ES2171260T3 - Compuestos derivados de acridona utiles como agentes antineoplasicos y antirretroviricos. - Google Patents
Compuestos derivados de acridona utiles como agentes antineoplasicos y antirretroviricos.Info
- Publication number
- ES2171260T3 ES2171260T3 ES97922508T ES97922508T ES2171260T3 ES 2171260 T3 ES2171260 T3 ES 2171260T3 ES 97922508 T ES97922508 T ES 97922508T ES 97922508 T ES97922508 T ES 97922508T ES 2171260 T3 ES2171260 T3 ES 2171260T3
- Authority
- ES
- Spain
- Prior art keywords
- useful
- agents
- acridona
- independently
- compounds derived
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 230000000118 anti-neoplastic effect Effects 0.000 title abstract 2
- -1 AMINO Chemical class 0.000 abstract 1
- 206010061598 Immunodeficiency Diseases 0.000 abstract 1
- 208000029462 Immunodeficiency disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000007813 immunodeficiency Effects 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A VARIOS COMPUESTOS NUEVOS DERIVADOS DE LA ACRIDONA, DE FORMULA (I) O (II). ESTOS COMPUESTOS SON POTENTES AGENTES ANTI - VIRALES, UTILES EN EL TRATAMIENTO DE ENFERMEDADES VIRALES, TALES COMO EL VIRUS DE LA INMUNODEFICIENCIA HUMANA (VIH). ADEMAS, ESTOS COMPUESTOS SON AGENTES ANTI NEOPLASICOS, UTILES EN EL TRATAMIENTO DE DIVERSAS FORMAS DE CANCER. EN LAS MENCIONADAS FORMULAS (I) O (II) R 1 Y R 2 SON INDEPENDIENTEMENTE - H, - OH, AMINO, ALQUILAMINO, DIALQUILAMINO, ALCOXI, ALQUILO, HALOALQUILO O HALOGENO; N ES 2 A 6, X Y X'' SON INDEPENDIENTEMENTE - N O - NO 2 Y E Y'' SON INDEPENDIENTEMENTE N, - CH, O - H; Y EL DOBLE GUION REPRESENTA UN DOBLE ENLACE O LA INEXISTENCIA DE ENLACE.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1532696P | 1996-04-12 | 1996-04-12 | |
US3505097P | 1997-01-22 | 1997-01-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2171260T3 true ES2171260T3 (es) | 2002-09-01 |
Family
ID=26687242
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97922508T Expired - Lifetime ES2171260T3 (es) | 1996-04-12 | 1997-04-09 | Compuestos derivados de acridona utiles como agentes antineoplasicos y antirretroviricos. |
Country Status (10)
Country | Link |
---|---|
US (2) | US6187775B1 (es) |
EP (1) | EP0892801B1 (es) |
JP (1) | JP4121151B2 (es) |
AT (1) | ATE211471T1 (es) |
AU (1) | AU725629B2 (es) |
DE (1) | DE69709857T2 (es) |
DK (1) | DK0892801T3 (es) |
ES (1) | ES2171260T3 (es) |
PT (1) | PT892801E (es) |
WO (1) | WO1997038999A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1293525B1 (it) * | 1997-08-01 | 1999-03-01 | Uni Degli Studi Camerino | Bis-acridincarbossiammidi aventi attivita' antitumorale |
JP2003525940A (ja) * | 2000-03-07 | 2003-09-02 | アメリカ合衆国 | 抗−腫瘍活性を有する、1,8−ナフタルイミドイミダゾ〔4,5,1−de〕アクリドン類 |
US7144843B2 (en) * | 2001-01-31 | 2006-12-05 | Meiji Seika Kaisha, Ltd. | Pest controllers |
US6670071B2 (en) * | 2002-01-15 | 2003-12-30 | Quallion Llc | Electric storage battery construction and method of manufacture |
EP4059923A1 (en) * | 2002-11-20 | 2022-09-21 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as hiv integrase inhibitor |
US8512144B2 (en) * | 2003-10-20 | 2013-08-20 | Tipping Point Group, Llc | Method and apparatus for providing secondary gaming machine functionality |
MY134672A (en) | 2004-05-20 | 2007-12-31 | Japan Tobacco Inc | Stable crystal of 4-oxoquinoline compound |
US7531554B2 (en) | 2004-05-20 | 2009-05-12 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
