LU88639I2 - Agents de contraste pour rayons x - Google Patents

Agents de contraste pour rayons x

Info

Publication number
LU88639I2
LU88639I2 LU88639C LU88639C LU88639I2 LU 88639 I2 LU88639 I2 LU 88639I2 LU 88639 C LU88639 C LU 88639C LU 88639 C LU88639 C LU 88639C LU 88639 I2 LU88639 I2 LU 88639I2
Authority
LU
Luxembourg
Prior art keywords
ch2ch
group
rays
contrast agents
ch2oh
Prior art date
Application number
LU88639C
Other languages
English (en)
French (fr)
Original Assignee
Nycomed Imaging S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging S A filed Critical Nycomed Imaging S A
Publication of LU88639I2 publication Critical patent/LU88639I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Medicinal Preparation (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
LU88639C 1982-11-08 1983-11-07 Agents de contraste pour rayons x LU88639I2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8231796 1982-11-08

Publications (1)

Publication Number Publication Date
LU88639I2 true LU88639I2 (fr) 1996-02-01

Family

ID=10534110

Family Applications (1)

Application Number Title Priority Date Filing Date
LU88639C LU88639I2 (fr) 1982-11-08 1983-11-07 Agents de contraste pour rayons x

Country Status (10)

Country Link
US (1) US5349085A (ref)
EP (1) EP0108638B1 (ref)
JP (1) JPS59104352A (ref)
AT (1) ATE20733T1 (ref)
DE (1) DE3364536D1 (ref)
DK (1) DK160868C (ref)
HK (1) HK46791A (ref)
LU (1) LU88639I2 (ref)
NL (1) NL950010I1 (ref)
NO (2) NO161368C (ref)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3731542A1 (de) * 1987-09-17 1989-03-30 Schering Ag Neue dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6-triiod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel
DE3739098A1 (de) * 1987-11-16 1989-05-24 Schering Ag Neue substituierte dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6- trijod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel
GB8919929D0 (en) * 1989-09-04 1989-10-18 Nycomed As Compositions
IT1252180B (it) * 1991-12-10 1995-06-05 Bracco Ind Chimica Spa 5,5'-(1,3-propandiil) bis (imino (2-osso-2,1-etandiil)acetilimino)-bis(2,4,6-triiodo-1,3-benzendicarbossiamidi),loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono
WO1994022810A1 (es) * 1993-04-01 1994-10-13 Centro Investigacion Justesa Imagen, S.A. Nuevos dimeros iodados no ionicos como agentes de contraste a los rayos x, metodo para su preparacion y composiciones galenicas que los contienen
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
US5840967A (en) * 1996-08-29 1998-11-24 Nycomed Imaging As Process for the preparation of contrast agents
GB9720969D0 (en) 1997-10-02 1997-12-03 Nycomed Imaging As Process
GB9903109D0 (en) 1999-02-11 1999-04-07 Nycomed Imaging As Process
AU2002245169A1 (en) 2000-11-10 2002-07-08 Wm. Marsh Rice University Fullerene (c60)-based x-ray contrast agent for diagnostic imaging
AU2003217676B2 (en) 2002-02-22 2009-06-11 Takeda Pharmaceutical Company Limited Active agent delivery systems and methods for protecting and administering active agents
KR100574087B1 (ko) 2004-09-09 2006-04-27 주식회사태준제약 아이오디사놀의 제조방법
PT1836239E (pt) 2005-01-13 2009-02-02 Cinv Ag Materiais compósitos contendo nanopartículas de carbono
WO2007073202A1 (en) 2005-12-19 2007-06-28 Ge Healthcare As Purification process of iodixanol
DE602007012208D1 (de) 2006-02-15 2011-03-10 Ge Healthcare As Kontrastmittel
FR2899581B1 (fr) * 2006-04-07 2008-06-27 Guerbet Sa Procede d'atomisation du ioxilan
US7662859B2 (en) 2007-02-16 2010-02-16 Ge Healthcare As Contrast agents
RU2469021C2 (ru) * 2007-07-12 2012-12-10 ДжиИ Хелткер АС Контрастные агенты
WO2009047316A1 (en) 2007-10-12 2009-04-16 Ge Healthcare As Contrast agents
US20100221191A1 (en) 2007-10-12 2010-09-02 Duncan George Wynn Contrast agents
EP2200656B1 (en) 2007-10-12 2012-12-05 GE Healthcare AS Contrast agents
CN101820922A (zh) 2007-10-12 2010-09-01 通用电气医疗集团股份有限公司 对比剂
EP2245004A2 (en) * 2008-02-27 2010-11-03 GE Healthcare AS Contrast agents
US8535642B2 (en) 2008-02-27 2013-09-17 Ge Healthcare As Contrast agents
WO2010060941A2 (en) * 2008-11-27 2010-06-03 Ge Healthcare As Contrast agents
