JP2000508662A - 抗新生物薬および抗レトロウイルス薬として有用なアクリドンから誘導された化合物 - Google Patents
抗新生物薬および抗レトロウイルス薬として有用なアクリドンから誘導された化合物Info
- Publication number
- JP2000508662A JP2000508662A JP9537456A JP53745697A JP2000508662A JP 2000508662 A JP2000508662 A JP 2000508662A JP 9537456 A JP9537456 A JP 9537456A JP 53745697 A JP53745697 A JP 53745697A JP 2000508662 A JP2000508662 A JP 2000508662A
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- compounds
- hiv
- Prior art date
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- Granted
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- 229940104230 thymidine Drugs 0.000 description 1
- AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000723 toxicological property Toxicity 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 229940045145 uridine Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 230000007501 viral attachment Effects 0.000 description 1
- 230000006514 viral protein processing Effects 0.000 description 1
- 230000006656 viral protein synthesis Effects 0.000 description 1
- 210000000605 viral structure Anatomy 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 238000012982 x-ray structure analysis Methods 0.000 description 1
- 229960000523 zalcitabine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.下記の一般式(I): (式中、 R1およびR2は独立して−H、−OH、アミノ、アルキルアミノ、ジアルキル アミノ、アルコキシ、アルキル、ハロアルキルまたはハロゲンであり; nは2〜6であり; XおよびX’は独立して−Nまたは−NO2であり; YおよびY’は独立して−Nまたは−CHまたは−Hであり; 二重破線は二重結合または結合なしを表し;したがって、XまたはX’が−N であり、YまたはY’が−CHまたは−Nである場合、二重破線は二重結合であ り、XまたはX’が−NO2であり、YまたはY’が−Hである場合、二重破線 は結合なしである)を含む組成物。 2.下記の一般式(II): (式中、 RはH、アルキル、または組成物をプロドラッグとして機能させる基であり; R1およびR2は独立して−H、−OH、アミノ、アルキルアミノ、ジアルキル アミノ、アルコキシ、アルキル、ハロアルキルまたはハロゲンであり; nは2〜6であり; XおよびX’は独立して−Nまたは−NO2であり; YおよびY’は独立して−Nまたは−CHまたは−Hであり; 二重破線は二重結合または結合なしを表し;したがって、XまたはX’が−N であり、YまたはY’が−CHまたは−Nである場合、二重破線は二重結合であ り、XまたはX’が−NO2であり、YまたはY’が−Hである場合、二重破線 は結合なしである)を含む組成物。 3.組成物が次式: (WMC−26の構造式をここに挿入) を含む、請求項2記載の組成物。 4.組成物が次式: (WMC−42をここに挿入) を含む、請求項2記載の組成物。 5.組成物が次式: (WMC−43をここに挿入)を含む、請求項2記載の組成物。 6.組成物が次式: を含む、請求項1記載の組成物。 7.組成物が次式: (WMC−70をここに挿入) を含む、請求項1記載の組成物。 8.ウイルスの複製を阻害する方法であって、有効量の請求項1記載の組成物 を投与する工程を含む方法。 9.請求項1記載の化合物および薬剤学的に許容しうるキャリヤーを含む薬剤 組成物。 10.ウイルスの複製を阻害する方法であって、有効量の請求項2記載の組成 物を投与する工程を含む方法。 11.請求項2記載の化合物および薬剤学的に許容しうるキャリヤーを含む薬 剤組成物。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1532696P | 1996-04-12 | 1996-04-12 | |
US3505097P | 1997-01-22 | 1997-01-22 | |
US60/015,326 | 1997-01-22 | ||
US60/035,050 | 1997-01-22 | ||
PCT/US1997/007070 WO1997038999A1 (en) | 1996-04-12 | 1997-04-09 | Acridone-derived compounds useful as antineoplastic and antiretroviral agents |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2000508662A true JP2000508662A (ja) | 2000-07-11 |
JP2000508662A5 JP2000508662A5 (ja) | 2004-10-28 |
JP4121151B2 JP4121151B2 (ja) | 2008-07-23 |
Family
ID=26687242
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53745697A Expired - Fee Related JP4121151B2 (ja) | 1996-04-12 | 1997-04-09 | 抗新生物薬および抗レトロウイルス薬として有用なアクリドンから誘導された化合物 |
Country Status (10)
Country | Link |
---|---|
US (2) | US6187775B1 (ja) |
EP (1) | EP0892801B1 (ja) |
JP (1) | JP4121151B2 (ja) |
AT (1) | ATE211471T1 (ja) |
AU (1) | AU725629B2 (ja) |
DE (1) | DE69709857T2 (ja) |
DK (1) | DK0892801T3 (ja) |
ES (1) | ES2171260T3 (ja) |
PT (1) | PT892801E (ja) |
WO (1) | WO1997038999A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007532692A (ja) * | 2004-06-30 | 2007-11-15 | カウンシル オブ サイエンティフィク アンド インダストリアル リサーチ | ピペラジン部分により結合したピロロ[2,1−c][1,4]ベンゾジアゼピン−ナフタルイミド結合体及びそれを調製するための方法 |
JP2018509453A (ja) * | 2015-03-20 | 2018-04-05 | ポリテクニカ グダニスカPolitechnika Gdanska | 抗腫瘍活性を有する不斉ビス−アクリジンおよびその使用 |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1293525B1 (it) * | 1997-08-01 | 1999-03-01 | Uni Degli Studi Camerino | Bis-acridincarbossiammidi aventi attivita' antitumorale |
JP2003525940A (ja) * | 2000-03-07 | 2003-09-02 | アメリカ合衆国 | 抗−腫瘍活性を有する、1,8−ナフタルイミドイミダゾ〔4,5,1−de〕アクリドン類 |
US7144843B2 (en) * | 2001-01-31 | 2006-12-05 | Meiji Seika Kaisha, Ltd. | Pest controllers |
US6670071B2 (en) * | 2002-01-15 | 2003-12-30 | Quallion Llc | Electric storage battery construction and method of manufacture |
