AR096100A2 - Cristal estable de derivado de 4-oxoquinolina, su uso como agente anti-hiv y su uso en composiciones anti-hiv - Google Patents

Cristal estable de derivado de 4-oxoquinolina, su uso como agente anti-hiv y su uso en composiciones anti-hiv

Info

Publication number
AR096100A2
AR096100A2 ARP140101722A ARP140101722A AR096100A2 AR 096100 A2 AR096100 A2 AR 096100A2 AR P140101722 A ARP140101722 A AR P140101722A AR P140101722 A ARP140101722 A AR P140101722A AR 096100 A2 AR096100 A2 AR 096100A2
Authority
AR
Argentina
Prior art keywords
crystal
hiv
oxoquinoline
derivative
ray powder
Prior art date
Application number
ARP140101722A
Other languages
English (en)
Inventor
Satoh Motohide
Motomura Takahisa
Matsuda Takashi
Kondo Kentaro
Ando Koji
Matsuda Koji
Miyake Shuji
Uehara Hideto
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35079161&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR096100(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of AR096100A2 publication Critical patent/AR096100A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Abstract

Reivindicación 1: Un cristal (cristal de forma II) de ácido 6-(3-cloro-2-fluorobencil)-1-[(S)-1-hidroximetil-2-metilpropil]-7-metoxi-4-oxo-1,4-dihidroquinolin-3-carboxílico, caracterizado porque posee un modelo de difracción de polvo con rayos X que posee crestas de difracción característica en ángulos de difracción 2q(º) de 6,56; 13,20; 19,86; 20,84; 21,22; 25,22º medido por difractómetro de polvo con rayos X. Reivindicación 2: Un cristal (cristal de forma III) de ácido 6-(3-cloro-2-fluorobencil)-1-[(S)-1-hidroximetil-2-metilpropil]-7-metoxi-4-oxo-1,4-dihidroquinolin-3-carboxílico, caracterizado porque posee un modelo de difracción de polvo con rayos X que posee crestas de difracción característica en ángulos de difracción 2q(º) de 8,54; 14,02; 15,68; 17,06; 17,24; 24,16; 25,74º medido por difractómetro de polvo con rayos X. Reivindicación 5: Un cristal mezcla caracterizado por que comprende el cristal de acuerdo con la reivindicación 1 y el cristal de acuerdo con la reivindicación 2 ó 3.
ARP140101722A 2004-05-20 2014-04-25 Cristal estable de derivado de 4-oxoquinolina, su uso como agente anti-hiv y su uso en composiciones anti-hiv AR096100A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2004150979 2004-05-20

Publications (1)

Publication Number Publication Date
AR096100A2 true AR096100A2 (es) 2015-12-09

Family

ID=35079161

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP050102058A AR049280A1 (es) 2004-05-20 2005-05-19 Cristal estable de derivado de 4 - oxoquinolina, su uso como agente anti - hiv y su uso en composiciones anti - hiv.
ARP140101722A AR096100A2 (es) 2004-05-20 2014-04-25 Cristal estable de derivado de 4-oxoquinolina, su uso como agente anti-hiv y su uso en composiciones anti-hiv

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP050102058A AR049280A1 (es) 2004-05-20 2005-05-19 Cristal estable de derivado de 4 - oxoquinolina, su uso como agente anti - hiv y su uso en composiciones anti - hiv.

