HK46791A - X-ray contrast agents - Google Patents

X-ray contrast agents

Info

Publication number
HK46791A
HK46791A HK467/91A HK46791A HK46791A HK 46791 A HK46791 A HK 46791A HK 467/91 A HK467/91 A HK 467/91A HK 46791 A HK46791 A HK 46791A HK 46791 A HK46791 A HK 46791A
Authority
HK
Hong Kong
Prior art keywords
ch2ch
group
contrast agents
ray contrast
ch2oh
Prior art date
Application number
HK467/91A
Other languages
English (en)
Inventor
Per-Egil Hansen
Hugo Holtermann
Knut Wille
Original Assignee
Nycomed As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed As filed Critical Nycomed As
Publication of HK46791A publication Critical patent/HK46791A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Medicinal Preparation (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
HK467/91A 1982-11-08 1991-06-11 X-ray contrast agents HK46791A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8231796 1982-11-08

Publications (1)

Publication Number Publication Date
HK46791A true HK46791A (en) 1991-06-21

Family

ID=10534110

Family Applications (1)

Application Number Title Priority Date Filing Date
HK467/91A HK46791A (en) 1982-11-08 1991-06-11 X-ray contrast agents

Country Status (10)

Country Link
US (1) US5349085A (da)
EP (1) EP0108638B1 (da)
JP (1) JPS59104352A (da)
AT (1) ATE20733T1 (da)
DE (1) DE3364536D1 (da)
DK (1) DK160868C (da)
HK (1) HK46791A (da)
LU (1) LU88639I2 (da)
NL (1) NL950010I2 (da)
NO (2) NO161368C (da)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3731542A1 (de) * 1987-09-17 1989-03-30 Schering Ag Neue dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6-triiod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel
DE3739098A1 (de) * 1987-11-16 1989-05-24 Schering Ag Neue substituierte dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6- trijod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel
GB8919929D0 (en) 1989-09-04 1989-10-18 Nycomed As Compositions
IT1252180B (it) * 1991-12-10 1995-06-05 Bracco Ind Chimica Spa 5,5'-(1,3-propandiil) bis (imino (2-osso-2,1-etandiil)acetilimino)-bis(2,4,6-triiodo-1,3-benzendicarbossiamidi),loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono
WO1994022810A1 (es) * 1993-04-01 1994-10-13 Centro Investigacion Justesa Imagen, S.A. Nuevos dimeros iodados no ionicos como agentes de contraste a los rayos x, metodo para su preparacion y composiciones galenicas que los contienen
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
US5840967A (en) * 1996-08-29 1998-11-24 Nycomed Imaging As Process for the preparation of contrast agents
GB9720969D0 (en) 1997-10-02 1997-12-03 Nycomed Imaging As Process
GB9903109D0 (en) * 1999-02-11 1999-04-07 Nycomed Imaging As Process
US6660248B2 (en) 2000-11-10 2003-12-09 William Marsh Rice University Fullerene (C60)-based X-ray contrast agent for diagnostic imaging
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
KR100574087B1 (ko) 2004-09-09 2006-04-27 주식회사태준제약 아이오디사놀의 제조방법
CN101098916A (zh) 2005-01-13 2008-01-02 金文申有限公司 含有碳纳米颗粒的复合材料
ES2413761T3 (es) 2005-12-19 2013-07-17 Ge Healthcare As Procedimiento de purificación de iodixanol
WO2007094683A1 (en) 2006-02-15 2007-08-23 Ge Healthcare As Contrast agents
FR2899581B1 (fr) * 2006-04-07 2008-06-27 Guerbet Sa Procede d'atomisation du ioxilan
US7662859B2 (en) 2007-02-16 2010-02-16 Ge Healthcare As Contrast agents
AU2008273037B2 (en) * 2007-07-12 2012-11-15 Ge Healthcare As Contrast agents
WO2009047316A1 (en) 2007-10-12 2009-04-16 Ge Healthcare As Contrast agents
CN101820923A (zh) 2007-10-12 2010-09-01 通用电气医疗集团股份有限公司 对比剂
CN101820924A (zh) 2007-10-12 2010-09-01 通用电气医疗集团股份有限公司 造影剂
US20100221192A1 (en) 2007-10-12 2010-09-02 Duncan George Wynn Contrast agents
EP2245003A2 (en) * 2008-02-27 2010-11-03 GE Healthcare AS Contrast agents
EP2245004A2 (en) * 2008-02-27 2010-11-03 GE Healthcare AS Contrast agents
WO2010060941A2 (en) * 2008-11-27 2010-06-03 Ge Healthcare As Contrast agents
EP2385845A1 (en) 2009-01-09 2011-11-16 Ge Healthcare As Contrast media compositions
