LT2511301T - Žmogaus antikūnas prieš erbb2 - Google Patents
Žmogaus antikūnas prieš erbb2Info
- Publication number
- LT2511301T LT2511301T LTEP12154574.3T LT12154574T LT2511301T LT 2511301 T LT2511301 T LT 2511301T LT 12154574 T LT12154574 T LT 12154574T LT 2511301 T LT2511301 T LT 2511301T
- Authority
- LT
- Lithuania
- Prior art keywords
- erbb
- human antibodies
- antibodies
- human
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Animal Husbandry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83551406P | 2006-08-04 | 2006-08-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
LT2511301T true LT2511301T (lt) | 2018-04-10 |
Family
ID=38925686
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTEP12154574.3T LT2511301T (lt) | 2006-08-04 | 2007-08-02 | Žmogaus antikūnas prieš erbb2 |
Country Status (22)
Country | Link |
---|---|
US (2) | US8350011B2 (lt) |
EP (2) | EP2054444B1 (lt) |
JP (1) | JP5638804B2 (lt) |
KR (1) | KR20090058512A (lt) |
CN (1) | CN101522717A (lt) |
AU (1) | AU2007281774A1 (lt) |
BR (1) | BRPI0714728A2 (lt) |
CA (1) | CA2659631A1 (lt) |
CY (1) | CY1120065T1 (lt) |
DK (1) | DK2511301T3 (lt) |
ES (2) | ES2661952T3 (lt) |
HU (1) | HUE038454T2 (lt) |
IL (1) | IL196701A0 (lt) |
LT (1) | LT2511301T (lt) |
MX (1) | MX2009001291A (lt) |
NO (1) | NO20090424L (lt) |
PL (1) | PL2511301T3 (lt) |
PT (1) | PT2511301T (lt) |
RU (1) | RU2009107494A (lt) |
SI (1) | SI2511301T1 (lt) |
WO (1) | WO2008019290A2 (lt) |
ZA (1) | ZA200900753B (lt) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009088805A2 (en) | 2008-01-03 | 2009-07-16 | The Scripps Research Institute | Antibody targeting through a modular recognition domain |
US8454960B2 (en) | 2008-01-03 | 2013-06-04 | The Scripps Research Institute | Multispecific antibody targeting and multivalency through modular recognition domains |
US8574577B2 (en) | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
US8557242B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | ERBB2 antibodies comprising modular recognition domains |
US8557243B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | EFGR antibodies comprising modular recognition domains |
WO2009102421A2 (en) | 2008-02-14 | 2009-08-20 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins that bind egfr |
PE20091931A1 (es) | 2008-05-22 | 2009-12-31 | Bristol Myers Squibb Co | Proteinas de dominio de armazon basadas en fibronectina multivalentes |
GB0812277D0 (en) * | 2008-07-04 | 2008-08-13 | Fusion Antibodies Ltd | Antibody and uses thereof |
US8734795B2 (en) | 2008-10-31 | 2014-05-27 | Biogen Idec Ma Inc. | Light targeting molecules and uses thereof |
TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之egfr/igfir結合分子 |
CN101591396B (zh) * | 2009-04-15 | 2013-01-09 | 北京天广实生物技术股份有限公司 | 一种抗erbB2人源抗体MIL-5及其应用 |
CN101633695B (zh) * | 2009-04-15 | 2012-12-12 | 北京天广实生物技术股份有限公司 | 基于erbB2蛋白胞外区C-端功能表位特征设计抗erbB2功能抗体 |
CN102167742B (zh) * | 2010-02-25 | 2014-05-14 | 上海百迈博制药有限公司 | 一种全人源抗her2单克隆抗体、其制备方法及用途 |
KR20130108069A (ko) * | 2010-04-15 | 2013-10-02 | 알퍼 바이오테크, 엘엘씨 | Her2 항원에 대한 모노클로날 항체 및 그를 위한 용도 |
CN103180339B (zh) | 2010-05-26 | 2016-04-27 | 百时美施贵宝公司 | 具有改善的稳定性的基于纤连蛋白的支架蛋白质 |
CA3051311A1 (en) | 2010-05-27 | 2011-12-01 | Genmab A/S | Monoclonal antibodies against her2 |
CN103153339B (zh) | 2010-05-27 | 2021-05-04 | 根马布股份公司 | 针对her2表位的单克隆抗体 |
AU2016201799B2 (en) * | 2010-05-27 | 2017-09-07 | Genmab A/S | Monoclonal antibodies aganst HER2 epitope |
