KR860000286A - 디히드로피리딘 유도체의 제조방법 - Google Patents

디히드로피리딘 유도체의 제조방법 Download PDF

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KR860000286A
KR860000286A KR1019850003934A KR850003934A KR860000286A KR 860000286 A KR860000286 A KR 860000286A KR 1019850003934 A KR1019850003934 A KR 1019850003934A KR 850003934 A KR850003934 A KR 850003934A KR 860000286 A KR860000286 A KR 860000286A
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compound
formula
alkyl
aryl
independently
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KR1019850003934A
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이. 애로우스미스 제이. (외 3)
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윌리엄 존 윌슨
화이자 코포레이션
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Publication of KR860000286A publication Critical patent/KR860000286A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

내용 없음

Description

디히드로피리딘 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. Q가 N인 일반식(Ⅰ)의 화합물을 수득하기 위하여, 일반식(Ⅱ)의 화합물을 일반식(Ⅲ)과 반응시키거나; Q가 N이며 R3및 R4가 모두 수소인 일반식(Ⅰ)의 화합물을 수득하기 위하여, 일반식(Ⅳ)의 화합물을 일반식(V)의 2-아미노-벤조니트릴과 반응시키거나; Q가 CH이며 R3및 R4가 모두 수소인 일반식(I)의 화합물을 수득하기 위하여, 일반식(I)의 화합물을 폐환시키고, 각각의 경우에, 임의로 약제학적으로 허용가능한 생성물의 염을 형성시킴을 특징으로 하여, 일반식(Ⅰ)의 1,4-디히드로피리딘 및 약제학적으로 허용가능한 그의 염을 제조하는 방법.
    (Ⅰ)
    (Ⅱ)
    (Ⅲ)
    (Ⅳ)
    (Ⅴ)
    (Ⅵ)
    상기식에서, R은 아릴 또는 헤테로 아릴이며, R1및 R2는 각각 독립적으로, C1내지 C4알킬, 2-히드록시에틸 또는 2-메톡시에틸이고, R3및 R4는 서로 독립적으로 H 또는 C1내지 C4알킬이거나, 이들이 결합하고 있는 질소원자와 함께 피롤리딘일, 피페리딜모르폴리노, 피페라진일 또는 N-(C1내지C4알킬) 피페라진일기이며; R5는 OH또는 C1내지C4알콕시에 의해 임의로 치환될 수 있는 C1내지C4알킬이고, Y는 측쇄일 수 있는 C2내지C6알킬렌 브리지이거나, R5는 Y에 있는 탄소원자에 연결된 C1내지C4알킬렌 브리지로서 이들이 결합하고 있는 질소원자와 함께 피페리딘환을 형성하며; Q는 CH또는 N이고, X는 각각 서로 독립적으로 C1내지 C4알킬, C1내지C4알콕시, 할로겐 또는 CF3이며, m은 0또는 1내지 3의 정수이고, Hal은 할로겐원자, 바람직하게는 클로로이다.
  2. 제1항에 있어서, R이 “아릴”이며, “아릴”은 페닐, 또는 니트로, 할로, C1내지 C4알킬, C1내지 C4알콕시, OH, CF3, OCHF|3, OCF3및 CN으로부터 각각 독립적으로 선택된 하나 또는 두개의 치환체에 의해 치환된 페닐이거나, 1-또는 2-나프틸이며; 또는 R이 “헤테로아릴”이며, “헤테로아릴”은 벤조푸라닐; 벤조티에닐; 메틸, 메틸티오. 시아노 또는 할로에 의해 임의로 치환된; 피리딜; 퀴놀릴; 벤즈옥사졸일; 피리미디닐티아졸일; 2,1,3-벤즈옥사디아졸-4-일; 2,1,3- 벤조티아디아졸-4-일; 또는 할로 또는 C1내지 C4알킬에 의해 임의로 일치환된 푸릴 또는 티에닐인 방법.
  3. 제2항에 있어서, R이 2-클로로페닐, 2-플루오로페닐, 2,3-디클로로페닐, 2-클로로-3-트리플루오로메틸페닐, 2,3-디플루오로페닐, 2-플루오로-3클로로페닐,2-브로모페닐, 또는 2-프리플루오로메틸페닐인 방법.
  4. 제1내지 3항중 어느 한 항에 있어서, R1이 CH3이며 R2가 C2H|5인 방법
  5. 제1내지 4항중 어느 한 항에 있어서, R3및 R4가 모두 H인 방법.
  6. 제1내지 5항중 어느 한 항에 있어서, R5가 CH3인 방법
  7. 제1내지 6항중 어느 한 항에 있어서,Y가 -(CH2)2-인 방법
  8. 제1내지 7항중 어느 한 항에 있어서, (X)m이 6,7-디메톡시인 방법
    ※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.
KR1019850003934A 1984-06-07 1985-06-05 디히드로피리딘 유도체의 제조방법 KR860000286A (ko)

