LU91867I9 - - Google Patents

Info

Publication number
LU91867I9
LU91867I9 LU91867C LU91867C LU91867I9 LU 91867 I9 LU91867 I9 LU 91867I9 LU 91867 C LU91867 C LU 91867C LU 91867 C LU91867 C LU 91867C LU 91867 I9 LU91867 I9 LU 91867I9
Authority
LU
Luxembourg
Application number
LU91867C
Other languages
French (fr)
Other versions
LU91867I2 (fr
Inventor
Alan Edward Royce
Tomoyuki Oomura
Madhusudhan Pudipeddi
Colleen Ruegger
Masaki Sasaki
Tokuhiro Tamura
Original Assignee
Novartis Ag
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32326722&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU91867(I9) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag, Mitsubishi Tanabe Pharma Corp filed Critical Novartis Ag
Publication of LU91867I2 publication Critical patent/LU91867I2/fr
Publication of LU91867I9 publication Critical patent/LU91867I9/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/145Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
LU91867C 2003-04-08 2011-09-08 Fingolimod et ses dérivés pharmaceutiquement acceptables (GILENYA®) LU91867I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46121503P 2003-04-08 2003-04-08
PCT/EP2004/003656 WO2004089341A1 (en) 2003-04-08 2004-04-06 Organic compounds

Publications (2)

Publication Number Publication Date
LU91867I2 LU91867I2 (fr) 2011-11-08
LU91867I9 true LU91867I9 (enEXAMPLES) 2019-01-03

Family

ID=32326722

Family Applications (1)

Application Number Title Priority Date Filing Date
LU91867C LU91867I2 (fr) 2003-04-08 2011-09-08 Fingolimod et ses dérivés pharmaceutiquement acceptables (GILENYA®)

Country Status (41)

