KR910009655A - 신규 비이온성 방사선 조영제 - Google Patents

신규 비이온성 방사선 조영제 Download PDF

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KR910009655A
KR910009655A KR1019900019274A KR900019274A KR910009655A KR 910009655 A KR910009655 A KR 910009655A KR 1019900019274 A KR1019900019274 A KR 1019900019274A KR 900019274 A KR900019274 A KR 900019274A KR 910009655 A KR910009655 A KR 910009655A
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compound
oxo
bis
hydroxymethyl
benzenedicarboxamide
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에스. 랑가나탄 라마샨드란
아루나샬램 탕가벨
아르. 마리넬리 에드먼드
필라이 래드하크리쉬나
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니콜라스 피. 말라테스티닉
이이.아르.스퀴브 앤드 산즈, 인크.
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
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Abstract

내용 없음

Description

신규 비이온성 방사선 조영제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (29)

  1. 하기식(I)의 화합물
    Ⅰ
    식중, Y는 단일 결합, -CH2CH2-, -CH2O-, -OCH2-, -N-CH2-, -CH2N-, -CH2-N--, -CH2-, -O- 또는 -N-이고, R1- 및 R2는 서로 동일하거나 상이한 것으로서
    R3및 R4는 서로 동일하거나 상이한 것으로서, 수소 원자, 메틸기 또는 -CH2CH2OH 이고, R3는 소수원자, 알킬기, -CH2CH2OH, CH2OH 또는 OH이고, R6는 알킬기, -CH2CH2OH, CH2OH OH 또는 수소 원자이며, R5와는 동일하거나 상이할 수 있고, m은 0 또는 1이되 단, 헤테로시클 고리의 메틸렌 또는 메틸기의 탄소 원자가 질소 및 산소 원자 모두에 결합하지 않으며, Y가 단일 결합일때, m 은 0이다.
  2. 제1항에 있어서, Y가 일 결합인 화합물.
  3. 제1항에 있어서, Y가 -CH2CH-인 화합물.
  4. 제1항에 있어서, Y가 -CH2O-인 화합물.
  5. 제1항에 있어서, Y가 -OCH2-인 화합물.
  6. 제1항에 있어서, Y가 -N-CH2-인 화합물.
  7. 제1항에 있어서, Y가 -CH2-N-인 화합물.
  8. 제1항에 있어서, Y가 -CH2-N-인 화합물.
  9. 제1항에 있어서, Y가 -CH2-인 화합물.
  10. 제1항에 있어서, Y가 -O-인 화합물.
  11. 제1항에 있어서, Y가 -N- 화합물.
  12. 제1항에 있어서, N,N′-비스(2,3-디히드록시프로필)-5-[4-(히드록시메틸)-2-옥소-3-옥사졸리디닐]-2,4,6-트리요오드-1,3-벤젠디ㅋ카르복스아미드.
  13. 제1항에 있어서, N,N′-비스(2,3-디히드폭시프로필)-5-[(R)-4-(히드록시메틸)-2-옥소-3-옥사졸리디닐]-2,4,6-트리요오드-1,3-벤젠디카르복스아미드.
  14. 제1항에 있어서, N,N′-비스[2-히드록시-1-(히드록시메틸)에틸]-2,4,6-트리요오드 -5-[4-(히드록시메틸)-2-옥소-3-옥사졸리디닐]-1,3-벤젠디카르복스아미드.
  15. 제1항에 있어서, N,N′-비스-[2-히드록시-1-(히드록시메틸)에틸]-5-[3-히드록시-2-오소-1-피롤리디닐]-2,4,6-트리요오드-1,3-벤젠디카르복스아미드.
  16. 제1항에 있어서, N,N′-비스-[2,3-디히도록시프로필]-5-[3-히드록시-2-옥소-1-피롤리디닐]-2,4,6-트리요오드-1,3-벤젠디카르복스아미드.
  17. 제1항에 있어서, 5-[2-(히드록시메틸)-5-옥소-1-피롤리디닐]-N,N′-비스[2,3-디히드록시프로필]-2,4,6-트로요오드-1,3-벤젠디카르복스아미드.
  18. 제1항에 있어서, N,N′-비스[2-히드록시-1-(히드록시메틸)에틸]-5-[3-(히드록시메틸)-5-옥소-4-모로폴리닐]-2,4,6-트리요오드-1,3-벤젠디카르복산아미드.
  19. 제1항에 있어서, N,N′-비스[2,3-(디히드록시프로필)-5-(3-히드록시-2-옥소-피페리디닐)-2,4,6-트리요오드-1,3-벤젠디카르복산아미드.
  20. 제1항에 있어서, N,N′-비스[2-히드록시-1-(히드록시메틸)에틸]-5-[3-히드록시-2-옥소-피페리디닐]-2,4,6-트리요오드-1,3-벤젠디카르복산아미드.
  21. 제1항에 있어서, N,N′-비스-[2,3-디히드록시-1-프로필]-5-[2-옥소-1-피롤리디닐]-2,4,6-트리요오드-1,3-벤젠디카르복스아미드.
  22. 제1항에 있어서, N,N′-비스-[2-(히디록시)-1-(히드록시메틸)에틸]-5-[2-(히드록시메틸]-5-옥소-1-피롤리디닐]-2,4,6-트리요오드-1,3-벤젠디카르복스아미드.
  23. 제1항에 있어서, N,N′-비스(2,3-디히드록시프로필)-5-[3-(히드록시메틸)-5-옥소-4-모르폴리닐]-2,4,6-트리요오드-1,3-벤젠디카르복스아미드.
  24. 제1항에 있어서, N,N′-비스-(2,3-디히드록시프로필)-5-(2-옥소-1-피페리디닐)-2,4,6-트리요오드-1,3-벤젠디카르복스아미드.
  25. 제1항에 있어서, 화합물을 진단시 조영제로서 이용하는 방법.
  26. 제25항에 있어서, 조영제가 생리학적으로 허용되는 매질중에 요오드 함량이 약 50-500mg/ml가 되도록 존재하는 방법.
  27. 2,4,6-트리요오드-1,3-벤젠디카르복스아미드 1-옥소--알케닐아미노 또는 1-옥소--옥사알케닐아미노 유도체를 염기 존재하에 요오드화제와 함께 반응시키는 것으로 이루어진 락탐의 제조방법.
  28. 제27항에 있어서, 요오드화제가 N-요오드숙신이미드인 방법.
  29. 제27항에 있어서, 염기가 수산화나트륨, 나트륨메톡시트 또는 수소화나트륨인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900019274A 1989-11-29 1990-11-27 신규 비이온성 방사선 조영제 KR0160981B1 (ko)

