ES2078321T3 - Agentes de contraste radiografico no ionicos. - Google Patents

Agentes de contraste radiografico no ionicos.

Info

Publication number
ES2078321T3
ES2078321T3 ES90312983T ES90312983T ES2078321T3 ES 2078321 T3 ES2078321 T3 ES 2078321T3 ES 90312983 T ES90312983 T ES 90312983T ES 90312983 T ES90312983 T ES 90312983T ES 2078321 T3 ES2078321 T3 ES 2078321T3
Authority
ES
Spain
Prior art keywords
chem
contrast agents
ch2ch2oh
hydrogen
different
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90312983T
Other languages
English (en)
Inventor
Ramachandran S Ranganathan
Edmund R Marinelli
Thangavel Arunachalam
Radhakrishna Pillai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco International BV filed Critical Bracco International BV
Application granted granted Critical
Publication of ES2078321T3 publication Critical patent/ES2078321T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C07D223/10—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D265/10—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

NUEVOS AGENTES DE CONTRASTE RADIOGRAFICO NO IONICOS QUE TIENEN LA FORMULA EN DONDE Y ES UN ENLACE SENCILLO -CH SUB 2 CH SUB 2-, -CH SUB 2O, -OCH SUB 2-, R SUB 1 Y R SUB 2 SON IGUALES O DIFERENTES Y SON R SUB 3 Y R SUB 4 SON IGUALES O DIFERENTES Y SON HIDROGENO, METILO O -CH SUB 2 CH SUB 2 OH; R SUB 5 ES HIDROGENO, ALQUILO, -CH SUB 2 CH SUB 2 OH, CH SUB 2 OH U OH Y R SUB 6 ES ALQUILO, -CH SUB 2 CH SUB 2 OH, CH SUB 2 OH, OH O HIDROGENO Y PUEDE SER IGUAL O DIFERENTE A R SUB 5 Y M ES CERO O UNO SIEMPRE Y CUANDO NO HAYA UN ATOMO DE METILENO O UNO DE CARBONO DE METINO DEL ANILLO HETEROCICLICO UNIDO A TANTO UN ATOMO DE NITROGENO COMO A UNO DE OXIGENO CON LA CONDICION ADICIONAL DE QUE CUANDO Y ES UN ENLACE SENCILLO M NO ES CERO. ESTOS NUEVOS AGENTES DE CONTRASTE SON DISOLUBLES EN AGUA Y TIENEN PROPIEDADES VENTAJOSAS DE OSMOLALIDAD.
ES90312983T 1989-11-29 1990-11-29 Agentes de contraste radiografico no ionicos. Expired - Lifetime ES2078321T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44286989A 1989-11-29 1989-11-29

Publications (1)

Publication Number Publication Date
ES2078321T3 true ES2078321T3 (es) 1995-12-16

Family

ID=23758470

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90312983T Expired - Lifetime ES2078321T3 (es) 1989-11-29 1990-11-29 Agentes de contraste radiografico no ionicos.

Country Status (24)

