LT3281939T - Derinys, apimantis stabilų 4-oksochinolino junginio kristalą - Google Patents

Derinys, apimantis stabilų 4-oksochinolino junginio kristalą

Info

Publication number
LT3281939T
LT3281939T LTEP17186674.2T LT17186674T LT3281939T LT 3281939 T LT3281939 T LT 3281939T LT 17186674 T LT17186674 T LT 17186674T LT 3281939 T LT3281939 T LT 3281939T
Authority
LT
Lithuania
Prior art keywords
combination
stable crystal
oxoquinoline compound
oxoquinoline
compound
Prior art date
Application number
LTEP17186674.2T
Other languages
English (en)
Lithuanian (lt)
Inventor
Motohide Satoh
Takahisa Motomura
Takashi Matsuda
Kentaro Kondo
Koji Ando
Koji Matsuda
Shuji Miyake
Hideto Uehara
Original Assignee
Japan Tobacco Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35079161&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT3281939(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Japan Tobacco Inc. filed Critical Japan Tobacco Inc.
Publication of LT3281939T publication Critical patent/LT3281939T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
LTEP17186674.2T 2004-05-20 2005-05-19 Derinys, apimantis stabilų 4-oksochinolino junginio kristalą LT3281939T (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2004150979 2004-05-20

Publications (1)

Publication Number Publication Date
LT3281939T true LT3281939T (lt) 2023-11-27

Family

ID=35079161

Family Applications (2)

Application Number Title Priority Date Filing Date
LTEP17186674.2T LT3281939T (lt) 2004-05-20 2005-05-19 Derinys, apimantis stabilų 4-oksochinolino junginio kristalą
LTPA2024001C LTC3281939I2 (enExample) 2004-05-20 2024-03-26

Family Applications After (1)

Application Number Title Priority Date Filing Date
LTPA2024001C LTC3281939I2 (enExample) 2004-05-20 2024-03-26

Country Status (33)

