LT3374B - Sbstituted corticoid-17-alkylcarbonates, process for preparing thereof and pharmaceutical preparations - Google Patents

Sbstituted corticoid-17-alkylcarbonates, process for preparing thereof and pharmaceutical preparations Download PDF

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Publication number
LT3374B
LT3374B LTIP709A LTIP709A LT3374B LT 3374 B LT3374 B LT 3374B LT IP709 A LTIP709 A LT IP709A LT IP709 A LTIP709 A LT IP709A LT 3374 B LT3374 B LT 3374B
Authority
LT
Lithuania
Prior art keywords
general formula
alkyl
corticoid
acid
hydrogen
Prior art date
Application number
LTIP709A
Other languages
English (en)
Lithuanian (lt)
Inventor
Ulrich Stache
Walter Duerckheimer
Hans-Georg Alpermann
Walter Petri
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of LTIP709A publication Critical patent/LTIP709A/xx
Publication of LT3374B publication Critical patent/LT3374B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
LTIP709A 1990-08-10 1993-06-25 Sbstituted corticoid-17-alkylcarbonates, process for preparing thereof and pharmaceutical preparations LT3374B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4025342A DE4025342A1 (de) 1990-08-10 1990-08-10 In 17-stellung substituierte corticoid-17-alkylcarbonate, verfahren zu deren herstellung und diese enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
LTIP709A LTIP709A (en) 1995-01-31
LT3374B true LT3374B (en) 1995-08-25

Family

ID=6411982

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP709A LT3374B (en) 1990-08-10 1993-06-25 Sbstituted corticoid-17-alkylcarbonates, process for preparing thereof and pharmaceutical preparations

Country Status (22)

Country Link
US (1) US5362721A (cs)
EP (1) EP0470617A3 (cs)
JP (1) JPH0641187A (cs)
KR (1) KR920004407A (cs)
AU (1) AU646066B2 (cs)
CA (1) CA2048841A1 (cs)
CZ (1) CZ279875B6 (cs)
DE (1) DE4025342A1 (cs)
EC (1) ECSP941049A (cs)
EG (1) EG19928A (cs)
FI (1) FI913775A (cs)
HU (1) HU211994B (cs)
IE (1) IE912827A1 (cs)
IL (1) IL99135A (cs)
LT (1) LT3374B (cs)
LV (1) LV10459B (cs)
MX (1) MX9100613A (cs)
NO (1) NO913115L (cs)
PT (1) PT98605A (cs)
RU (1) RU2060997C1 (cs)
TW (1) TW203056B (cs)
ZA (1) ZA916291B (cs)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4328819A1 (de) * 1993-08-27 1995-03-02 Hoechst Ag Corticosteroid-17-alkylcarbonat-21/0/-Carbonsäure- und Kohlensäureester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE4333920A1 (de) 1993-10-05 1995-04-13 Hoechst Ag Corticoid-17,21-dicarbonsäureester sowie Corticosteroid-17-carbonsäureester-21-kohlensäureester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
US5981517A (en) * 1996-05-09 1999-11-09 Soft Drugs, Inc. Androstene derivatives
US6759398B2 (en) * 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
GB0019172D0 (en) * 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
OA12394A (en) 2000-08-05 2004-07-09 Glaxo Group Ltd 6.Alpha-,9.alpha.-difluoro-17.alpha.-'(2-furanylcarboxyl)oxyl-11.beta.-hydroxy-16.alpha.-methyl-3-oxo-androst-1,4,-diene-17-carbothioic acid s-fuoromethyl ester as an anti-inflammatory agent.
US6777399B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858596B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
EP2039700A2 (en) * 2001-04-30 2009-03-25 Glaxo Group Limited Novel anti-inflammatory androstane derivatives
ATE399174T1 (de) * 2001-06-12 2008-07-15 Glaxo Group Ltd Neue anti inflammatorische 17.alpha.- heterozyklische ester von 17.beta.-carbothioat androstan derivativen
US20050175545A1 (en) * 2002-02-04 2005-08-11 Keith Biggadike Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) * 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
AU2006211907B2 (en) * 2005-02-04 2011-09-08 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Nandrolone 17beta-carbonates
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
GB0523251D0 (en) * 2005-11-15 2005-12-21 Glaxo Group Ltd Novel compounds
GB0615108D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations
UA116622C2 (uk) * 2011-11-11 2018-04-25 Аллерган, Інк. Похідні 4-прегенен-11ss-17-21-тріол-3,20-діону для лікування хвороб очей
CN116135871A (zh) * 2021-11-16 2023-05-19 石家庄迪斯凯威医药科技有限公司 一种具有抗耐药性的抗菌化合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1668079A1 (de) 1968-01-18 1971-07-22 Hoechst Ag Verfahren zur Herstellung von 17alpha,21-Orthcarbonaten von Steroid-derivaten
EP0004975A2 (de) 1978-04-25 1979-10-31 Hoechst Aktiengesellschaft Corticoid-17-Alkylcarbonate, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel gegen Dermatosen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2735110A1 (de) * 1977-08-04 1979-02-15 Hoechst Ag Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung
SE449106B (sv) * 1980-07-10 1987-04-06 Otsuka Pharma Co Ltd Steroid med anti-inflammatorisk verkan samt komposition innehallande denna
AU558725B2 (en) * 1983-09-07 1987-02-05 Mitsubishi Kasei Corporation Corticoid derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1668079A1 (de) 1968-01-18 1971-07-22 Hoechst Ag Verfahren zur Herstellung von 17alpha,21-Orthcarbonaten von Steroid-derivaten
EP0004975A2 (de) 1978-04-25 1979-10-31 Hoechst Aktiengesellschaft Corticoid-17-Alkylcarbonate, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel gegen Dermatosen

Also Published As

Publication number Publication date
RU2060997C1 (ru) 1996-05-27
IE912827A1 (en) 1992-02-12
DE4025342A1 (de) 1992-02-13
EP0470617A2 (de) 1992-02-12
LTIP709A (en) 1995-01-31
EG19928A (en) 1996-07-31
HU211994B (en) 1996-01-29
KR920004407A (ko) 1992-03-27
HU912643D0 (en) 1992-01-28
TW203056B (cs) 1993-04-01
AU8256091A (en) 1992-02-13
AU646066B2 (en) 1994-02-03
JPH0641187A (ja) 1994-02-15
LV10459B (en) 1995-08-20
FI913775A0 (fi) 1991-08-08
US5362721A (en) 1994-11-08
HUT59155A (en) 1992-04-28
NO913115L (no) 1992-02-11
NO913115D0 (no) 1991-08-09
IL99135A0 (en) 1992-07-15
CZ279875B6 (cs) 1995-07-12
IL99135A (en) 1995-12-08
FI913775A (fi) 1992-02-11
PT98605A (pt) 1992-06-30
ECSP941049A (es) 1994-11-16
ZA916291B (en) 1992-04-29
CS246191A3 (en) 1992-03-18
CA2048841A1 (en) 1992-02-11
LV10459A (lv) 1995-02-20
MX9100613A (es) 1992-04-01
EP0470617A3 (en) 1992-04-01

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Effective date: 19970625