LT3398B - Process for preparing deacylated 10-baccatine iii - Google Patents

Process for preparing deacylated 10-baccatine iii Download PDF

Info

Publication number
LT3398B
LT3398B LTIP1397A LTIP1397A LT3398B LT 3398 B LT3398 B LT 3398B LT IP1397 A LTIP1397 A LT IP1397A LT IP1397 A LTIP1397 A LT IP1397A LT 3398 B LT3398 B LT 3398B
Authority
LT
Lithuania
Prior art keywords
process according
deacetyl
ether
baccatin iii
butyl
Prior art date
Application number
LTIP1397A
Other languages
English (en)
Lithuanian (lt)
Inventor
Jean-Claude Gaullier
Bernadette Mandard
Rodolphe Margraff
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of LTIP1397A publication Critical patent/LTIP1397A/xx
Publication of LT3398B publication Critical patent/LT3398B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Fats And Perfumes (AREA)
  • Pyrane Compounds (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Compounds Of Unknown Constitution (AREA)
LTIP1397A 1992-10-05 1993-10-04 Process for preparing deacylated 10-baccatine iii LT3398B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9211746A FR2696463B1 (fr) 1992-10-05 1992-10-05 Procédé d'obtention de la désacétyl-10 baccatine III.

Publications (2)

Publication Number Publication Date
LTIP1397A LTIP1397A (en) 1994-11-25
LT3398B true LT3398B (en) 1995-09-25

Family

ID=9434124

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP1397A LT3398B (en) 1992-10-05 1993-10-04 Process for preparing deacylated 10-baccatine iii

Country Status (30)

