28 Inhibidores de la sulfatasa esteroidea.
ES99203449T Expired - Lifetime ES2204059T3 (es) 1991-08-29 1992-08-28 Utilizacion de un compuesto de esterol que comprende un grupo ester del acido sulfamico para la preparacion de medicamentos para el control de la produccion de estrogenos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES98204337T Expired - Lifetime ES2193475T3 (es) 1991-08-29 1992-08-28 Composiciones farmaceuticas que contienen derivados de sulfamato como inhibidores de la sulfatasa esteroidea.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES98204340T Expired - Lifetime ES2196483T3 (es) 1991-08-29 1992-08-28 Inhibidores de la sulfatasa esteroidea.
ES99203449T Expired - Lifetime ES2204059T3 (es) 1991-08-29 1992-08-28 Utilizacion de un compuesto de esterol que comprende un grupo ester del acido sulfamico para la preparacion de medicamentos para el control de la produccion de estrogenos.

Country Status (26)

Country Link
US (3) US5616574A (es)
EP (6) EP1099706B1 (es)
JP (6) JP3219408B2 (es)
KR (4) KR100258396B1 (es)
AT (5) ATE194843T1 (es)
AU (2) AU689043B2 (es)
BR (1) BR9206434A (es)
CA (4) CA2305749A1 (es)
CY (4) CY2253B1 (es)
CZ (1) CZ295939B6 (es)
DE (5) DE69233020T2 (es)
DK (4) DK0921130T3 (es)
ES (4) ES2193475T3 (es)
FI (5) FI940903A (es)
GB (1) GB9118478D0 (es)
GE (6) GEP20022766B (es)
GR (1) GR3034579T3 (es)
HK (3) HK1020672A1 (es)
HU (1) HUT66097A (es)
LV (1) LV12618B (es)
NO (6) NO307301B1 (es)
RU (4) RU2001125673A (es)
SG (7) SG88783A1 (es)
SK (4) SK282189B6 (es)
UA (4) UA41875C2 (es)
WO (1) WO1993005064A1 (es)

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GB9625334D0 (en) * 1996-12-05 1997-01-22 Imperial College Compound
GB9603325D0 (en) * 1996-02-16 1996-04-17 Imperial College A compound
US6903084B2 (en) * 1991-08-29 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
WO1995026717A1 (en) * 1994-04-05 1995-10-12 Celltech Therapeutics Limited Use of estrone derivatives as steroid sulphatase inhibitors
DE4447714C2 (de) * 1994-08-09 1998-02-05 Jenapharm Gmbh Verwendung von Estra-1,3,5(10)-trien-Derivaten zur Hormonsubstitutions-Therapie
DE4429397C2 (de) * 1994-08-09 2003-11-20 Jenapharm Gmbh Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
GB9422777D0 (en) * 1994-11-11 1995-01-04 Imperial College Assay
US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
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US6921776B1 (en) 1996-02-16 2005-07-26 Sterix Limited Compound
US6506792B1 (en) 1997-03-04 2003-01-14 Sterix Limited Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using
ATE286038T1 (de) * 1996-03-05 2005-01-15 Sterix Ltd Verbindungen mit sulfonsäure-amidgruppe
KR20000035979A (ko) * 1996-09-12 2000-06-26 야마구찌 다까시 3-치환-ｄ-호모-1,3,5(10)-에스트라트리엔 유도체
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US20040127473A1 (en) * 1996-12-05 2004-07-01 Reed Michael John Compound
WO1999064013A1 (en) * 1998-06-10 1999-12-16 Sterix Limited Pharmaceutical composition with tumor necrosis factor a and 2-methoxyestrone-3-o-sulphamate for inhibition of estrone sulphatase
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GB9708716D0 (en) * 1997-04-29 1997-06-18 Imperial College Chronic heart failure
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GB2331987B (en) * 1997-12-04 2002-11-27 Imperial College Polycyclic sulphamate inhibitors of oestrone sulphatase
US6046186A (en) * 1997-12-24 2000-04-04 Sri International Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
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US6248780B1 (en) 1998-10-01 2001-06-19 Duquesne University Of The Holy Ghost Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
WO2000053620A1 (fr) * 1999-03-10 2000-09-14 Nippon Organon K. K. Nouveaux derives d'oestradiol
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JP5543920B2 (ja) 2007-09-17 2014-07-09 プレグレム エスアー 閉経前の女性におけるエストロゲン依存症状の治療
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Also Published As

