CY2253B1 - Steroid sulphatase inhibitors - Google Patents

Steroid sulphatase inhibitors

Info

Publication number
CY2253B1
CY2253B1 CY0100047A CY0100047A CY2253B1 CY 2253 B1 CY2253 B1 CY 2253B1 CY 0100047 A CY0100047 A CY 0100047A CY 0100047 A CY0100047 A CY 0100047A CY 2253 B1 CY2253 B1 CY 2253B1
Authority
CY
Cyprus
Prior art keywords
sub
compound
steroid sulphatase
enzyme
sulphate
Prior art date
Application number
CY0100047A
Other languages
English (en)
Inventor
Michael John Reed
Barry Victor Lloyd Potter
Original Assignee
Sterix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterix Ltd filed Critical Sterix Ltd
Publication of CY2253B1 publication Critical patent/CY2253B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Surgical Instruments (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CY0100047A 1991-08-29 2001-12-17 Steroid sulphatase inhibitors CY2253B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919118478A GB9118478D0 (en) 1991-08-29 1991-08-29 Steroid sulphatase inhibitors

Publications (1)

Publication Number Publication Date
CY2253B1 true CY2253B1 (en) 2003-07-04

Family

ID=10700604

Family Applications (4)

Application Number Title Priority Date Filing Date
CY0100047A CY2253B1 (en) 1991-08-29 2001-12-17 Steroid sulphatase inhibitors
CY0300089A CY2394B1 (en) 1991-08-29 2003-12-04 Use of sulphamate derivatives as steroid sulphatase inhibitors.
CY0300092A CY2397B1 (en) 1991-08-29 2003-12-09 Use of a ring system compound comprising a sulphamic acid ester group for the manufacture of medicaments for the control of oestrogen production.
CY0300093A CY2398B1 (en) 1991-08-29 2003-12-09 Steroid sulphatase inhibitors.

Family Applications After (3)

Application Number Title Priority Date Filing Date
CY0300089A CY2394B1 (en) 1991-08-29 2003-12-04 Use of sulphamate derivatives as steroid sulphatase inhibitors.
CY0300092A CY2397B1 (en) 1991-08-29 2003-12-09 Use of a ring system compound comprising a sulphamic acid ester group for the manufacture of medicaments for the control of oestrogen production.
CY0300093A CY2398B1 (en) 1991-08-29 2003-12-09 Steroid sulphatase inhibitors.

Country Status (26)

Country Link
US (3) US5616574A (no)
EP (6) EP0928609B1 (no)
JP (6) JP3219408B2 (no)
KR (4) KR100258396B1 (no)
AT (5) ATE194843T1 (no)
AU (2) AU689043B2 (no)
BR (1) BR9206434A (no)
CA (4) CA2305749A1 (no)
CY (4) CY2253B1 (no)
CZ (1) CZ295939B6 (no)
DE (5) DE69233431T2 (no)
DK (4) DK0921130T3 (no)
ES (4) ES2193475T3 (no)
FI (5) FI940903A (no)
GB (1) GB9118478D0 (no)
GE (6) GEP20063773B (no)
GR (1) GR3034579T3 (no)
HK (3) HK1019753A1 (no)
HU (1) HUT66097A (no)
LV (1) LV12618B (no)
NO (6) NO307301B1 (no)
RU (4) RU2001125673A (no)
SG (7) SG106116A1 (no)
SK (4) SK282187B6 (no)
UA (4) UA41875C2 (no)
WO (1) WO1993005064A1 (no)

Families Citing this family (72)

