GB1516095A - 17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series - Google Patents
17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane seriesInfo
- Publication number
- GB1516095A GB1516095A GB33786/74A GB3378674A GB1516095A GB 1516095 A GB1516095 A GB 1516095A GB 33786/74 A GB33786/74 A GB 33786/74A GB 3378674 A GB3378674 A GB 3378674A GB 1516095 A GB1516095 A GB 1516095A
- Authority
- GB
- United Kingdom
- Prior art keywords
- diesters
- 17alpha
- steroids
- dihydroxy
- pregnane series
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
- C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
17 alpha ,21-Diesters of 17 alpha ,21-dihydroxysteroids of the pregnane series corresponding to the formula I in which the symbols X, Y, R<1> and R<2> have the meaning stated in Claim 1 are prepared by reacting a compound which has the group -CH2OCO(CH2)nZ in position 21, where Z is a substituent which can easily be replaced, with a compound of the formula H-NR<3>R<4>. The compounds are distinguished not only by a good topical antiinflammatory effect but also by an excellent systemic antiinflammatory effect. <IMAGE>
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB33786/74A GB1516095A (en) | 1974-07-31 | 1974-07-31 | 17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series |
CH996575A CH615442A5 (en) | 1974-07-31 | 1975-07-30 | Process for the preparation of 17alpha,21-diesters of 17alpha,21-dihydroxysteroids of the pregnane series |
BE158780A BE831931A (en) | 1974-07-31 | 1975-07-30 | NEW 17ALPHA, 21-DIESTERS OF 17ALPHA, 21-DIHYDROXY STEROIDS AND THEIR PREPARATION |
ES439852A ES439852A1 (en) | 1974-07-31 | 1975-07-30 | 17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series |
AU83531/75A AU492456B2 (en) | 1974-07-31 | 1975-07-30 | 17,21-diesters of 17, 21-dihydroxy-steroids of the pregnane series |
DE19752534051 DE2534051A1 (en) | 1974-07-31 | 1975-07-30 | 17 ALPHA, 21-DIESTER OF 17 ALPHA, 21-DIHYDROXYSTEROID DERIVATIVES, METHODS FOR THEIR MANUFACTURING AND PHARMACEUTICAL PREPARATIONS WHICH CONTAIN THEM |
ZA00754907A ZA754907B (en) | 1974-07-31 | 1975-07-30 | 17,21-diesters of 17,21-dihydroxy steroids of the pregnane series containing a basic 21-ester grouping |
NL7509075A NL7509075A (en) | 1974-07-31 | 1975-07-30 | PROCESS FOR PREPARATION OF NEW 17 (ALPHA), 21 DIESTERS OF 17 (ALPHA), 21 DIHYDROXYSTEROIDS FROM THE PREGNAN SERIES. |
JP50092137A JPS51125059A (en) | 1974-07-31 | 1975-07-30 | Production of novel steroid |
IE1708/75A IE42124B1 (en) | 1974-07-31 | 1975-07-30 | 17,21-diesters of 17,21-dihydroxy steroids of the pregnaneseries |
FR7523787A FR2280383A1 (en) | 1974-07-31 | 1975-07-30 | NEW 17A, 21-DIESTERS OF 17A, 21-DIHYDROXY STEROIDS, THEIR PREPARATION PROCESS, AND THEIR APPLICATION |
DK346975AA DK139303B (en) | 1974-07-31 | 1975-07-30 | Analogous process for the preparation of 11-oxygenated 17alpha, 21-diacyloxy-9alpha-halogen-16beta-methylpregn-4-ene-3,20-diones or acid addition salts thereof. |
CA232,579A CA1058610A (en) | 1974-07-31 | 1975-07-30 | 17a, 21-diesters of the pregnane series |
SE7508654A SE7508654L (en) | 1974-07-31 | 1975-07-30 | PROCEDURE FOR THE MANUFACTURE OF STEROIDS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB33786/74A GB1516095A (en) | 1974-07-31 | 1974-07-31 | 17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1516095A true GB1516095A (en) | 1978-06-28 |
Family
ID=10357423
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB33786/74A Expired GB1516095A (en) | 1974-07-31 | 1974-07-31 | 17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series |
Country Status (13)
Country | Link |
---|---|
JP (1) | JPS51125059A (en) |
BE (1) | BE831931A (en) |
CA (1) | CA1058610A (en) |
CH (1) | CH615442A5 (en) |
DE (1) | DE2534051A1 (en) |
DK (1) | DK139303B (en) |
ES (1) | ES439852A1 (en) |
FR (1) | FR2280383A1 (en) |
GB (1) | GB1516095A (en) |
IE (1) | IE42124B1 (en) |
NL (1) | NL7509075A (en) |
SE (1) | SE7508654L (en) |
ZA (1) | ZA754907B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6835724B2 (en) | 1993-10-05 | 2004-12-28 | Aventis Pharma Deutschland Gmbh | Corticoid 17,21-dicarboxylic esters and corticosteroid 17-carboxylic ester 21-carbonic esters, processes for their preparation and pharmaceuticals containing these compounds |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4456602A (en) * | 1982-08-23 | 1984-06-26 | The Upjohn Company | Amine containing ester prodrugs of corticosteroids |
