ES2155515T3 - Derivados de difluorostatona macrociclica utiles como agentes antivirales. - Google Patents

Derivados de difluorostatona macrociclica utiles como agentes antivirales.

Info

Publication number
ES2155515T3
ES2155515T3 ES95903633T ES95903633T ES2155515T3 ES 2155515 T3 ES2155515 T3 ES 2155515T3 ES 95903633 T ES95903633 T ES 95903633T ES 95903633 T ES95903633 T ES 95903633T ES 2155515 T3 ES2155515 T3 ES 2155515T3
Authority
ES
Spain
Prior art keywords
pct
useful
hiv
antiviral agents
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95903633T
Other languages
English (en)
Inventor
Robert A Farr
Brent L Podlogar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2155515T3 publication Critical patent/ES2155515T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA NUEVOS DERIVADOS DE DIFLUOROSTATONA MACROCICLICA QUE SON UTILES COMO AGENTES ANTIVIRALES. MAS ESPECIFICAMENTE, ESTOS NUEVOS COMPUESTOS SON UTILES COMO INHIBIDORES DE PROTEASAS RETROVIRALES REQUERIDAS PARA LA REPRODUCCION, PARTICULARMENTE LAS PROTEASAS VIRALES HIV-1 Y HIV-2, EN LA PREVENCION O TRATAMIENTO DE LA INFECCION POR EL VIRUS DE INMUNODEFICIENCIA HUMANA (HIV), Y EN EL TRATAMIENTO DE LAS CONSIGUIENTES CONDICIONES PATOLOGICAS TALES COMO EL SINDROME DE INMUNODEFICIENCIA ADQUIRIDA (SIDA) EN MAMIFEROS CAPACES DE SER INFECTADOS CON EL VIRUS DEL VIH.
ES95903633T 1994-02-04 1994-11-28 Derivados de difluorostatona macrociclica utiles como agentes antivirales. Expired - Lifetime ES2155515T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19208094A 1994-02-04 1994-02-04

Publications (1)

Publication Number Publication Date
ES2155515T3 true ES2155515T3 (es) 2001-05-16

Family

ID=22708156

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95903633T Expired - Lifetime ES2155515T3 (es) 1994-02-04 1994-11-28 Derivados de difluorostatona macrociclica utiles como agentes antivirales.

Country Status (20)

Country Link
US (1) US5969132A (es)
EP (1) EP0742791B1 (es)
JP (1) JP3574455B2 (es)
KR (1) KR100367379B1 (es)
CN (1) CN1142830A (es)
AT (1) ATE198602T1 (es)
AU (1) AU684875B2 (es)
CA (1) CA2182476C (es)
DE (1) DE69426574T2 (es)
DK (1) DK0742791T3 (es)
ES (1) ES2155515T3 (es)
FI (1) FI963073A (es)
GR (1) GR3035623T3 (es)
HU (1) HUT74384A (es)
IL (1) IL112514A0 (es)
NO (1) NO963254L (es)
NZ (1) NZ277410A (es)
PT (1) PT742791E (es)
WO (1) WO1995021186A1 (es)
ZA (1) ZA95756B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2338789T3 (es) 2003-06-18 2010-05-12 Tranzyme Pharma Inc. Antagonistas macrociclicos del receptor de motilina.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH672792A5 (es) * 1985-02-19 1989-12-29 Sandoz Ag
EP0218688B1 (en) * 1985-04-19 1990-09-12 The Upjohn Company Dihalo-statine substituted renin inhibitors
HUT58764A (en) * 1988-07-08 1992-03-30 Smithkline Beckman Corp Process for producing peptides, pharmaceutical compositions containing them and amino-acid intermediates
US5071837A (en) * 1990-11-28 1991-12-10 Warner-Lambert Company Novel renin inhibiting peptides
NZ241099A (en) * 1991-01-02 1994-08-26 Merrell Dow Pharma Difluorostatone analogues and derivatives and pharmaceutical compositions
HUT76648A (en) * 1994-07-15 1997-10-28 Merrell Pharma Inc Difluorostatone, pharmaceutical compositions containing them and process for producing them

Also Published As

Publication number Publication date
CA2182476C (en) 2000-12-26
FI963073A0 (fi) 1996-08-02
NZ277410A (en) 1997-02-24
DE69426574D1 (de) 2001-02-15
ZA95756B (en) 1995-10-05
HU9602158D0 (en) 1996-09-30
JPH09508417A (ja) 1997-08-26
AU1262295A (en) 1995-08-21
NO963254D0 (no) 1996-08-02
HUT74384A (en) 1996-12-30
EP0742791B1 (en) 2001-01-10
ATE198602T1 (de) 2001-01-15
FI963073A (fi) 1996-08-02
NO963254L (no) 1996-08-02
KR100367379B1 (ko) 2003-04-11
GR3035623T3 (en) 2001-06-29
US5969132A (en) 1999-10-19
CN1142830A (zh) 1997-02-12
PT742791E (pt) 2001-06-29
DK0742791T3 (da) 2001-04-02
JP3574455B2 (ja) 2004-10-06
EP0742791A1 (en) 1996-11-20
AU684875B2 (en) 1998-01-08
IL112514A0 (en) 1995-05-26
DE69426574T2 (de) 2001-08-09
WO1995021186A1 (en) 1995-08-10

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