Country Link
US (11) US20060275357A1 (enEXAMPLES)
EP (5) EP2319502A1 (enEXAMPLES)
JP (3) JP5495467B2 (enEXAMPLES)
KR (3) KR101367574B1 (enEXAMPLES)
CN (2) CN101797241B (enEXAMPLES)
AR (3) AR043987A1 (enEXAMPLES)
AT (3) AT501681B1 (enEXAMPLES)
AU (1) AU2004228929B2 (enEXAMPLES)
BE (2) BE1015972A5 (enEXAMPLES)
BR (1) BRPI0409250B8 (enEXAMPLES)
CA (2) CA2707750A1 (enEXAMPLES)
CL (2) CL2004000745A1 (enEXAMPLES)
CY (3) CY1110260T1 (enEXAMPLES)
DE (4) DE202004021680U1 (enEXAMPLES)
DK (2) DK1613288T3 (enEXAMPLES)
EC (1) ECSP056090A (enEXAMPLES)
ES (3) ES2228282B1 (enEXAMPLES)
FR (2) FR2854073B1 (enEXAMPLES)
GB (1) GB2400318B (enEXAMPLES)
GR (1) GR1005052B (enEXAMPLES)
HR (3) HRP20100600A2 (enEXAMPLES)
HU (2) HUE028247T2 (enEXAMPLES)
IL (3) IL170888A (enEXAMPLES)
IS (2) IS2682B (enEXAMPLES)
IT (1) ITMI20040682A1 (enEXAMPLES)
LU (1) LU91867I2 (enEXAMPLES)
MA (1) MA27729A1 (enEXAMPLES)
MX (1) MXPA05010860A (enEXAMPLES)
MY (1) MY141249A (enEXAMPLES)
NO (4) NO329332B1 (enEXAMPLES)
NZ (3) NZ586280A (enEXAMPLES)
PE (5) PE20130200A1 (enEXAMPLES)
PL (2) PL1613288T3 (enEXAMPLES)
PT (1) PT1613288E (enEXAMPLES)
RU (5) RU2358716C2 (enEXAMPLES)
SG (1) SG175449A1 (enEXAMPLES)
SI (2) SI1613288T1 (enEXAMPLES)
TN (1) TNSN05256A1 (enEXAMPLES)
TW (1) TWI332847B (enEXAMPLES)
WO (1) WO2004089341A1 (enEXAMPLES)
ZA (1) ZA200507394B (enEXAMPLES)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0513935A (pt) * 2004-07-30 2008-05-20 Novartis Ag formulações de compostos de 2-amina-1,3-propanodiol
CN1891212B (zh) * 2005-07-07 2010-10-13 马启明 一种口服制剂及其制备方法
JO2655B1 (en) * 2005-09-09 2012-06-17 نوفارتيس ايه جي Treatment of autoimmune diseases
EP1948678B1 (en) 2005-11-09 2013-05-01 Onyx Therapeutics, Inc. Compounds for enzyme inhibition
TWI389683B (zh) * 2006-02-06 2013-03-21 Kyorin Seiyaku Kk A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
MY183014A (en) 2006-06-19 2021-02-05 Onyx Therapeutics Inc Compounds for enzyme inhibition
GB0612721D0 (en) 2006-06-27 2006-08-09 Novartis Ag Organic compounds
CA2953372C (en) * 2006-09-26 2020-06-23 Novartis Ag Pharmaceutical composition comprising an s1p receptor modulator
EP1923058A1 (en) * 2006-09-26 2008-05-21 Novartis AG Coated pharmaceutical composition comprising an S1P agonist or modulator
AU2011235934A1 (en) * 2006-09-26 2011-11-03 Novartis Ag Pharmaceutical compositions comprising an S1P modulator
EP1923055A1 (en) * 2006-09-26 2008-05-21 Novartis AG Freeze-dried pharmaceutical composition comprising an S1P agonist or modulator
EP1905434A1 (en) * 2006-09-26 2008-04-02 Novartis AG Organic compounds comprising an S1P receptor agonist and their therapeutic use
EP1923054A1 (en) * 2006-09-26 2008-05-21 Novartis AG Fast disintegrating pharmaceutical composition comprising an S1P agonist or modulator
WO2008124210A1 (en) * 2007-02-14 2008-10-16 Emory University Methods and compositions for treating or preventing infection using leukocyte sequestration agents
EP2140867B2 (en) * 2007-03-29 2023-08-16 Daiichi Sankyo Company, Limited Pharmaceutical composition
NZ584814A (en) 2007-10-04 2012-03-30 Onyx Therapeutics Inc Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
AU2012216630B2 (en) * 2007-10-12 2015-01-22 Novartis Ag Compositions comprising sphingosine 1 phosphate (S1P) receptor modulators
