KR880012554A - 디하이드로 피리딘 - Google Patents

디하이드로 피리딘 Download PDF

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Publication number
KR880012554A
KR880012554A KR1019880004453A KR880004453A KR880012554A KR 880012554 A KR880012554 A KR 880012554A KR 1019880004453 A KR1019880004453 A KR 1019880004453A KR 880004453 A KR880004453 A KR 880004453A KR 880012554 A KR880012554 A KR 880012554A
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KR
South Korea
Prior art keywords
compound
alkyl
halo
aryl
phenyl
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KR1019880004453A
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English (en)
Inventor
알커 데이비드
에드워드 크로스 피터
Original Assignee
알렌제이. 스피겔
화이자 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 알렌제이. 스피겔, 화이자 인코포레이티드 filed Critical 알렌제이. 스피겔
Publication of KR880012554A publication Critical patent/KR880012554A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

내용 없음

Description

디하이드로 피리딘
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 일반식(Ⅰ)의 화합물 또는 이의 약제학적으로 허용되는 산부가염.
    상기식에서, R은 임의로 치환된 아릴 또는 헤테로아릴 그룹이고 :R1및 R2는 각각 독립적으로 C1-C2알킬 또는 2-메톡시 에틸이고 :X는 O 또는 S:Y는 -CH=CH- 또는 -C C-:및 Z는 -CHR5OH(이때, R5는 H, C1-C4알킬 또는 아릴이다 ), -CHNH2, -CO2R6(이때, R6은 H 또는 C1-C4알킬이다),(이때, R3및 R4는 각각 독립적으로 H 또는 C1-C4알킬이다), 또는 R3및 R4는 이들과 결합된 질소원자와 함께 N, 0 또는 S중 신택된 하나 이상의 추가 헤테로원자를 임의로 함유하는 5 또는 6원환을 이루고, 단 Y가 -C C-인 경우 Z는 CO2(C1-C4)알킬이 아니다.
  2. 제1항에 있어서, R이 아릴이고 아릴은 페닐이거나 니트로, 할로, C1-C4알킬, C1-C4알콕시, 하이드록시 트리플루오로메틸 및 시나오 중 각각 독립적으로 선택된 하나 또는 두개의 치환체로 치환된 페닐이거나, 또는 1-또는 2-나프틸이거나: 또는 R이 헤테로아릴이고 헤테로아릴은 벤조푸라닐, 벤조티에닐:메틸, 메틸티오 시아노 또는 할로에 의해 임의로 치환된 피리딜이거나, 퀴놀일, 벤즈옥사졸일, 벤조티아졸일, 푸릴, 피리미디닐, 티아졸일, 2,1,3-벤조옥사디아졸-4-일, 2,1,3-벤조티아디아졸-4-일, 또는 할로 또는 C1-C4알킬로 임의로 모노치환된 티에닐인 일반식(Ⅰ)의 화합물.
  3. 제2항에 있어서, R이 할로 및 CF1중 선택된 1 또는 2개의 치환체로 치환된 페닐이거나, 2-클로로-3-디클로로페닐인 화합물.
  4. 제3항에 있어서, R이 2-클로로페닐 또는 2,3-디클로로페닐인 화합물.
  5. 제1 내지 4항중 어느 한 항에 있어서, R1및 R3가 각각 메틸 또는 에틸인 화합물.
  6. 제1 내지 5중항 어느 한 항에 있어서, Z가 -CHR5OH인 경우, R5가 페닐, n-부틸 또는 수소인 화합물.
  7. 제1 내지 제5항중 어느 한 항에 있어서, Z가 -CO2R6인 경우, R6가 수소인 화합물.
  8. 제1 내지 5항중 어느 한 항에 있어서, Z가인 경우, R3및 R4가 둘다 메틸이거나 이들이 결합된 질소원자와 함께 피롤리디닐 피페리디노, 모르폴리노, 피레라지닐 또는 N(C1-C4알킬)피페라지닐 그룹을 형성하는 화합물.
  9. 제1항에서 청구된 일반식(Ⅰ)의 화합물(단서 조항이 붙지 않음) 또는 이의 약제학적으로 허용되는 산부가염을 약제학적으로 허용되는 희석제 또는 담체와 함께 포함하는 약제학적 조성물.
  10. 제1항에 있어서, 의약적 용도의 화합물(단서 조항이 붙지 않음).
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880004453A 1987-04-21 1988-04-20 디하이드로 피리딘 KR880012554A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878709447A GB8709447D0 (en) 1987-04-21 1987-04-21 Dihydropyridines
GB8709447 1987-04-21

Publications (1)

Publication Number Publication Date
KR880012554A true KR880012554A (ko) 1988-11-28

Family

ID=10616115

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880004453A KR880012554A (ko) 1987-04-21 1988-04-20 디하이드로 피리딘

Country Status (19)

Country Link
US (1) US4957930A (ko)
EP (1) EP0295769A3 (ko)
JP (1) JPS63280062A (ko)
KR (1) KR880012554A (ko)
CN (1) CN88102381A (ko)
AU (1) AU592498B2 (ko)
CS (1) CS270242B2 (ko)
DD (1) DD273437A5 (ko)
DK (1) DK213988A (ko)
FI (1) FI881824A (ko)
GB (1) GB8709447D0 (ko)
HU (1) HUT46894A (ko)
IL (1) IL86108A0 (ko)
NO (1) NO881709L (ko)
NZ (1) NZ224298A (ko)
PL (1) PL271920A1 (ko)
PT (1) PT87272A (ko)
YU (1) YU78388A (ko)
ZA (1) ZA882765B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2014089C (en) * 1989-07-21 1997-01-14 Vernon L. Lamb Apparatus and method for making pressboard from poly-coated paper using relative movement of facing webs
CN103274993A (zh) * 2013-06-13 2013-09-04 南京工业大学 二氢吡啶和吡咯类杂环的新合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
JPS60120861A (ja) * 1983-12-02 1985-06-28 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体
GB8412208D0 (en) * 1984-05-12 1984-06-20 Pfizer Ltd Quinolone inotropic agents
EP0200524A3 (en) * 1985-05-03 1987-06-16 Pfizer Limited Dihydropyridine calcium antagonists

Also Published As

Publication number Publication date
NO881709D0 (no) 1988-04-20
HUT46894A (en) 1988-12-28
DK213988A (da) 1988-10-22
CS270242B2 (en) 1990-06-13
IL86108A0 (en) 1988-11-15
AU592498B2 (en) 1990-01-11
JPS63280062A (ja) 1988-11-17
GB8709447D0 (en) 1987-05-28
FI881824A (fi) 1988-10-22
FI881824A0 (fi) 1988-04-19
CN88102381A (zh) 1988-11-09
DD273437A5 (de) 1989-11-15
PL271920A1 (en) 1989-03-20
US4957930A (en) 1990-09-18
CS273488A2 (en) 1989-10-13
PT87272A (pt) 1989-05-12
AU1478788A (en) 1988-10-27
DK213988D0 (da) 1988-04-20
ZA882765B (en) 1989-12-27
NO881709L (no) 1988-10-24
EP0295769A2 (en) 1988-12-21
NZ224298A (en) 1990-03-27
YU78388A (en) 1990-04-30
EP0295769A3 (en) 1989-02-08

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