Country Link
US (7) US7635704B2 (enExample)
EP (4) EP2514746A1 (enExample)
JP (1) JP3754064B2 (enExample)
KR (1) KR20080064909A (enExample)
CN (1) CN1956961B (enExample)
AR (2) AR049280A1 (enExample)
AU (1) AU2005245296B2 (enExample)
BE (1) BE2024C511I2 (enExample)
BR (1) BRPI0510114B8 (enExample)
CA (1) CA2566922C (enExample)
CY (4) CY1113010T1 (enExample)
DK (2) DK3281939T3 (enExample)
ES (2) ES2960824T3 (enExample)
FI (2) FI3281939T3 (enExample)
FR (1) FR23C1040I1 (enExample)
HR (2) HRP20120681T1 (enExample)
HU (2) HUE064615T2 (enExample)
IL (1) IL179250A0 (enExample)
LT (2) LT3281939T (enExample)
LU (1) LUC00334I2 (enExample)
MX (1) MXPA06013405A (enExample)
MY (1) MY134672A (enExample)
NO (8) NO339223B1 (enExample)
NZ (1) NZ551839A (enExample)
PE (2) PE20060358A1 (enExample)
PL (2) PL3281939T3 (enExample)
PT (2) PT1636190E (enExample)
RS (2) RS52375B (enExample)
RU (1) RU2330845C1 (enExample)
SI (2) SI1636190T1 (enExample)
TW (1) TWI329015B (enExample)
WO (1) WO2005113508A1 (enExample)
ZA (1) ZA200610647B (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6891227B2 (en) 2002-03-20 2005-05-10 International Business Machines Corporation Self-aligned nanotube field effect transistor and method of fabricating same
SI1564210T1 (sl) * 2002-11-20 2010-01-29 Japan Tobacco Inc 4-oksokinolinske spojine in njihova uporaba kot inhibitorji HIV integraze
MY134672A (en) * 2004-05-20 2007-12-31 Japan Tobacco Inc Stable crystal of 4-oxoquinoline compound
WO2007063869A1 (ja) * 2005-11-30 2007-06-07 Japan Tobacco Inc. 高純度キノロン化合物の製造方法
US20090233964A1 (en) * 2005-12-30 2009-09-17 Gilead Sciences, Inc. Methods for improving the pharmacokinetics of hiv integrase inhibitors
SG170796A1 (en) * 2005-12-30 2011-05-30 Gilead Sciences Inc Us Methods for improving the pharmacokinetics of hiv integrase inhibitors
AU2013203476C1 (en) * 2005-12-30 2016-11-17 Gilead Sciences, Inc. Methods for improving the pharmacokinetics of hiv integrase inhibitors
EP1978960A4 (en) 2006-02-01 2009-12-02 Japan Tobacco Inc USE OF 6- (3-CHLORO-2-FLUORBENZYL) -1 - [(2S) -1-HYDROXY-3-METHYLBUTAN-2-YL [-7-METHOXY-4-OXO-1,4-DIHYDROCHINOLINE-3- CARBOXYLIC ACID OR SALT THEREOF FOR THE TREATMENT OF RETROVIRUS INFECTION
WO2007092802A1 (en) * 2006-02-09 2007-08-16 Boehringer Ingelheim International Gmbh Method for treating hiv infection through co-administration of tipranavir and gs 9137
JP4669040B2 (ja) 2006-03-06 2011-04-13 日本たばこ産業株式会社 ４−オキソキノリン化合物の製造方法
CN101437801B (zh) 2006-03-06 2013-02-06 日本烟草产业株式会社 制备4-氧代喹啉化合物的方法
