KR970704685A - 신경이완제로서 유용한 N-치환 아자비시클로헵탄 유도체(N-Substituted Azabicycloheptane Derivatives Useful as Neuroleptics) - Google Patents

신경이완제로서 유용한 N-치환 아자비시클로헵탄 유도체(N-Substituted Azabicycloheptane Derivatives Useful as Neuroleptics) Download PDF

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Publication number
KR970704685A
KR970704685A KR1019970700754A KR19970700754A KR970704685A KR 970704685 A KR970704685 A KR 970704685A KR 1019970700754 A KR1019970700754 A KR 1019970700754A KR 19970700754 A KR19970700754 A KR 19970700754A KR 970704685 A KR970704685 A KR 970704685A
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South Korea
Prior art keywords
hydrogen
formula
rti
unsubstituted
chlorine
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KR1019970700754A
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English (en)
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게르트 슈타이너
라이너 문샤우어
토마스 회거
릴리안네 운거
한스-위르겐 테쉔도르프
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스타르크, 카르크
바스프 악티엔게젤샤프트
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Application filed by 스타르크, 카르크, 바스프 악티엔게젤샤프트 filed Critical 스타르크, 카르크
Publication of KR970704685A publication Critical patent/KR970704685A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • C07D209/92—Naphthostyrils

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Luminescent Compositions (AREA)

Abstract

본 발명은 A, R1및 n이 명세서에서 전술한 의미를 가지는 하기 화학식 (Ⅰ)의 화합물에 관한 것이다. 본 발명의 신규 화합물은 질병 치료에 적합하다.

Description

신경이완제로서 유용한 N-치환 아자비시클로헵탄 유도체(N-Substituted Azabicycloheptane Derivatives Useful as Neuroleptics)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 하기 화학식 (Ⅰ)의 N-치환 3-아자비시클로〔3.2.0〕-헵탄 유도체 및 그의 생리학상 허용되는 산 부가염.
    상기 식에서, R1은 비치환되거나, 또는 할로겐 원자로 일-또는 이치환된 나프틸 또는 페난트릴이고, n은 1, 2, 3 또는 4이고, A는 하기 기, 또는 비치환 또는 할로겐-치환된 나프틸이고,
    R2은 수소, 히드록시, C1-C4-알킬, 니트로 또는 메톡시, 또는 불소, 염소, 브롬 또는 요오드이고, R3은 수소, 불소 또는 염소이고, R4는 수소 또는 메틸이고, R5는 수소 또는 염소이다.
  2. 질병 치료용의 제1항의 화학식 (Ⅰ)의 화합물.
  3. 환자에게 제1항의 화학식 (Ⅰ)의 화합물의 유효량을 투여하는 것을 포함하는 정신 질병의 치료 방법.
  4. 하기 화학식(Ⅱ)의 화합물을 하기 화학식 (Ⅲ)의 3-아자비시클로〔3.2.0〕헵탄 유도체와 반응시키고, 필요하다면 이와 같이 하여 얻어진 화합물을 생리학상 허용되는 산을 이용하여 이들의 염으로 전환시키는 것을 포함하는 제1항의 화학식 (Ⅰ)의 화합물의 제조 방법.
    상기 식에서, A 및 n은 상기 정의된 바와 같고, Nu는 이핵성 이탈기이고, R1은 비치환되거나 또는 할로겐 원자에 의해 일 또는 이치환된 나프틸 또는 페난트릴이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019970700754A 1994-08-04 1995-07-22 신경이완제로서 유용한 N-치환 아자비시클로헵탄 유도체(N-Substituted Azabicycloheptane Derivatives Useful as Neuroleptics) KR970704685A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4427647A DE4427647A1 (de) 1994-08-04 1994-08-04 N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
DEP4427647.8 1994-08-04
PCT/EP1995/002912 WO1996004245A1 (de) 1994-08-04 1995-07-22 N-substituierte azabicycloheptan-derivate als neuroleptika usw.