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GB9625334D0 (en) * 1996-12-05 1997-01-22 Imperial College Compound
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
GB9604709D0 (en) * 1996-03-05 1996-05-01 Imperial College A compound
GB9603325D0 (en) 1996-02-16 1996-04-17 Imperial College A compound
US6011024A (en) * 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
US6903084B2 (en) 1991-08-29 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
EP0758230B1 (en) * 1994-04-05 2003-06-11 Celltech Therapeutics Limited Use of steroid sulphatase inhibitors
DE4429397C2 (de) * 1994-08-09 2003-11-20 Jenapharm Gmbh Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE4429398C2 (de) * 1994-08-09 1997-09-11 Jenapharm Gmbh Verwendung von Estra-1,3,5(10)-trien-Derivaten zur hormonalen Kontrazeption
GB9422777D0 (en) * 1994-11-11 1995-01-04 Imperial College Assay
US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
US5705495A (en) * 1995-10-19 1998-01-06 Jenapharm Gmbh & Co. Kg. Sulfamate derivatives of 1,3,5(10)-estratriene derivatives, methods for their production and pharmaceuticals containing these compounds
US6921776B1 (en) 1996-02-16 2005-07-26 Sterix Limited Compound
US6506792B1 (en) 1997-03-04 2003-01-14 Sterix Limited Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using
ES2233998T3 (es) * 1996-03-05 2005-06-16 Sterix Limited Compuestos que comprenden un grupo sulfamato.
KR20000035979A (ko) * 1996-09-12 2000-06-26 야마구찌 다까시 3-치환-ｄ-호모-1,3,5(10)-에스트라트리엔 유도체
US20040127473A1 (en) * 1996-12-05 2004-07-01 Reed Michael John Compound
US6642220B1 (en) * 1996-12-05 2003-11-04 Sterix Limited Compounds that inhibit oestrone sulphatase; compositions thereof; and methods employing the same
US5763432A (en) * 1997-01-29 1998-06-09 Sri International Steriod inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use
DE19712488A1 (de) * 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben
GB9708716D0 (en) * 1997-04-29 1997-06-18 Imperial College Chronic heart failure
US6288050B1 (en) * 1997-07-18 2001-09-11 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
US6376687B1 (en) 1997-07-18 2002-04-23 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
US5880115A (en) * 1997-07-18 1999-03-09 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
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GB2331988B (en) 1997-12-04 2003-04-16 Imperial College Polycyclic sulphamate inhibitors or oestrone sulphatase
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CA2330611A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
JP2002517449A (ja) * 1998-06-10 2002-06-18 ステリックス リミテッド エストロンスルファターゼの阻害のための腫瘍壊死因子ａおよび２−メトキシエストロン−３−ｏ−スルファメートを有する薬学的組成物
US6248780B1 (en) 1998-10-01 2001-06-19 Duquesne University Of The Holy Ghost Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
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JP2000309599A (ja) 1999-04-13 2000-11-07 Kyowa Hakko Kogyo Co Ltd エストラ−１，３，５（１０），１６−テトラエン誘導体
AU2005225148B2 (en) * 1999-04-30 2008-04-03 Sterix Limited Use
WO2000066095A2 (en) * 1999-04-30 2000-11-09 Sterix Limited Use of estrone derivatives as antitumour agents
US7078395B1 (en) 1999-06-16 2006-07-18 Sterix Limited Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling
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US6583130B1 (en) 1999-09-13 2003-06-24 Schering Ag C13-substituted estra-1,3,5,(10)-trien-3-yl sulfamates, methods of preparing same, and pharmaceutical compositions containing these compounds
DK1237902T3 (da) * 1999-12-13 2006-03-06 Sterix Ltd Halogenerede sulphamat-, fosfonat-, thiofosfonat-, sulfonat- og sulfonamidforbindelser som hæmmere af steroid sulfatase
US7335650B2 (en) 2000-01-14 2008-02-26 Sterix Limited Composition
WO2001081364A1 (fr) * 2000-04-24 2001-11-01 Kyowa Hakko Kogyo Co., Ltd. Derives d'estra-1,3,5(10)-triene
DE10027887A1 (de) * 2000-05-31 2001-12-13 Jenapharm Gmbh Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
GB0020498D0 (en) * 2000-08-18 2000-10-11 Sterix Ltd Compound
EP1406634A1 (en) 2001-07-13 2004-04-14 Schering Aktiengesellschaft Combination of drospirenone and an estrogen sulphamate for hrt
ATE445838T1 (de) 2001-07-25 2009-10-15 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
DE10139494A1 (de) * 2001-08-13 2003-03-06 Jenapharm Gmbh Antitumor wirksame 2-Alkoxyestradiolsulfamate
US8026229B2 (en) 2001-08-13 2011-09-27 Sterix Limited Antitumor-active 2-alkoxyestradiol sulfamates
DE60229009D1 (de) 2001-10-18 2008-10-30 Sterix Ltd Steroidale Verbindungen zur Hemmung von steroid Sulfotase
WO2003033518A1 (en) * 2001-10-18 2003-04-24 Sterix Limited Steroidal compounds for inhibiting steroid sulphatase
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GB0511190D0 (en) * 2005-06-01 2005-07-06 Sterix Ltd Use
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GB0624105D0 (en) * 2006-12-01 2007-01-10 Sterix Ltd Use
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EP2149371A1 (en) * 2008-07-28 2010-02-03 PregLem S.A. Use of steroid sulfatase inhibitors for the treatment of preterm labor
HUE059078T2 (hu) 2009-02-20 2022-10-28 Enhanx Biopharm Inc Glutation-alapú hatóanyagszállító rendszer
JP2012526144A (ja) 2009-05-06 2012-10-25 ラボラトリー スキン ケア インコーポレイテッド 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法
GB0914767D0 (en) 2009-08-24 2009-09-30 Sterix Ltd Compound
CN110974840A (zh) * 2019-12-27 2020-04-10 天津市肿瘤医院 一种类固醇硫酸酯酶抑制剂及其药物用途

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GB9118465D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
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US5880115A (en) * 1997-07-18 1999-03-09 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same

