LT3447B - Positive inotropic and lusitropic pyrroloquinolinone derivatives, method for preparing thereof, pharmaceutical composition and method for preparing the same - Google Patents

Positive inotropic and lusitropic pyrroloquinolinone derivatives, method for preparing thereof, pharmaceutical composition and method for preparing the same Download PDF

Info

Publication number
LT3447B
LT3447B LTIP1960A LTIP1960A LT3447B LT 3447 B LT3447 B LT 3447B LT IP1960 A LTIP1960 A LT IP1960A LT IP1960 A LTIP1960 A LT IP1960A LT 3447 B LT3447 B LT 3447B
Authority
LT
Lithuania
Prior art keywords
formula
compound
compounds
optionally substituted
quinolin
Prior art date
Application number
LTIP1960A
Other languages
English (en)
Lithuanian (lt)
Inventor
Eddy Jean Edgard Freyne
Alfons Herman Marg Raeymaekers
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of LTIP1960A publication Critical patent/LTIP1960A/xx
Publication of LT3447B publication Critical patent/LT3447B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
LTIP1960A 1993-06-21 1994-06-17 Positive inotropic and lusitropic pyrroloquinolinone derivatives, method for preparing thereof, pharmaceutical composition and method for preparing the same LT3447B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93201771 1993-06-21

Publications (2)

Publication Number Publication Date
LTIP1960A LTIP1960A (en) 1995-01-31
LT3447B true LT3447B (en) 1995-10-25

Family

ID=8213908

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP1960A LT3447B (en) 1993-06-21 1994-06-17 Positive inotropic and lusitropic pyrroloquinolinone derivatives, method for preparing thereof, pharmaceutical composition and method for preparing the same

Country Status (29)

Country Link
US (1) US5602134A (bg)
EP (1) EP0707586B1 (bg)
JP (1) JP2812804B2 (bg)
KR (1) KR0181560B1 (bg)
CN (1) CN1043765C (bg)
AT (1) ATE171179T1 (bg)
AU (1) AU679077B2 (bg)
BG (1) BG62171B1 (bg)
BR (1) BR9406899A (bg)
CA (1) CA2163122C (bg)
CZ (1) CZ284350B6 (bg)
DE (1) DE69413398T2 (bg)
FI (1) FI109124B (bg)
HU (1) HU220670B1 (bg)
IL (1) IL110055A (bg)
LT (1) LT3447B (bg)
LV (1) LV11545B (bg)
MY (1) MY110751A (bg)
NO (1) NO305366B1 (bg)
OA (1) OA10202A (bg)
PH (1) PH31308A (bg)
PL (1) PL176783B1 (bg)
RU (1) RU2129554C1 (bg)
SG (1) SG49717A1 (bg)
SI (1) SI9420041A (bg)
SK (1) SK280400B6 (bg)
TW (1) TW593317B (bg)
WO (1) WO1995000512A1 (bg)
ZA (1) ZA944382B (bg)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7208497B2 (en) 2001-07-02 2007-04-24 Novo Nordisk A/S Substituted piperazines and diazepanes
EP1434765B1 (en) * 2001-09-14 2009-12-02 High Point Pharmaceuticals, LLC Substituted piperidines with selective binding to histamine h3-receptor
US20030186963A1 (en) 2001-09-14 2003-10-02 Dorwald Florencio Zaragoza Substituted piperidines
TWI498115B (zh) * 2007-12-27 2015-09-01 Daiichi Sankyo Co Ltd 咪唑羰基化合物
GB0808953D0 (en) * 2008-05-16 2008-06-25 Shire Llc substituted quinazolines
GB0808944D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
RU2457208C2 (ru) * 2009-07-06 2012-07-27 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО "ПГФА Росздрава") 1H-ПИРРОЛО[3,4-b]ХИНОЛИН-3,9(2H,4H)-ДИОНЫ, ОБЛАДАЮЩИЕ ПРОТИВОТУБЕРКУЛЕЗНОЙ АКТИВНОСТЬЮ, И СПОСОБ ИХ ПОЛУЧЕНИЯ
WO2024149378A1 (zh) * 2023-01-13 2024-07-18 上海超阳药业有限公司 喹啉酮化合物和萘啶酮化合物及其用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2190676B (en) 1986-05-23 1990-05-30 Bristol Myers Co Imidazoquinolinylether derivatives
EP0406958A2 (en) 1989-07-07 1991-01-09 Janssen Pharmaceutica N.V. Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives
EP0426180A2 (en) 1989-11-01 1991-05-08 Bristol-Myers Squibb Company Imidazo[4,5-b] quinolinyloxyalkanoic acid amides with enhanced water solubility
US5196428A (en) 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1030196C (zh) * 1989-07-07 1995-11-01 詹森药业有限公司 增强收缩力和舒张力的-二氢咪唑并喹唑啉酮衍生物的制备方法
US5220023A (en) * 1989-07-18 1993-06-15 Janssen Pharmaceutica N.V. Glycine derivatives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2190676B (en) 1986-05-23 1990-05-30 Bristol Myers Co Imidazoquinolinylether derivatives
EP0406958A2 (en) 1989-07-07 1991-01-09 Janssen Pharmaceutica N.V. Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives
EP0426180A2 (en) 1989-11-01 1991-05-08 Bristol-Myers Squibb Company Imidazo[4,5-b] quinolinyloxyalkanoic acid amides with enhanced water solubility
US5196428A (en) 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas

Also Published As

Publication number Publication date
AU7000894A (en) 1995-01-17
EP0707586B1 (en) 1998-09-16
NO955028D0 (no) 1995-12-12
WO1995000512A1 (en) 1995-01-05
HUT72090A (en) 1996-03-28
CA2163122C (en) 2005-06-14
FI956143A0 (fi) 1995-12-20
NO305366B1 (no) 1999-05-18
MY110751A (en) 1999-02-27
PH31308A (en) 1998-07-06
LV11545B (en) 1997-08-20
ZA944382B (en) 1995-12-20
HU220670B1 (hu) 2002-04-29
IL110055A0 (en) 1994-10-07
HU9501970D0 (en) 1995-09-28
PL176783B1 (pl) 1999-07-30
IL110055A (en) 1997-09-30
TW593317B (en) 2004-06-21
KR0181560B1 (ko) 1999-05-01
SK159695A3 (en) 1997-01-08
AU679077B2 (en) 1997-06-19
CN1043765C (zh) 1999-06-23
BG100209A (bg) 1996-07-31
LTIP1960A (en) 1995-01-31
NO955028L (no) 1995-12-12
DE69413398T2 (de) 1999-04-15
US5602134A (en) 1997-02-11
EP0707586A1 (en) 1996-04-24
CN1125945A (zh) 1996-07-03
DE69413398D1 (de) 1998-10-22
JPH09500108A (ja) 1997-01-07
RU2129554C1 (ru) 1999-04-27
FI956143A (fi) 1995-12-20
JP2812804B2 (ja) 1998-10-22
CA2163122A1 (en) 1995-01-05
ATE171179T1 (de) 1998-10-15
CZ284350B6 (cs) 1998-10-14
FI109124B (fi) 2002-05-31
PL312252A1 (en) 1996-04-01
SG49717A1 (en) 1998-06-15
SI9420041A (en) 1996-08-31
CZ336695A3 (en) 1996-03-13
SK280400B6 (sk) 2000-01-18
BR9406899A (pt) 1996-04-09
OA10202A (en) 1996-12-18
LV11545A (lv) 1996-10-20
BG62171B1 (bg) 1999-04-30

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Effective date: 19980617