NO913115L - I 17-stilling substituerte kortikoid-17-alkylkarbonater og fremgangsmaate for fremstilling derav. - Google Patents

I 17-stilling substituerte kortikoid-17-alkylkarbonater og fremgangsmaate for fremstilling derav.

Info

Publication number
NO913115L
NO913115L NO91913115A NO913115A NO913115L NO 913115 L NO913115 L NO 913115L NO 91913115 A NO91913115 A NO 91913115A NO 913115 A NO913115 A NO 913115A NO 913115 L NO913115 L NO 913115L
Authority
NO
Norway
Prior art keywords
formula
halogen
sulfonic acid
local
corticoid
Prior art date
Application number
NO91913115A
Other languages
English (en)
Other versions
NO913115D0 (no
Inventor
Ulrich Stache
Walter Duerckheimer
Hans Georg Alpermann
Walter Petri
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO913115D0 publication Critical patent/NO913115D0/no
Publication of NO913115L publication Critical patent/NO913115L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Kortikoid-17-alkylkarbonnter med formel I CH2-R(i) CO ...0-CO-0-R(2) ...R3 (D med A - CHOH l en hvilken som helst sterlsk anordning, C=0, CH2; Y-H, F, Cl; Z - H. F. CH3; R(l) - Hal, 0- acyl, karbonylalkyl, sulfonsyrealkylester, sulfon- syrearylester; R(2) - forgrenet alkyl eller ((^2)2-4- OCR3 og R(3) - H, metyl, oppnås ved at man hydrolyserer en forbindelse med formel V CO ...O"" \ 0R(2) '¿ R(3) (V) med en svak syre og forestrer den oppnådde 21-hydroksy- forblndelsen med formel I med R^ - OH med et halogenld eller anhydrld av en karboksylsyre med formel VI R(4)-(CH2)n-COOH (VI) eller et lialogenformat med formel VII R(4 )-(CH2 )n-OCO-halogen (VII) eller et sulfonsyrehalogenld med formel VIII R(5)-S02-halogen (VIII) og eventuelt omsetter den derved oppnådde 21-sulfon- syreesteren med halogenldsalter til 21-halogenlder med formel I med R(l) Ilk klor. brom. Jod, fluor. Forbindelsene har fremragende lokal og toplsk anti- floglstlsk virkning. De utmerker seg ved et spesielt godt forhold mellom lokal og systemlsk antl- Inflammatorlsk virksomhet og viser også tlldels sterkere lokale antlfloglstiske virksomheter enn de Isomere kortlkold-17-alkylkarbonatene med en lineær alkylgruppe i 17-alkylkartionatdelen.
NO91913115A 1990-08-10 1991-08-09 I 17-stilling substituerte kortikoid-17-alkylkarbonater og fremgangsmaate for fremstilling derav. NO913115L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4025342A DE4025342A1 (de) 1990-08-10 1990-08-10 In 17-stellung substituierte corticoid-17-alkylcarbonate, verfahren zu deren herstellung und diese enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
NO913115D0 NO913115D0 (no) 1991-08-09
NO913115L true NO913115L (no) 1992-02-11

Family

ID=6411982

Family Applications (1)

Application Number Title Priority Date Filing Date
NO91913115A NO913115L (no) 1990-08-10 1991-08-09 I 17-stilling substituerte kortikoid-17-alkylkarbonater og fremgangsmaate for fremstilling derav.

Country Status (22)