ES2864671T3 (es) * 2007-10-12 2021-10-14 Novartis Ag Composiciones que comprenden moduladores del receptor de esfingosina 1-fosfato (s1p)
JP5534645B2 (ja) * 2008-01-11 2014-07-02 日医工株式会社 無包装状態において安定性に優れた塩酸サルポグレラート含有経口投与製剤
TW200946105A (en) 2008-02-07 2009-11-16 Kyorin Seiyaku Kk Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient
EP2278960B2 (en) 2008-03-17 2019-11-13 Actelion Pharmaceuticals Ltd. Dosing regimen for a selective sip1 receptor agonist
JP5756749B2 (ja) * 2008-06-20 2015-07-29 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung 直接圧縮性および迅速崩壊性錠剤マトリックス
CN102076335A (zh) 2008-06-20 2011-05-25 诺瓦提斯公司 用于治疗多发性硬化的儿科组合物
HRP20120121T1 (hr) * 2008-09-04 2012-03-31 Cargill Incorporated Tabletiranje eritritola
MX2011004225A (es) 2008-10-21 2011-06-21 Onyx Therapeutics Inc Terapia de combinacion con epoxicetonas peptidicas.
WO2010055027A2 (en) 2008-11-11 2010-05-20 Novartis Ag Organic compounds
ES2643161T3 (es) * 2008-11-11 2017-11-21 Novartis Ag Formas cristalinas de HCL de fingolimod
AU2013100533B4 (en) * 2008-11-11 2013-12-12 Novartis Ag Crystalline forms of fingolimod HCL
CN102256984B (zh) 2008-12-17 2014-09-03 第一三共株式会社 制备二胺衍生物的方法
WO2010082531A1 (ja) 2009-01-13 2010-07-22 第一三共株式会社 活性化血液凝固因子阻害剤
WO2010104078A1 (ja) 2009-03-10 2010-09-16 第一三共株式会社 ジアミン誘導体の製造方法
WO2010104106A1 (ja) 2009-03-13 2010-09-16 第一三共株式会社 光学活性なジアミン誘導体の製造方法
TWI504598B (zh) 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
MY155256A (en) * 2009-06-18 2015-09-30 Daiichi Sankyo Co Ltd Pharmaceutical composition having improved solubility
US9675566B2 (en) 2009-07-16 2017-06-13 Pathologica Llc Method of treatment with anti-inflammatory and analgesic compounds which are GI-, renal-, and platelet-sparing
US8853147B2 (en) 2009-11-13 2014-10-07 Onyx Therapeutics, Inc. Use of peptide epoxyketones for metastasis suppression
BR112012022060A2 (pt) 2010-03-01 2018-05-08 Onyx Therapeutics Inc composto para a inibição de imunoproteassoma
JP5692873B2 (ja) 2010-03-19 2015-04-01 第一三共株式会社 ジアミン誘導体の結晶およびその製造方法
KR101792299B1 (ko) 2010-03-19 2017-10-31 다이이찌 산쿄 가부시키가이샤 항응고제의 용출 개선 방법
CA2797029A1 (en) * 2010-04-22 2011-10-27 Ratiopharm Gmbh A method of preparing an oral dosage form comprising fingolimod
CN103080078B (zh) 2010-07-02 2015-02-11 第一三共株式会社 光学活性二胺衍生物盐的制备方法
WO2012070059A1 (en) 2010-11-25 2012-05-31 Shilpa Medicare Limited Fingolimod polymorphs and their processes
UA114283C2 (uk) 2011-01-07 2017-05-25 Новартіс Аг Композиції імуносупресантів
CA2825014C (en) 2011-01-19 2019-01-08 John Mckearn Controlled release oral pharmaceutical dosage forms comprising mgbg
JO3177B1 (ar) 2011-04-01 2018-03-08 Novartis Ag تركيبات تتالف من 2-أمينو-2- [ 2- ( 4- أكتيل فينيل ) إثيل ] بروبان - 3, 1- ديول
EP2739272A1 (en) * 2011-08-01 2014-06-11 Teva Pharmaceutical Industries Ltd. Process for preparing pharmaceutical compositions comprising fingolimod
TWI578988B (zh) 2011-08-10 2017-04-21 第一三共股份有限公司 含二胺衍生物之醫藥組成物
WO2013091704A1 (en) 2011-12-22 2013-06-27 Synthon Bv Pharmaceutical composition comprising fingolimod
RU2482842C1 (ru) * 2012-04-26 2013-05-27 Открытое акционерное общество "Новосибхимфарм" Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний (варианты) и способ ее получения
