ATE14439T1 - Veraenderte d-retro cyclische hexapeptide, analoge von somatostatin, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen. - Google Patents

Veraenderte d-retro cyclische hexapeptide, analoge von somatostatin, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Info

Publication number
ATE14439T1
ATE14439T1 AT82102924T AT82102924T ATE14439T1 AT E14439 T1 ATE14439 T1 AT E14439T1 AT 82102924 T AT82102924 T AT 82102924T AT 82102924 T AT82102924 T AT 82102924T AT E14439 T1 ATE14439 T1 AT E14439T1
Authority
AT
Austria
Prior art keywords
loweralkyl
benzyl
loweralkoxy
substituent
halogen
Prior art date
Application number
AT82102924T
Other languages
English (en)
Inventor
Roger M Freidinger
Daniel F Veber
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE14439T1 publication Critical patent/ATE14439T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides
AT82102924T 1981-04-13 1982-04-06 Veraenderte d-retro cyclische hexapeptide, analoge von somatostatin, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen. ATE14439T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/254,010 US4360516A (en) 1981-04-13 1981-04-13 Modified D-retro cyclic hexapeptide somatostatin analogs
EP82102924A EP0063308B1 (de) 1981-04-13 1982-04-06 Veränderte D-retro cyclische Hexapeptide, Analoge von Somatostatin, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

Publications (1)

Publication Number Publication Date
ATE14439T1 true ATE14439T1 (de) 1985-08-15

Family

ID=22962578

Family Applications (1)

Application Number Title Priority Date Filing Date
AT82102924T ATE14439T1 (de) 1981-04-13 1982-04-06 Veraenderte d-retro cyclische hexapeptide, analoge von somatostatin, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Country Status (9)

Country Link
US (1) US4360516A (de)
EP (1) EP0063308B1 (de)
JP (1) JPS57179142A (de)
AT (1) ATE14439T1 (de)
DE (1) DE3264861D1 (de)
DK (1) DK159382A (de)
ES (1) ES511335A0 (de)
GR (1) GR75544B (de)
PT (1) PT74720B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4427661A (en) * 1982-07-30 1984-01-24 Merck & Co., Inc. Fluorinated cyclic hexapeptide somatostatin analogs
CH655505B (de) * 1982-08-24 1986-04-30
DE3303345A1 (de) * 1983-02-02 1984-08-02 Hoechst Ag, 6230 Frankfurt Cyclische peptide mit somatostatin-wirkung
US4508711A (en) * 1983-04-18 1985-04-02 American Cyanamid Company Cyclic pentapeptide displaying somatostatin antagonism and method of treatment of mammals therewith
US4522813A (en) * 1983-10-27 1985-06-11 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4612302A (en) * 1983-11-14 1986-09-16 Brigham And Women's Hospital Clinical use of somatostatin analogues
US4612366A (en) * 1985-06-17 1986-09-16 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
WO1992013958A1 (en) * 1991-02-06 1992-08-20 Georgetown University Receptor blocking peptides of fibroblast growth factor receptor
WO1992013554A1 (en) * 1991-02-08 1992-08-20 Biomeasure, Inc. Method of treating benign and malignant proliferative skin disease
US5811512A (en) * 1991-08-22 1998-09-22 The Trustees Of The University Of Pennsylvania Non-peptide peptidomimetics and related cyclic hexapeptides
US5504069A (en) * 1993-02-11 1996-04-02 Biomeasure, Inc. Inhibition of trauma-induced tumor growth
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
US5770687A (en) * 1995-06-07 1998-06-23 Peptor Limited Comformationally constrained backbone cyclized somatostatin analogs
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
EP0981364B1 (de) * 1997-05-13 2006-03-01 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Methoden und zusammensetzungen zur behandlung der hyperlipidämie
ATE245998T1 (de) * 1997-05-13 2003-08-15 Sod Conseils Rech Applic Somatostatin agoniste zur reduzierung von körpergewicht
EP0980253B1 (de) * 1997-05-13 2004-03-31 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Somatostatin und somatostatin agoniste zur behandlung der insulinsunempfindlichkeit und syndrome x
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
DE60231403D1 (de) 2001-06-08 2009-04-16 Sod Conseils Rech Applic Chimere somatostatin-dopamin-analoga
SG173223A1 (en) 2003-04-22 2011-08-29 Ipsen Pharma Sas Peptide vectors
AU2009259034B2 (en) 2008-06-12 2013-10-31 Ipsen Bioinnovation Limited Suppression of cancers
EP2310028B1 (de) 2008-06-12 2016-11-16 Ipsen Bioinnovation Limited Fusionsproteine zur Verwendung bei der Behandlung von Akromegalie
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
WO2014197938A1 (en) 2013-06-13 2014-12-18 Antisense Therapeutics Ltd Combination therapy

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1101843A (en) * 1976-08-02 1981-05-26 Daniel F. Veber Cyclic hexapeptides useful for increasing feed efficiency
US4162248A (en) * 1976-10-14 1979-07-24 Merck & Co., Inc. Somatostatin analogs
LU78191A1 (de) * 1977-09-28 1979-05-25 Ciba Geigy Ag Verfahren zur herstellung von neuen cyclopeptiden
US4190648A (en) * 1979-03-13 1980-02-26 Merck & Co., Inc. Peptides having somatostatin activity
NZ195303A (en) * 1979-10-31 1984-10-19 Merck & Co Inc Cyclic hexapeptide somatostatin analogues,and pharmaceutical compositions
US4235886A (en) * 1979-10-31 1980-11-25 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs

Also Published As

Publication number Publication date
JPS57179142A (en) 1982-11-04
ES8304068A1 (es) 1983-02-16
US4360516A (en) 1982-11-23
EP0063308B1 (de) 1985-07-24
PT74720B (en) 1985-01-08
DE3264861D1 (en) 1985-08-29
JPH0360839B2 (de) 1991-09-17
EP0063308A1 (de) 1982-10-27
PT74720A (en) 1982-05-01
GR75544B (de) 1984-07-27
DK159382A (da) 1982-10-14
ES511335A0 (es) 1983-02-16

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UEP Publication of translation of european patent specification
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