DK160868C - Trijodfenylderivater, fremgangsmaader til fremstilling deraf og radiologisk praeparat indeholdende dem - Google Patents
Trijodfenylderivater, fremgangsmaader til fremstilling deraf og radiologisk praeparat indeholdende demInfo
- Publication number
- DK160868C DK160868C DK508283A DK508283A DK160868C DK 160868 C DK160868 C DK 160868C DK 508283 A DK508283 A DK 508283A DK 508283 A DK508283 A DK 508283A DK 160868 C DK160868 C DK 160868C
- Authority
- DK
- Denmark
- Prior art keywords
- phenenous
- radiological
- procedures
- derivatives
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8231796 | 1982-11-08 | ||
GB8231796 | 1982-11-08 |
Publications (4)
Publication Number | Publication Date |
---|---|
DK508283D0 DK508283D0 (da) | 1983-11-07 |
DK508283A DK508283A (da) | 1984-05-09 |
DK160868B DK160868B (da) | 1991-04-29 |
DK160868C true DK160868C (da) | 1991-10-14 |
Family
ID=10534110
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK508283A DK160868C (da) | 1982-11-08 | 1983-11-07 | Trijodfenylderivater, fremgangsmaader til fremstilling deraf og radiologisk praeparat indeholdende dem |
Country Status (10)
Country | Link |
---|---|
US (1) | US5349085A (da) |
EP (1) | EP0108638B1 (da) |
JP (1) | JPS59104352A (da) |
AT (1) | ATE20733T1 (da) |
DE (1) | DE3364536D1 (da) |
DK (1) | DK160868C (da) |
HK (1) | HK46791A (da) |
LU (1) | LU88639I2 (da) |
NL (1) | NL950010I2 (da) |
NO (2) | NO161368C (da) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3731542A1 (de) * | 1987-09-17 | 1989-03-30 | Schering Ag | Neue dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6-triiod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel |
DE3739098A1 (de) * | 1987-11-16 | 1989-05-24 | Schering Ag | Neue substituierte dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6- trijod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel |
GB8919929D0 (en) * | 1989-09-04 | 1989-10-18 | Nycomed As | Compositions |
IT1252180B (it) * | 1991-12-10 | 1995-06-05 | Bracco Ind Chimica Spa | 5,5'-(1,3-propandiil) bis (imino (2-osso-2,1-etandiil)acetilimino)-bis(2,4,6-triiodo-1,3-benzendicarbossiamidi),loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono |
WO1994022810A1 (es) * | 1993-04-01 | 1994-10-13 | Centro Investigacion Justesa Imagen, S.A. | Nuevos dimeros iodados no ionicos como agentes de contraste a los rayos x, metodo para su preparacion y composiciones galenicas que los contienen |
US5840967A (en) * | 1996-08-29 | 1998-11-24 | Nycomed Imaging As | Process for the preparation of contrast agents |
GB9618056D0 (en) * | 1996-08-29 | 1996-10-09 | Nycomed Imaging As | Process |
GB9720969D0 (en) * | 1997-10-02 | 1997-12-03 | Nycomed Imaging As | Process |
GB9903109D0 (en) * | 1999-02-11 | 1999-04-07 | Nycomed Imaging As | Process |
WO2003079972A2 (en) | 2002-02-22 | 2003-10-02 | New River Parmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
WO2002051301A2 (en) | 2000-11-10 | 2002-07-04 | Wm. Marsh Rice University | Fullerene (c60)-based x-ray contrast agent for diagnostic imaging |
KR100574087B1 (ko) | 2004-09-09 | 2006-04-27 | 주식회사태준제약 | 아이오디사놀의 제조방법 |
CN101098916A (zh) | 2005-01-13 | 2008-01-02 | 金文申有限公司 | 含有碳纳米颗粒的复合材料 |
ES2413761T3 (es) | 2005-12-19 | 2013-07-17 | Ge Healthcare As | Procedimiento de purificación de iodixanol |
ES2357861T3 (es) | 2006-02-15 | 2011-05-03 | Ge Healthcare As | Agentes de contraste. |
