ES2155515T3 - Derivados de difluorostatona macrociclica utiles como agentes antivirales. - Google Patents
Derivados de difluorostatona macrociclica utiles como agentes antivirales.Info
- Publication number
- ES2155515T3 ES2155515T3 ES95903633T ES95903633T ES2155515T3 ES 2155515 T3 ES2155515 T3 ES 2155515T3 ES 95903633 T ES95903633 T ES 95903633T ES 95903633 T ES95903633 T ES 95903633T ES 2155515 T3 ES2155515 T3 ES 2155515T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- useful
- hiv
- antiviral agents
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Abstract
LA PRESENTE INVENCION PROPORCIONA NUEVOS DERIVADOS DE DIFLUOROSTATONA MACROCICLICA QUE SON UTILES COMO AGENTES ANTIVIRALES. MAS ESPECIFICAMENTE, ESTOS NUEVOS COMPUESTOS SON UTILES COMO INHIBIDORES DE PROTEASAS RETROVIRALES REQUERIDAS PARA LA REPRODUCCION, PARTICULARMENTE LAS PROTEASAS VIRALES HIV-1 Y HIV-2, EN LA PREVENCION O TRATAMIENTO DE LA INFECCION POR EL VIRUS DE INMUNODEFICIENCIA HUMANA (HIV), Y EN EL TRATAMIENTO DE LAS CONSIGUIENTES CONDICIONES PATOLOGICAS TALES COMO EL SINDROME DE INMUNODEFICIENCIA ADQUIRIDA (SIDA) EN MAMIFEROS CAPACES DE SER INFECTADOS CON EL VIRUS DEL VIH.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19208094A | 1994-02-04 | 1994-02-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2155515T3 true ES2155515T3 (es) | 2001-05-16 |
Family
ID=22708156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95903633T Expired - Lifetime ES2155515T3 (es) | 1994-02-04 | 1994-11-28 | Derivados de difluorostatona macrociclica utiles como agentes antivirales. |
Country Status (20)
Country | Link |
---|---|
US (1) | US5969132A (es) |
EP (1) | EP0742791B1 (es) |
JP (1) | JP3574455B2 (es) |
KR (1) | KR100367379B1 (es) |
CN (1) | CN1142830A (es) |
AT (1) | ATE198602T1 (es) |
AU (1) | AU684875B2 (es) |
CA (1) | CA2182476C (es) |
DE (1) | DE69426574T2 (es) |
DK (1) | DK0742791T3 (es) |
ES (1) | ES2155515T3 (es) |
FI (1) | FI963073A (es) |
GR (1) | GR3035623T3 (es) |
HU (1) | HUT74384A (es) |
IL (1) | IL112514A0 (es) |
NO (1) | NO963254L (es) |
NZ (1) | NZ277410A (es) |
PT (1) | PT742791E (es) |
WO (1) | WO1995021186A1 (es) |
ZA (1) | ZA95756B (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2338789T3 (es) | 2003-06-18 | 2010-05-12 | Tranzyme Pharma Inc. | Antagonistas macrociclicos del receptor de motilina. |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH672792A5 (es) * | 1985-02-19 | 1989-12-29 | Sandoz Ag | |
EP0218688B1 (en) * | 1985-04-19 | 1990-09-12 | The Upjohn Company | Dihalo-statine substituted renin inhibitors |
HUT58764A (en) * | 1988-07-08 | 1992-03-30 | Smithkline Beckman Corp | Process for producing peptides, pharmaceutical compositions containing them and amino-acid intermediates |
US5071837A (en) * | 1990-11-28 | 1991-12-10 | Warner-Lambert Company | Novel renin inhibiting peptides |
NZ241099A (en) * | 1991-01-02 | 1994-08-26 | Merrell Dow Pharma | Difluorostatone analogues and derivatives and pharmaceutical compositions |
HUT76648A (en) * | 1994-07-15 | 1997-10-28 | Merrell Pharma Inc | Difluorostatone, pharmaceutical compositions containing them and process for producing them |
-
1994
- 1994-11-28 US US08/676,208 patent/US5969132A/en not_active Expired - Fee Related
- 1994-11-28 NZ NZ277410A patent/NZ277410A/en unknown
- 1994-11-28 CA CA002182476A patent/CA2182476C/en not_active Expired - Fee Related
- 1994-11-28 PT PT95903633T patent/PT742791E/pt unknown
- 1994-11-28 DE DE69426574T patent/DE69426574T2/de not_active Expired - Fee Related
- 1994-11-28 HU HU9602158A patent/HUT74384A/hu unknown
- 1994-11-28 KR KR1019960704227A patent/KR100367379B1/ko not_active IP Right Cessation
- 1994-11-28 AT AT95903633T patent/ATE198602T1/de not_active IP Right Cessation
- 1994-11-28 JP JP52059495A patent/JP3574455B2/ja not_active Expired - Fee Related
- 1994-11-28 ES ES95903633T patent/ES2155515T3/es not_active Expired - Lifetime
- 1994-11-28 DK DK95903633T patent/DK0742791T3/da active
- 1994-11-28 EP EP95903633A patent/EP0742791B1/en not_active Expired - Lifetime
- 1994-11-28 AU AU12622/95A patent/AU684875B2/en not_active Ceased
- 1994-11-28 WO PCT/US1994/013711 patent/WO1995021186A1/en active IP Right Grant
- 1994-11-28 CN CN94194939A patent/CN1142830A/zh active Pending
-
1995
- 1995-01-31 ZA ZA95756A patent/ZA95756B/xx unknown
- 1995-02-01 IL IL11251495A patent/IL112514A0/xx unknown
-
1996
- 1996-08-02 NO NO963254A patent/NO963254L/no not_active Application Discontinuation
- 1996-08-02 FI FI963073A patent/FI963073A/fi not_active IP Right Cessation
-
2001
- 2001-03-23 GR GR20010400468T patent/GR3035623T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2182476C (en) | 2000-12-26 |
FI963073A0 (fi) | 1996-08-02 |
NZ277410A (en) | 1997-02-24 |
DE69426574D1 (de) | 2001-02-15 |
ZA95756B (en) | 1995-10-05 |
HU9602158D0 (en) | 1996-09-30 |
JPH09508417A (ja) | 1997-08-26 |
AU1262295A (en) | 1995-08-21 |
NO963254D0 (no) | 1996-08-02 |
HUT74384A (en) | 1996-12-30 |
EP0742791B1 (en) | 2001-01-10 |
ATE198602T1 (de) | 2001-01-15 |
FI963073A (fi) | 1996-08-02 |
NO963254L (no) | 1996-08-02 |
KR100367379B1 (ko) | 2003-04-11 |
GR3035623T3 (en) | 2001-06-29 |
US5969132A (en) | 1999-10-19 |
CN1142830A (zh) | 1997-02-12 |
PT742791E (pt) | 2001-06-29 |
DK0742791T3 (da) | 2001-04-02 |
JP3574455B2 (ja) | 2004-10-06 |
EP0742791A1 (en) | 1996-11-20 |
AU684875B2 (en) | 1998-01-08 |
IL112514A0 (en) | 1995-05-26 |
DE69426574T2 (de) | 2001-08-09 |
WO1995021186A1 (en) | 1995-08-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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