Country Link
US (1) US5362721A (no)
EP (1) EP0470617A3 (no)
JP (1) JPH0641187A (no)
KR (1) KR920004407A (no)
AU (1) AU646066B2 (no)
CA (1) CA2048841A1 (no)
CZ (1) CZ279875B6 (no)
DE (1) DE4025342A1 (no)
EC (1) ECSP941049A (no)
EG (1) EG19928A (no)
FI (1) FI913775A (no)
HU (1) HU211994B (no)
IE (1) IE912827A1 (no)
IL (1) IL99135A (no)
LT (1) LT3374B (no)
LV (1) LV10459B (no)
MX (1) MX9100613A (no)
NO (1) NO913115L (no)
PT (1) PT98605A (no)
RU (1) RU2060997C1 (no)
TW (1) TW203056B (no)
ZA (1) ZA916291B (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4328819A1 (de) * 1993-08-27 1995-03-02 Hoechst Ag Corticosteroid-17-alkylcarbonat-21/0/-Carbonsäure- und Kohlensäureester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE4333920A1 (de) 1993-10-05 1995-04-13 Hoechst Ag Corticoid-17,21-dicarbonsäureester sowie Corticosteroid-17-carbonsäureester-21-kohlensäureester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
US5981517A (en) * 1996-05-09 1999-11-09 Soft Drugs, Inc. Androstene derivatives
US6858596B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6759398B2 (en) * 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
SK287576B6 (sk) 2000-08-05 2011-03-04 Glaxo Group Limited S-fluórmetylester kyseliny 6alfa, 9alfa-difluór-17alfa-[(2- furanylkarboxyl)oxy]-11beta-hydroxy-16alfa-metyl-3-oxo-androsta- 1,4-dién-17beta-karbotiovej, spôsob jeho prípravy, farmaceutický prostriedok s jeho obsahom, jeho použitie a medziprodukty
US6777399B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
AR033290A1 (es) * 2001-04-30 2003-12-10 Glaxo Group Ltd Derivados antiinflamatorios de androstano
WO2002100879A1 (en) * 2001-06-12 2002-12-19 Glaxo Group Limited Novel anti-inflammatory 17.alpha.-heterocyclic-esters of 17.beta.carbothioate androstane derivatives
US20050175545A1 (en) * 2002-02-04 2005-08-11 Keith Biggadike Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
ATE426610T1 (de) * 2005-02-04 2009-04-15 Us Gov Health & Human Serv Nandrolon-17ss-carbonate
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
GB0523251D0 (en) * 2005-11-15 2005-12-21 Glaxo Group Ltd Novel compounds
GB0615108D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations
UA116622C2 (uk) 2011-11-11 2018-04-25 Аллерган, Інк. Похідні 4-прегенен-11ss-17-21-тріол-3,20-діону для лікування хвороб очей
CN116135871A (zh) * 2021-11-16 2023-05-19 石家庄迪斯凯威医药科技有限公司 一种具有抗耐药性的抗菌化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1668079B2 (de) 1968-01-18 1976-09-16 Hoechst Ag, 6000 Frankfurt Dialkylorthocarbonate von 17alpha, 21-dihydroxysteroiden und verfahren zu ihrer herstellung
DE2735110A1 (de) * 1977-08-04 1979-02-15 Hoechst Ag Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung
DE2817988A1 (de) * 1978-04-25 1979-11-08 Hoechst Ag Corticoid 17-alkylcarbonate und verfahren zu deren herstellung
SE449106B (sv) * 1980-07-10 1987-04-06 Otsuka Pharma Co Ltd Steroid med anti-inflammatorisk verkan samt komposition innehallande denna
AU558725B2 (en) * 1983-09-07 1987-02-05 Mitsubishi Kasei Corporation Corticoid derivatives

Also Published As

Publication number Publication date
ECSP941049A (es) 1994-11-16
HUT59155A (en) 1992-04-28
LTIP709A (en) 1995-01-31
EP0470617A3 (en) 1992-04-01
IL99135A (en) 1995-12-08
EG19928A (en) 1996-07-31
NO913115D0 (no) 1991-08-09
CS246191A3 (en) 1992-03-18
LV10459B (en) 1995-08-20
AU8256091A (en) 1992-02-13
FI913775A (fi) 1992-02-11
HU211994B (en) 1996-01-29
LT3374B (en) 1995-08-25
KR920004407A (ko) 1992-03-27
LV10459A (lv) 1995-02-20
CA2048841A1 (en) 1992-02-11
HU912643D0 (en) 1992-01-28
CZ279875B6 (cs) 1995-07-12
DE4025342A1 (de) 1992-02-13
IE912827A1 (en) 1992-02-12
MX9100613A (es) 1992-04-01
PT98605A (pt) 1992-06-30
EP0470617A2 (de) 1992-02-12
IL99135A0 (en) 1992-07-15
FI913775A0 (fi) 1991-08-08
JPH0641187A (ja) 1994-02-15
AU646066B2 (en) 1994-02-03
RU2060997C1 (ru) 1996-05-27
TW203056B (no) 1993-04-01
ZA916291B (en) 1992-04-29
US5362721A (en) 1994-11-08

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