ES439852A1 - 17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series - Google Patents

17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series

Info

Publication number
ES439852A1
ES439852A1 ES439852A ES439852A ES439852A1 ES 439852 A1 ES439852 A1 ES 439852A1 ES 439852 A ES439852 A ES 439852A ES 439852 A ES439852 A ES 439852A ES 439852 A1 ES439852 A1 ES 439852A1
Authority
ES
Spain
Prior art keywords
formula
group
see
previously defined
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES439852A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Publication of ES439852A1 publication Critical patent/ES439852A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group

Abstract

A procedure for the preparation of new 17α, 21-diesters of 17α, 21-diliidroxi-este-roide of the pregnane series of the general formula: **(See formula)** [where X represents a β-hydroxy or keto group, Y represents a fluorine or chlorine atom, represents a hydrogen atom or an alcohol group containing 1 to 3 carbon atoms, R2 represents a group of formula - (CH2) nNR3R4 (where n is 1, 2 or 3 and R3 as well as R4, which may be the same or different, each represent an alcohol group containing 1 to 4 carbon atoms, or R3 and R4 together with the adjacent nitrogen atom form a saturated, substituted or unsubstituted, 4- to 7-membered monocyclic heterocyclic ring (which may, if desired, also contain a sulfur or oxygen atom or other nitrogen atom), or R2 represents a 6-monocyclic heterocyclic ring nitrogen-containing members, substituted or unsubstituted, attached to the adjacent carbonyl group through a ring carbon atom, and (see graphic) represents a single or double bond]; and acid addition salts thereof, characterized in that a compound of formula is reacted **(See formula)** [where R1, X, Y and (see graph) are as previously defined and R5 represents a hydroxy group or a group of the formula -OCO (CH2) nZ (where n is as previously defined and Z represents an easily displaceable substituent], with a compound of formula H.R6 III [where R6 represents a group of the formula -OCOR2 (where R2 is as defined above) or a reactive derivative thereof, when R5 in formula II represents a hydroxy group; or R6 represents a group of formula (see formula) (where R3 and R4 are as previously defined) when R5 in formula II represents a group of formula -OCO (CH2) nZ (where n and Z are as previously defined)] or a derivative functional thereof; and, if desired, the resulting compound of formula I is converted to an acid addition salt thereof. (Machine-translation by Google Translate, not legally binding)
ES439852A 1974-07-31 1975-07-30 17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series Expired ES439852A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB33786/74A GB1516095A (en) 1974-07-31 1974-07-31 17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series

Publications (1)

Publication Number Publication Date
ES439852A1 true ES439852A1 (en) 1977-03-01

Family

ID=10357423

Family Applications (1)

Application Number Title Priority Date Filing Date
ES439852A Expired ES439852A1 (en) 1974-07-31 1975-07-30 17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series

Country Status (13)

Country Link
JP (1) JPS51125059A (en)
BE (1) BE831931A (en)
CA (1) CA1058610A (en)
CH (1) CH615442A5 (en)
DE (1) DE2534051A1 (en)
DK (1) DK139303B (en)
ES (1) ES439852A1 (en)
FR (1) FR2280383A1 (en)
GB (1) GB1516095A (en)
IE (1) IE42124B1 (en)
NL (1) NL7509075A (en)
SE (1) SE7508654L (en)
ZA (1) ZA754907B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4456602A (en) * 1982-08-23 1984-06-26 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4443440A (en) * 1982-08-30 1984-04-17 The Upjohn Company Amine containing ester prodrugs of corticosteroids
FR2600653B1 (en) * 1986-06-24 1988-12-16 Pasteur Strasbourg Universite COMPOUNDS FOR ASSOCIATIVE SYNTHESIS OF SULFUR OR NON-SULFUR AMINO ACIDS WITH D-4 PREGNENE 3,20-DIONE DERIVATIVES OR WITH D-1,4 PREGNADIENE 3,20-DIONE DERIVATIVES WITH GLUCOCORTICOID AND ANTI-INFLAMMATORY PROPERTIES, METHODS OBTAINED, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. PHARMACOLOGICAL PROPERTIES AND APPLICATIONS
DE4333920A1 (en) 1993-10-05 1995-04-13 Hoechst Ag Corticoid-17,21-dicarboxylic acid esters and corticosteroid-17-carboxylic acid ester-21-carbonic acid esters, processes for their preparation and medicaments containing them

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1044212B (en) * 1971-03-17 1980-03-20 Sigma Tau Ind Farmaceuti ESTERS OF BESAMETAZONE AND BETAMETAZONE
GB1440063A (en) * 1972-08-11 1976-06-23 Glaxo Lab Ltd 17alpha-esters of 17alpha,21-dihydroxy-20-oxo-steroids

Also Published As

Publication number Publication date
CA1058610A (en) 1979-07-17
NL7509075A (en) 1976-02-03
DK139303C (en) 1979-08-06
FR2280383A1 (en) 1976-02-27
JPS51125059A (en) 1976-11-01
IE42124B1 (en) 1980-06-04
IE42124L (en) 1976-01-31
DK139303B (en) 1979-01-29
CH615442A5 (en) 1980-01-31
DK346975A (en) 1976-02-01
AU8353175A (en) 1977-02-03
GB1516095A (en) 1978-06-28
FR2280383B1 (en) 1978-10-06
SE7508654L (en) 1976-02-02
ZA754907B (en) 1976-07-28
DE2534051A1 (en) 1976-02-19
BE831931A (en) 1976-01-30

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