EP4059923A1 (en) * | 2002-11-20 | 2022-09-21 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as hiv integrase inhibitor |
US8512144B2 (en) * | 2003-10-20 | 2013-08-20 | Tipping Point Group, Llc | Method and apparatus for providing secondary gaming machine functionality |
MY134672A (en) | 2004-05-20 | 2007-12-31 | Japan Tobacco Inc | Stable crystal of 4-oxoquinoline compound |
US7531554B2 (en) | 2004-05-20 | 2009-05-12 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
US8377586B2 (en) * | 2005-10-05 | 2013-02-19 | California Institute Of Technology | Fluoride ion electrochemical cell |
US7829578B1 (en) | 2005-12-12 | 2010-11-09 | Oregon Health & Science University | Aromatic ketones and uses thereof |
WO2007092436A2 (en) * | 2006-02-08 | 2007-08-16 | Xanthus Pharmaceuticals, Inc. | Compounds for treating inflammatory disorders, demyelinating disorders and cancers |
PL1992607T3 (pl) | 2006-03-06 | 2015-05-29 | Japan Tobacco Inc | Sposób wytwarzania związku 4-oksochinolinowego |
WO2007136858A2 (en) * | 2006-05-19 | 2007-11-29 | H. Lee Moffitt Cancer Center & Research Institute | Small molecule inhibitors of stat3 with anti-tumor activity |
WO2008016661A2 (en) * | 2006-08-02 | 2008-02-07 | Xanthus Pharmaceuticals, Inc. | Morpholino compounds for treating inflammatory and demyelinating diseases and cancers |
EP2086521A2 (en) * | 2006-11-07 | 2009-08-12 | Government of the United States of America, Represented by the Secretary, Department of Health and Human Services | Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs |
WO2008064011A1 (en) * | 2006-11-13 | 2008-05-29 | The Government Of The U.S. Of America As Represented By The Department Of Veterans Affairs | Acridone compounds |
US8598354B2 (en) | 2008-12-05 | 2013-12-03 | University Of South Florida | Compounds having antiparasitic or anti-infectious activity |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9104548D0 (en) * | 1991-03-05 | 1991-04-17 | Cholody Wienlaw M | Antineoplastic modified imidazoacridines |
US5508289A (en) * | 1994-03-14 | 1996-04-16 | The United States America As Represented By The Department Of Health And Human Services | Bis-acridone chemotherapeutic derivatives |
-
1997
- 1997-04-09 EP EP97922508A patent/EP0892801B1/en not_active Expired - Lifetime
- 1997-04-09 JP JP53745697A patent/JP4121151B2/ja not_active Expired - Fee Related
- 1997-04-09 WO PCT/US1997/007070 patent/WO1997038999A1/en active IP Right Grant
- 1997-04-09 US US09/155,141 patent/US6187775B1/en not_active Expired - Lifetime
- 1997-04-09 ES ES97922508T patent/ES2171260T3/es not_active Expired - Lifetime
- 1997-04-09 DE DE69709857T patent/DE69709857T2/de not_active Expired - Lifetime
- 1997-04-09 PT PT97922508T patent/PT892801E/pt unknown
- 1997-04-09 DK DK97922508T patent/DK0892801T3/da active
- 1997-04-09 AT AT97922508T patent/ATE211471T1/de active
- 1997-04-09 AU AU28157/97A patent/AU725629B2/en not_active Ceased
-
2001
- 2001-01-15 US US09/760,047 patent/US6541483B2/en not_active Expired - Fee Related
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007532692A (ja) * | 2004-06-30 | 2007-11-15 | カウンシル オブ サイエンティフィク アンド インダストリアル リサーチ | ピペラジン部分により結合したピロロ[2,1−c][1,4]ベンゾジアゼピン−ナフタルイミド結合体及びそれを調製するための方法 |
JP2018509453A (ja) * | 2015-03-20 | 2018-04-05 | ポリテクニカ グダニスカPolitechnika Gdanska | 抗腫瘍活性を有する不斉ビス−アクリジンおよびその使用 |
JP7226918B2 (ja) | 2015-03-20 | 2023-02-21 | ポリテクニカ グダニスカ | 抗腫瘍活性を有する不斉ビス-アクリジンおよびその使用 |
Also Published As
Publication number | Publication date |
---|---|
US20010009914A1 (en) | 2001-07-26 |
PT892801E (pt) | 2002-06-28 |
ATE211471T1 (de) | 2002-01-15 |
EP0892801A1 (en) | 1999-01-27 |
US6541483B2 (en) | 2003-04-01 |
ES2171260T3 (es) | 2002-09-01 |
DK0892801T3 (da) | 2002-04-22 |
DE69709857T2 (de) | 2002-08-29 |
AU725629B2 (en) | 2000-10-19 |
WO1997038999A1 (en) | 1997-10-23 |
AU2815797A (en) | 1997-11-07 |
JP4121151B2 (ja) | 2008-07-23 |
DE69709857D1 (de) | 2002-02-28 |
EP0892801B1 (en) | 2002-01-02 |
US6187775B1 (en) | 2001-02-13 |
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