ES8704480A1 - Un procedimiento para la preparacion de derivados de 1,4-dihidropiridina. - Google Patents

Un procedimiento para la preparacion de derivados de 1,4-dihidropiridina.

Info

Publication number
ES8704480A1
ES8704480A1 ES543997A ES543997A ES8704480A1 ES 8704480 A1 ES8704480 A1 ES 8704480A1 ES 543997 A ES543997 A ES 543997A ES 543997 A ES543997 A ES 543997A ES 8704480 A1 ES8704480 A1 ES 8704480A1
Authority
ES
Spain
Prior art keywords
alkyl
independently
cardiovascular agents
alkoxy
attached
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543997A
Other languages
English (en)
Other versions
ES543997A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp
Original Assignee
Pfizer Corp Belgium
Pfizer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp filed Critical Pfizer Corp Belgium
Publication of ES8704480A1 publication Critical patent/ES8704480A1/es
Publication of ES543997A0 publication Critical patent/ES543997A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCEDIMIENTO PARA PRODUCIR DERIVADOS DE 1,4-DIHIDROPIRIDINA. CONSISTE EN HACER REACCIONAR A UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) EN UN DISOLVENTE ORGANICO COMO N-BUTANOL Y ALCOHOL ISOAMILICO, EN PRESENCIA DE UNA BASE COMO 4-DIMETILAMINOPIRIDINA, ENTRE 100 Y 150JC, DURANTE 2 A 24 HORAS, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y UNA SAL FARMACEUTICAMENTE ACEPTABLE. SIENDO: R, ARILO O HETEROARILO; R1 Y R2, ALQUILO DE C 1 A 4, 2-HIDROXIETILO Y OTROS; R3 Y R4, H, ALQUILO DE C 1 A 4 Y OTROS; R5, ALQUILO DE C 1 A 4 SUSTITUIDO CON OH; X, ALQUILO DE C 1 A 4, ALCOXI DE C 1 A 4 Y OTROS; Y, UN PUENTE DE ALQUILENO DE C 2 A 6; Q, N; HAL, HALOGENO Y M, 1 A 3. SE UTILIZA PARA TRATAR LA HIPERTENSION, LA INSUFICIENCIA CARDIACA Y LA ANGINA DE PECHO.
ES543997A 1984-06-07 1985-06-07 Un procedimiento para la preparacion de derivados de 1,4-dihidropiridina. Expired ES8704480A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848414518A GB8414518D0 (en) 1984-06-07 1984-06-07 Therapeutic agents

Publications (2)

Publication Number Publication Date
ES8704480A1 true ES8704480A1 (es) 1987-04-01
ES543997A0 ES543997A0 (es) 1987-04-01

Family

ID=10562060

Family Applications (1)

Application Number Title Priority Date Filing Date
ES543997A Expired ES8704480A1 (es) 1984-06-07 1985-06-07 Un procedimiento para la preparacion de derivados de 1,4-dihidropiridina.

Country Status (14)

Country Link
US (1) US4647565A (es)
EP (1) EP0168151A1 (es)
JP (1) JPS6133185A (es)
KR (1) KR860000286A (es)
AU (1) AU554571B2 (es)
DK (1) DK253585A (es)
ES (1) ES8704480A1 (es)
FI (1) FI852221L (es)
GB (1) GB8414518D0 (es)
GR (1) GR851380B (es)
HU (1) HUT37933A (es)
IL (1) IL75427A0 (es)
PL (1) PL253820A1 (es)
PT (1) PT80596B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4568677A (en) * 1983-07-23 1986-02-04 Pfizer Inc. 2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and antihypertensive agents
GR851819B (es) * 1984-08-17 1985-11-26 Wyeth John & Brother Ltd
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
US6976162B1 (en) * 2000-06-28 2005-12-13 Intel Corporation Platform and method for establishing provable identities while maintaining privacy
ATE445838T1 (de) 2001-07-25 2009-10-15 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
CA2663377A1 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
HUE059078T2 (hu) 2009-02-20 2022-10-28 Enhanx Biopharm Inc Glutation-alapú hatóanyagszállító rendszer
JP2012526144A (ja) 2009-05-06 2012-10-25 ラボラトリー スキン ケア インコーポレイテッド 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK140695C (da) * 1976-05-07 1980-05-12 Synthelabo Analogifremgangsmaade til fremstilling af 2,4-diamino-6,7-dimethoxyquinazolinderivater eller syreadditionssalte heraf
DK159079A (da) * 1978-05-18 1979-11-19 Pfizer Fremgangsmaade til fremstilling af derivater af 4-amino-2-piperidinoquinazolin eller syreadditionssalte deraf
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
ATE20064T1 (de) * 1982-07-22 1986-06-15 Pfizer Anti-ischaemische und antihypertensive dihydropyridin-derivate.

Also Published As

Publication number Publication date
HUT37933A (en) 1986-03-28
GR851380B (es) 1985-11-25
KR860000286A (ko) 1986-01-27
DK253585D0 (da) 1985-06-06
DK253585A (da) 1985-12-08
FI852221L (fi) 1985-12-08
IL75427A0 (en) 1985-10-31
JPS6133185A (ja) 1986-02-17
PT80596A (en) 1985-07-01
ES543997A0 (es) 1987-04-01
FI852221A0 (fi) 1985-06-03
GB8414518D0 (en) 1984-07-11
PL253820A1 (en) 1986-07-01
PT80596B (en) 1987-04-21
US4647565A (en) 1987-03-03
AU4334785A (en) 1985-12-12
AU554571B2 (en) 1986-08-28
EP0168151A1 (en) 1986-01-15

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