NO1994015I1 - Iodixanol/ 1,3-bis(acetylamino-N,N<O>1</O>-bis[3,5-bis(2,3-dihydroksypropylaminokrabonyl)-2,4,6-trijod-fenyl]-2-hydroksypropan - Google Patents
Iodixanol/ 1,3-bis(acetylamino-N,N<O>1</O>-bis[3,5-bis(2,3-dihydroksypropylaminokrabonyl)-2,4,6-trijod-fenyl]-2-hydroksypropanInfo
- Publication number
- NO1994015I1 NO1994015I1 NO1994015C NO1994015C NO1994015I1 NO 1994015 I1 NO1994015 I1 NO 1994015I1 NO 1994015 C NO1994015 C NO 1994015C NO 1994015 C NO1994015 C NO 1994015C NO 1994015 I1 NO1994015 I1 NO 1994015I1
- Authority
- NO
- Norway
- Prior art keywords
- bis
- acetylamino
- ch2ch
- dihydroxypropylaminocarbonyl
- iodixanol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Meat, Egg Or Seafood Products (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Polyesters Or Polycarbonates (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8231796 | 1982-11-08 | ||
EP83306766A EP0108638B1 (en) | 1982-11-08 | 1983-11-07 | X-ray contrast agents |
Publications (1)
Publication Number | Publication Date |
---|---|
NO1994015I1 true NO1994015I1 (no) | 1994-09-05 |
Family
ID=10534110
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO834056A NO161368C (no) | 1982-11-08 | 1983-11-07 | Roentgenkontrastmidler samt radiologiske preparater derav. |
NO1994015C NO1994015I1 (no) | 1982-11-08 | 1994-09-05 | Iodixanol/ 1,3-bis(acetylamino-N,N<O>1</O>-bis[3,5-bis(2,3-dihydroksypropylaminokrabonyl)-2,4,6-trijod-fenyl]-2-hydroksypropan |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO834056A NO161368C (no) | 1982-11-08 | 1983-11-07 | Roentgenkontrastmidler samt radiologiske preparater derav. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5349085A (no) |
EP (1) | EP0108638B1 (no) |
JP (1) | JPS59104352A (no) |
AT (1) | ATE20733T1 (no) |
DE (1) | DE3364536D1 (no) |
DK (1) | DK160868C (no) |
HK (1) | HK46791A (no) |
LU (1) | LU88639I2 (no) |
NL (1) | NL950010I2 (no) |
NO (2) | NO161368C (no) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3731542A1 (de) * | 1987-09-17 | 1989-03-30 | Schering Ag | Neue dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6-triiod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel |
DE3739098A1 (de) * | 1987-11-16 | 1989-05-24 | Schering Ag | Neue substituierte dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6- trijod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel |
GB8919929D0 (en) | 1989-09-04 | 1989-10-18 | Nycomed As | Compositions |
IT1252180B (it) * | 1991-12-10 | 1995-06-05 | Bracco Ind Chimica Spa | 5,5'-(1,3-propandiil) bis (imino (2-osso-2,1-etandiil)acetilimino)-bis(2,4,6-triiodo-1,3-benzendicarbossiamidi),loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono |
WO1994022810A1 (es) * | 1993-04-01 | 1994-10-13 | Centro Investigacion Justesa Imagen, S.A. | Nuevos dimeros iodados no ionicos como agentes de contraste a los rayos x, metodo para su preparacion y composiciones galenicas que los contienen |
US5840967A (en) * | 1996-08-29 | 1998-11-24 | Nycomed Imaging As | Process for the preparation of contrast agents |
GB9618056D0 (en) * | 1996-08-29 | 1996-10-09 | Nycomed Imaging As | Process |
GB9720969D0 (en) | 1997-10-02 | 1997-12-03 | Nycomed Imaging As | Process |
GB9903109D0 (en) * | 1999-02-11 | 1999-04-07 | Nycomed Imaging As | Process |
US6660248B2 (en) | 2000-11-10 | 2003-12-09 | William Marsh Rice University | Fullerene (C60)-based X-ray contrast agent for diagnostic imaging |
AU2003217676B2 (en) | 2002-02-22 | 2009-06-11 | Takeda Pharmaceutical Company Limited | Active agent delivery systems and methods for protecting and administering active agents |