RU2506949C1 (ru) * 2012-06-13 2014-02-20 Открытое акционерное общество "Новосибхимфарм" Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний
TW201414751A (zh) 2012-07-09 2014-04-16 歐尼克斯治療公司 肽環氧酮蛋白酶抑制劑之前驅藥物
RU2496486C1 (ru) * 2012-07-11 2013-10-27 Александр Васильевич Иващенко Фармацевтическая композиция с улучшенной сыпучестью, лекарственное средство, способ получения и применение
AU2014205529B2 (en) * 2013-01-08 2018-08-09 Pathologica Llc Methods and compositions for treatment of demyelinating diseases
WO2014141298A2 (en) * 2013-03-11 2014-09-18 Astron Research Limited Stable pharmaceutical composition of fingolimod
ES2733920T3 (es) * 2013-04-26 2019-12-03 Univ Kyoto Composición que comprende un agonista del receptor 1 de esfingosina-1-fosfato para inhibir la formación y/o el aumento de tamaño de un aneurisma cerebral o para reducirlo
WO2013190151A1 (en) * 2013-05-13 2013-12-27 Synthon B.V. Pharmaceutical composition comprising fingolimod
CA2920758A1 (en) * 2013-07-29 2015-02-05 Aizant Drug Research Solutions Pvt Ltd Pharmaceutical compositions of fingolimod
RU2530626C1 (ru) * 2013-10-21 2014-10-10 Ооо "Валента-Интеллект" Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний
US20170231928A1 (en) * 2014-08-22 2017-08-17 Sunshine Lake Pharma Co., Ltd. Solid composition of fingolimod and preparation thereof
WO2016042493A1 (en) * 2014-09-19 2016-03-24 Aizant Drug Research Pvt. Ltd Pharmaceutical compositions of fingolimod
US9925138B2 (en) 2015-01-20 2018-03-27 Handa Pharmaceuticals, Llc Stable solid fingolimod dosage forms
AU2016209466A1 (en) * 2015-01-20 2017-08-10 Handa Pharmaceuticals, Llc Stable solid fingolimod dosage forms
CA2973540A1 (en) 2015-02-26 2016-09-01 Novartis Ag Treatment of autoimmune disease in a patient receiving additionally a beta-blocker
RU2577230C1 (ru) * 2015-04-09 2016-03-10 Общество с ограниченной ответственностью "Лонг Шенг Фарма Рус" Способ получения капсул финголимода гидрохлорида
US9690975B2 (en) * 2015-05-28 2017-06-27 Axogen Corporation Quantitative structural assay of a nerve graft
US11434200B2 (en) 2017-03-09 2022-09-06 Novartis Ag Solid forms comprising an oxime ether compound and a coformer, compositions and methods of use thereof
WO2018178744A1 (en) 2017-03-29 2018-10-04 Deva Holding Anonim Sirketi Stable formulations of fingolimod
GR1009654B (el) 2018-08-31 2019-11-18 Φαρματεν Α.Β.Ε.Ε. Φαρμακευτικο σκευασμα που περιλαμβανει εναν ανοσοτροποποιητικο παραγοντα και μεθοδος για την παρασκευη αυτου
DE102018217334A1 (de) * 2018-10-10 2020-04-16 Harbins Ruhr Bioscience, Inc. Sphingoid-Base und/oder Wirkstoff zur Verwendung bei der Prophylaxe und/oder Therapie einer viralen Infektion und/oder viralen Infektionskrankheit oder der Desinfektion, Nahrungsmittel/Nahrungsergänzungsmittel, Futtermittel/Futterergänzungsmittel und Pflanzenschutzmittel
JP7503420B2 (ja) * 2020-05-18 2024-06-20 東和薬品株式会社 フィンゴリモドを含む医薬組成物とその製造方法及び安定化方法
EP4181906A1 (en) 2020-07-16 2023-05-24 Harbins Ruhr Bioscience, Inc. Sphingoid compounds for use in prophylaxis and/or therapy of coronaviridae infection
AU2022214268A1 (en) * 2021-01-28 2023-07-27 Priothera Limited Methods of treatment with s1p receptor modulators