FR2899581B1 (fr) * | 2006-04-07 | 2008-06-27 | Guerbet Sa | Procede d'atomisation du ioxilan |
US7662859B2 (en) | 2007-02-16 | 2010-02-16 | Ge Healthcare As | Contrast agents |
ES2486296T3 (es) * | 2007-07-12 | 2014-08-18 | Ge Healthcare As | Agentes de contraste |
US20100209356A1 (en) | 2007-10-12 | 2010-08-19 | Duncan George Wynn | Contrast agents |
ES2389974T3 (es) | 2007-10-12 | 2012-11-05 | Ge Healthcare As | Agentes de contraste |
EP2200656B1 (en) | 2007-10-12 | 2012-12-05 | GE Healthcare AS | Contrast agents |
WO2009047318A1 (en) | 2007-10-12 | 2009-04-16 | Ge Healthcare As | Contrast agents |
US8535642B2 (en) | 2008-02-27 | 2013-09-17 | Ge Healthcare As | Contrast agents |
US20110008263A1 (en) * | 2008-02-27 | 2011-01-13 | Hanno Priebe | Contrast agents |
WO2010060941A2 (en) * | 2008-11-27 | 2010-06-03 | Ge Healthcare As | Contrast agents |
US20110256068A1 (en) * | 2009-01-09 | 2011-10-20 | Wistand Lars-Goeran | Contrast media compositions |
US8962887B2 (en) * | 2009-07-21 | 2015-02-24 | Ge Healthcare As | Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol |
US20110021832A1 (en) * | 2009-07-21 | 2011-01-27 | Ge Healthcare As | Synthesis of iodixanol in water |
US7999135B2 (en) | 2009-07-21 | 2011-08-16 | Ge Healthcare As | Crystallization of iodixanol using ultrasound |
US7754920B1 (en) * | 2009-07-21 | 2010-07-13 | Ge Healthcare As | Solvent reduction in crystallisation of intermediate for non-ionic X-ray contrast agents |
US20110021822A1 (en) * | 2009-07-21 | 2011-01-27 | Ge Healthcare As | continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents |
US20110021821A1 (en) * | 2009-07-21 | 2011-01-27 | Ge Healthcare As | Continuous acetylation process in synthesis of non-ionic x-ray contrast agents |
US7999134B2 (en) | 2009-07-21 | 2011-08-16 | Ge Healthcare As | Crystallization of iodixanol using milling |
US8962886B2 (en) * | 2009-07-21 | 2015-02-24 | Ge Healthcare As | Synthesis of iodixanol in methanol |
US7696381B1 (en) | 2009-07-21 | 2010-04-13 | Ge Healthcare As | Alternative dimerisation reagents for synthesis of iodixanol |
US8969619B2 (en) | 2009-07-21 | 2015-03-03 | Ge Healthcare As | Synthesis of iodixanol in propyleneglycol |
KR101545045B1 (ko) * | 2009-10-29 | 2015-08-17 | 지이 헬스케어 에이에스 | 탁월한 안전성 프로파일을 갖는 혈장 양이온을 포함하는 진단학적 조성물 |
CN102725249B (zh) * | 2009-11-26 | 2014-12-10 | 好利安中国控股有限公司 | 碘克沙醇的制备和纯化 |
WO2012007456A1 (en) | 2010-07-12 | 2012-01-19 | Ge Healthcare As | X-ray imaging at low contrast agent concentrations and/or low dose radiation |
WO2012136813A2 (en) | 2011-04-07 | 2012-10-11 | Universitetet I Oslo | Agents for medical radar diagnosis |
CN102816125B (zh) * | 2011-06-08 | 2014-03-26 | 浙江司太立制药股份有限公司 | 一种造影剂 |
SG11201403963XA (en) | 2012-01-11 | 2014-08-28 | Ge Healthcare As | X-ray imaging contrast media with low iodine concentration and x-ray imaging process |
RU2654461C2 (ru) | 2012-09-27 | 2018-05-18 | ДжиИ Хелткер АС | Получение промежуточного соединения синтеза иоформинола |
JP6248119B2 (ja) | 2012-11-12 | 2017-12-13 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | X線造影剤の中間体の製造 |
WO2016079330A1 (en) | 2014-11-21 | 2016-05-26 | Technical University Of Denmark | Gel formulations for local drug release |
PT108524B (pt) | 2015-06-02 | 2017-12-15 | Hovione Farmaciência S A | Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos |
EP3458029A1 (en) | 2016-05-20 | 2019-03-27 | Technical University of Denmark | Palpable marker composition |
CN111440084B (zh) * | 2019-01-16 | 2023-01-06 | 苏州纳微科技股份有限公司 | 一种碘克沙醇的纯化方法 |
CA3143104A1 (en) | 2019-06-12 | 2020-12-17 | Technical University Of Denmark | Dissacharide formulations for controlled drug release |
CN113121377A (zh) * | 2019-12-31 | 2021-07-16 | 江苏汉邦科技有限公司 | 碘克沙醇的纯化方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE344166B (da) * | 1966-12-13 | 1972-04-04 | Pharmacia Ab | |
US3763227A (en) * | 1967-12-28 | 1973-10-02 | Pharmacia Ab | Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof |
SE315974B (da) * | 1967-12-28 | 1969-10-13 | Pharmacia Ab | |
SE315975B (da) * | 1967-12-28 | 1969-10-13 | Pharmacia Ab | |
US3804892A (en) * | 1967-12-28 | 1974-04-16 | Pharmacia Ab | Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof |
ES381202A1 (es) * | 1969-06-27 | 1973-04-16 | Nyegaard & Co As | Un procedimiento para la preparacion de agentes de contras-te de rayos x. |
NL7102816A (da) * | 1970-03-12 | 1971-09-14 | ||
DD104193A5 (da) * | 1972-12-22 | 1974-03-05 | ||
GB1548594A (en) * | 1976-06-11 | 1979-07-18 | Nyegaard & Co As | Triiodoisophthalic acid amides |
DE2628517C2 (de) * | 1976-06-23 | 1985-02-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel |
IT1207226B (it) * | 1979-08-09 | 1989-05-17 | Bracco Ind Chimica Spa | Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono. |
DE3038853A1 (de) * | 1980-10-10 | 1982-05-27 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii) |
FR2511871A1 (fr) * | 1981-08-28 | 1983-03-04 | Guerbet Sa | Procede pour augmenter la tolerance des produits opacifiants et produits opacifiants ainsi obtenus |
-
1983
- 1983-11-07 LU LU88639C patent/LU88639I2/fr unknown
- 1983-11-07 DE DE8383306766T patent/DE3364536D1/de not_active Expired
- 1983-11-07 EP EP83306766A patent/EP0108638B1/en not_active Expired
- 1983-11-07 NO NO834056A patent/NO161368C/no not_active IP Right Cessation
- 1983-11-07 DK DK508283A patent/DK160868C/da not_active IP Right Cessation
- 1983-11-07 AT AT83306766T patent/ATE20733T1/de active
- 1983-11-07 JP JP58207650A patent/JPS59104352A/ja active Granted
-
1991
- 1991-06-11 HK HK467/91A patent/HK46791A/xx not_active IP Right Cessation
-
1992
- 1992-10-13 US US07/960,231 patent/US5349085A/en not_active Expired - Lifetime
-
1994
- 1994-09-05 NO NO1994015C patent/NO1994015I1/no unknown
-
1995
- 1995-06-15 NL NL950010C patent/NL950010I2/nl unknown
Also Published As
Publication number | Publication date |
---|---|
DE3364536D1 (en) | 1986-08-21 |
EP0108638B1 (en) | 1986-07-16 |
DK508283A (da) | 1984-05-09 |
ATE20733T1 (de) | 1986-08-15 |
EP0108638A1 (en) | 1984-05-16 |
HK46791A (en) | 1991-06-21 |
LU88639I2 (fr) | 1996-02-01 |
NO161368C (no) | 1989-08-09 |
DK160868B (da) | 1991-04-29 |
DK508283D0 (da) | 1983-11-07 |
NO834056L (no) | 1984-05-09 |
NO161368B (no) | 1989-05-02 |
NL950010I1 (nl) | 1997-02-03 |
JPS6355509B2 (da) | 1988-11-02 |
NL950010I2 (nl) | 1997-02-03 |
US5349085A (en) | 1994-09-20 |
NO1994015I1 (no) | 1994-09-05 |
JPS59104352A (ja) | 1984-06-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CTFF | Application for supplementary protection certificate (spc) filed |
Free format text: CA 1995 00006, 950504 |
|
CTFG | Supplementary protection certificate (spc) issued |
Free format text: CA 1995 00006, 950504, EXPIRES: 20080205 |
|
PUP | Patent expired |