AP2985A (en) 2006-07-07 2014-09-30 Gilead Sciences Inc Modulators of pharmacokinetic properties of therapeutics
EP2069280B1 (en) 2006-09-12 2015-03-25 Gilead Sciences, Inc. Process and intermediates for preparing HIV integrase inhibitors
EP2118082B1 (en) * 2007-02-23 2014-10-01 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
JP5547066B2 (ja) * 2007-06-29 2014-07-09 ギリアード サイエンシーズ， インコーポレイテッド 治療用組成物およびその使用
MX2009013828A (es) * 2007-06-29 2010-03-10 Gilead Sciences Inc Composiciones terapeuticas y su uso.
AR068403A1 (es) 2007-09-11 2009-11-18 Gilead Sciences Inc Proceso e intermediarios para la preparacion de inhibidores de integrasa
EA022950B1 (ru) 2008-05-02 2016-03-31 Джилид Сайэнс, Инк. Применение частиц носителя диоксида кремния для улучшения технологических характеристик фармацевтического агента
CN102307573B (zh) 2009-02-06 2013-09-11 吉里德科学公司 用于联合治疗的片剂
WO2010137032A2 (en) * 2009-05-14 2010-12-02 Matrix Laboratories Ltd. Novel polymorphic forms of elvitegravir and its pharmaceutically acceptable salts
WO2011004389A2 (en) * 2009-06-18 2011-01-13 Matrix Laboratories Ltd An improved process for the preparation of elvitegravir
CN102212032B (zh) * 2011-04-20 2013-07-31 复旦大学 一种5-羟基喹诺酮类衍生物及其制备方法和用途
CA2878478A1 (en) 2012-07-06 2014-01-09 Genentech, Inc. N-substituted benzamides and methods of use thereof
JP6147856B2 (ja) 2012-08-03 2017-06-14 ギリアード サイエンシーズ， インコーポレイテッド インテグラーゼインヒビターを調製するためのプロセスおよび中間体
CN103819402B (zh) * 2012-11-17 2016-03-30 上海迪赛诺化学制药有限公司 埃替拉韦中间体及其制备方法和应用
CN103864682B (zh) * 2012-12-18 2016-12-28 上海迪赛诺化学制药有限公司 一种制备iii型埃替拉韦晶体的方法
PT3067358T (pt) 2012-12-21 2019-11-18 Gilead Sciences Inc Compostos carbamoílpiridona policíclicos e sua utilização farmacêutica
AU2014286993B2 (en) 2013-07-12 2018-10-25 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their use for the treatment of HIV infections
NO2865735T3 (enExample) 2013-07-12 2018-07-21
CN105315203A (zh) * 2014-06-06 2016-02-10 上海迪赛诺化学制药有限公司 一种v型埃替拉韦晶体及其制备方法
NO2717902T3 (enExample) 2014-06-20 2018-06-23
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
TWI744723B (zh) 2014-06-20 2021-11-01 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
TWI695003B (zh) 2014-12-23 2020-06-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
NZ735575A (en) 2015-04-02 2018-11-30 Gilead Sciences Inc Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
CN106008195B (zh) * 2016-05-19 2018-08-03 绍兴文理学院 一种2，4-二氟-5-碘苯甲酸的制备方法
EP3984536B1 (en) * 2020-10-19 2025-06-25 Centre national de la recherche scientifique Inhibition of the hiv-1 replication by compounds directed against a new target of the viral cycle