CN101928345B (zh) * | 2010-06-21 | 2012-08-29 | 中国科学技术大学 | 一种人源化抗体及其人源化改造方法 |
WO2012009705A1 (en) | 2010-07-15 | 2012-01-19 | Zyngenia, Inc. | Ang-2 binding complexes and uses thereof |
PT2606070T (pt) * | 2010-08-20 | 2017-03-31 | Novartis Ag | Anticorpos para o recetor 3 do fator de crescimento epidérmico (her3) |
WO2012120004A1 (en) * | 2011-03-07 | 2012-09-13 | F. Hoffmann-La Roche Ag | In vivo selection of therapeutically active antibodies |
JP2014514314A (ja) | 2011-04-20 | 2014-06-19 | ゲンマブ エー/エス | Her2およびcd3に対する二重特異性抗体 |
WO2012162561A2 (en) | 2011-05-24 | 2012-11-29 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
CN102492039B (zh) * | 2011-11-21 | 2015-03-11 | 无锡天演生物技术有限公司 | 全人源抗人her2单抗 |
ES2687974T3 (es) | 2012-03-14 | 2018-10-30 | Regeneron Pharmaceuticals, Inc. | Moléculas multiespecíficas de unión a antígeno y uso de las mismas |
KR101505157B1 (ko) | 2012-05-08 | 2015-03-24 | 주식회사 종근당 | 항―ErbB2 항체 변이체 |
AR094781A1 (es) * | 2013-02-13 | 2015-08-26 | Laboratoire Français Du Fractionnement Et Des Biotechnologies | Anticuerpos anti-her2 (receptor 2 del factor de crecimiento epidérmico humano) altamente galactosilados y sus usos |
WO2014144600A2 (en) | 2013-03-15 | 2014-09-18 | Viktor Roschke | Multivalent and monovalent multispecific complexes and their uses |
KR101453462B1 (ko) * | 2013-05-16 | 2014-10-23 | 앱클론(주) | Her2에 특이적으로 결합하는 항체 |
WO2014200891A1 (en) * | 2013-06-11 | 2014-12-18 | THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTEMENT OF HEALTH & HUMAN SERVICES | Her2-specific monoclonal antibodies and conjugates thereof |
US10519247B2 (en) * | 2013-11-01 | 2019-12-31 | Board Of Regents,The University Of Texas System | Targeting HER2 and HER3 with bispecific antibodies in cancerous cells |
WO2015157592A1 (en) * | 2014-04-11 | 2015-10-15 | Medimmune, Llc | Bispecific her2 antibodies |
TWI695011B (zh) * | 2014-06-18 | 2020-06-01 | 美商梅爾莎納醫療公司 | 抗her2表位之單株抗體及其使用之方法 |
KR101515535B1 (ko) | 2015-01-28 | 2015-05-06 | 주식회사 종근당 | 항―ErbB2 항체 변이체 |
MY197218A (en) | 2015-07-06 | 2023-06-02 | Regeneron Pharma | Multispecific antigen-binding molecules and uses thereof |
WO2017054141A1 (zh) * | 2015-09-29 | 2017-04-06 | 北京天成新脉生物技术有限公司 | Her2线性表位中和活性单克隆抗体及其应用 |
RU2640259C2 (ru) * | 2015-12-09 | 2017-12-27 | Федеральное государственное бюджетное учреждение науки Институт теоретической и экспериментальной биофизики Российской академии наук (ИТЭБ РАН) | Антитело МАТ40, которое связывается с доменом I экстраклеточной части рецептора эпидермального фактора роста HER2/CD340, и его применение для лечения рака |
TWI758267B (zh) | 2015-12-14 | 2022-03-21 | 美商宏觀基因股份有限公司 | 對於pd-1和ctla-4具有免疫反應性的雙特異性分子及其使用方法 |
SG10201601719RA (en) | 2016-03-04 | 2017-10-30 | Agency Science Tech & Res | Anti-LAG-3 Antibodies |
CN108778347A (zh) * | 2016-03-24 | 2018-11-09 | 拜耳制药股份公司 | 放射性药物配合物 |
EP3448891A1 (en) | 2016-04-28 | 2019-03-06 | Regeneron Pharmaceuticals, Inc. | Methods of making multispecific antigen-binding molecules |
SG10201603721TA (en) | 2016-05-10 | 2017-12-28 | Agency Science Tech & Res | Anti-CTLA-4 Antibodies |
US11459394B2 (en) | 2017-02-24 | 2022-10-04 | Macrogenics, Inc. | Bispecific binding molecules that are capable of binding CD137 and tumor antigens, and uses thereof |
BR112020011810A2 (pt) | 2017-12-12 | 2020-11-17 | Macrogenics, Inc. | molécula de ligação cd16 x antígeno de doença, composição farmacêutica, uso da composição farmacêutica, e método para o tratamento de uma doença |