Country Link
US (1) US5393895A (ja)
EP (1) EP0663910B1 (ja)
JP (1) JP3299754B2 (ja)
KR (1) KR100301236B1 (ja)
CN (1) CN1043530C (ja)
AT (1) ATE148883T1 (ja)
AU (1) AU680629B2 (ja)
CA (1) CA2146373C (ja)
CZ (2) CZ284615B6 (ja)
DE (1) DE69308155T2 (ja)
DK (1) DK0663910T3 (ja)
EE (1) EE03126B1 (ja)
ES (1) ES2098061T3 (ja)
FI (1) FI109794B (ja)
FR (1) FR2696463B1 (ja)
GE (1) GEP20001937B (ja)
GR (1) GR3022617T3 (ja)
HU (1) HU226862B1 (ja)
LT (1) LT3398B (ja)
LV (1) LV10621B (ja)
MX (1) MX9305771A (ja)
NO (1) NO310413B1 (ja)
NZ (1) NZ256450A (ja)
PL (1) PL177316B1 (ja)
RU (1) RU2107065C1 (ja)
SK (1) SK280949B6 (ja)
TW (1) TW255890B (ja)
UA (1) UA44227C2 (ja)
WO (1) WO1994007882A1 (ja)
ZA (1) ZA937313B (ja)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2696462B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé d'obtention de la désacétyl-10 baccatine III.
ATE420628T1 (de) 1993-07-19 2009-01-15 Angiotech Pharm Inc Anti-angiogene mittel und verfahren zu deren verwendung
WO1995012445A1 (de) * 1993-11-02 1995-05-11 Rhône-Poulenc Rorer GmbH Verfahren und vorrichtung zum auftrennen eines gemisches
FR2714053B1 (fr) * 1993-12-22 1996-03-08 Pf Medicament Procédé d'extraction et d'isolement de la 10-désacétylbaccatine III.
CN1112433A (zh) * 1994-05-24 1995-11-29 郭明 红豆杉属植物提取物及其应用
CA2178541C (en) 1995-06-07 2009-11-24 Neal E. Fearnot Implantable medical device
FR2736355B1 (fr) * 1995-07-07 1997-11-07 Pf Medicament Procede d'extraction et d'isolement de la 10-desacetylbaccatine iii
US5750736A (en) * 1996-07-11 1998-05-12 Napro Biotherapeutics, Inc. Method for acylating 10-deacetylbaccatin III selectively at the c-10 position
US5965752A (en) * 1996-08-23 1999-10-12 Institut National De La Recherche Scientifique Preparative scale isolation and purification of taxanes
DE69812395T2 (de) 1997-08-21 2004-02-05 Florida State University, Tallahassee Verfahren zur synthese von taxanen
US6002024A (en) * 1998-07-27 1999-12-14 Dabur Research Foundation Process for the isolation of 14β-hydroxy-10-deacetyl baccatin-III
US6136989A (en) * 1998-12-30 2000-10-24 Phytogen Life Sciences, Incorporated Method for high yield and large scale extraction of paclitaxel from paclitaxel-containing material
US6495705B2 (en) 2000-03-16 2002-12-17 Napro Biotherapeutics, Inc. Efficient process for the production of 10-DAB III by selective hydrazinolysis of various taxanes
US6281368B1 (en) 2000-03-16 2001-08-28 Napro Biotherapeutics, Inc. Simple and efficient hydrazinolysis of C-10 and C-13 ester functionalities of taxanes to obtain 10-DAB III
CA2307393A1 (en) 2000-05-01 2001-11-01 The University Of British Columbia Ginsenoside chemotherapy
US20030157170A1 (en) * 2001-03-13 2003-08-21 Richard Liggins Micellar drug delivery vehicles and precursors thereto and uses thereof
WO2002072150A2 (en) 2001-03-13 2002-09-19 Angiotech Pharmaceuticals Inc. Micellar drug delivery vehicles and uses thereof
ATE363898T1 (de) 2001-04-20 2007-06-15 Univ British Columbia Mizellares arzneistoffverabreichungssystem für hydrophobe arzneistoffe
US7351542B2 (en) 2002-05-20 2008-04-01 The Regents Of The University Of California Methods of modulating tubulin deacetylase activity
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
JP2007525188A (ja) 2003-05-16 2007-09-06 インターミューン インコーポレイテッド 合成ケモカイン受容体リガンドおよびその使用方法
US8003122B2 (en) 2004-03-31 2011-08-23 Cordis Corporation Device for local and/or regional delivery employing liquid formulations of therapeutic agents
US7989490B2 (en) 2004-06-02 2011-08-02 Cordis Corporation Injectable formulations of taxanes for cad treatment
US7846940B2 (en) 2004-03-31 2010-12-07 Cordis Corporation Solution formulations of sirolimus and its analogs for CAD treatment
PL1778660T3 (pl) * 2004-07-02 2009-07-31 Ivax Pharmaceuticals Sro Sposób rozdzielania paklitakselu i cefalomanniny
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
WO2006089218A2 (en) 2005-02-17 2006-08-24 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for modulating angiogenesis
WO2007062036A2 (en) 2005-11-21 2007-05-31 Med Institute, Inc. Implantable medical device coatings with biodegradable elastomer and releasable therapeutic agent
US8168216B2 (en) 2006-03-22 2012-05-01 Medigene Ag Treatment of triple receptor negative breast cancer
EP2043704B2 (en) 2006-06-30 2017-04-19 Cook Medical Technologies LLC Methods of manufacturing and modifying taxane coatings for implantable medical devices
US8409601B2 (en) 2008-03-31 2013-04-02 Cordis Corporation Rapamycin coated expandable devices
US8420110B2 (en) 2008-03-31 2013-04-16 Cordis Corporation Drug coated expandable devices
US8273404B2 (en) 2008-05-19 2012-09-25 Cordis Corporation Extraction of solvents from drug containing polymer reservoirs