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7607683A (nl) * 1976-07-12 1978-01-16 Akzo Nv Werkwijze ter bereiding van nieuwe peptiden en peptide-derivaten en de toepassing hiervan.
US4110332A (en) * 1977-05-05 1978-08-29 Chevron Research Company 1-Triorganostannyl-3-organothio-4-substituted-1,2,4-delta2 -triazolidin-5-ones
US4559153A (en) 1983-10-25 1985-12-17 Phillips Petroleum Company Metal working lubricant
US5112616A (en) * 1988-11-30 1992-05-12 Schering Corporation Fast dissolving buccal tablet
JP2841857B2 (ja) * 1990-11-29 1998-12-24 田辺製薬株式会社 長期間安定な経口用医薬製剤
DE122011100012I1 (de) 1992-10-21 2011-10-20 Mitsubishi Tanabe Pharma Corp 2-Amino-1, 3-propandiolverbindung und immunosuppressium.
DK0778263T3 (da) 1994-08-22 2002-04-22 Mitsubishi Pharma Corp Benzenforbindelser og farmaceutisk anvendelse af disse
DE69633613T2 (de) 1995-12-28 2006-02-09 Mitsubishi Pharma Corp. 2-amino-2-(2-(4-octylphenyl)ethyl)propan-1,3-diol enthaltendes Arzneimittel zur topischen Anwendung zur Behandlung von Erkrankungen,die durch eine Störung des Immunsystems hervorgerufen werden
JP2002241272A (ja) 1996-07-18 2002-08-28 Mitsubishi Pharma Corp 医薬処方組成物
US6476004B1 (en) * 1996-07-18 2002-11-05 Mitsubishi Pharma Corporation Pharmaceutical composition
JPH11209277A (ja) * 1998-01-19 1999-08-03 Yoshitomi Pharmaceut Ind Ltd 医薬組成物
GB9624038D0 (en) 1996-11-19 1997-01-08 Sandoz Ltd Organic compounds
DK0990440T3 (da) * 1997-02-27 2009-02-23 Novartis Ag Farmaceutisk sammensætning indeholdende 2-amino-2[2-(4-octylphenyl)-ethyl]-propan-1,3-diol, en lecithin og et saccharid
AU735853B2 (en) * 1997-04-04 2001-07-19 Mitsubishi Pharma Corporation 2-aminopropane-1,3-diol compound, Pharmaceutical use thereof and synthetic intermediates therefor
JPH1180026A (ja) * 1997-09-02 1999-03-23 Yoshitomi Pharmaceut Ind Ltd 新規免疫抑制剤、その使用方法およびその同定方法
JP3545595B2 (ja) 1998-04-01 2004-07-21 花王株式会社 スフィンゴ糖脂質の製造法
JP4627356B2 (ja) * 1999-06-30 2011-02-09 昭 松森 ウイルス性心筋炎の予防または治療薬剤
KR20020027463A (ko) * 1999-07-12 2002-04-13 우에노 도시오 스핀고신-1-인산 수용체 아고니스트 또는스핀고신-1-인산을 유효 성분으로서 함유하는 선유화 억제제
BR0112484A (pt) 2000-07-13 2003-09-23 Sankyo Co Composto ou um seu sal, éster ou outro derivado farmacologicamente aceitável, composição farmacêutica, uso de um composto ou de um seu sal, éster ou outro derivado farmacologicamente aceitável, e, processo para a preparação do mesmo
WO2002018395A1 (en) 2000-08-31 2002-03-07 Merck & Co., Inc. Phosphate derivatives as immunoregulatory agents
US6953332B1 (en) 2000-11-28 2005-10-11 St. Jude Medical, Inc. Mandrel for use in forming valved prostheses having polymer leaflets by dip coating
IL157773A0 (en) 2001-03-26 2004-03-28 Novartis Ag 2-amino-propanol derivatives
US7521192B2 (en) 2001-04-18 2009-04-21 Rigel Pharmaceuticals, Inc. EDG: modulators of lymphocyte activation and migration
JP2002316985A (ja) 2001-04-20 2002-10-31 Sankyo Co Ltd ベンゾチオフェン誘導体
JPWO2003020313A1 (ja) 2001-09-04 2004-12-16 小野薬品工業株式会社 スフィンゴシン−1−リン酸受容体調節剤からなる呼吸器疾患治療剤
EP1431275B1 (en) 2001-09-27 2010-04-07 Kyorin Pharmaceutical Co., Ltd. Diaryl ether derivative, addition salt thereof, and immunosuppressant
BRPI0212894B8 (pt) 2001-09-27 2021-05-25 Kyorin Seiyaku Kk composto ou sal do mesmo farmaceuticamente aceitável e composição farmacêutica
EP1470137B1 (en) 2002-01-18 2009-09-02 Merck & Co., Inc. Edg receptor agonists
JP4709488B2 (ja) 2002-01-18 2011-06-22 メルク・シャープ・エンド・ドーム・コーポレイション Edg受容体作動薬としてのN−(ベンジル)アミノアルキルカルボン酸化合物、ホスフィン酸化合物、ホスホン酸化合物およびテトラゾール類
WO2003062392A2 (en) 2002-01-18 2003-07-31 Ceretek Llc Methods of treating conditions associated with an edg receptor
EP1469863A2 (en) 2002-01-18 2004-10-27 Merck & Co., Inc. Selective s1p1/edg1 receptor agonists
CN101884781B (zh) * 2004-07-16 2012-07-18 杏林制药株式会社 用于对器官或组织的移植的排异反应或骨髓移植的移植物抗宿主反应预防或治疗的药物组合物