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3472859A (en) * 1966-11-01 1969-10-14 Sterling Drug Inc 1-alkyl-1,4-dihydro-4-oxo-3 quinoline-carboxylic acids and esters
JPS567162B1 (enExample) 1970-09-14 1981-02-16
JPS4826772A (enExample) 1971-08-11 1973-04-09
JPS6450979A (en) 1987-08-21 1989-02-27 Hitachi Shipbuilding Eng Co Method for discriminating whistle sound
JPH0651229B2 (ja) 1989-07-31 1994-07-06 新日本製鐵株式会社 プラズマアーク溶接方法および装置
IL100555A (en) 1991-02-07 2000-08-31 Hoechst Marion Roussel Inc N-substituted quinoline derivatives their preparation their use for the preparation of medicaments and the pharmaceutical compositions containing them
NO304832B1 (no) 1992-05-27 1999-02-22 Ube Industries Aminokinolonderivater samt middel mot HIV
JP2993316B2 (ja) 1992-05-27 1999-12-20 宇部興産株式会社 アリール基又は複素芳香環基置換アミノキノロン誘導体及びエイズ治療剤
JPH06199835A (ja) 1993-01-08 1994-07-19 Hokuriku Seiyaku Co Ltd ８−ジフルオロメトキシキノリン−３−カルボン酸誘導体
JPH06271568A (ja) 1993-03-22 1994-09-27 Hokuriku Seiyaku Co Ltd ７−フェニルピペラジニルキノリン−３−カルボン酸誘導体
JP2930539B2 (ja) 1994-07-18 1999-08-03 三共株式会社 トリフルオロメチルキノリンカルボン酸誘導体
MX9700497A (es) 1994-07-18 1997-04-30 Ube Industries Derivado de acido trifluorometilquinolinocarboxilico.
JPH0826772A (ja) 1994-07-22 1996-01-30 Sony Corp 融着用ガラス、その製造方法及び製造装置、並びに磁気ヘッドの製造方法
JP4121151B2 (ja) 1996-04-12 2008-07-23 アメリカ合衆国 抗新生物薬および抗レトロウイルス薬として有用なアクリドンから誘導された化合物
FR2761687B1 (fr) * 1997-04-08 2000-09-15 Centre Nat Rech Scient Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiques
JP3776203B2 (ja) 1997-05-13 2006-05-17 第一製薬株式会社 Ｉｃａｍ−１産生阻害剤
GB9721964D0 (en) 1997-10-16 1997-12-17 Pfizer Ltd Isoquinolines
US6399629B1 (en) 1998-06-01 2002-06-04 Microcide Pharmaceuticals, Inc. Efflux pump inhibitors
SE9802549D0 (sv) * 1998-07-15 1998-07-15 Active Biotech Ab Quinoline derivatives
US6248736B1 (en) 1999-01-08 2001-06-19 Pharmacia & Upjohn Company 4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents
US6248739B1 (en) 1999-01-08 2001-06-19 Pharmacia & Upjohn Company Quinolinecarboxamides as antiviral agents
PE20011349A1 (es) 2000-06-16 2002-01-19 Upjohn Co 1-aril-4-oxo-1,4-dihidro-3-quinolincarboxamidas como agentes antivirales
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
DE60124577T2 (de) 2000-10-12 2007-09-27 Merck & Co., Inc. Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer
AU2002230392A1 (en) 2000-10-12 2002-05-15 Merck & Co., Inc. AZA-and polyaza-naphthalenyl ketones useful as HIV integrase inhibitors
PL365027A1 (en) 2001-03-01 2004-12-27 Shionogi & Co, Ltd. Nitrogen-containing heteroaryl compounds having hiv integrase inhibitory activity
JP2002293745A (ja) 2001-03-29 2002-10-09 St Marianna Univ School Of Medicine 慢性関節リウマチ治療剤
US20030138483A1 (en) * 2001-05-25 2003-07-24 Sergio Petriconi Soft elastic capsules and compositions thereof
US6627646B2 (en) * 2001-07-17 2003-09-30 Sepracor Inc. Norastemizole polymorphs
FR2827600A1 (fr) 2001-07-20 2003-01-24 Lipha Derives acides de quinolone et leurs applications en therapeutique
RU2206564C1 (ru) * 2002-03-07 2003-06-20 Общество с ограниченной ответственностью "Поливит" Способ получения этилового эфира 6-фтор-7-хлор-1,4-дигидро-4-оксо-3-хинолинкарбоновой кислоты
JP4035765B2 (ja) 2002-10-31 2008-01-23 横河電機株式会社 フーリエ変換型赤外線分光計
SI1564210T1 (sl) 2002-11-20 2010-01-29 Japan Tobacco Inc 4-oksokinolinske spojine in njihova uporaba kot inhibitorji HIV integraze
JP3567162B1 (ja) 2002-11-20 2004-09-22 日本たばこ産業株式会社 ４−オキソキノリン化合物及びそのｈｉｖインテグラーゼ阻害剤としての利用
WO2005113509A1 (en) * 2004-05-20 2005-12-01 Japan Tobacco Inc. Novel 4-oxoquinoline compound and use thereof as hiv integrase inhibitor
MY134672A (en) * 2004-05-20 2007-12-31 Japan Tobacco Inc Stable crystal of 4-oxoquinoline compound
EP3287130A1 (en) 2004-05-21 2018-02-28 Japan Tobacco Inc. Combinations comprising a 4-isoquinolone derivative and protease inhibitors

