KR920014818A - 항균제 - Google Patents

항균제 Download PDF

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Publication number
KR920014818A
KR920014818A KR1019920000197A KR920000197A KR920014818A KR 920014818 A KR920014818 A KR 920014818A KR 1019920000197 A KR1019920000197 A KR 1019920000197A KR 920000197 A KR920000197 A KR 920000197A KR 920014818 A KR920014818 A KR 920014818A
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KR
South Korea
Prior art keywords
compound
alkyl
amino
hydrogen
nitrogen
Prior art date
Application number
KR1019920000197A
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English (en)
Inventor
존 테르난스키 로버트
Original Assignee
리로이 휘테커
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 리로이 휘테커, 일라이 릴리 앤드 캄파니 filed Critical 리로이 휘테커
Publication of KR920014818A publication Critical patent/KR920014818A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

항균제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. 하기 일반식(1)의 화합물 또는 그의 약학적으로 허용가능한 염 :
    상기식에서, R은 수소, C1-C6알킬, C2-C6알케닐, C2-C|6알키닐, C3-C6사이클로알킬 또는 C1-C6할로알킬이고, A 및 A'는 독립적으로 수소, C1-C6알킬, 니트로, 아미노, 질소 또는 황을 함유하는 5내지 6원의 헤테로사이클, C1-C6알콕시 또는 페낼이거나, 또는 A 및 A'는 함께 일반식
    (여기에서, X는 수소, 할로, C1-C6알킬, C1-C6알콕시, C1-C6알콕시카보닐, 아미노, 니트로 또는 카복시이고, Y는 질소 또는 탄소이다)의 그룹을 형성한다.
  2. 제1항에 있어서, R이 C1-C6알킬 또는 C1-C6할로알킬인 화합물.
  3. 제2항에 있어서, R이 메틸 또는 플루오로-C1-C6알킬인 화합물.
  4. 제3항에 있어서, R이 2-플루오로에트-1-일인 화합물.
  5. 제1항에 있어서, A 및 A'가 일반식
    의 그룹을 형성하는 화합물.
  6. 제5항에 있어서, Y가 질소인 화합물.
  7. 제6항에 있어서, A 및 A'가 구조식의 그룹을 형성하는 화합물.
  8. 제7항에있어서, R이 메틸 또는 2-플루오로에트-1-일인 화합물.
  9. 하기 일반식(2)의 화합물 :
    상기식에서, R0는 아미노 또는 보호된 아미노이고, R'은 수소 또는 카복시-보호 그룹이며, A 및 A'는 독립적으로 수소, C1-C6알킬, 페닐, 니트로, 아미노, 질소 또는 황을 함유하는 5내지 6원의 헤테로 사이클 또는 C1-C6알콕시이거나, 또는 A 및 A'는 함께 일반식
    (여기에서, X 는 수소, C1-C6알킬, C1-C6알콕시, C1-C6알콕시카보닐,아미노, 니트로, 또는 카복시이고, Y는 질소 또는 탄소이다)의 그룹을 형성한다.
  10. 제9항에 있어서, A 및 A'가 함께 일반식
    의 그룹을 형성하는 화합물.
  11. 제10항에 있어서, A 및 A'구조식의 그룹을 형성하는 화합물.
  12. 하나 이상의 약학적으로 허용가능한 담체, 부형체 또는 희석제와 함께 제1항 내지 제8항중 어느 한항에 청구된 화합물을 포함하는 약학 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920000197A 1991-01-18 1992-01-09 항균제 KR920014818A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64295991A 1991-01-18 1991-01-18
US07/642,959 1991-01-18

Publications (1)

Publication Number Publication Date
KR920014818A true KR920014818A (ko) 1992-08-25

Family

ID=24578768

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920000197A KR920014818A (ko) 1991-01-18 1992-01-09 항균제

Country Status (23)