EP2859916B1 (en) 2008-05-22 2017-11-29 Galera Labs, LLC Combination of an antimitotic agent and a selective superoxide dismutase mimetic in antitumor therapy
WO2010005850A1 (en) 2008-07-08 2010-01-14 The J. David Gladstone Institutes Methods and compositions for modulating angiogenesis
US8642063B2 (en) 2008-08-22 2014-02-04 Cook Medical Technologies Llc Implantable medical device coatings with biodegradable elastomer and releasable taxane agent
US20120302954A1 (en) 2011-05-25 2012-11-29 Zhao Jonathon Z Expandable devices coated with a paclitaxel composition
US20120303115A1 (en) 2011-05-25 2012-11-29 Dadino Ronald C Expandable devices coated with a rapamycin composition
EP2760848B1 (en) 2011-09-26 2018-11-28 Fresenius Kabi Oncology Limited Processes for the preparation of cabazitaxel involving c(7)-oh and c(13)-oh silylation or just c(7)-oh silylation
US9956385B2 (en) 2012-06-28 2018-05-01 The Spectranetics Corporation Post-processing of a medical device to control morphology and mechanical properties
US9181343B2 (en) 2012-07-19 2015-11-10 Redwood Bioscience Inc. Antibody specific for CD22 and methods of use thereof
CA2890190A1 (en) 2012-11-12 2014-05-15 Redwood Bioscience, Inc. Compounds and methods for producing a conjugate
CN103804326A (zh) * 2012-11-15 2014-05-21 刘胜远 一种从含10-去乙酰基巴卡亭ⅲ的浸膏分离和提纯10-去乙酰基巴卡亭ⅲ的方法
CA2901115A1 (en) 2013-02-15 2014-08-21 The Regents Of The University Of California Heterodimeric conditionally active chimeric antigen receptor and methods of use thereof
CN103145652B (zh) * 2013-03-05 2015-09-30 无锡尔云科技有限公司 一种从红豆杉属植物中提取紫杉醇及其衍生物的方法
CN105358531B (zh) 2013-03-14 2017-11-14 利兰-斯坦福大学初级学院的董事会 线粒体醛脱氢酶‑2调节剂和其使用方法
JP6745218B2 (ja) 2013-11-27 2020-08-26 レッドウッド バイオサイエンス， インコーポレイテッド ヒドラジニル−ピロロ化合物及び複合体を生成するための方法
PL3107899T3 (pl) 2014-02-19 2021-01-25 Aviv Therapeutics, Inc. Policykliczne amidy wiążące mitochondrialną dehydrogenazę aldehydową-2 (aldh2) i ich zastosowanie w leczeniu nowotworów
EP3352796A4 (en) 2015-09-25 2019-05-01 ZY Therapeutics Inc. PARTICLE-BASED MEDICINAL FORMULATION COMPRISING A POLYSACCHARIDE-VITAMIN CONJUGATE
EP3373977A4 (en) 2015-11-12 2019-07-17 The Board of Trustees of the Leland Stanford Junior University CELLULAR PENETRATION-RICH GUANIDINIC OLIGOPHOSPHOTRIESTERS FOR THE DELIVERY OF MEDICATION AND PROBE
TWI760319B (zh) 2015-12-30 2022-04-11 杏國新藥股份有限公司 乳癌治療
JP2019515677A (ja) 2016-04-26 2019-06-13 アール．ピー．シェーラー テクノロジーズ エルエルシー 抗体複合体ならびにそれを作製および使用する方法
EP3463308B1 (en) 2016-06-01 2021-12-01 Servier IP UK Limited Formulations of polyalkylene oxide-asparaginase and methods of making and using the same
TW201825087A (zh) 2017-01-05 2018-07-16 杏國新藥股份有限公司 胰臟癌治療
MX2019008503A (es) 2017-01-18 2019-09-13 F1 Oncology Inc Receptores de antigenos quimericos contra axl o ror2 y metodos de uso de los mismos.
EP3388082A1 (en) 2017-04-13 2018-10-17 Galera Labs, LLC Combination cancer immunotherapy with pentaaza macrocyclic ring complex
KR20200118823A (ko) 2018-01-31 2020-10-16 갈레라 랩스, 엘엘씨 펜타아자 마크로시클릭 고리 복합체 및 백금-기재 항암제를 사용한 조합 암 요법
CN112368011A (zh) 2018-04-11 2021-02-12 俄亥俄州创新基金会 缓释微粒用于眼用药物递送的方法和组合物
CN108904137A (zh) * 2018-05-27 2018-11-30 肖军威 一种卫生巾芯片的制备方法及卫生巾芯片的加工设备
JP2021530507A (ja) 2018-07-18 2021-11-11 マンザニータ ファーマシューティカルズ，インク． 神経細胞に抗がん剤を送達するためのコンジュゲート、その使用方法及び製造方法
US11529402B2 (en) 2019-01-14 2022-12-20 Ignite Immunotherapy, Inc. Recombinant vaccinia virus and methods of use thereof
WO2020165730A1 (en) 2019-02-14 2020-08-20 Ignite Immunotherapy, Inc. Recombinant vaccinia virus and methods of use thereof
AU2020253449A1 (en) 2019-04-02 2021-11-18 Kenjockety Biotechnology, Inc. Efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto
CN110317183B (zh) * 2019-08-08 2021-03-12 无锡紫杉药业有限公司 一种红豆杉天然提取产物的纯化方法
CA3163805A1 (en) 2019-12-12 2021-06-17 Ignite Immunotherapy, Inc. Variant oncolytic vaccinia virus and methods of use thereof
BR112022013870A2 (pt) 2020-01-29 2022-09-13 Kenjockety Biotechnology Inc Anticorpos anti-mdr1 e usos dos mesmos
AU2021283080A1 (en) 2020-06-04 2022-12-15 Kenjockety Biotechnology, Inc. ABCG2 efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto
US20230212305A1 (en) 2020-06-04 2023-07-06 Kenjockety Biotechnology, Inc. Anti-abcg2 antibodies and uses thereof
KR20230023032A (ko) 2020-07-14 2023-02-16 화이자 인코포레이티드 재조합 백시니아 바이러스
CN116490522A (zh) 2020-09-02 2023-07-25 肯乔克蒂生物技术股份有限公司 抗abcc1抗体及其应用
US20240010747A1 (en) 2020-11-13 2024-01-11 Kenjockety Biotechnology, Inc. Anti-mrp4 (encoded by abcc4 gene) antibodies and uses thereof
CN112694458A (zh) * 2020-12-29 2021-04-23 重庆臻源红豆杉发展有限公司 一种10-去乙酰基巴卡亭ⅲ提取纯化方法
WO2023114658A1 (en) 2021-12-13 2023-06-22 Kenjockety Biotechnology, Inc. Anti-abcb1 antibodies
WO2023159220A1 (en) 2022-02-18 2023-08-24 Kenjockety Biotechnology, Inc. Anti-cd47 antibodies