Also Published As

Publication number Publication date
NO995076L (no) 1994-04-29
GR3034579T3 (en) 2001-01-31
NO318009B1 (no) 2005-01-17
NO20025725D0 (no) 2002-11-28
SK282188B6 (sk) 2001-12-03
EP1099706A2 (en) 2001-05-16
ATE194843T1 (de) 2000-08-15
NO995075L (no) 1994-04-29
JP2000355598A (ja) 2000-12-26
NO307301B1 (no) 2000-03-13
GEP20063773B (en) 2006-03-27
HK1019753A1 (en) 2000-02-25
EP0928609A3 (en) 2001-11-07
SG103820A1 (en) 2004-05-26
EP1099706B1 (en) 2004-10-06
CY2397B1 (en) 2004-09-10
DK0928609T3 (da) 2003-07-21
NO308903B1 (no) 2000-11-13
EP1099706A3 (en) 2002-09-04
FI20002261A (fi) 2000-10-13
SK282186B6 (sk) 2001-12-03
LV12618A (en) 2001-02-20
KR100321019B1 (ko) 2002-03-20
CA2114630A1 (en) 1993-03-18
DE69233053T2 (de) 2003-11-20
AU689043B2 (en) 1998-03-19
SG88782A1 (en) 2002-05-21
EP0921130A3 (en) 2001-09-05
NO20002595D0 (no) 2000-05-19
SK282189B6 (sk) 2001-12-03
JP3581820B2 (ja) 2004-10-27
FI20002259A (fi) 2000-10-13
CA2305758A1 (en) 1993-03-18
EP0921130B1 (en) 2003-05-07
UA41875C2 (uk) 2001-10-15
JP3219408B2 (ja) 2001-10-15
GEP20022803B (en) 2002-09-25
AU2490592A (en) 1993-04-05
CY2394B1 (en) 2004-09-10
FI20002260A (fi) 2000-10-13
FI940903A0 (fi) 1994-02-25
RU2210574C2 (ru) 2003-08-20
NO940635D0 (no) 1994-02-24
CA2305749A1 (en) 1993-03-18
UA70957C2 (uk) 2004-11-15
HK1025051A1 (en) 2000-11-03
JP2002255993A (ja) 2002-09-11
AU717116B2 (en) 2000-03-16
RU2182152C2 (ru) 2002-05-10
DE69231280T2 (de) 2000-11-30
ATE246706T1 (de) 2003-08-15
ES2196483T3 (es) 2003-12-16
JPH07501515A (ja) 1995-02-16
NO940635L (no) 1994-04-29
JP2000355542A (ja) 2000-12-26
BR9206434A (pt) 1994-09-27
ES2193475T3 (es) 2003-11-01
EP1522543A1 (en) 2005-04-13
DE69233149T2 (de) 2004-06-24
US5830886A (en) 1998-11-03
EP0641355A1 (en) 1995-03-08
ATE237333T1 (de) 2003-05-15
JP3581821B2 (ja) 2004-10-27
DE69233149D1 (de) 2003-09-11
EP0928609B1 (en) 2003-04-16
DE69233431T2 (de) 2006-02-23
CZ295939B6 (cs) 2005-12-14
SK282187B6 (sk) 2001-12-03
EP0928609A2 (en) 1999-07-14
US6159960A (en) 2000-12-12
UA70956C2 (uk) 2004-11-15
JP2000038341A (ja) 2000-02-08
GEP20022637B (en) 2002-02-25
NO20044458L (no) 1994-04-29
DE69233020T2 (de) 2003-11-06
DK0921130T3 (da) 2003-07-21
RU2207134C2 (ru) 2003-06-27
EP0982032A2 (en) 2000-03-01
KR100322650B1 (ko) 2002-03-20
HK1020672A1 (en) 2000-05-19
ES2148178T3 (es) 2000-10-16
SG103374A1 (en) 2004-04-29
DE69231280D1 (de) 2000-08-24
AU5837396A (en) 1996-09-05
JP2003176297A (ja) 2003-06-24
HUT66097A (en) 1994-09-28
DE69233053D1 (de) 2003-06-12
NO314287B1 (no) 2003-03-03
CZ44094A3 (en) 1995-01-18
CA2305767A1 (en) 1993-03-18
DE69233020D1 (de) 2003-05-22
RU2001125673A (ru) 2003-06-27
NO308774B1 (no) 2000-10-30
RU94019334A (ru) 1996-10-20
UA70958C2 (uk) 2004-11-15
GEP20033094B (en) 2003-10-27
WO1993005064A1 (en) 1993-03-18
GEP20022802B (en) 2002-09-25
SG115508A1 (en) 2005-10-28
EP0982032B1 (en) 2003-08-06
FI20050991A (fi) 2005-10-03
NO995075D0 (no) 1999-10-18
ES2204059T3 (es) 2004-04-16
US5616574A (en) 1997-04-01
CA2114630C (en) 2003-09-30
KR100258396B1 (ko) 2000-08-01
LV12618B (en) 2001-07-20
HU9400583D0 (en) 1994-05-30
EP0982032A3 (en) 2002-03-20
SG106116A1 (en) 2004-09-30
NO995076D0 (no) 1999-10-18
DE69233431D1 (de) 2004-11-11
DK0641355T3 (da) 2000-10-09
ATE239753T1 (de) 2003-05-15
SG73391A1 (en) 2006-08-30
GB9118478D0 (en) 1991-10-16
JP3581802B2 (ja) 2004-10-27
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