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KR0160981B1 KR0160981B1 (ko) 1998-12-01

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US5869024A (en) * 1989-11-29 1999-02-09 Bracco International B.V. Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
CA2068089C (en) * 1991-05-31 2003-09-16 Ramachandran S. Ranganathan Method and compositions for using non-ionic contrast agents to reduce the risk of clot formulation in diagnostic procedures
US5278311A (en) * 1992-06-05 1994-01-11 E. R. Squibb & Sons, Inc. Nonionic radiographic contrast agents
US5359077A (en) * 1992-06-05 1994-10-25 Bristol-Myers Squibb Company Process for preparation of 2-oxo-1 piperidinyl derivatives
US5686061A (en) * 1994-04-11 1997-11-11 The Board Of Regents Of The University Of Texas System Particulate contrast media derived from non-ionic water soluble contrast agents for CT enhancement of hepatic tumors
AR037460A1 (es) * 2001-11-30 2004-11-10 Smithkline Beecham Plc Compuesto de hidroxietileno, composicion farmaceutica que lo comprende, uso del mismo para la fabricacion de un medicamento y procedimiento para su preparacion
CN101891696A (zh) * 2009-05-22 2010-11-24 史命锋 一种多碘苯环化合物及其制备方法和应用
WO2016004563A1 (en) * 2014-07-07 2016-01-14 Chih-Yung Lin Aqueous tissue clearing solution and uses thereof

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KR100513900B1 (ko) * 1999-07-12 2005-09-07 주식회사 효성 폴리에스터 인조 스웨드의 제조방법

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CZ280698B6 (cs) 1996-04-17
FI905883A (fi) 1991-05-30
NO905107D0 (no) 1990-11-26
EP0431838B1 (en) 1995-10-25
IE904181A1 (en) 1991-06-05
IE73448B1 (en) 1997-06-04
FI905883A0 (fi) 1990-11-29
PL288021A1 (en) 1991-12-02
MX23489A (es) 1993-10-01
EP0431838A1 (en) 1991-06-12
HU907680D0 (en) 1991-06-28
NZ236143A (en) 1993-08-26
NO174925B (no) 1994-04-25
CZ595490A3 (en) 1995-12-13
CA2029830A1 (en) 1991-05-30
KR0160981B1 (ko) 1998-12-01
ES2078321T3 (es) 1995-12-16
ZA909140B (en) 1991-09-25
AU623293B2 (en) 1992-05-07
NO905107L (no) 1991-05-30
JP2931089B2 (ja) 1999-08-09
EG19359A (en) 1994-12-30
FI97130B (fi) 1996-07-15
IL96324A0 (en) 1991-08-16
RU2046795C1 (ru) 1995-10-27
FI97130C (fi) 1996-10-25
HUT56075A (en) 1991-07-29
JPH03176470A (ja) 1991-07-31
PL164291B1 (pl) 1994-07-29
CN1052114A (zh) 1991-06-12
DE69023210T2 (de) 1996-03-28
NO174925C (no) 1994-08-03
GR3018215T3 (en) 1996-02-29
IL96324A (en) 1995-01-24
ATE129493T1 (de) 1995-11-15
DE69023210D1 (de) 1995-11-30
AU6663790A (en) 1991-06-06
CN1107468A (zh) 1995-08-30
PT96020A (pt) 1991-09-13
PT96020B (pt) 1998-02-27
DK0431838T3 (da) 1995-12-04

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