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Application Number Priority Date Filing Date Title
GB8414518 1984-06-07
GB848414518A GB8414518D0 (en) 1984-06-07 1984-06-07 Therapeutic agents

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KR860000286A true KR860000286A (ko) 1986-01-27

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US (1) US4647565A (ko)
EP (1) EP0168151A1 (ko)
JP (1) JPS6133185A (ko)
KR (1) KR860000286A (ko)
AU (1) AU554571B2 (ko)
DK (1) DK253585A (ko)
ES (1) ES8704480A1 (ko)
FI (1) FI852221L (ko)
GB (1) GB8414518D0 (ko)
GR (1) GR851380B (ko)
HU (1) HUT37933A (ko)
IL (1) IL75427A0 (ko)
PL (1) PL253820A1 (ko)
PT (1) PT80596B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4568677A (en) * 1983-07-23 1986-02-04 Pfizer Inc. 2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and antihypertensive agents
GR851819B (ko) * 1984-08-17 1985-11-26 Wyeth John & Brother Ltd
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
US6976162B1 (en) * 2000-06-28 2005-12-13 Intel Corporation Platform and method for establishing provable identities while maintaining privacy
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
EP1889198B1 (en) 2005-04-28 2014-11-26 Proteus Digital Health, Inc. Pharma-informatics system
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
DK3395372T3 (da) 2009-02-20 2022-04-19 Enhanx Biopharm Inc System til afgivelse af glutathion-baseret medikament
EP2427178B1 (en) 2009-05-06 2023-01-04 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

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DK140695C (da) * 1976-05-07 1980-05-12 Synthelabo Analogifremgangsmaade til fremstilling af 2,4-diamino-6,7-dimethoxyquinazolinderivater eller syreadditionssalte heraf
DK159079A (da) * 1978-05-18 1979-11-19 Pfizer Fremgangsmaade til fremstilling af derivater af 4-amino-2-piperidinoquinazolin eller syreadditionssalte deraf
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
DE3363743D1 (en) * 1982-07-22 1986-07-03 Pfizer Ltd Dihydropyridine anti-ischaemic and antihypertensive agents

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PT80596A (en) 1985-07-01
AU4334785A (en) 1985-12-12
DK253585A (da) 1985-12-08
IL75427A0 (en) 1985-10-31
HUT37933A (en) 1986-03-28
ES8704480A1 (es) 1987-04-01
GR851380B (ko) 1985-11-25
FI852221A0 (fi) 1985-06-03
ES543997A0 (es) 1987-04-01
AU554571B2 (en) 1986-08-28
DK253585D0 (da) 1985-06-06
PL253820A1 (en) 1986-07-01
US4647565A (en) 1987-03-03
PT80596B (en) 1987-04-21
GB8414518D0 (en) 1984-07-11
EP0168151A1 (en) 1986-01-15
FI852221L (fi) 1985-12-08
JPS6133185A (ja) 1986-02-17

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