US4443440A (en) * | 1982-08-30 | 1984-04-17 | The Upjohn Company | Amine containing ester prodrugs of corticosteroids |
FR2600653B1 (en) * | 1986-06-24 | 1988-12-16 | Pasteur Strasbourg Universite | COMPOUNDS FOR ASSOCIATIVE SYNTHESIS OF SULFUR OR NON-SULFUR AMINO ACIDS WITH D-4 PREGNENE 3,20-DIONE DERIVATIVES OR WITH D-1,4 PREGNADIENE 3,20-DIONE DERIVATIVES WITH GLUCOCORTICOID AND ANTI-INFLAMMATORY PROPERTIES, METHODS OBTAINED, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. PHARMACOLOGICAL PROPERTIES AND APPLICATIONS |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1044212B (en) * | 1971-03-17 | 1980-03-20 | Sigma Tau Ind Farmaceuti | ESTERS OF BESAMETAZONE AND BETAMETAZONE |
GB1440063A (en) * | 1972-08-11 | 1976-06-23 | Glaxo Lab Ltd | 17alpha-esters of 17alpha,21-dihydroxy-20-oxo-steroids |
-
1974
- 1974-07-31 GB GB33786/74A patent/GB1516095A/en not_active Expired
-
1975
- 1975-07-30 ES ES439852A patent/ES439852A1/en not_active Expired
- 1975-07-30 JP JP50092137A patent/JPS51125059A/en active Pending
- 1975-07-30 DK DK346975AA patent/DK139303B/en unknown
- 1975-07-30 CA CA232,579A patent/CA1058610A/en not_active Expired
- 1975-07-30 SE SE7508654A patent/SE7508654L/en unknown
- 1975-07-30 IE IE1708/75A patent/IE42124B1/en unknown
- 1975-07-30 FR FR7523787A patent/FR2280383A1/en active Granted
- 1975-07-30 CH CH996575A patent/CH615442A5/en not_active IP Right Cessation
- 1975-07-30 ZA ZA00754907A patent/ZA754907B/en unknown
- 1975-07-30 BE BE158780A patent/BE831931A/en unknown
- 1975-07-30 DE DE19752534051 patent/DE2534051A1/en not_active Withdrawn
- 1975-07-30 NL NL7509075A patent/NL7509075A/en not_active Application Discontinuation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6835724B2 (en) | 1993-10-05 | 2004-12-28 | Aventis Pharma Deutschland Gmbh | Corticoid 17,21-dicarboxylic esters and corticosteroid 17-carboxylic ester 21-carbonic esters, processes for their preparation and pharmaceuticals containing these compounds |
Also Published As
Publication number | Publication date |
---|---|
JPS51125059A (en) | 1976-11-01 |
DK346975A (en) | 1976-02-01 |
AU8353175A (en) | 1977-02-03 |
CH615442A5 (en) | 1980-01-31 |
FR2280383B1 (en) | 1978-10-06 |
FR2280383A1 (en) | 1976-02-27 |
IE42124B1 (en) | 1980-06-04 |
SE7508654L (en) | 1976-02-02 |
NL7509075A (en) | 1976-02-03 |
DE2534051A1 (en) | 1976-02-19 |
DK139303B (en) | 1979-01-29 |
ES439852A1 (en) | 1977-03-01 |
ZA754907B (en) | 1976-07-28 |
DK139303C (en) | 1979-08-06 |
BE831931A (en) | 1976-01-30 |
IE42124L (en) | 1976-01-31 |
CA1058610A (en) | 1979-07-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SE8104132L (en) | SOFT STEROIDS WITH ANTI-FLAMMATORY EFFECTS | |
ES464555A1 (en) | Thiazolidine thiazane and morpholine carboxylic acids and esters | |
GB1516095A (en) | 17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series | |
ES464728A1 (en) | Propionic acid derivatives | |
FR2337162B1 (en) | ||
GB1492640A (en) | L-pyroglutamyl-l-prolinamide | |
GB1413183A (en) | Diazo-type photographic lightsensitive materials and development thereof | |
ES417737A1 (en) | Steroids of the pregnane series | |
ES438430A1 (en) | Certain antiinflammatory dihydrobenzofuran and dihydronaphthofuran acetic acid compounds | |
ES456090A1 (en) | 2-amino-or acylamino)-1-sulphonyl-benzoimidazole derivativves | |
ES454283A1 (en) | Organic compounds | |
IE44230L (en) | 1, 3-diaza-bicyclo [3,2, 0] heptane derivatives | |
ES445263A1 (en) | Dimercaptoethyl ether sulfonium compounds and use as antiinflammatory and antirheumatic agents | |
GB1208230A (en) | Novel esters of 21-hydroxy-pregnanes, processes for their preparation, and compositions incorporating them | |
GB1084759A (en) | Steroid compounds | |
ES435329A1 (en) | 2,3,8,12b-tetrahydro-1h-3a 8-methanodibenzo-3,4,6,7-cyclohepta -1,2-c-pyrrole and derivatives thereof | |
GB1375357A (en) | ||
GB1047790A (en) | Improvements in or relating to steroid compounds | |
ES442837A2 (en) | 3-alkyl-7-oxoalkyl-xanthine derivatives | |
GB1541185A (en) | 5-fluorouracil derivatives and their preparation | |
GB1134314A (en) | New carbonic acid esters | |
ES373966A1 (en) | Procedure for the obtaining of phenyl-triazolidin-4-oles. (Machine-translation by Google Translate, not legally binding) | |
ES461263A1 (en) | 21,21-Dihalo steroids | |
ES388308A1 (en) | Organic acid 2,6-disubstituted phenyl hydrazides | |
GB957954A (en) | Steroids and their production |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |