KR890012970A - 테트라히드로 이소퀴놀린 유도체 - Google Patents

테트라히드로 이소퀴놀린 유도체 Download PDF

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Publication number
KR890012970A
KR890012970A KR1019890002060A KR890002060A KR890012970A KR 890012970 A KR890012970 A KR 890012970A KR 1019890002060 A KR1019890002060 A KR 1019890002060A KR 890002060 A KR890002060 A KR 890002060A KR 890012970 A KR890012970 A KR 890012970A
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KR
South Korea
Prior art keywords
compound
tetrahydro
group
substituted
isoquinolinol
Prior art date
Application number
KR1019890002060A
Other languages
English (en)
Inventor
네일러 알란
브루스 주드 던칸
브래즈호우 죤
에드워드 베이즈 데이비드
게일 헤이즈 앤
Original Assignee
추후보충
글락소 그룹 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888804107A external-priority patent/GB8804107D0/en
Priority claimed from GB888816550A external-priority patent/GB8816550D0/en
Application filed by 추후보충, 글락소 그룹 리미티드 filed Critical 추후보충
Publication of KR890012970A publication Critical patent/KR890012970A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

내용 없음.

Description

테트라히드로 이소퀴놀린 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. 하기 일반식(Ⅰ)의 화합물 및 그의 생리적으로 허용되는 염.
    상기식중, R1은 히드록시 또는 C1-6알콕시기이고, R2와 R3는 동일하거나 상이한 것으로서, C136알킬 또는 C3-6알케닐이기거나, 또는 -NR2R3는 5원 (질소 원자에 인접한 산소 원자를 임의로 포함함) 또는 6원 고리로서, 이 고라는 불포화 1단위를 포함하고, 비치환되거나 히드록시, 옥소, 임의 치환된 메틸리덴, COR4(여기에서, R4는 C1-6알킬, 아릴 또는 아르(C1-6)알킬기임) 또는 =NOR5기 (여기에서, R5는 C1-6알킬기임)에 의해 치환되고, X는 직접 결합, -CH2또는 -CH2O기이고, Ar은 치환된 페닐기임.
  2. 제1항에 있어서, R1이 히드록실기인 화합물.
  3. 제1항 또는 제2항에 있어서, R1이 테트라히드로 이소퀴놀린 핵의 6, 또는 7번 위치인 화합물.
  4. 제1항 또는 제2항에 있어서, 치환체 R1이 테트라히드로 이소퀴놀린 핵의 5번 위치인 화합물.
  5. 제1항 또는 제4항에 있어서, -NR2R3가 비치환 또는 치환된 피롤리딘 또는 테트라히드로피리딘 고리인 화합물.
  6. 제1항 내지 제4항에 있어서, -NR2R3가 비치환 피롤리딘 고리인 화합물.
  7. 제1항 내지 제6항에 있어서, X가 -CH2-인 화합물.
  8. 제1항 내지 제7항에 있어서, Ar이 3,4위치에서 페닐 치환되거나, 3,4위치가 할로겐인 화합물.
  9. 하기 화합물 및 그의 생리적으로 허용되는 염.
    2-[(3,4-디클로로 페닐)아세틸]-1,2,3,4-테트라히드로-1[(3-히드록시-1-피롤리디닐)메틸]-5-이소퀴놀리놀, 2-[(3,4-디클로로 페닐)아세틸]-1,2,3,4-테트라히드로-1[(3-옥소-1-피롤리디닐)메틸]-5-이소퀴놀리놀, 2-[(3,4-디클로로 페닐)아세틸]-1,2,3,4-테트라히드로-5-메톡시-1[(1-피롤리디닐)메틸]-5-이소퀴놀리놀.
  10. 2-[(3,4-디클로로 페닐)아세틸]-1,2,3,4-테트라히드로-1-[(1-피롤리디닐)메틸]-5-이소퀴놀리놀 및 그의 생리적으로 허용되는 염.
  11. 제1항에 의한 일반식(I)의 화합물 및 제약상 허용되는 담체로 되는 제약 조성물.
  12. 제1항에 의한 일반식(I)의 화합물 유효량을 투여함으로 되는, 동통 또는 뇌빈혈 환자의 치료 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임
KR1019890002060A 1988-02-23 1989-02-22 테트라히드로 이소퀴놀린 유도체 KR890012970A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB888804107A GB8804107D0 (en) 1988-02-23 1988-02-23 Chemical compounds
GB8804107 1988-02-23
GB8816550 1988-07-12
GB888816550A GB8816550D0 (en) 1988-07-12 1988-07-12 Chemical compounds

