DE69426574D1 - Makrocyclische difluorostatonderivate als antivirale mittel - Google Patents

Makrocyclische difluorostatonderivate als antivirale mittel

Info

Publication number
DE69426574D1
DE69426574D1 DE69426574T DE69426574T DE69426574D1 DE 69426574 D1 DE69426574 D1 DE 69426574D1 DE 69426574 T DE69426574 T DE 69426574T DE 69426574 T DE69426574 T DE 69426574T DE 69426574 D1 DE69426574 D1 DE 69426574D1
Authority
DE
Germany
Prior art keywords
pct
hiv
derivatives
macrocyclic
difluorostaton
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69426574T
Other languages
English (en)
Other versions
DE69426574T2 (de
Inventor
Robert A Farr
Brent L Podlogar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of DE69426574D1 publication Critical patent/DE69426574D1/de
Application granted granted Critical
Publication of DE69426574T2 publication Critical patent/DE69426574T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69426574T 1994-02-04 1994-11-28 Makrocyclische difluorostatonderivate als antivirale mittel Expired - Fee Related DE69426574T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19208094A 1994-02-04 1994-02-04
PCT/US1994/013711 WO1995021186A1 (en) 1994-02-04 1994-11-28 Macrocyclic difluorostatone derivatives useful as antiviral agents

Publications (2)

Publication Number Publication Date
DE69426574D1 true DE69426574D1 (de) 2001-02-15
DE69426574T2 DE69426574T2 (de) 2001-08-09

Family

ID=22708156

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69426574T Expired - Fee Related DE69426574T2 (de) 1994-02-04 1994-11-28 Makrocyclische difluorostatonderivate als antivirale mittel

Country Status (20)

Country Link
US (1) US5969132A (de)
EP (1) EP0742791B1 (de)
JP (1) JP3574455B2 (de)
KR (1) KR100367379B1 (de)
CN (1) CN1142830A (de)
AT (1) ATE198602T1 (de)
AU (1) AU684875B2 (de)
CA (1) CA2182476C (de)
DE (1) DE69426574T2 (de)
DK (1) DK0742791T3 (de)
ES (1) ES2155515T3 (de)
FI (1) FI963073A (de)
GR (1) GR3035623T3 (de)
HU (1) HUT74384A (de)
IL (1) IL112514A0 (de)
NO (1) NO963254L (de)
NZ (1) NZ277410A (de)
PT (1) PT742791E (de)
WO (1) WO1995021186A1 (de)
ZA (1) ZA95756B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4928261B2 (ja) 2003-06-18 2012-05-09 トランザイム・ファーマ・インコーポレイテッド モチリン受容体の大環状拮抗薬

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH672792A5 (de) * 1985-02-19 1989-12-29 Sandoz Ag
DE3674131D1 (de) * 1985-04-19 1990-10-18 Upjohn Co Substituierte dihalo-statin-reninhemmungsmittel.
HUT58764A (en) * 1988-07-08 1992-03-30 Smithkline Beckman Corp Process for producing peptides, pharmaceutical compositions containing them and amino-acid intermediates
US5071837A (en) * 1990-11-28 1991-12-10 Warner-Lambert Company Novel renin inhibiting peptides
HU210647B (en) * 1991-01-02 1995-06-28 Merrell Dow Pharma Process for producing antiviral difluoro-statone derivatives and pharmaceutical compositions containing them
JPH10505582A (ja) * 1994-07-15 1998-06-02 メリル・フアーマシユウテイカルズ・インコーポレイテツド ジフルオロスタトン抗ウイルス剤

Also Published As

Publication number Publication date
IL112514A0 (en) 1995-05-26
ATE198602T1 (de) 2001-01-15
AU684875B2 (en) 1998-01-08
EP0742791A1 (de) 1996-11-20
ES2155515T3 (es) 2001-05-16
CA2182476C (en) 2000-12-26
ZA95756B (en) 1995-10-05
NO963254D0 (no) 1996-08-02
HU9602158D0 (en) 1996-09-30
DK0742791T3 (da) 2001-04-02
EP0742791B1 (de) 2001-01-10
NZ277410A (en) 1997-02-24
WO1995021186A1 (en) 1995-08-10
FI963073A0 (fi) 1996-08-02
CN1142830A (zh) 1997-02-12
DE69426574T2 (de) 2001-08-09
GR3035623T3 (en) 2001-06-29
HUT74384A (en) 1996-12-30
NO963254L (no) 1996-08-02
FI963073A (fi) 1996-08-02
PT742791E (pt) 2001-06-29
KR100367379B1 (ko) 2003-04-11
JP3574455B2 (ja) 2004-10-06
US5969132A (en) 1999-10-19
JPH09508417A (ja) 1997-08-26
AU1262295A (en) 1995-08-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee