KR920014810A - 항균제 - Google Patents
항균제 Download PDFInfo
- Publication number
- KR920014810A KR920014810A KR1019920000198A KR920000198A KR920014810A KR 920014810 A KR920014810 A KR 920014810A KR 1019920000198 A KR1019920000198 A KR 1019920000198A KR 920000198 A KR920000198 A KR 920000198A KR 920014810 A KR920014810 A KR 920014810A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- alkyl
- hydrogen
- amino
- nitrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (12)
- 하기 일반식(1)의 화합물 또는 그의 약학적으로 허용 가능한 염 :상기 식에서 R은 수소, C1-C6알킬, C2-C6알케닐, C2-C|6알키닐, C3-C6사이클로알킬 또는 C1-C6할로알킬이고, A 및 A'는 독립적으로 수소, C1-C6알킬, 니트로, 아미노, 질소 및 황중에서 선택된 1,2또는 3개의 헤테로원자를 함유하는 5 내지 6원의 유기 헤테로사이클, C1-C6알콕시 또는 페닐이거나, 또는 A 및 A'는 함께 일반식(여기에서, X는 수소, 할로, C1-C6알킬, C1-C6알콕시, C1-C6알콕시카보닐, 아미노, 니트로 또는 카복시이고, Y는 질소 또는 탄소이다)의 그룹을 형성한다.
- 제1항에 있어서, R이 C1-C6알킬 또는 C1-C6할로알킬인 화합물.
- 제2항에 있어서, R이 메틸 또는 플루오로 -C1-C6알킬인 화합물.
- 제3항에 있어서, R이 2-플루오로에트-1-일인 화합물.
- 제1항에 있어서, A 및 A'가 일반식의 그룹을 형성하는 화합물.
- 제5항에 있어서, Y가 질소인 화합물.
- 제6항에 있어서, A 및 A' 가 구조식의 그룹을 형성하는 화합물.
- 제7항에 있어서, R이 메틸 또는 2-플루오로에틸인 화합물.
- 하기 일반식(2)의 화합물 :상기 식에서, R0는 아미노 또는 보호된 아미노이고, R1은 수소 또는 카복시-보호 그룹이며 A 및 A'는 독립적으로 수소, C1-C6알킬, 페닐, 니트로, 아미노, 질소 및 황중에서 선택된 1,2또는 3개의 헤테로원자를 함유하는 5 내지 6원의 유기 헤테로사이클 또는 C1-C6알콕시이거나, 또는 A 및 A'는 함께 일반식(여기에서, X는 수소, C1-C6알킬, C1-C6알콕시, C1-C6알콕시카보닐, 아미노, 니트로, 또는 카복시이고, Y는 질소 또는 탄소이다)의 그룹을 형성한다.
- 제9항에 있어서, A 및 A'가 함께 일반식의 그룹을 형성하는 화합물.
- 제10항에 있어서, A 및 A'가 구조식의 그룹을 형성하는 화합물.
- 하나 이상의 약학적으로 허용가능한 담체, 부형제 또는 희석제와 함께 제1항 내지 제8항중 어느 한 항에 청구된 화합물을 포함하는 약학 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/643,244 US5077287A (en) | 1991-01-18 | 1991-01-18 | 3-thiazolylthio carbacephem antibacterial agents |
US07/643,244 | 1991-01-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR920014810A true KR920014810A (ko) | 1992-08-25 |
Family
ID=24579974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019920000198A KR920014810A (ko) | 1991-01-18 | 1992-01-09 | 항균제 |
Country Status (21)
Country | Link |
---|---|
US (1) | US5077287A (ko) |
EP (1) | EP0495585A1 (ko) |
JP (1) | JPH04321686A (ko) |
KR (1) | KR920014810A (ko) |
CN (1) | CN1063284A (ko) |
AU (1) | AU642334B2 (ko) |
BR (1) | BR9200058A (ko) |
CA (1) | CA2058592C (ko) |
CZ (1) | CZ281909B6 (ko) |
FI (1) | FI920110A (ko) |
HU (1) | HUT60268A (ko) |
IE (1) | IE920084A1 (ko) |
IL (1) | IL100575A (ko) |
MX (1) | MX9200105A (ko) |
MY (1) | MY131300A (ko) |
NO (1) | NO301328B1 (ko) |
NZ (1) | NZ241250A (ko) |
PT (1) | PT99984B (ko) |
RU (1) | RU2107067C1 (ko) |
YU (1) | YU2392A (ko) |
ZA (1) | ZA9225B (ko) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5272265A (en) * | 1990-02-12 | 1993-12-21 | Eli Lilly And Company | 3-(substituted or unsubstituted) thiazolo-1-carba (1-dethia)cephems |
US5179088A (en) * | 1990-02-12 | 1993-01-12 | Eli Lilly And Company | 1-carba(dethia)cephalosporin antibiotics |
IL100576A (en) * | 1991-01-18 | 1995-11-27 | Eli Lilley And Company | Cephalosporin antibiotics |
JP3238209B2 (ja) * | 1992-09-30 | 2001-12-10 | 塩野義製薬株式会社 | チオメチルチオカルバセファロスポリン誘導体 |
US5525599A (en) * | 1993-07-21 | 1996-06-11 | Eli Lilly And Company | 7-substituted-amino-3-substituted-3-cephem-4-carboxylic acids |
DE4333697A1 (de) * | 1993-10-02 | 1995-04-06 | Merck Patent Gmbh | Verfahren zur Herstellung von 3-Aminopyridinen aus 3-Nitropyridinen |
US5496816A (en) * | 1994-03-14 | 1996-03-05 | Merck & Co., Inc. | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment |
US5688786A (en) * | 1994-04-01 | 1997-11-18 | Microcide Pharmaceuticals, Inc. | β-lactam antibiotics |
US5698547A (en) * | 1994-04-01 | 1997-12-16 | Microcide Pharmaceuticals, Inc. | Cephalosporin antibiotics |
US5789584A (en) * | 1994-04-01 | 1998-08-04 | Microcide Pharmaceuticals, Inc. | Substituted-pyridinyl cephalosporin antibiotics active against methicillin resistant bacteria |
US5498777A (en) * | 1994-07-20 | 1996-03-12 | Merck & Co., Inc. | 3-thioheteroaryl cephalosporin compounds, compositions and methods of use |
US5565445A (en) * | 1995-02-22 | 1996-10-15 | Merck & Co., Inc. | 3-thioheteroaryl 1-carba-1-dethiacephalosporin compounds, compositions and methods of use |
WO1996038450A1 (en) * | 1995-05-31 | 1996-12-05 | Microcide Pharmaceuticals, Inc. | Cephalosporin antibiotics |
MY127641A (en) * | 1995-10-12 | 2006-12-29 | Essential Therapeutics Inc | Cephalosporin antibiotics |
WO1998046566A1 (en) * | 1997-04-17 | 1998-10-22 | Microcide Pharmaceuticals, Inc. | IMPROVED β-LACTAM ANTIBIOTICS |
US6025352A (en) * | 1997-09-29 | 2000-02-15 | Microcide Pharmaceuticals, Inc. | Cephalosporin antibiotics |
US6030965A (en) * | 1997-09-30 | 2000-02-29 | Microcide Pharmaceuticals, Inc. | Cephalosporin antibiotics |
US6362009B1 (en) | 1997-11-21 | 2002-03-26 | Merck & Co., Inc. | Solid phase synthesis of heterocycles |
US20080146535A1 (en) * | 2003-04-30 | 2008-06-19 | Tomasz Glinka | Compositions comprising carbacephem beta-lactam antibiotics and beta-lactamase inhibitors |
DE602004024297D1 (de) * | 2003-04-30 | 2010-01-07 | Trine Pharmaceuticals Inc | Carbacephem beta-lactam-antibiotika |
CN101835777A (zh) * | 2007-10-25 | 2010-09-15 | 尔察祯有限公司 | 碳头孢烯β-内酰胺抗生素 |
WO2010030810A1 (en) * | 2008-09-10 | 2010-03-18 | Achaogen, Inc. | Carbacephem beta-lactam antibiotics |
WO2010123997A1 (en) * | 2009-04-22 | 2010-10-28 | Achaogen, Inc. | Carbacephem beta-lactam antibiotics |
US9433621B2 (en) | 2010-02-18 | 2016-09-06 | Merck Sharp & Dohme Corp. | Substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA766941B (en) * | 1975-11-21 | 1978-06-28 | Merck & Co Inc | 3-(substituted thio)cephalosporins,derivatives and nuclear analogues thereof |
JPS6058920B2 (ja) * | 1978-12-26 | 1985-12-23 | 協和醗酵工業株式会社 | セフアロスポリン類縁体 |
JPS60174787A (ja) * | 1984-02-21 | 1985-09-09 | Kyowa Hakko Kogyo Co Ltd | 3位置換カルバセフエム化合物 |
