KR880009964A - 아릴피페라지닐-에틸(또는 부틸)-페닐-헤테로시클릭 화합물 - Google Patents
아릴피페라지닐-에틸(또는 부틸)-페닐-헤테로시클릭 화합물 Download PDFInfo
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- KR880009964A KR880009964A KR1019880001454A KR880001454A KR880009964A KR 880009964 A KR880009964 A KR 880009964A KR 1019880001454 A KR1019880001454 A KR 1019880001454A KR 880001454 A KR880001454 A KR 880001454A KR 880009964 A KR880009964 A KR 880009964A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (9)
- 하기 일반식으로 표시되는 화합물 또는 그의 제약상 허용되는 산 부가염.상기식중, Ar은 페닐 또는 3-트리플루오로메틸페닐기, 3-시아노피리딜기, 나프틸기, 또는 5- 또는 6-원 방향족 헤테로시클릭 고리이고, 이 고리는 1개의 질소, 산소 또는 황원자, 또는 2개의 질소(이중 1개는 산소 또는 황원자에 의해 치환될 수 있음)을 갖거나, 또는 이 고리는 벤조기와 축합되며, 상기 나프틸기, 헤테로시클릭 고리 또는 벤조헤테로시클릭 고리 각각은 1개의 플루오로, 클로로 또는 트리플루오로메틸기에 의해 임의로 치환될 수 있고, 상기 나프틸기 또는 벤조헤테로시클릭 고리의 경우에 있어서 치환은 피페라지닐기와 결합되지 않은 고리에서 행해지고, n은 2,3 또는 4이고, R은 수소원자 또는 (C1-C3)알킬기이고, X는 질소, 산소 또는 황원자이고, Z-Y는 C-H, C-OH, C-SH, C-NH2, C-(C1-C3)알킬, C-(C1-C3)알킬아미노기 또는 질소원자이고, 단 Z-Y가 질소원자일 경우, X는 산소원자가 아님.
- 제1항에 있어서, n이 2이고, R이 수소원자임을 특징으로 하는 화합물.
- 제1항 또는 제2항에 있어서, Ar이 나프틸기 또는 벤조기와 축합된 5- 또는 6-원 방향족 헤테로시클릭 고리임을 특징으로 하는 화합물.
- 제1항 내지 제 3항중 어느 하나의 항에 있어서, X가 황원자이고, Y가 아미노기임을 특징으로 하는 화합물.
- 정신 질환치료에 유효한 양의 제1항에 의한 화합물 및 제약상 허용되는 담체 또는 희석제로 되는 제약 조성물.
- 제5항에 있어서, n이 2이고, R이 수소원자임을 특징으로 하는 조성물.
- 제5항 또는 제6항에 있어서, Ar이 나프틸기 또는 벤조기와 축합된 5- 또는 6-원 방향족 헤테로시클릭 고리임을 특징으로 하는 조성물.
- 제5항 내지 제7항중 어느 하나의 항에 있어서, X가 황원자이고 Y가 아미노기임을 특징으로 하는 조성물.
- 정신 질환을 치료하기 위한 제1항에 의한 화합물.※참고사항:최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8700340 | 1987-02-17 | ||
USPCT/US87/00340 | 1987-02-17 | ||
US87/00340 | 1987-02-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR880009964A true KR880009964A (ko) | 1988-10-06 |
KR900004126B1 KR900004126B1 (ko) | 1990-06-16 |
Family
ID=22202287
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880001454A KR900004126B1 (ko) | 1987-02-17 | 1988-02-13 | 아릴피페라지닐-에틸(또는 부틸)-페닐-헤테로시클릭 화합물 |
Country Status (30)
Country | Link |
---|---|
EP (1) | EP0279598B1 (ko) |
JP (1) | JPH0699405B2 (ko) |
KR (1) | KR900004126B1 (ko) |
CN (1) | CN1015627B (ko) |
AP (1) | AP88A (ko) |
AR (1) | AR245125A1 (ko) |
AT (1) | ATE94537T1 (ko) |
AU (1) | AU583761B2 (ko) |
CA (1) | CA1312080C (ko) |
CS (1) | CS272783B2 (ko) |
DD (1) | DD272080A5 (ko) |
DE (1) | DE3884007T2 (ko) |
DK (1) | DK170878B1 (ko) |
EG (1) | EG18635A (ko) |
ES (1) | ES2058249T3 (ko) |
FI (1) | FI91752C (ko) |
HU (1) | HU207731B (ko) |
IE (1) | IE61258B1 (ko) |
IL (1) | IL85368A0 (ko) |
IN (1) | IN171858B (ko) |
MA (1) | MA21183A1 (ko) |
MX (1) | MX174210B (ko) |
MY (1) | MY103210A (ko) |
NO (1) | NO170582C (ko) |
NZ (1) | NZ223530A (ko) |
PL (1) | PL157118B1 (ko) |
PT (1) | PT86766B (ko) |
SU (1) | SU1634136A3 (ko) |
YU (1) | YU46624B (ko) |
ZA (1) | ZA881064B (ko) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX173362B (es) * | 1987-03-02 | 1994-02-23 | Pfizer | Compuestos de piperazinil heterociclicos y procedimiento para su preparacion |
SE8803429D0 (sv) * | 1988-09-28 | 1988-09-28 | Pharmacia Ab | Novel pyridyl- and pyrimidyl derivatives |
US5166157A (en) * | 1989-12-20 | 1992-11-24 | Adir Et Compagnie | Naphthyl piperazines useful as 5-HT1A receptor ligands |
US5166156A (en) * | 1989-12-20 | 1992-11-24 | Adir Et Compagnie | Naphthyl piperazines useful as 5-HT1A receptor ligands |
US5162324A (en) * | 1989-12-20 | 1992-11-10 | Adir Et Compagnie | Naphyl piperazines useful as 5-HT1A receptor ligands |
FR2655988B1 (fr) * | 1989-12-20 | 1994-05-20 | Adir Cie | Nouveaux derives de la napht-1-yl piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
US5162321A (en) * | 1989-12-20 | 1992-11-10 | Adir Et Compagnie | 1-naphthyl piperazines useful as 5-HT1A receptor ligands |