JP7337079B2 (ja) | 2018-02-15 | 2023-09-01 | マクロジェニクス,インコーポレーテッド | 変異型cd3結合ドメイン、及び疾患の治療のための併用療法におけるその使用 |
MX2022010537A (es) | 2020-02-26 | 2022-09-21 | Vir Biotechnology Inc | Anticuerpos contra el coronavirus de tipo 2 causante del sindrome respiratorio agudo severo (sars-cov-2) y metodos de uso de los mismos. |
TW202241935A (zh) | 2020-12-18 | 2022-11-01 | 美商世紀治療股份有限公司 | 具有可調適受體專一性之嵌合抗原受體系統 |
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-
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- 2007-08-02 CN CNA2007800370952A patent/CN101522717A/zh active Pending
- 2007-08-02 US US12/376,196 patent/US8350011B2/en not_active Expired - Fee Related
- 2007-08-02 AU AU2007281774A patent/AU2007281774A1/en not_active Abandoned
- 2007-08-02 EP EP07813707.2A patent/EP2054444B1/en active Active
- 2007-08-02 MX MX2009001291A patent/MX2009001291A/es unknown
- 2007-08-02 JP JP2009523054A patent/JP5638804B2/ja not_active Expired - Fee Related
- 2007-08-02 KR KR1020097004290A patent/KR20090058512A/ko not_active Application Discontinuation
- 2007-08-02 SI SI200732014T patent/SI2511301T1/en unknown
- 2007-08-02 WO PCT/US2007/075078 patent/WO2008019290A2/en active Application Filing
- 2007-08-02 EP EP12154574.3A patent/EP2511301B1/en active Active
- 2007-08-02 DK DK12154574.3T patent/DK2511301T3/en active
- 2007-08-02 CA CA002659631A patent/CA2659631A1/en not_active Abandoned
- 2007-08-02 BR BRPI0714728-7A patent/BRPI0714728A2/pt not_active Application Discontinuation
- 2007-08-02 PL PL12154574T patent/PL2511301T3/pl unknown
- 2007-08-02 ES ES12154574.3T patent/ES2661952T3/es active Active
- 2007-08-02 ES ES07813707.2T patent/ES2613957T3/es active Active
- 2007-08-02 PT PT121545743T patent/PT2511301T/pt unknown
- 2007-08-02 LT LTEP12154574.3T patent/LT2511301T/lt unknown
- 2007-08-02 RU RU2009107494/10A patent/RU2009107494A/ru unknown
- 2007-08-02 HU HUE12154574A patent/HUE038454T2/hu unknown
-
2009
- 2009-01-25 IL IL196701A patent/IL196701A0/en unknown
- 2009-01-28 NO NO20090424A patent/NO20090424L/no not_active Application Discontinuation
- 2009-01-30 ZA ZA200900753A patent/ZA200900753B/xx unknown
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2012
- 2012-12-11 US US13/710,883 patent/US8858942B2/en not_active Expired - Fee Related
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2018
- 2018-03-06 CY CY20181100280T patent/CY1120065T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CY1120065T1 (el) | 2018-12-12 |
DK2511301T3 (en) | 2018-03-12 |
CN101522717A (zh) | 2009-09-02 |
HUE038454T2 (hu) | 2018-10-29 |
BRPI0714728A2 (pt) | 2013-05-14 |
US20100158926A1 (en) | 2010-06-24 |
EP2054444A2 (en) | 2009-05-06 |
WO2008019290A2 (en) | 2008-02-14 |
PL2511301T3 (pl) | 2018-05-30 |
US8350011B2 (en) | 2013-01-08 |
JP5638804B2 (ja) | 2014-12-10 |
RU2009107494A (ru) | 2010-09-10 |
EP2511301B1 (en) | 2017-12-06 |
EP2511301A3 (en) | 2013-05-01 |
JP2009545325A (ja) | 2009-12-24 |
WO2008019290A3 (en) | 2008-04-03 |
PT2511301T (pt) | 2018-03-08 |
MX2009001291A (es) | 2009-03-10 |
ZA200900753B (en) | 2010-09-29 |
ES2613957T3 (es) | 2017-05-29 |
EP2511301A2 (en) | 2012-10-17 |
IL196701A0 (en) | 2011-08-01 |
KR20090058512A (ko) | 2009-06-09 |
US8858942B2 (en) | 2014-10-14 |
AU2007281774A1 (en) | 2008-02-14 |
NO20090424L (no) | 2009-03-03 |
EP2054444B1 (en) | 2016-11-02 |
SI2511301T1 (en) | 2018-05-31 |
CA2659631A1 (en) | 2008-02-14 |
ES2661952T3 (es) | 2018-04-04 |
US20130089544A1 (en) | 2013-04-11 |
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