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4814470A (en) 1986-07-17 1989-03-21 Rhone-Poulenc Sante Taxol derivatives, their preparation and pharmaceutical compositions containing them
US4924011A (en) 1988-04-06 1990-05-08 Centre National De La Recherche Scientifique Process for preparing taxol
US4924012A (en) 1988-04-06 1990-05-08 Rhone-Poulenc Sante Process for preparing derivatives of baccatine III and of 10-deacetyl baccatine III
EP0400971A2 (en) 1989-05-31 1990-12-05 Florida State University Method for preparation of taxol
EP0428376A1 (en) 1989-11-14 1991-05-22 Florida State University Method for preparation of taxol using an oxazinone
WO1992009589A1 (fr) 1990-11-23 1992-06-11 Rhone-Poulenc Rorer S.A. Procede de preparation de derives du taxane, nouveaux derives obtenus et compositions pharmaceutiques qui les contiennent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380916A (en) 1990-11-02 1995-01-10 University Of Florida Method for the isolation and purification of taxane derivatives
JP3222466B2 (ja) * 1991-04-19 2001-10-29 ザ・ユニバーシティ・オブ・ミシシッピー タクサン類を単離するための方法および組成物
IT1258838B (it) 1992-01-31 1996-02-29 Indena Spa Processo per l'estrazione di tassolo e derivati da cultivar del genere taxus

