FI890867A - Tetrahydroisokinolinderivat. - Google Patents
Tetrahydroisokinolinderivat. Download PDFInfo
- Publication number
- FI890867A FI890867A FI890867A FI890867A FI890867A FI 890867 A FI890867 A FI 890867A FI 890867 A FI890867 A FI 890867A FI 890867 A FI890867 A FI 890867A FI 890867 A FI890867 A FI 890867A
- Authority
- FI
- Finland
- Prior art keywords
- tetrahydroisokinolinderivat
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888804107A GB8804107D0 (en) | 1988-02-23 | 1988-02-23 | Chemical compounds |
GB888816550A GB8816550D0 (en) | 1988-07-12 | 1988-07-12 | Chemical compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
FI890867A0 FI890867A0 (fi) | 1989-02-23 |
FI890867A true FI890867A (fi) | 1989-08-24 |
Family
ID=26293523
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI890867A FI890867A (fi) | 1988-02-23 | 1989-02-23 | Tetrahydroisokinolinderivat. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0330469A3 (fi) |
JP (1) | JPH01301662A (fi) |
KR (1) | KR890012970A (fi) |
AU (1) | AU3029389A (fi) |
DK (1) | DK84789A (fi) |
FI (1) | FI890867A (fi) |
PT (1) | PT89780A (fi) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE632371A (fi) * | 1962-05-15 | 1963-09-02 | ||
DE68910999T2 (de) * | 1988-02-19 | 1994-03-24 | Smithkline Beecham Farma | 1,2,3,4-Tetrahydroisoquinoline, Verfharen zu ihrer Herstellung und ihre Verwendung als Kappa-Rezeptor Agonisten. |
GB8827479D0 (en) * | 1988-11-24 | 1988-12-29 | Zambeletti Spa L | Novel compounds |
FI895821A0 (fi) * | 1988-12-07 | 1989-12-05 | Wellcome Found | Farmaceutiskt aktiva cns foereningar. |
GB8830219D0 (en) * | 1988-12-23 | 1989-02-22 | Zambeletti Spa L | Novel compounds |
DE3935371A1 (de) * | 1988-12-23 | 1990-07-05 | Merck Patent Gmbh | Stickstoffhaltige ringverbindungen |
GB8916395D0 (en) * | 1989-07-18 | 1989-09-06 | Zambeletti Spa L | Pharmaceuticals |
KR927003571A (ko) * | 1989-11-24 | 1992-12-18 | 크리스티아노 스테이들러 | N-아실-치환된 아자시클릭 화합물, 그의 제조방법 및 약제로서 그의 사용 |
GB8926560D0 (en) * | 1989-11-24 | 1990-01-17 | Zambeletti Spa L | Pharmaceuticals |
US5428042A (en) * | 1990-04-28 | 1995-06-27 | Dr Lo Zambeletti S.P.A. | 1-(2H-1-oxo-3,4-dihydronaphtyl-6-yl)-acetyl-piperidines as kappa agonists |
WO1992017467A1 (en) * | 1991-04-06 | 1992-10-15 | Dr Lo. Zambeletti S.P.A. | Substituted azacyclic compounds, process for their preparation and their use as analgesics |
EP0585296A1 (en) * | 1991-05-21 | 1994-03-09 | Smithkline Beecham Farmaceutici S.p.A. | 2-(pyrrolidinyl-1-methyl)-piperidine derivatives and their use as kappa-recept or agonists |
IT1273751B (it) * | 1994-02-11 | 1997-07-10 | Smithkline Beecham Farma | Derivati azaciclici |
US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
US5763445A (en) | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
US5760023A (en) * | 1997-07-14 | 1998-06-02 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
BR9810706A (pt) * | 1997-07-14 | 2000-08-08 | Adolor Corp | Processo para a prevenção ou tratamento do prurido em um mamìfero em necessidade de tal prevenção ou tratamento |
EP1280777B1 (en) | 2000-05-11 | 2005-11-23 | Bristol-Myers Squibb Company | Tetrahydroisoquinoline analogs useful as growth hormone secretagogues |
US6649606B1 (en) | 2001-11-09 | 2003-11-18 | Bristol-Myers Squibb Co. | Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity |
CN100503571C (zh) * | 2006-07-12 | 2009-06-24 | 中国药科大学 | 四氢异喹啉类衍生物、其制备方法及其医药用途 |
EP2361244B1 (en) | 2008-11-24 | 2013-07-10 | Council of Scientific & Industrial Research | A process for the preparation of optically active n-benzyl-3 hydroxypyrrolidines |
CN103435545B (zh) * | 2013-08-14 | 2015-10-07 | 中国药科大学 | 四氢异喹啉季铵盐类衍生物、其制备方法及其镇痛用途 |
CN103554021A (zh) * | 2013-11-25 | 2014-02-05 | 中国药科大学 | 一类茚酮四氢异喹啉衍生物、其制备方法及医药用途 |
HUE064111T2 (hu) | 2018-10-22 | 2024-02-28 | C4X Discovery Ltd | Gyógyhatású vegyületek |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2361390A1 (de) * | 1973-12-10 | 1975-06-19 | Merck Patent Gmbh | Isochinolinderivate und verfahren zu ihrer herstellung |
GB8531615D0 (en) * | 1985-12-23 | 1986-02-05 | Zambeletti Spa L | Compounds |
GB8601796D0 (en) * | 1986-01-24 | 1986-02-26 | Zambeletti Spa L | Compounds |
DE68910999T2 (de) * | 1988-02-19 | 1994-03-24 | Smithkline Beecham Farma | 1,2,3,4-Tetrahydroisoquinoline, Verfharen zu ihrer Herstellung und ihre Verwendung als Kappa-Rezeptor Agonisten. |
-
1989
- 1989-02-22 KR KR1019890002060A patent/KR890012970A/ko not_active Application Discontinuation
- 1989-02-22 PT PT89780A patent/PT89780A/pt not_active Application Discontinuation
- 1989-02-23 JP JP1041961A patent/JPH01301662A/ja active Pending
- 1989-02-23 AU AU30293/89A patent/AU3029389A/en not_active Abandoned
- 1989-02-23 EP EP89301773A patent/EP0330469A3/en not_active Withdrawn
- 1989-02-23 DK DK084789A patent/DK84789A/da not_active Application Discontinuation
- 1989-02-23 FI FI890867A patent/FI890867A/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JPH01301662A (ja) | 1989-12-05 |
EP0330469A2 (en) | 1989-08-30 |
EP0330469A3 (en) | 1990-05-09 |
AU3029389A (en) | 1989-08-24 |
KR890012970A (ko) | 1989-09-20 |
DK84789D0 (da) | 1989-02-23 |
FI890867A0 (fi) | 1989-02-23 |
DK84789A (da) | 1989-08-24 |
PT89780A (pt) | 1989-10-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application lapsed |
Owner name: GLAXO GROUP LIMITED |