Country Status (30)

Country Link
US (6) US7635704B2 (es)
EP (4) EP2514746A1 (es)
JP (1) JP3754064B2 (es)
KR (1) KR20080064909A (es)
CN (1) CN1956961B (es)
AR (2) AR049280A1 (es)
AU (1) AU2005245296B2 (es)
BR (1) BRPI0510114B8 (es)
CA (1) CA2566922C (es)
CY (1) CY1113010T1 (es)
DK (2) DK1636190T3 (es)
ES (2) ES2388441T3 (es)
FI (2) FI3281939T3 (es)
HK (1) HK1083341A1 (es)
HR (2) HRP20231588T3 (es)
IL (1) IL179250A0 (es)
LT (1) LT3281939T (es)
MX (1) MXPA06013405A (es)
MY (1) MY134672A (es)
NO (6) NO20230913A1 (es)
NZ (1) NZ551839A (es)
PE (2) PE20120361A1 (es)
PL (2) PL3281939T3 (es)
PT (2) PT3281939T (es)
RS (2) RS52375B (es)
RU (1) RU2330845C1 (es)
SI (2) SI3281939T1 (es)
TW (1) TWI329015B (es)
WO (1) WO2005113508A1 (es)
ZA (1) ZA200610647B (es)

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Also Published As

Publication number Publication date
ES2960824T3 (es) 2024-03-06
PL3281939T3 (pl) 2024-03-18
CA2566922C (en) 2011-01-11
AU2005245296B2 (en) 2010-08-12
US20180029989A1 (en) 2018-02-01
HRP20120681T1 (hr) 2012-09-30
TW200600097A (en) 2006-01-01
US8981103B2 (en) 2015-03-17
HRP20231588T3 (hr) 2024-03-15
LT3281939T (lt) 2023-11-27
PT3281939T (pt) 2023-11-22
JP3754064B2 (ja) 2006-03-08
DK1636190T3 (da) 2012-09-24
NO20220690A1 (no) 2007-02-07
NO20230913A1 (no) 2007-02-07
IL179250A0 (en) 2007-03-08
CY1113010T1 (el) 2016-04-13
ZA200610647B (en) 2008-06-25
EP4299563A3 (en) 2024-02-28
TWI329015B (en) 2010-08-21
EP1636190A1 (en) 2006-03-22
BRPI0510114A (pt) 2007-09-25
RS64845B1 (sr) 2023-12-29
EP3281939A1 (en) 2018-02-14
CN1956961B (zh) 2010-05-26
NO20190051A1 (no) 2007-02-07
SI1636190T1 (sl) 2012-09-28
PE20060358A1 (es) 2006-05-12
AR049280A1 (es) 2006-07-12
NZ551839A (en) 2009-11-27
WO2005113508A1 (en) 2005-12-01
EP3281939B1 (en) 2023-10-18
MXPA06013405A (es) 2007-03-01
NO339223B1 (no) 2016-11-21
KR20080064909A (ko) 2008-07-09
NO20200873A1 (no) 2007-02-07
CN1956961A (zh) 2007-05-02
JP2006001927A (ja) 2006-01-05
US20060030710A1 (en) 2006-02-09
CA2566922A1 (en) 2005-12-01
BRPI0510114B1 (pt) 2020-09-15
US20220235009A1 (en) 2022-07-28
FI3281939T3 (fi) 2023-10-23
FIC20240008I1 (fi) 2024-03-20
BRPI0510114B8 (pt) 2021-05-25
DK3281939T3 (da) 2024-01-22
ES2388441T3 (es) 2012-10-15
SI3281939T1 (sl) 2024-02-29
HK1083341A1 (en) 2006-06-30
US20190185433A1 (en) 2019-06-20
PT1636190E (pt) 2012-08-20
US7635704B2 (en) 2009-12-22
EP1636190B1 (en) 2012-06-27
NO20065790L (no) 2007-02-07
US20100204271A1 (en) 2010-08-12
EP4299563A2 (en) 2024-01-03
AU2005245296A1 (en) 2005-12-01
US20150361044A1 (en) 2015-12-17
MY134672A (en) 2007-12-31
NO20161297A1 (no) 2007-02-07
PL1636190T3 (pl) 2012-10-31
EP2514746A1 (en) 2012-10-24
RU2330845C1 (ru) 2008-08-10
PE20120361A1 (es) 2012-05-03
RS52375B (en) 2012-12-31

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