Also Published As

Publication number Publication date
ITMI20040682A1 (it) 2004-07-06
FR11C0036I1 (fr) 2011-10-14
US20140011885A1 (en) 2014-01-09
US20220031609A1 (en) 2022-02-03
CN101797241B (zh) 2013-03-27
NO20100250L (no) 2006-01-09
CL2011000450A1 (es) 2011-11-25
EP2008650A2 (en) 2008-12-31
CN101797241A (zh) 2010-08-11
LU91867I2 (fr) 2011-11-08
DE102004016947A1 (de) 2004-10-21
RU2005134173A (ru) 2006-09-10
CY1117071T1 (el) 2017-04-05
PL1613288T3 (pl) 2009-07-31
IS2682B (is) 2010-10-15
EP2316431B1 (en) 2015-09-30
DE202004021680U1 (de) 2010-04-22
EP1613288A1 (en) 2006-01-11
RU2009105403A (ru) 2010-08-27
CL2004000745A1 (es) 2005-02-11
BE1015972A5 (fr) 2005-12-06
DK1613288T3 (da) 2009-03-23
EP2008650A3 (en) 2011-04-27
AU2004228929B2 (en) 2008-02-07
IL197578A (en) 2015-10-29
ZA200507394B (en) 2007-03-28
SI2316431T1 (sl) 2016-04-29
RU2010147000A (ru) 2012-08-10
HUS1100016I1 (hu) 2016-08-29
FR2854073A1 (fr) 2004-10-29
FR2854073B1 (fr) 2008-03-14
US20140255497A1 (en) 2014-09-11
HRP20050886B1 (en) 2011-01-31
PE20131352A1 (es) 2013-11-14
JP5543298B2 (ja) 2014-07-09
KR20050121712A (ko) 2005-12-27
PE20150676A1 (es) 2015-05-17
IE20040246A1 (en) 2004-12-15
IS8885A (is) 2010-02-25
US20090203798A1 (en) 2009-08-13
ES2320767T3 (es) 2009-05-28
HK1091114A1 (en) 2007-01-12
HK1071685A1 (en) 2005-07-29
US20110105620A1 (en) 2011-05-05
WO2004089341A1 (en) 2004-10-21
DK2316431T3 (en) 2016-01-11
MY141249A (en) 2010-03-31
JP2011006461A (ja) 2011-01-13
CN1767819B (zh) 2010-07-28
NO2011016I1 (no) 2011-09-19
JP2013177404A (ja) 2013-09-09
CY2011013I2 (el) 2014-04-09
BE2011C030I2 (enEXAMPLES) 2023-03-07
US20190175527A1 (en) 2019-06-13
KR20120101148A (ko) 2012-09-12
US20080311188A1 (en) 2008-12-18
AT501681A1 (de) 2006-10-15
US20060275357A1 (en) 2006-12-07
PE20050396A1 (es) 2005-07-05
SI1613288T1 (sl) 2009-04-30
ES2228282B1 (es) 2006-02-16
CY1110260T1 (el) 2014-04-09
SG175449A1 (en) 2011-11-28
CA2521325A1 (en) 2004-10-21
CN1767819A (zh) 2006-05-03
HRP20100601A2 (hr) 2011-03-31
AU2004228929A1 (en) 2004-10-21
HRP20100600A2 (hr) 2011-03-31
NZ592339A (en) 2012-09-28
ATE414508T1 (de) 2008-12-15
PE20130200A1 (es) 2013-03-09
GB0407819D0 (en) 2004-05-12
NO20055231L (no) 2006-01-09
PL2316431T3 (pl) 2016-09-30
BRPI0409250B1 (pt) 2017-07-11
DE602004017847D1 (de) 2009-01-02
EP2319502A1 (en) 2011-05-11
ES2228282A1 (es) 2005-04-01
KR101367574B1 (ko) 2014-02-25
IL197578A0 (en) 2011-07-31
MXPA05010860A (es) 2006-05-25
RU2475236C2 (ru) 2013-02-20
GR1005052B (el) 2005-11-30
MA27729A1 (fr) 2006-01-02
RU2475237C2 (ru) 2013-02-20
NO2011016I2 (no) 2012-08-27
IL242037A0 (en) 2015-11-30
AR078781A2 (es) 2011-11-30
NO334116B1 (no) 2013-12-16
RU2012148593A (ru) 2014-05-20
EP2769713A1 (en) 2014-08-27
PT1613288E (pt) 2009-02-25
HRP20100601B1 (hr) 2016-12-02
NZ542622A (en) 2009-01-31
AR078782A2 (es) 2011-11-30
CY2011013I1 (el) 2014-04-09
GB2400318A (en) 2004-10-13
AR043987A1 (es) 2005-08-17
CA2707750A1 (en) 2004-10-21
NO20055231D0 (no) 2005-11-07
TWI332847B (en) 2010-11-11
JP5495467B2 (ja) 2014-05-21
IL170888A (en) 2010-06-16
TW200503784A (en) 2005-02-01
BRPI0409250A (pt) 2006-03-28
BRPI0409250B8 (pt) 2022-01-18
JP2004307506A (ja) 2004-11-04
NO20131287L (no) 2006-01-09
EP2316431A1 (en) 2011-05-04
NO329332B1 (no) 2010-09-27
HRP20050886A2 (en) 2006-11-30
EP1613288B1 (en) 2008-11-19
AT501681B1 (de) 2012-04-15
IS8114A (is) 2005-11-01
HUE028247T2 (en) 2016-12-28
PE20090743A1 (es) 2009-07-17
FR11C0036I2 (fr) 2023-12-29
KR20110005320A (ko) 2011-01-17
ES2556947T3 (es) 2016-01-21
HK1155647A1 (en) 2012-05-25
US20130108675A1 (en) 2013-05-02
ECSP056090A (es) 2006-03-01
GB2400318B (en) 2005-08-10
NO335120B1 (no) 2014-09-22
TNSN05256A1 (en) 2007-07-10
US20200237690A1 (en) 2020-07-30
CA2521325C (en) 2010-09-14
RU2010146697A (ru) 2012-05-27
NZ586280A (en) 2011-12-22
DE122011100047I1 (de) 2011-12-15
RU2358716C2 (ru) 2009-06-20
GR20040100121A (el) 2004-12-17
US8324283B2 (en) 2012-12-04
US20170290787A1 (en) 2017-10-12
AT504853A2 (de) 2008-08-15