Publications (1)

Publication Number Publication Date
KR890012970A true KR890012970A (ko) 1989-09-20

Family

ID=26293523

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890002060A KR890012970A (ko) 1988-02-23 1989-02-22 테트라히드로 이소퀴놀린 유도체

Country Status (7)

Country Link
EP (1) EP0330469A3 (ko)
JP (1) JPH01301662A (ko)
KR (1) KR890012970A (ko)
AU (1) AU3029389A (ko)
DK (1) DK84789A (ko)
FI (1) FI890867A (ko)
PT (1) PT89780A (ko)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL292784A (ko) * 1962-05-15
EP0330360B1 (en) * 1988-02-19 1993-12-01 SmithKline Beecham Farmaceutici S.p.A. 1,2,3,4-Tetrahydroisoquinolines, processes for their preparation, and their use as kappa-receptor agonists
GB8827479D0 (en) * 1988-11-24 1988-12-29 Zambeletti Spa L Novel compounds
FI895821A0 (fi) * 1988-12-07 1989-12-05 Wellcome Found Farmaceutiskt aktiva cns foereningar.
GB8830219D0 (en) * 1988-12-23 1989-02-22 Zambeletti Spa L Novel compounds
DE3935371A1 (de) * 1988-12-23 1990-07-05 Merck Patent Gmbh Stickstoffhaltige ringverbindungen
GB8916395D0 (en) * 1989-07-18 1989-09-06 Zambeletti Spa L Pharmaceuticals
GB8926560D0 (en) * 1989-11-24 1990-01-17 Zambeletti Spa L Pharmaceuticals
US5322848A (en) * 1989-11-24 1994-06-21 Dr. Lo Zembeletti S.P.A. N-acyl-substituted azacyclic compounds, processes for their preparation, and their use as pharmaceuticals
JPH05506650A (ja) * 1990-04-28 1993-09-30 スミスクライン　ビーチャム　ファルマシューティッチ　エッセ　ピ　ア アザ環式誘導体
WO1992017467A1 (en) * 1991-04-06 1992-10-15 Dr Lo. Zambeletti S.P.A. Substituted azacyclic compounds, process for their preparation and their use as analgesics
EP0585296A1 (en) * 1991-05-21 1994-03-09 Smithkline Beecham Farmaceutici S.p.A. 2-(pyrrolidinyl-1-methyl)-piperidine derivatives and their use as kappa-recept or agonists
IT1273751B (it) * 1994-02-11 1997-07-10 Smithkline Beecham Farma Derivati azaciclici
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
CA2288828A1 (en) * 1997-07-14 1999-01-28 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
CN1244561C (zh) 2000-05-11 2006-03-08 布里斯托尔-迈尔斯斯奎布公司 可用作生长激素促分泌素的四氢异喹啉类似物
US6649606B1 (en) 2001-11-09 2003-11-18 Bristol-Myers Squibb Co. Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity
CN100503571C (zh) * 2006-07-12 2009-06-24 中国药科大学 四氢异喹啉类衍生物、其制备方法及其医药用途
JP5779100B2 (ja) 2008-11-24 2015-09-16 カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ 光学的に活性なｎ−ベンジル−３−ヒドロキシピロリジンの製造方法
CN103435545B (zh) * 2013-08-14 2015-10-07 中国药科大学 四氢异喹啉季铵盐类衍生物、其制备方法及其镇痛用途
CN103554021A (zh) * 2013-11-25 2014-02-05 中国药科大学 一类茚酮四氢异喹啉衍生物、其制备方法及医药用途

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DE2361390A1 (de) * 1973-12-10 1975-06-19 Merck Patent Gmbh Isochinolinderivate und verfahren zu ihrer herstellung
GB8531615D0 (en) * 1985-12-23 1986-02-05 Zambeletti Spa L Compounds
GB8601796D0 (en) * 1986-01-24 1986-02-26 Zambeletti Spa L Compounds
EP0330360B1 (en) * 1988-02-19 1993-12-01 SmithKline Beecham Farmaceutici S.p.A. 1,2,3,4-Tetrahydroisoquinolines, processes for their preparation, and their use as kappa-receptor agonists

Also Published As

Publication number Publication date
FI890867A (fi) 1989-08-24
PT89780A (pt) 1989-10-04
DK84789D0 (da) 1989-02-23
EP0330469A3 (en) 1990-05-09
DK84789A (da) 1989-08-24
EP0330469A2 (en) 1989-08-30
JPH01301662A (ja) 1989-12-05
FI890867A0 (fi) 1989-02-23
AU3029389A (en) 1989-08-24

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