DE69611783T2 (de) * | 1995-06-06 | 2001-09-20 | Aventis Pharma Inc | Benzisoxazol- und indazol- derivate als antipsychotika |
GB9517381D0 (en) * | 1995-08-24 | 1995-10-25 | Pharmacia Spa | Aryl and heteroaryl piperazine derivatives |
WO1997024343A1 (en) | 1995-12-29 | 1997-07-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Phenyl thiazole derivatives with anti herpes virus properties |
US6288091B1 (en) | 1995-12-29 | 2001-09-11 | Boehringer Ingelheim Ltd. | Antiherpes virus compounds and methods for their preparation and use |
WO1999001420A1 (fr) | 1997-07-03 | 1999-01-14 | Taito Co., Ltd. | Procede de preparation de derives d'acide 2-aminomalonique, et intermediaires utilises dans ce procede |
CA2891122C (en) | 2012-11-14 | 2021-07-20 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2927924A (en) * | 1958-04-03 | 1960-03-08 | Lilly Co Eli | Novel phenethyl-substituted piperazines |
FR1300728A (ko) * | 1959-10-20 | 1962-07-02 | ||
DE1695410A1 (de) * | 1967-04-20 | 1971-04-08 | Merck Patent Gmbh | Verfahren zur Herstellung von 1-(Thiazolyl-5-alkyl)-4-(pyridyl-2)-piperazinen |
JPS5910675B2 (ja) * | 1976-03-22 | 1984-03-10 | ウェルファイド株式会社 | アラルキルアミン誘導体 |
US4411901A (en) * | 1981-12-23 | 1983-10-25 | Mead Johnson & Company | Benzisothiazole and benzisoxazole piperazine derivatives |
US4619930A (en) * | 1985-01-16 | 1986-10-28 | Bristol-Myers Company | Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use |
JPH075579B2 (ja) * | 1986-09-01 | 1995-01-25 | 吉富製薬株式会社 | アミノチアゾ−ル化合物 |
-
1987
- 1987-02-17 MX MX010428A patent/MX174210B/es unknown
-
1988
- 1988-01-27 IN IN64/DEL/88A patent/IN171858B/en unknown
- 1988-02-09 IL IL85368A patent/IL85368A0/xx not_active IP Right Cessation
- 1988-02-12 EP EP88301171A patent/EP0279598B1/en not_active Expired - Lifetime
- 1988-02-12 DE DE88301171T patent/DE3884007T2/de not_active Expired - Fee Related
- 1988-02-12 AT AT88301171T patent/ATE94537T1/de not_active IP Right Cessation
- 1988-02-12 ES ES88301171T patent/ES2058249T3/es not_active Expired - Lifetime
- 1988-02-13 KR KR1019880001454A patent/KR900004126B1/ko not_active IP Right Cessation
- 1988-02-15 CN CN88100986A patent/CN1015627B/zh not_active Expired
- 1988-02-15 CA CA000558900A patent/CA1312080C/en not_active Expired - Fee Related
- 1988-02-15 PL PL1988270653A patent/PL157118B1/pl unknown
- 1988-02-15 PT PT86766A patent/PT86766B/pt not_active IP Right Cessation
- 1988-02-15 JP JP63032593A patent/JPH0699405B2/ja not_active Expired - Fee Related
- 1988-02-15 MA MA21420A patent/MA21183A1/fr unknown
- 1988-02-16 DK DK078888A patent/DK170878B1/da not_active IP Right Cessation
- 1988-02-16 NO NO880667A patent/NO170582C/no not_active IP Right Cessation
- 1988-02-16 SU SU4355194A patent/SU1634136A3/ru active
- 1988-02-16 MY MYPI88000161A patent/MY103210A/en unknown
- 1988-02-16 NZ NZ223530A patent/NZ223530A/xx unknown
- 1988-02-16 YU YU30388A patent/YU46624B/sh unknown
- 1988-02-16 DD DD88312959A patent/DD272080A5/de not_active IP Right Cessation
- 1988-02-16 CS CS96488A patent/CS272783B2/cs not_active IP Right Cessation
- 1988-02-16 HU HU88748A patent/HU207731B/hu unknown
- 1988-02-16 ZA ZA881064A patent/ZA881064B/xx unknown
- 1988-02-16 AU AU11740/88A patent/AU583761B2/en not_active Ceased
- 1988-02-16 FI FI880716A patent/FI91752C/fi active IP Right Grant
- 1988-02-16 IE IE42088A patent/IE61258B1/en not_active IP Right Cessation
- 1988-02-16 AR AR88310090A patent/AR245125A1/es active
- 1988-02-16 AP APAP/P/1988/000082A patent/AP88A/en active
- 1988-02-17 EG EG9388A patent/EG18635A/xx active
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