JPH0653739B2 (ja) * | 1984-11-15 | 1994-07-20 | 協和醗酵工業株式会社 | 3位置換カルバセフエム化合物 |
US4885291A (en) * | 1988-01-14 | 1989-12-05 | Eli Lilly And Company | 1-carba(dethia)-3-cephem derivatives |
IL100576A (en) * | 1991-01-18 | 1995-11-27 | Eli Lilley And Company | Cephalosporin antibiotics |
-
1991
- 1991-01-18 US US07/643,244 patent/US5077287A/en not_active Expired - Lifetime
-
1992
- 1992-01-01 IL IL10057592A patent/IL100575A/en not_active IP Right Cessation
- 1992-01-02 ZA ZA9225A patent/ZA9225B/xx unknown
- 1992-01-03 CZ CS9211A patent/CZ281909B6/cs unknown
- 1992-01-06 CA CA002058592A patent/CA2058592C/en not_active Expired - Fee Related
- 1992-01-07 PT PT99984A patent/PT99984B/pt not_active IP Right Cessation
- 1992-01-08 NO NO920103A patent/NO301328B1/no not_active IP Right Cessation
- 1992-01-08 MY MYPI92000033A patent/MY131300A/en unknown
- 1992-01-08 NZ NZ241250A patent/NZ241250A/xx unknown
- 1992-01-09 JP JP4002224A patent/JPH04321686A/ja active Pending
- 1992-01-09 KR KR1019920000198A patent/KR920014810A/ko not_active Application Discontinuation
- 1992-01-09 EP EP92300182A patent/EP0495585A1/en not_active Ceased
- 1992-01-09 AU AU10135/92A patent/AU642334B2/en not_active Ceased
- 1992-01-09 HU HU9200081A patent/HUT60268A/hu unknown
- 1992-01-10 IE IE008492A patent/IE920084A1/en unknown
- 1992-01-10 CN CN92100136A patent/CN1063284A/zh active Pending
- 1992-01-10 YU YU2392A patent/YU2392A/sh unknown
- 1992-01-10 FI FI920110A patent/FI920110A/fi not_active Application Discontinuation
- 1992-01-10 BR BR929200058A patent/BR9200058A/pt not_active Application Discontinuation
- 1992-01-10 MX MX9200105A patent/MX9200105A/es unknown
-
1993
- 1993-01-22 RU RU93004457A patent/RU2107067C1/ru active
Also Published As
Publication number | Publication date |
---|---|
YU2392A (sh) | 1994-12-28 |
BR9200058A (pt) | 1992-09-08 |
PT99984B (pt) | 1999-06-30 |
NO920103L (no) | 1992-07-20 |
EP0495585A1 (en) | 1992-07-22 |
CS1192A3 (en) | 1992-08-12 |
HU9200081D0 (en) | 1992-03-30 |
CZ281909B6 (cs) | 1997-03-12 |
IL100575A (en) | 1996-11-14 |
CA2058592C (en) | 2001-12-25 |
FI920110A (fi) | 1992-07-19 |
PT99984A (pt) | 1993-01-29 |
IE920084A1 (en) | 1992-07-29 |
CN1063284A (zh) | 1992-08-05 |
FI920110A0 (fi) | 1992-01-10 |
US5077287A (en) | 1991-12-31 |
NZ241250A (en) | 1993-02-25 |
AU642334B2 (en) | 1993-10-14 |
NO920103D0 (no) | 1992-01-08 |
MX9200105A (es) | 1992-07-01 |
MY131300A (en) | 2007-08-30 |
CA2058592A1 (en) | 1992-07-19 |
RU2107067C1 (ru) | 1998-03-20 |
JPH04321686A (ja) | 1992-11-11 |
NO301328B1 (no) | 1997-10-13 |
IL100575A0 (en) | 1992-09-06 |
HUT60268A (en) | 1992-08-28 |
AU1013592A (en) | 1992-07-23 |
ZA9225B (en) | 1993-07-02 |
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A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E601 | Decision to refuse application |