Publications (1)

Publication Number Publication Date
KR970704685A true KR970704685A (ko) 1997-09-06

Family

ID=6524943

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019970700754A KR970704685A (ko) 1994-08-04 1995-07-22 신경이완제로서 유용한 N-치환 아자비시클로헵탄 유도체(N-Substituted Azabicycloheptane Derivatives Useful as Neuroleptics)

Country Status (29)

Country Link
US (1) US5753690A (ko)
EP (1) EP0775113B1 (ko)
JP (1) JPH10503504A (ko)
KR (1) KR970704685A (ko)
CN (1) CN1064959C (ko)
AT (1) ATE200482T1 (ko)
AU (1) AU699021B2 (ko)
BG (1) BG63632B1 (ko)
CA (1) CA2196700A1 (ko)
CZ (1) CZ289080B6 (ko)
DE (2) DE4427647A1 (ko)
DK (1) DK0775113T3 (ko)
ES (1) ES2156212T3 (ko)
FI (1) FI970449A (ko)
GR (1) GR3035744T3 (ko)
HR (1) HRP950437B1 (ko)
HU (1) HUT77768A (ko)
IL (1) IL114719A (ko)
MX (1) MX9700854A (ko)
NO (1) NO307376B1 (ko)
NZ (1) NZ290429A (ko)
PL (1) PL182810B1 (ko)
PT (1) PT775113E (ko)
RU (1) RU2160254C2 (ko)
SI (1) SI9520086B (ko)
TW (1) TW378203B (ko)
UA (1) UA44736C2 (ko)
WO (1) WO1996004245A1 (ko)
ZA (1) ZA956476B (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19836404A1 (de) * 1998-08-12 2000-02-17 Basf Ag N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
US6458821B1 (en) 1998-08-12 2002-10-01 Abbott Laboratories N-substituted azabicycloheptane derivatives, production and use thereof
DE19836406A1 (de) 1998-08-12 2000-02-17 Basf Ag N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
DE19854147A1 (de) * 1998-11-24 2000-05-25 Basf Ag Verwendung von N-substituierten Azabicycloalkan-Derivaten zur Verwendung bei der Bekämpfung der Cocainsucht
US7834048B2 (en) * 2004-10-14 2010-11-16 Abbott Gmbh & Co. Kg Azabicycloheptyl compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
EP1874801A4 (en) * 2005-03-07 2009-03-25 Univ North Carolina RECA ACTIVITY INHIBITORS TO CONTROL ANTIBIOTIC-RESISTANT BACTERIAL PATHOGENS
FR2953514B1 (fr) * 2009-12-09 2011-12-23 Servier Lab Nouveaux derives azabicyclo[3.2.0]hept-3-yl, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP3978497A4 (en) * 2019-05-30 2022-07-13 Shanghai Institute of Materia Medica, Chinese Academy of Sciences FUSED CYCLIC COMPOUND, METHOD FOR PREPARING IT AND ITS USE

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4243287A1 (de) * 1992-06-19 1993-12-23 Basf Ag N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
DE4219973A1 (de) * 1992-06-19 1993-12-23 Basf Ag N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
GB9321481D0 (en) * 1993-10-18 1993-12-08 Alcan Int Ltd Tin oxide
DE4341402A1 (de) * 1993-12-04 1995-06-08 Basf Ag N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung

Also Published As

Publication number Publication date
JPH10503504A (ja) 1998-03-31
DE4427647A1 (de) 1996-02-08
DK0775113T3 (da) 2001-05-07
EP0775113A1 (de) 1997-05-28
SI9520086A (en) 1997-08-31
DE59509186D1 (de) 2001-05-17
CZ31197A3 (en) 1997-10-15
ZA956476B (en) 1997-02-03
US5753690A (en) 1998-05-19
ES2156212T3 (es) 2001-06-16
IL114719A0 (en) 1995-11-27
AU3116595A (en) 1996-03-04
CA2196700A1 (en) 1996-02-15
PT775113E (pt) 2001-09-28
NO970474D0 (no) 1997-02-03
EP0775113B1 (de) 2001-04-11
UA44736C2 (uk) 2002-03-15
NO307376B1 (no) 2000-03-27
BG63632B1 (bg) 2002-07-31
HRP950437A2 (en) 1997-08-31
HUT77768A (hu) 1998-08-28
GR3035744T3 (en) 2001-07-31
MX9700854A (es) 1997-04-30
TW378203B (en) 2000-01-01
IL114719A (en) 2001-03-19
WO1996004245A1 (de) 1996-02-15
NZ290429A (en) 1998-02-26
SI9520086B (sl) 2002-02-28
FI970449A0 (fi) 1997-02-03
PL318459A1 (en) 1997-06-09
HRP950437B1 (en) 2002-06-30
CN1064959C (zh) 2001-04-25
RU2160254C2 (ru) 2000-12-10
CZ289080B6 (cs) 2001-10-17
FI970449A (fi) 1997-04-03
PL182810B1 (pl) 2002-03-29
AU699021B2 (en) 1998-11-19
ATE200482T1 (de) 2001-04-15
NO970474L (no) 1997-04-01
CN1156989A (zh) 1997-08-13
BG101221A (en) 1997-08-29

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