Also Published As

Publication number Publication date
CA2566922C (en) 2011-01-11
PL3281939T3 (pl) 2024-03-18
BRPI0510114B1 (pt) 2020-09-15
WO2005113508A1 (en) 2005-12-01
HUS2400006I1 (hu) 2024-04-28
NO339223B1 (no) 2016-11-21
US8981103B2 (en) 2015-03-17
SI3281939T1 (sl) 2024-02-29
NZ551839A (en) 2009-11-27
DK3281939T3 (da) 2024-01-22
CY1113010T1 (el) 2016-04-13
US20100204271A1 (en) 2010-08-12
RS52375B (sr) 2012-12-31
NO20200873A1 (no) 2007-02-07
CY2024008I1 (el) 2024-09-20
RS64845B1 (sr) 2023-12-29
EP3281939A1 (en) 2018-02-14
AR049280A1 (es) 2006-07-12
LUC00334I2 (enExample) 2024-07-01
PT3281939T (pt) 2023-11-22
DK1636190T3 (da) 2012-09-24
ES2388441T3 (es) 2012-10-15
EP4299563A2 (en) 2024-01-03
AU2005245296B2 (en) 2010-08-12
PE20060358A1 (es) 2006-05-12
NO20240384A1 (no) 2007-02-07
MXPA06013405A (es) 2007-03-01
ZA200610647B (en) 2008-06-25
FR23C1040I1 (fr) 2023-12-29
LTC3281939I2 (enExample) 2025-04-25
BRPI0510114A (pt) 2007-09-25
NO20230913A1 (no) 2007-02-07
PE20120361A1 (es) 2012-05-03
AU2005245296A1 (en) 2005-12-01
NO347902B1 (no) 2024-05-06
MY134672A (en) 2007-12-31
CN1956961B (zh) 2010-05-26
CY2015009I2 (el) 2024-09-20
CN1956961A (zh) 2007-05-02
NO20161297A1 (no) 2007-02-07
NO20190051A1 (no) 2007-02-07
CY2015009I1 (el) 2024-09-20
EP2514746A1 (en) 2012-10-24
JP2006001927A (ja) 2006-01-05
US20060030710A1 (en) 2006-02-09
US20190185433A1 (en) 2019-06-20
TWI329015B (en) 2010-08-21
NO20065790L (no) 2007-02-07
EP3281939B1 (en) 2023-10-18
US20180029989A1 (en) 2018-02-01
EP1636190B1 (en) 2012-06-27
NO2024034I1 (no) 2024-07-15
US20250091995A1 (en) 2025-03-20
BE2024C511I2 (enExample) 2024-10-08
HUE064615T2 (hu) 2024-04-28
KR20080064909A (ko) 2008-07-09
CY1126560T1 (el) 2024-09-20
SI1636190T1 (sl) 2012-09-28
IL179250A0 (en) 2007-03-08
HRP20120681T1 (hr) 2012-09-30
HRP20231588T3 (hr) 2024-03-15
ES2960824T3 (es) 2024-03-06
FI3281939T3 (fi) 2023-10-23
HK1083341A1 (en) 2006-06-30
CY2024008I2 (el) 2024-09-20
NO20220690A1 (no) 2007-02-07
RU2330845C1 (ru) 2008-08-10
AR096100A2 (es) 2015-12-09
US20220235009A1 (en) 2022-07-28
TW200600097A (en) 2006-01-01
LTPA2024001I1 (enExample) 2024-04-10
PL1636190T3 (pl) 2012-10-31
EP4299563A3 (en) 2024-02-28
FIC20240008I1 (fi) 2024-03-20
EP1636190A1 (en) 2006-03-22
US20150361044A1 (en) 2015-12-17
PT1636190E (pt) 2012-08-20
BRPI0510114B8 (pt) 2021-05-25
JP3754064B2 (ja) 2006-03-08
CA2566922A1 (en) 2005-12-01
US7635704B2 (en) 2009-12-22

Similar Documents

Publication Publication Date Title
HUE064615T2 (hu) Egy 4-oxokinolin-vegyület stabil kristályát tartalmazó kombináció
AU157195S (en) Watch
IL181732A0 (en) 2-morpholino-4-pyrimidone compound
IL181297A0 (en) Benzamide compounds
GB0504995D0 (en) Use of a compound
GB0415663D0 (en) Compound
GB0408771D0 (en) Compound
GB0421106D0 (en) Compound
AU158223S (en) Wristwatch
ZA200703622B (en) Novel use of α-sympathomlmetics having a 2-imidazoline structure
GB0410498D0 (en) Crystal
GB0425969D0 (en) Compound
GB0411562D0 (en) Compound
ZA200701801B (en) Benzamide compounds
GB0427758D0 (en) Novel benzamide compounds
GB0522829D0 (en) Use of a compound
GB0428295D0 (en) Compound
GB0422648D0 (en) Benzamide compounds
HK1104936A (en) Benzamide compounds
HU2974U (en) Fluid-displaying watch
GB0415064D0 (en) Watch
AU154459S (en) A wristwatch
AU154561S (en) A wristwatch
AU301423S (en) A watch
IL177451A0 (en) Crystalline forms of a pharmaceutical compound