KR100574087B1 (ko) | 2004-09-09 | 2006-04-27 | 주식회사태준제약 | 아이오디사놀의 제조방법 |
EP2014728A1 (en) | 2005-01-13 | 2009-01-14 | Cinvention Ag | Composite material coatings |
WO2007073202A1 (en) | 2005-12-19 | 2007-06-28 | Ge Healthcare As | Purification process of iodixanol |
CN101379023A (zh) | 2006-02-15 | 2009-03-04 | 通用电气医疗集团股份有限公司 | 造影剂 |
FR2899581B1 (fr) * | 2006-04-07 | 2008-06-27 | Guerbet Sa | Procede d'atomisation du ioxilan |
US7662859B2 (en) | 2007-02-16 | 2010-02-16 | Ge Healthcare As | Contrast agents |
JP5340281B2 (ja) * | 2007-07-12 | 2013-11-13 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤 |
JP2011500533A (ja) | 2007-10-12 | 2011-01-06 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤 |
JP2011500531A (ja) | 2007-10-12 | 2011-01-06 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤 |
WO2009047315A1 (en) | 2007-10-12 | 2009-04-16 | Ge Healthcare As | Contrast agents |
ES2389975T3 (es) | 2007-10-12 | 2012-11-05 | Ge Healthcare As | Agentes de contraste |
EP2245004A2 (en) * | 2008-02-27 | 2010-11-03 | GE Healthcare AS | Contrast agents |
EP2245003A2 (en) * | 2008-02-27 | 2010-11-03 | GE Healthcare AS | Contrast agents |
WO2010060941A2 (en) * | 2008-11-27 | 2010-06-03 | Ge Healthcare As | Contrast agents |
US20110256068A1 (en) * | 2009-01-09 | 2011-10-20 | Wistand Lars-Goeran | Contrast media compositions |
US20110021832A1 (en) * | 2009-07-21 | 2011-01-27 | Ge Healthcare As | Synthesis of iodixanol in water |
US7999134B2 (en) * | 2009-07-21 | 2011-08-16 | Ge Healthcare As | Crystallization of iodixanol using milling |
US7696381B1 (en) | 2009-07-21 | 2010-04-13 | Ge Healthcare As | Alternative dimerisation reagents for synthesis of iodixanol |
US8962886B2 (en) * | 2009-07-21 | 2015-02-24 | Ge Healthcare As | Synthesis of iodixanol in methanol |
US8969619B2 (en) * | 2009-07-21 | 2015-03-03 | Ge Healthcare As | Synthesis of iodixanol in propyleneglycol |
US8962887B2 (en) * | 2009-07-21 | 2015-02-24 | Ge Healthcare As | Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol |
US20110021822A1 (en) * | 2009-07-21 | 2011-01-27 | Ge Healthcare As | continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents |
US20110021821A1 (en) * | 2009-07-21 | 2011-01-27 | Ge Healthcare As | Continuous acetylation process in synthesis of non-ionic x-ray contrast agents |
US7999135B2 (en) | 2009-07-21 | 2011-08-16 | Ge Healthcare As | Crystallization of iodixanol using ultrasound |
US7754920B1 (en) * | 2009-07-21 | 2010-07-13 | Ge Healthcare As | Solvent reduction in crystallisation of intermediate for non-ionic X-ray contrast agents |
NZ598540A (en) * | 2009-10-29 | 2014-03-28 | Ge Healthcare As | Diagnostic composition comprising plasma cations having superior safety profile |
EP2504298B1 (en) * | 2009-11-26 | 2016-09-21 | iMAX Diagnostic Imaging Holding Limited | Preparation and purification of iodixanol |
RU2566281C2 (ru) | 2010-07-12 | 2015-10-20 | ДжиИ Хелткер АС | Рентгеновская визуализация при низких концентрациях контрастного агента и/или низкой дозе излучения |
WO2012136813A2 (en) | 2011-04-07 | 2012-10-11 | Universitetet I Oslo | Agents for medical radar diagnosis |
CN102816125B (zh) * | 2011-06-08 | 2014-03-26 | 浙江司太立制药股份有限公司 | 一种造影剂 |
CN107982550A (zh) | 2012-01-11 | 2018-05-04 | 通用电气医疗集团股份有限公司 | 具有低碘浓度的x-射线成像造影介质和x-射线成像方法 |
RU2654461C2 (ru) | 2012-09-27 | 2018-05-18 | ДжиИ Хелткер АС | Получение промежуточного соединения синтеза иоформинола |