Publication number Publication date
NO995075L (no) 1994-04-29
GEP20022803B (en) 2002-09-25
DK0928609T3 (da) 2003-07-21
EP0982032A3 (en) 2002-03-20
DE69233020T2 (de) 2003-11-06
DE69231280T2 (de) 2000-11-30
GEP20022766B (en) 2002-08-26
NO940635L (es) 1994-04-29
SG106116A1 (en) 2004-09-30
DE69233020D1 (de) 2003-05-22
UA41875C2 (uk) 2001-10-15
ATE194843T1 (de) 2000-08-15
RU2001125673A (ru) 2003-06-27
AU1007799A (en) 1999-03-04
SK282188B6 (sk) 2001-12-03
ATE239753T1 (de) 2003-05-15
RU94019334A (ru) 1996-10-20
UA70958C2 (uk) 2004-11-15
RU2210574C2 (ru) 2003-08-20
ATE278704T1 (de) 2004-10-15
SK24694A3 (en) 1994-11-09
NO995076L (no) 1994-04-29
AU2490592A (en) 1993-04-05
CY2394B1 (en) 2004-09-10
JP3581802B2 (ja) 2004-10-27
UA70957C2 (uk) 2004-11-15
NO307301B1 (no) 2000-03-13
LV12618A (en) 2001-02-20
NO20025725L (no) 1994-04-29
EP1522543A1 (en) 2005-04-13
NO308774B1 (no) 2000-10-30
ATE237333T1 (de) 2003-05-15
NO995075D0 (no) 1999-10-18
US6159960A (en) 2000-12-12
FI940903A (fi) 1994-04-20
EP0928609A2 (en) 1999-07-14
DE69233149T2 (de) 2004-06-24
DK0982032T3 (da) 2003-11-03
SK282187B6 (sk) 2001-12-03
JP3581820B2 (ja) 2004-10-27
RU2182152C2 (ru) 2002-05-10
DE69233053T2 (de) 2003-11-20
CZ295939B6 (cs) 2005-12-14
FI20002261A (fi) 2000-10-13
JP3219408B2 (ja) 2001-10-15
NO20025725D0 (no) 2002-11-28
CA2305758A1 (en) 1993-03-18
RU2207134C2 (ru) 2003-06-27
ES2196483T3 (es) 2003-12-16
JPH07501515A (ja) 1995-02-16
GR3034579T3 (en) 2001-01-31
FI20002259A (fi) 2000-10-13
UA70956C2 (uk) 2004-11-15
SG88782A1 (en) 2002-05-21
SG103820A1 (en) 2004-05-26
NO940635D0 (no) 1994-02-24
GEP20033094B (en) 2003-10-27
CY2397B1 (en) 2004-09-10
EP0928609A3 (en) 2001-11-07
DE69233431T2 (de) 2006-02-23
NO2595A (no) 1994-04-29
NO20002595D0 (no) 2000-05-19
EP1099706A2 (en) 2001-05-16
HK1025051A1 (en) 2000-11-03
JP2000038341A (ja) 2000-02-08
AU668882B2 (en) 1996-05-23
NO308903B1 (no) 2000-11-13
ES2204059T3 (es) 2004-04-16
KR100321019B1 (ko) 2002-03-20
CY2253B1 (en) 2003-07-04
JP2000355542A (ja) 2000-12-26
EP0641355A1 (en) 1995-03-08
DE69233053D1 (de) 2003-06-12
HK1019753A1 (en) 2000-02-25
CA2305749A1 (en) 1993-03-18
EP1099706A3 (en) 2002-09-04
SG103374A1 (en) 2004-04-29
GEP20063773B (en) 2006-03-27
FI940903A0 (fi) 1994-02-25
NO20044458L (no) 1994-04-29
NO314287B1 (no) 2003-03-03
LV12618B (en) 2001-07-20
AU689043B2 (en) 1998-03-19
KR100322650B1 (ko) 2002-03-20
WO1993005064A1 (en) 1993-03-18
NO995076D0 (no) 1999-10-18
US5616574A (en) 1997-04-01
JP2000355598A (ja) 2000-12-26
BR9206434A (pt) 1994-09-27
HU9400583D0 (en) 1994-05-30
SK282189B6 (sk) 2001-12-03
AU717116B2 (en) 2000-03-16
CA2305767A1 (en) 1993-03-18
CA2114630C (en) 2003-09-30
NO318009B1 (no) 2005-01-17
EP1099706B1 (en) 2004-10-06
DK0921130T3 (da) 2003-07-21
GEP20022802B (en) 2002-09-25
FI20050991A (fi) 2005-10-03
JP3581821B2 (ja) 2004-10-27
JP2002255993A (ja) 2002-09-11
EP0982032B1 (en) 2003-08-06
SG115508A1 (en) 2005-10-28
ATE246706T1 (de) 2003-08-15
CY2398B1 (en) 2004-09-10
HK1020672A1 (en) 2000-05-19
CA2114630A1 (en) 1993-03-18
EP0641355B1 (en) 2000-07-19
DE69233431D1 (de) 2004-11-11
DK0641355T3 (da) 2000-10-09
EP0921130B1 (en) 2003-05-07
FI20002260A (fi) 2000-10-13
DE69231280D1 (de) 2000-08-24
SG73391A1 (en) 2006-08-30
JP2003176297A (ja) 2003-06-24
EP0921130A3 (en) 2001-09-05
SK282186B6 (sk) 2001-12-03
SG88783A1 (en) 2002-05-21
GB9118478D0 (en) 1991-10-16
KR100258396B1 (ko) 2000-08-01
EP0982032A2 (en) 2000-03-01
HUT66097A (en) 1994-09-28
EP0921130A2 (en) 1999-06-09
ES2193475T3 (es) 2003-11-01
US5830886A (en) 1998-11-03
CZ44094A3 (en) 1995-01-18
GEP20022637B (en) 2002-02-25
DE69233149D1 (de) 2003-09-11
EP0928609B1 (en) 2003-04-16
KR100321018B1 (ko) 2002-03-20
AU5837396A (en) 1996-09-05

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