PT892801E - Compostos derivados de acridona uteis como agentes antineoplasicos e antiretrovirais - Google Patents
Compostos derivados de acridona uteis como agentes antineoplasicos e antiretroviraisInfo
- Publication number
- PT892801E PT892801E PT97922508T PT97922508T PT892801E PT 892801 E PT892801 E PT 892801E PT 97922508 T PT97922508 T PT 97922508T PT 97922508 T PT97922508 T PT 97922508T PT 892801 E PT892801 E PT 892801E
- Authority
- PT
- Portugal
- Prior art keywords
- acridone
- utilis
- antineoplastic
- compounds
- independently
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- GDALETGZDYOOGB-UHFFFAOYSA-N Acridone Natural products C1=C(O)C=C2N(C)C3=CC=CC=C3C(=O)C2=C1O GDALETGZDYOOGB-UHFFFAOYSA-N 0.000 title abstract 2
- FZEYVTFCMJSGMP-UHFFFAOYSA-N acridone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3NC2=C1 FZEYVTFCMJSGMP-UHFFFAOYSA-N 0.000 title abstract 2
- 229940034982 antineoplastic agent Drugs 0.000 title abstract 2
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- 230000000118 anti-neoplastic effect Effects 0.000 title 1
- 229940124522 antiretrovirals Drugs 0.000 title 1
- 239000003903 antiretrovirus agent Substances 0.000 title 1
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1532696P | 1996-04-12 | 1996-04-12 | |
| US3505097P | 1997-01-22 | 1997-01-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT892801E true PT892801E (pt) | 2002-06-28 |
Family
ID=26687242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97922508T PT892801E (pt) | 1996-04-12 | 1997-04-09 | Compostos derivados de acridona uteis como agentes antineoplasicos e antiretrovirais |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6187775B1 (pt) |
| EP (1) | EP0892801B1 (pt) |
| JP (1) | JP4121151B2 (pt) |
| AT (1) | ATE211471T1 (pt) |
| AU (1) | AU725629B2 (pt) |
| DE (1) | DE69709857T2 (pt) |
| DK (1) | DK0892801T3 (pt) |
| ES (1) | ES2171260T3 (pt) |
| PT (1) | PT892801E (pt) |
| WO (1) | WO1997038999A1 (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1293525B1 (it) * | 1997-08-01 | 1999-03-01 | Uni Degli Studi Camerino | Bis-acridincarbossiammidi aventi attivita' antitumorale |
| AU4005401A (en) | 2000-03-07 | 2001-09-17 | Us Health | 1,8-naphthalimide imidazo(4,5,1-de)acridones with anti-tumor activity |
| US7144843B2 (en) * | 2001-01-31 | 2006-12-05 | Meiji Seika Kaisha, Ltd. | Pest controllers |
| US6670071B2 (en) * | 2002-01-15 | 2003-12-30 | Quallion Llc | Electric storage battery construction and method of manufacture |
| CA2470365C (en) | 2002-11-20 | 2011-05-17 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as hiv integrase inhibitor |
| US8512144B2 (en) * | 2003-10-20 | 2013-08-20 | Tipping Point Group, Llc | Method and apparatus for providing secondary gaming machine functionality |
| US7531554B2 (en) | 2004-05-20 | 2009-05-12 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
| MY134672A (en) | 2004-05-20 | 2007-12-31 | Japan Tobacco Inc | Stable crystal of 4-oxoquinoline compound |
| JP4638485B2 (ja) * | 2004-06-30 | 2011-02-23 | カウンシル オブ サイエンティフィク アンド インダストリアル リサーチ | ピペラジン部分により結合したピロロ［２，１−ｃ］［１，４］ベンゾジアゼピン−ナフタルイミド結合体及びそれを調製するための方法 |
| US8377586B2 (en) * | 2005-10-05 | 2013-02-19 | California Institute Of Technology | Fluoride ion electrochemical cell |
| US7829578B1 (en) | 2005-12-12 | 2010-11-09 | Oregon Health & Science University | Aromatic ketones and uses thereof |
| WO2007092436A2 (en) * | 2006-02-08 | 2007-08-16 | Xanthus Pharmaceuticals, Inc. | Compounds for treating inflammatory disorders, demyelinating disorders and cancers |
| ES2531190T3 (es) | 2006-03-06 | 2015-03-11 | Japan Tobacco Inc | Método para producir un compuesto de 4-oxoquinolina |
| WO2007136858A2 (en) * | 2006-05-19 | 2007-11-29 | H. Lee Moffitt Cancer Center & Research Institute | Small molecule inhibitors of stat3 with anti-tumor activity |
| WO2008016661A2 (en) * | 2006-08-02 | 2008-02-07 | Xanthus Pharmaceuticals, Inc. | Morpholino compounds for treating inflammatory and demyelinating diseases and cancers |
| JP2010509241A (ja) * | 2006-11-07 | 2010-03-25 | アメリカ合衆国 | 膜貫通ペプチドからなる自己凝集性ナノ粒子および抗癌剤の特異的腫瘍内送達のためのその利用 |
| WO2008064011A1 (en) | 2006-11-13 | 2008-05-29 | The Government Of The U.S. Of America As Represented By The Department Of Veterans Affairs | Acridone compounds |
| US8598354B2 (en) | 2008-12-05 | 2013-12-03 | University Of South Florida | Compounds having antiparasitic or anti-infectious activity |