JP4638485B2 (ja) * | 2004-06-30 | 2011-02-23 | カウンシル オブ サイエンティフィク アンド インダストリアル リサーチ | ピペラジン部分により結合したピロロ[2,1−c][1,4]ベンゾジアゼピン−ナフタルイミド結合体及びそれを調製するための方法 |
US8377586B2 (en) * | 2005-10-05 | 2013-02-19 | California Institute Of Technology | Fluoride ion electrochemical cell |
US7829578B1 (en) | 2005-12-12 | 2010-11-09 | Oregon Health & Science University | Aromatic ketones and uses thereof |
WO2007092436A2 (en) * | 2006-02-08 | 2007-08-16 | Xanthus Pharmaceuticals, Inc. | Compounds for treating inflammatory disorders, demyelinating disorders and cancers |
PL1992607T3 (pl) | 2006-03-06 | 2015-05-29 | Japan Tobacco Inc | Sposób wytwarzania związku 4-oksochinolinowego |
WO2007136858A2 (en) * | 2006-05-19 | 2007-11-29 | H. Lee Moffitt Cancer Center & Research Institute | Small molecule inhibitors of stat3 with anti-tumor activity |
WO2008016661A2 (en) * | 2006-08-02 | 2008-02-07 | Xanthus Pharmaceuticals, Inc. | Morpholino compounds for treating inflammatory and demyelinating diseases and cancers |
EP2086521A2 (en) * | 2006-11-07 | 2009-08-12 | Government of the United States of America, Represented by the Secretary, Department of Health and Human Services | Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs |
WO2008064011A1 (en) * | 2006-11-13 | 2008-05-29 | The Government Of The U.S. Of America As Represented By The Department Of Veterans Affairs | Acridone compounds |
US8598354B2 (en) | 2008-12-05 | 2013-12-03 | University Of South Florida | Compounds having antiparasitic or anti-infectious activity |
EP3070078B1 (en) * | 2015-03-20 | 2017-10-04 | Politechnika Gdanska | Asymmetric bis-acridines with antitumor activity and use thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9104548D0 (en) * | 1991-03-05 | 1991-04-17 | Cholody Wienlaw M | Antineoplastic modified imidazoacridines |
US5508289A (en) * | 1994-03-14 | 1996-04-16 | The United States America As Represented By The Department Of Health And Human Services | Bis-acridone chemotherapeutic derivatives |
-
1997
- 1997-04-09 EP EP97922508A patent/EP0892801B1/en not_active Expired - Lifetime
- 1997-04-09 JP JP53745697A patent/JP4121151B2/ja not_active Expired - Fee Related
- 1997-04-09 WO PCT/US1997/007070 patent/WO1997038999A1/en active IP Right Grant
- 1997-04-09 US US09/155,141 patent/US6187775B1/en not_active Expired - Lifetime
- 1997-04-09 ES ES97922508T patent/ES2171260T3/es not_active Expired - Lifetime
- 1997-04-09 DE DE69709857T patent/DE69709857T2/de not_active Expired - Lifetime
- 1997-04-09 PT PT97922508T patent/PT892801E/pt unknown
- 1997-04-09 DK DK97922508T patent/DK0892801T3/da active
- 1997-04-09 AT AT97922508T patent/ATE211471T1/de active
- 1997-04-09 AU AU28157/97A patent/AU725629B2/en not_active Ceased
-
2001
- 2001-01-15 US US09/760,047 patent/US6541483B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20010009914A1 (en) | 2001-07-26 |
PT892801E (pt) | 2002-06-28 |
ATE211471T1 (de) | 2002-01-15 |
EP0892801A1 (en) | 1999-01-27 |
US6541483B2 (en) | 2003-04-01 |
DK0892801T3 (da) | 2002-04-22 |
DE69709857T2 (de) | 2002-08-29 |
AU725629B2 (en) | 2000-10-19 |
WO1997038999A1 (en) | 1997-10-23 |
AU2815797A (en) | 1997-11-07 |
JP4121151B2 (ja) | 2008-07-23 |
DE69709857D1 (de) | 2002-02-28 |
EP0892801B1 (en) | 2002-01-02 |
JP2000508662A (ja) | 2000-07-11 |
US6187775B1 (en) | 2001-02-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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