BR112015006502B1 (pt) | 2012-11-12 | 2021-03-09 | Ge Healthcare As | processo para a preparação de um composto, produto seco do composto a, e, processo para preparar um agente de contraste |
CN115501172A (zh) | 2014-11-21 | 2022-12-23 | 丹麦技术大学 | 用于局部药物释放的凝胶制剂 |
PT108524B (pt) | 2015-06-02 | 2017-12-15 | Hovione Farmaciência S A | Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos |
US11058780B2 (en) | 2016-05-20 | 2021-07-13 | Technical University Of Denmark | Palpable marker composition |
CN111440084B (zh) * | 2019-01-16 | 2023-01-06 | 苏州纳微科技股份有限公司 | 一种碘克沙醇的纯化方法 |
US20220339285A1 (en) | 2019-06-12 | 2022-10-27 | Technical University Of Denmark | Dissacharide formulations for controlled drug release |
CN113121377A (zh) * | 2019-12-31 | 2021-07-16 | 江苏汉邦科技有限公司 | 碘克沙醇的纯化方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE344166B (no) * | 1966-12-13 | 1972-04-04 | Pharmacia Ab | |
SE315974B (no) * | 1967-12-28 | 1969-10-13 | Pharmacia Ab | |
US3763227A (en) * | 1967-12-28 | 1973-10-02 | Pharmacia Ab | Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof |
SE315975B (no) * | 1967-12-28 | 1969-10-13 | Pharmacia Ab | |
US3804892A (en) * | 1967-12-28 | 1974-04-16 | Pharmacia Ab | Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof |
IL34803A (en) * | 1969-06-27 | 1975-03-13 | Nyegaard & Co As | N-hydroxyalkyl substituted benzamides and iodo methanesulfonamide and radiological compositions containing them |
NL7102816A (no) * | 1970-03-12 | 1971-09-14 | ||
DD104193A5 (no) * | 1972-12-22 | 1974-03-05 | ||
GB1548594A (en) * | 1976-06-11 | 1979-07-18 | Nyegaard & Co As | Triiodoisophthalic acid amides |
DE2628517C2 (de) * | 1976-06-23 | 1985-02-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel |
IT1207226B (it) * | 1979-08-09 | 1989-05-17 | Bracco Ind Chimica Spa | Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono. |
DE3038853A1 (de) * | 1980-10-10 | 1982-05-27 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii) |
FR2511871A1 (fr) * | 1981-08-28 | 1983-03-04 | Guerbet Sa | Procede pour augmenter la tolerance des produits opacifiants et produits opacifiants ainsi obtenus |
-
1983
- 1983-11-07 NO NO834056A patent/NO161368C/no not_active IP Right Cessation
- 1983-11-07 AT AT83306766T patent/ATE20733T1/de active
- 1983-11-07 DE DE8383306766T patent/DE3364536D1/de not_active Expired
- 1983-11-07 EP EP83306766A patent/EP0108638B1/en not_active Expired
- 1983-11-07 LU LU88639C patent/LU88639I2/fr unknown
- 1983-11-07 JP JP58207650A patent/JPS59104352A/ja active Granted
- 1983-11-07 DK DK508283A patent/DK160868C/da not_active IP Right Cessation
-
1991
- 1991-06-11 HK HK467/91A patent/HK46791A/xx not_active IP Right Cessation
-
1992
- 1992-10-13 US US07/960,231 patent/US5349085A/en not_active Expired - Lifetime
-
1994
- 1994-09-05 NO NO1994015C patent/NO1994015I1/no unknown
-
1995
- 1995-06-15 NL NL950010C patent/NL950010I2/nl unknown
Also Published As
Publication number | Publication date |
---|---|
DK508283A (da) | 1984-05-09 |
JPS59104352A (ja) | 1984-06-16 |
DK160868B (da) | 1991-04-29 |
NO161368C (no) | 1989-08-09 |
JPS6355509B2 (no) | 1988-11-02 |
US5349085A (en) | 1994-09-20 |
EP0108638A1 (en) | 1984-05-16 |
EP0108638B1 (en) | 1986-07-16 |
ATE20733T1 (de) | 1986-08-15 |
NL950010I1 (nl) | 1997-02-03 |
HK46791A (en) | 1991-06-21 |
DK160868C (da) | 1991-10-14 |
DE3364536D1 (en) | 1986-08-21 |
LU88639I2 (fr) | 1996-02-01 |
NO161368B (no) | 1989-05-02 |
DK508283D0 (da) | 1983-11-07 |
NO834056L (no) | 1984-05-09 |
NL950010I2 (nl) | 1997-02-03 |
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