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4814470A (en) 1986-07-17 1989-03-21 Rhone-Poulenc Sante Taxol derivatives, their preparation and pharmaceutical compositions containing them
US4924011A (en) 1988-04-06 1990-05-08 Centre National De La Recherche Scientifique Process for preparing taxol
US4924012A (en) 1988-04-06 1990-05-08 Rhone-Poulenc Sante Process for preparing derivatives of baccatine III and of 10-deacetyl baccatine III
EP0400971A2 (en) 1989-05-31 1990-12-05 Florida State University Method for preparation of taxol
EP0428376A1 (en) 1989-11-14 1991-05-22 Florida State University Method for preparation of taxol using an oxazinone
WO1992009589A1 (fr) 1990-11-23 1992-06-11 Rhone-Poulenc Rorer S.A. Procede de preparation de derives du taxane, nouveaux derives obtenus et compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
UA44227C2 (uk) 2002-02-15
DE69308155D1 (de) 1997-03-27
CA2146373A1 (fr) 1994-04-14
AU680629B2 (en) 1997-08-07
GEP20001937B (en) 2000-02-05
ES2098061T3 (es) 1997-04-16
US5393895A (en) 1995-02-28
NO951282L (no) 1995-04-03
PL177316B1 (pl) 1999-10-29
CZ284615B6 (cs) 1999-01-13
GR3022617T3 (en) 1997-05-31
RU95110687A (ru) 1996-12-27
DE69308155T2 (de) 1997-08-07
FR2696463B1 (fr) 1994-11-25
MX9305771A (es) 1994-05-31
FI951596A0 (fi) 1995-04-04
JPH08501792A (ja) 1996-02-27
DK0663910T3 (da) 1997-03-10
NZ256450A (en) 1996-11-26
ATE148883T1 (de) 1997-02-15
PL308244A1 (en) 1995-07-24
KR950703550A (ko) 1995-09-20
NO951282D0 (no) 1995-04-03
SK43395A3 (en) 1995-08-09
TW255890B (ja) 1995-09-01
RU2107065C1 (ru) 1998-03-20
LTIP1397A (en) 1994-11-25
AU5115593A (en) 1994-04-26
HUT72449A (en) 1996-04-29
HU226862B1 (en) 2009-12-28
CA2146373C (fr) 2006-08-29
EP0663910A1 (fr) 1995-07-26
FI109794B (fi) 2002-10-15
CZ84595A3 (en) 1995-09-13
LV10621B (en) 1995-10-20
CZ287065B6 (cs) 2000-08-16
CN1043530C (zh) 1999-06-02
EP0663910B1 (fr) 1997-02-12
ZA937313B (en) 1994-04-25
FI951596A (fi) 1995-04-04
EE03126B1 (et) 1998-10-15
WO1994007882A1 (fr) 1994-04-14
HU9500973D0 (en) 1995-06-28
KR100301236B1 (ko) 2001-11-22
LV10621A (lv) 1995-04-20
NO310413B1 (no) 2001-07-02
CN1085551A (zh) 1994-04-20
SK280949B6 (sk) 2000-09-12
JP3299754B2 (ja) 2002-07-08
FR2696463A1 (fr) 1994-04-08

Similar Documents

Publication Publication Date Title
LT3398B (en) Process for preparing deacylated 10-baccatine iii
US5393896A (en) Process for obtaining 10-deacetylbaccatin III
US5453521A (en) Process for obtaining 10-deacetylbaccatin III
EP1010697B1 (en) Process for isolation of 14-b hydroxy-10-deacetyl baccatin-III
US20070112207A1 (en) Method for separation and purification of 13-dehydroxybaccatin iii and 10-deacetylpaclitaxel from taxans-containing materials
US6124482A (en) Process for isolation of 10-deacetyl baccatin-III
KR960037669A (ko) 결정화에 의한 택서스속 식물체로부터 택솔의 정제방법
NZ552549A (en) Methods for obtaining paclitaxel from taxus plants

Legal Events

Date Code Title Description
PD9A Change of patent owner

Owner name: AVENTIS PHARMA S.A., FR

Effective date: 20041206

MK9A Expiry of a patent

Effective date: 20131004