Country Link
EP (1) EP0431838B1 (es)
JP (1) JP2931089B2 (es)
KR (1) KR0160981B1 (es)
CN (2) CN1052114A (es)
AT (1) ATE129493T1 (es)
AU (1) AU623293B2 (es)
CA (1) CA2029830A1 (es)
CZ (1) CZ280698B6 (es)
DE (1) DE69023210T2 (es)
DK (1) DK0431838T3 (es)
EG (1) EG19359A (es)
ES (1) ES2078321T3 (es)
FI (1) FI97130C (es)
GR (1) GR3018215T3 (es)
HU (1) HUT56075A (es)
IE (1) IE73448B1 (es)
IL (1) IL96324A (es)
MX (1) MX23489A (es)
NO (1) NO174925C (es)
NZ (1) NZ236143A (es)
PL (1) PL164291B1 (es)
PT (1) PT96020B (es)
RU (1) RU2046795C1 (es)
ZA (1) ZA909140B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869024A (en) * 1989-11-29 1999-02-09 Bracco International B.V. Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
CA2068089C (en) * 1991-05-31 2003-09-16 Ramachandran S. Ranganathan Method and compositions for using non-ionic contrast agents to reduce the risk of clot formulation in diagnostic procedures
US5359077A (en) * 1992-06-05 1994-10-25 Bristol-Myers Squibb Company Process for preparation of 2-oxo-1 piperidinyl derivatives
US5278311A (en) * 1992-06-05 1994-01-11 E. R. Squibb & Sons, Inc. Nonionic radiographic contrast agents
US5686061A (en) * 1994-04-11 1997-11-11 The Board Of Regents Of The University Of Texas System Particulate contrast media derived from non-ionic water soluble contrast agents for CT enhancement of hepatic tumors
KR100513900B1 (ko) * 1999-07-12 2005-09-07 주식회사 효성 폴리에스터 인조 스웨드의 제조방법
TW200304374A (en) 2001-11-30 2003-10-01 Smithkline Beecham Plc Novel compounds
CN101891696A (zh) * 2009-05-22 2010-11-24 史命锋 一种多碘苯环化合物及其制备方法和应用
WO2016004563A1 (en) * 2014-07-07 2016-01-14 Chih-Yung Lin Aqueous tissue clearing solution and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH512247A (de) * 1968-05-02 1971-09-15 Bracco Ind Chimica Spa Neue Röntgenkontrastmittel und Verfahren zu ihrer Herstellung
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
US4066743A (en) * 1976-06-21 1978-01-03 Mallinckrodt, Inc. X-ray contrast agents
DE2928417A1 (de) * 1979-07-12 1981-01-29 Schering Ag Trijodierte basen
IT1193211B (it) * 1979-08-09 1988-06-15 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
DE3150916A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
JP2568166B2 (ja) * 1982-10-01 1996-12-25 ニユコメド・イメージング・アクシェセルカペト Ｘ線造影剤
DE3429949A1 (de) * 1984-08-10 1986-02-20 Schering AG, 1000 Berlin und 4709 Bergkamen Neue nicht -ionische 2,4,6-trijod-isophthalsaeure-bis-amide, verfahren zu ihrer herstellung und ihre verwendung als roentgenkontrastmittel

Also Published As

Publication number Publication date
DE69023210D1 (de) 1995-11-30
DE69023210T2 (de) 1996-03-28
FI97130C (fi) 1996-10-25
IE904181A1 (en) 1991-06-05
GR3018215T3 (en) 1996-02-29
KR0160981B1 (ko) 1998-12-01
FI97130B (fi) 1996-07-15
NO174925B (no) 1994-04-25
ZA909140B (en) 1991-09-25
FI905883A (fi) 1991-05-30
IE73448B1 (en) 1997-06-04
DK0431838T3 (da) 1995-12-04
NO905107D0 (no) 1990-11-26
EP0431838B1 (en) 1995-10-25
MX23489A (es) 1993-10-01
NO905107L (no) 1991-05-30
HU907680D0 (en) 1991-06-28
KR910009655A (ko) 1991-06-28
NO174925C (no) 1994-08-03
IL96324A (en) 1995-01-24
PL164291B1 (pl) 1994-07-29
CZ280698B6 (cs) 1996-04-17
PL288021A1 (en) 1991-12-02
CN1107468A (zh) 1995-08-30
RU2046795C1 (ru) 1995-10-27
CN1052114A (zh) 1991-06-12
EG19359A (en) 1994-12-30
PT96020A (pt) 1991-09-13
ATE129493T1 (de) 1995-11-15
HUT56075A (en) 1991-07-29
IL96324A0 (en) 1991-08-16
JPH03176470A (ja) 1991-07-31
CA2029830A1 (en) 1991-05-30
AU623293B2 (en) 1992-05-07
EP0431838A1 (en) 1991-06-12
PT96020B (pt) 1998-02-27
AU6663790A (en) 1991-06-06
NZ236143A (en) 1993-08-26
CZ595490A3 (en) 1995-12-13
JP2931089B2 (ja) 1999-08-09
FI905883A0 (fi) 1990-11-29

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