US7696381B1 (en) 2009-07-21 2010-04-13 Ge Healthcare As Alternative dimerisation reagents for synthesis of iodixanol
US8962887B2 (en) * 2009-07-21 2015-02-24 Ge Healthcare As Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol
US20110021832A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Synthesis of iodixanol in water
US8969619B2 (en) * 2009-07-21 2015-03-03 Ge Healthcare As Synthesis of iodixanol in propyleneglycol
US20110021821A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
US7754920B1 (en) * 2009-07-21 2010-07-13 Ge Healthcare As Solvent reduction in crystallisation of intermediate for non-ionic X-ray contrast agents
US7999135B2 (en) 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using ultrasound
US7999134B2 (en) * 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using milling
US20110021822A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
US8962886B2 (en) 2009-07-21 2015-02-24 Ge Healthcare As Synthesis of iodixanol in methanol
PL2493511T3 (pl) * 2009-10-29 2014-05-30 Ge Healthcare As Kompozycja diagnostyczna zawierająca kationy osocza i mająca doskonały profil bezpieczeństwa
JP5775524B2 (ja) * 2009-11-26 2015-09-09 アイマックス ダイアグノスティック イメージング ホールディング リミテッド イオジキサノールの調製及び精製
CN105194692A (zh) 2010-07-12 2015-12-30 通用电气医疗集团股份有限公司 以低造影剂浓度和/或低剂量辐射的x-射线成像
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
CN102816125B (zh) * 2011-06-08 2014-03-26 浙江司太立制药股份有限公司 一种造影剂
AU2013208955B2 (en) 2012-01-11 2017-11-16 Ge Healthcare As X-ray imaging contrast media with low iodine concentration and X-ray imaging process
US9884808B2 (en) 2012-09-27 2018-02-06 Ge Healthcare As Preparation of an intermediate compound of ioforminol
CN110229079A (zh) 2012-11-12 2019-09-13 通用电气医疗集团股份有限公司 X-射线造影剂中间体的制备
EP3220887A1 (en) 2014-11-21 2017-09-27 Technical University of Denmark Gel formulations for local drug release
PT108524B (pt) 2015-06-02 2017-12-15 Hovione Farmaciência S A Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos
WO2017198858A1 (en) 2016-05-20 2017-11-23 Technical University Of Denmark Palpable marker composition
CN111440084B (zh) * 2019-01-16 2023-01-06 苏州纳微科技股份有限公司 一种碘克沙醇的纯化方法
EP3982922A1 (en) 2019-06-12 2022-04-20 Technical University of Denmark Dissacharide formulations for controlled drug release
CN113121377A (zh) * 2019-12-31 2021-07-16 江苏汉邦科技有限公司 碘克沙醇的纯化方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE344166B (da) * 1966-12-13 1972-04-04 Pharmacia Ab
US3804892A (en) * 1967-12-28 1974-04-16 Pharmacia Ab Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof
US3763227A (en) * 1967-12-28 1973-10-02 Pharmacia Ab Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof
SE315975B (da) * 1967-12-28 1969-10-13 Pharmacia Ab
SE315974B (da) * 1967-12-28 1969-10-13 Pharmacia Ab
NO129093B (da) * 1969-06-27 1974-02-25 Nyegaard & Co As
NL7102816A (da) * 1970-03-12 1971-09-14
DD104193A5 (da) * 1972-12-22 1974-03-05
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
DE2628517C2 (de) * 1976-06-23 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
DE3038853A1 (de) * 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
FR2511871A1 (fr) * 1981-08-28 1983-03-04 Guerbet Sa Procede pour augmenter la tolerance des produits opacifiants et produits opacifiants ainsi obtenus

Also Published As

Publication number Publication date
NO1994015I1 (no) 1994-09-05
NO161368C (no) 1989-08-09
DK508283D0 (da) 1983-11-07
DK160868C (da) 1991-10-14
EP0108638B1 (en) 1986-07-16
JPS6355509B2 (da) 1988-11-02
EP0108638A1 (en) 1984-05-16
JPS59104352A (ja) 1984-06-16
NO161368B (no) 1989-05-02
DE3364536D1 (en) 1986-08-21
NL950010I1 (nl) 1997-02-03
LU88639I2 (fr) 1996-02-01
NO834056L (no) 1984-05-09
DK160868B (da) 1991-04-29
NL950010I2 (nl) 1997-02-03
ATE20733T1 (de) 1986-08-15
DK508283A (da) 1984-05-09
US5349085A (en) 1994-09-20

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Legal Events

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