| EP3070078B1 (en) * | 2015-03-20 | 2017-10-04 | Politechnika Gdanska | Asymmetric bis-acridines with antitumor activity and use thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9104548D0 (en) * | 1991-03-05 | 1991-04-17 | Cholody Wienlaw M | Antineoplastic modified imidazoacridines |
| US5508289A (en) * | 1994-03-14 | 1996-04-16 | The United States America As Represented By The Department Of Health And Human Services | Bis-acridone chemotherapeutic derivatives |
-
1997
- 1997-04-09 AU AU28157/97A patent/AU725629B2/en not_active Ceased
- 1997-04-09 US US09/155,141 patent/US6187775B1/en not_active Expired - Lifetime
- 1997-04-09 DE DE69709857T patent/DE69709857T2/de not_active Expired - Lifetime
- 1997-04-09 EP EP97922508A patent/EP0892801B1/en not_active Expired - Lifetime
- 1997-04-09 PT PT97922508T patent/PT892801E/pt unknown
- 1997-04-09 DK DK97922508T patent/DK0892801T3/da active
- 1997-04-09 AT AT97922508T patent/ATE211471T1/de active
- 1997-04-09 JP JP53745697A patent/JP4121151B2/ja not_active Expired - Fee Related
- 1997-04-09 WO PCT/US1997/007070 patent/WO1997038999A1/en active IP Right Grant
- 1997-04-09 ES ES97922508T patent/ES2171260T3/es not_active Expired - Lifetime
-
2001
- 2001-01-15 US US09/760,047 patent/US6541483B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69709857T2 (de) | 2002-08-29 |
| US6541483B2 (en) | 2003-04-01 |
| DK0892801T3 (da) | 2002-04-22 |
| US6187775B1 (en) | 2001-02-13 |
| EP0892801B1 (en) | 2002-01-02 |
| ES2171260T3 (es) | 2002-09-01 |
| JP4121151B2 (ja) | 2008-07-23 |
| EP0892801A1 (en) | 1999-01-27 |
| AU2815797A (en) | 1997-11-07 |
| DE69709857D1 (de) | 2002-02-28 |
| JP2000508662A (ja) | 2000-07-11 |
| AU725629B2 (en) | 2000-10-19 |
| WO1997038999A1 (en) | 1997-10-23 |
| US20010009914A1 (en) | 2001-07-26 |
| ATE211471T1 (de) | 2002-01-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT892801E (pt) | Compostos derivados de acridona uteis como agentes antineoplasicos e antiretrovirais | |
| BR9815166A (pt) | "método de inibição da replicação de vìrus, composto, método de inibição da replicação de citomegalovìrus, composto antiviral, utilização de um composto, composição farmacêutica, composição farmacêutica inibidora da replicação de vìrus e de citomegalovìrus e composição farmacêutica antiviral" | |
| PE10399A1 (es) | Derivados de aminoacidos | |
| DE69909756D1 (de) | Antivirale pyrimidinderivate | |
| ES2149267T3 (es) | Carbonilos ciclicos substituidos y derivados de los mismos utiles como inhibidores de la proteasa retroviral. | |
| ES2086376T3 (es) | Nucleosidos pirimidinicos antivirales. | |
| ATE254132T1 (de) | Antivirale pyrimidin nucleoside derivate | |
| ATE219366T1 (de) | Verwendung von 5-fluoro-2'-deoxy-3'-thiacytidin zur behandlung von hepatitis b | |
| JO2403B1 (en) | Nickeloside derivatives antiviral | |
| BR9710355A (pt) | Composição útil para o tratamento de infecções virais em um mamìfero, processo para tratar uma infecção viral em um mamìfero, e, produto medicinal. | |
| TR200002761T2 (tr) | HIV enfeksiyonlarının tedavisi için üç-ikameli 1,3,5-triazin türevleri. | |
| BR0110023A (pt) | Derivados de nucleosìdeo 3'-ou-2' substituìdos para tratamento de infecções por vìrus da hepatite | |
| DK0758327T3 (da) | Pyranonforbindelser, der er nyttige til behandling af retrovirale infektioner | |
| TR200300544T1 (tr) | Erimiş siklik bileşimler ve tıbbi kullanımları | |
| ES2191075T3 (es) | 8-arilalquil- y 8-arilheteroalquil-5,11-dihidro-6h-dipirido-(3,2-b:2',3'-e)(1,4)diazepinas y su uso en la prevencion o tratamiento de infecciones por hiv. | |
| WO1999058526A8 (en) | Novel 2,5-pyridinedicarboxylic acid derivatives | |
| EA199900843A1 (ru) | Синтез 1,3-оксаселеноланнуклеозидов, их активность против вируса иммунодефицита человека и против вируса гепатита-b | |
| AU643987B2 (en) | Chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents | |
| CA2250863A1 (en) | Acridone-derived compounds useful as antineoplastic and antiretroviral agents | |
| ATE198746T1 (de) | Pyrimidinderivate und pharmazeutische zusammensetzungen | |
| DK0906909T3 (da) | Hydroxy- og polyhydroxyderivater af coumarin, deres fremstilling og antivirale virkning | |
| ES2155515T3 (es) | Derivados de difluorostatona macrociclica utiles como agentes antivirales. | |
| MY157594A (en) | Compositions of matter useful in the treatment of viral infections derived from plant extracts |