Similar Documents

Publication Publication Date Title
BE2013C075I2 (enEXAMPLES)
BE2013C070I2 (enEXAMPLES)
BE2013C067I2 (enEXAMPLES)
BE2013C038I2 (enEXAMPLES)
BE2013C036I2 (enEXAMPLES)
BE2011C030I2 (enEXAMPLES)
IN2008MU01654A (enEXAMPLES)
BE2013C034I2 (enEXAMPLES)
IN2005DE04524A (enEXAMPLES)
JP2004008796A5 (enEXAMPLES)
BE2012C053I2 (enEXAMPLES)
IN232619B (enEXAMPLES)
JP2003304446A5 (enEXAMPLES)
JP2004026308A5 (enEXAMPLES)
JP2004005424A5 (enEXAMPLES)
JP2004214046A5 (enEXAMPLES)
JP2004092902A5 (enEXAMPLES)
JP2004048077A5 (enEXAMPLES)
AU2002359010A1 (enEXAMPLES)
AU2002333044A1 (enEXAMPLES)
AU2002362930A1 (enEXAMPLES)
AU2003207787A1 (enEXAMPLES)
AU2002356903A1 (enEXAMPLES)
AU2002355123A1 (enEXAMPLES)
AU2002353888A1 (enEXAMPLES)