Country Link
US (1) US5362722A (ko)
EP (1) EP0495584B1 (ko)
JP (1) JP3164390B2 (ko)
KR (1) KR920014818A (ko)
CN (1) CN1063286A (ko)
AT (1) ATE187729T1 (ko)
AU (1) AU642333B2 (ko)
BR (1) BR9200057A (ko)
CA (1) CA2058822C (ko)
CZ (1) CZ281684B6 (ko)
DE (1) DE69230415T2 (ko)
ES (1) ES2141096T3 (ko)
FI (1) FI920111A (ko)
HU (1) HUT60276A (ko)
IE (1) IE920085A1 (ko)
IL (1) IL100576A (ko)
MX (1) MX9200102A (ko)
NO (1) NO301330B1 (ko)
NZ (1) NZ241249A (ko)
PT (1) PT99983B (ko)
RU (1) RU2104280C1 (ko)
YU (1) YU2292A (ko)
ZA (1) ZA9224B (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5077287A (en) * 1991-01-18 1991-12-31 Eli Lilly And Company 3-thiazolylthio carbacephem antibacterial agents
JPH05132488A (ja) * 1991-08-13 1993-05-28 Meiji Seika Kaisha Ltd 新規セフアロスポリン誘導体
JP2857532B2 (ja) * 1992-03-12 1999-02-17 明治製菓株式会社 新規セファロスポリン誘導体
US5525599A (en) * 1993-07-21 1996-06-11 Eli Lilly And Company 7-substituted-amino-3-substituted-3-cephem-4-carboxylic acids
US5496816A (en) * 1994-03-14 1996-03-05 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
US5498777A (en) * 1994-07-20 1996-03-12 Merck & Co., Inc. 3-thioheteroaryl cephalosporin compounds, compositions and methods of use
TWI290136B (en) 2000-04-05 2007-11-21 Daiichi Seiyaku Co Ethylenediamine derivatives
EP1405852B9 (en) 2001-06-20 2013-03-27 Daiichi Sankyo Company, Limited Diamine derivatives
US7365205B2 (en) 2001-06-20 2008-04-29 Daiichi Sankyo Company, Limited Diamine derivatives

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5214789A (en) * 1975-07-22 1977-02-03 Shionogi & Co Ltd Process for preparing 3-substiuted cephem compounds by ring closure
ZA766941B (en) * 1975-11-21 1978-06-28 Merck & Co Inc 3-(substituted thio)cephalosporins,derivatives and nuclear analogues thereof
EP0009008A3 (de) * 1978-09-08 1980-05-14 Ciba-Geigy Ag Cephalosporinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
US4500526A (en) * 1982-06-28 1985-02-19 Bristol-Myers Company Cephalosporin derivatives
GB8410992D0 (en) * 1984-04-30 1984-06-06 Glaxo Group Ltd Process
JPH0653739B2 (ja) * 1984-11-15 1994-07-20 協和醗酵工業株式会社 ３位置換カルバセフエム化合物
GB2177691A (en) * 1985-07-18 1987-01-28 Glaxo Group Ltd Cephalosporin antibiotics
US5142039A (en) * 1987-07-31 1992-08-25 Eli Lilly And Company β-lactam antibiotics
JP2568248B2 (ja) * 1988-04-22 1996-12-25 第一製薬株式会社 ３−セフェム−４−カルボン酸
US5332731A (en) * 1989-12-07 1994-07-26 Meiji Seika Kaisha, Ltd. Cephalosporin derivatives
JPH0686459B2 (ja) * 1989-12-07 1994-11-02 明治製菓株式会社 ３―置換チオ―３―セフエム化合物の製造法
IE65926B1 (en) * 1990-07-19 1995-11-29 Shionogi & Co Thioalkylthio cephalosporin derivatives
US5247073A (en) * 1991-01-18 1993-09-21 Eli Lilly And Company 7-(Amino or protected amino)-3-thioheterobicyclic cephalosporins
US5077287A (en) * 1991-01-18 1991-12-31 Eli Lilly And Company 3-thiazolylthio carbacephem antibacterial agents
JPH05132488A (ja) * 1991-08-13 1993-05-28 Meiji Seika Kaisha Ltd 新規セフアロスポリン誘導体
JPH09109037A (ja) * 1995-10-23 1997-04-28 Denso Corp スライド機能付き締付け装置

Also Published As

Publication number Publication date
HU9200082D0 (en) 1992-03-30
IE920085A1 (en) 1992-07-29
PT99983B (pt) 1999-06-30
PT99983A (pt) 1993-01-29
DE69230415T2 (de) 2000-05-11
JPH04321691A (ja) 1992-11-11
RU2104280C1 (ru) 1998-02-10
CS1292A3 (en) 1992-08-12
BR9200057A (pt) 1992-09-08
HUT60276A (en) 1992-08-28
JP3164390B2 (ja) 2001-05-08
EP0495584B1 (en) 1999-12-15
ZA9224B (en) 1993-07-02
DE69230415D1 (de) 2000-01-20
FI920111A0 (fi) 1992-01-10
CA2058822C (en) 2000-06-27
IL100576A0 (en) 1992-09-06
MX9200102A (es) 1992-07-01
EP0495584A3 (en) 1992-11-04
NO920102L (no) 1992-07-20
AU642333B2 (en) 1993-10-14
NO920102D0 (no) 1992-01-08
CZ281684B6 (cs) 1996-12-11
NZ241249A (en) 1993-04-28
ES2141096T3 (es) 2000-03-16
CA2058822A1 (en) 1992-07-19
EP0495584A2 (en) 1992-07-22
US5362722A (en) 1994-11-08
NO301330B1 (no) 1997-10-13
IL100576A (en) 1995-11-27
CN1063286A (zh) 1992-08-05
AU1013492A (en) 1992-07-23
YU2292A (sh) 1994-11-15
FI920111A (fi) 1992-07-19
ATE187729T1 (de) 2000-01-15

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