CN102271715A (zh) * 2009-01-09 2011-12-07 通用电气医疗集团股份有限公司 对比剂组合物
US7999134B2 (en) * 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using milling
US8969619B2 (en) 2009-07-21 2015-03-03 Ge Healthcare As Synthesis of iodixanol in propyleneglycol
US20110021821A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
US8962887B2 (en) * 2009-07-21 2015-02-24 Ge Healthcare As Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol
US20110021822A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
US20110021832A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Synthesis of iodixanol in water
US8962886B2 (en) 2009-07-21 2015-02-24 Ge Healthcare As Synthesis of iodixanol in methanol
US7999135B2 (en) 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using ultrasound
US7696381B1 (en) 2009-07-21 2010-04-13 Ge Healthcare As Alternative dimerisation reagents for synthesis of iodixanol
US7754920B1 (en) * 2009-07-21 2010-07-13 Ge Healthcare As Solvent reduction in crystallisation of intermediate for non-ionic X-ray contrast agents
PL2493511T3 (pl) * 2009-10-29 2014-05-30 Ge Healthcare As Kompozycja diagnostyczna zawierająca kationy osocza i mająca doskonały profil bezpieczeństwa
KR101699226B1 (ko) 2009-11-26 2017-01-24 호비온 차이나 홀딩 리미티드 이오딕사놀의 제조 및 정제
SG186905A1 (en) 2010-07-12 2013-02-28 Ge Healthcare As X-ray imaging at low contrast agent concentrations and/or low dose radiation
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
CN102816125B (zh) * 2011-06-08 2014-03-26 浙江司太立制药股份有限公司 一种造影剂
WO2013104690A1 (en) 2012-01-11 2013-07-18 Ge Healthcare As X-ray imaging contrast media with low iodine concentration and x-ray imaging process
KR20150061635A (ko) 2012-09-27 2015-06-04 지이 헬스케어 에이에스 아이오포르미놀의 중간체 화합물의 제조법
BR112015006502B1 (pt) 2012-11-12 2021-03-09 Ge Healthcare As processo para a preparação de um composto, produto seco do composto a, e, processo para preparar um agente de contraste
WO2016079330A1 (en) 2014-11-21 2016-05-26 Technical University Of Denmark Gel formulations for local drug release
PT108524B (pt) 2015-06-02 2017-12-15 Hovione Farmaciência S A Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos
SG11201809729XA (en) 2016-05-20 2018-12-28 Univ Denmark Tech Dtu Palpable marker composition
CN111440084B (zh) * 2019-01-16 2023-01-06 苏州纳微科技股份有限公司 一种碘克沙醇的纯化方法
WO2020249801A1 (en) 2019-06-12 2020-12-17 Technical University Of Denmark Dissacharide formulations for controlled drug release
CN113121377A (zh) * 2019-12-31 2021-07-16 江苏汉邦科技有限公司 碘克沙醇的纯化方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE344166B (ref) * 1966-12-13 1972-04-04 Pharmacia Ab
US3804892A (en) * 1967-12-28 1974-04-16 Pharmacia Ab Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof
SE315975B (ref) * 1967-12-28 1969-10-13 Pharmacia Ab
SE315974B (ref) * 1967-12-28 1969-10-13 Pharmacia Ab
US3763227A (en) * 1967-12-28 1973-10-02 Pharmacia Ab Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof
CH544551A (de) * 1969-06-27 1973-11-30 Nyegaard & Co As Neue Röntgenkontrastmittel
NL7102816A (ref) * 1970-03-12 1971-09-14
DD104193A5 (ref) * 1972-12-22 1974-03-05
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
DE2628517C2 (de) * 1976-06-23 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
DE3038853A1 (de) * 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
FR2511871A1 (fr) * 1981-08-28 1983-03-04 Guerbet Sa Procede pour augmenter la tolerance des produits opacifiants et produits opacifiants ainsi obtenus

Also Published As

Publication number Publication date
DK508283A (da) 1984-05-09
DK508283D0 (da) 1983-11-07
JPS59104352A (ja) 1984-06-16
NO834056L (no) 1984-05-09
DE3364536D1 (en) 1986-08-21
NL950010I2 (nl) 1997-02-03
NO1994015I1 (no) 1994-09-05
DK160868C (da) 1991-10-14
JPS6355509B2 (ref) 1988-11-02
EP0108638A1 (en) 1984-05-16
US5349085A (en) 1994-09-20
DK160868B (da) 1991-04-29
NO161368B (no) 1989-05-02
ATE20733T1 (de) 1986-08-15
NO161368C (no) 1989-08-09
HK46791A (en) 1991-06-21
NL950010I1 (nl) 1997-02-03
EP0108638B1 (en) 1986-07-16

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