FI880716A0 - Menetelmä terapeuttisesti käyttökelpoisten aryylipiperatsinyylialkyleenifenyylisubstituoitujen heterosyklisten yhdisteiden valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten aryylipiperatsinyylialkyleenifenyylisubstituoitujen heterosyklisten yhdisteiden valmistamiseksi

Info

Publication number
FI880716A0
FI880716A0 FI880716A FI880716A FI880716A0 FI 880716 A0 FI880716 A0 FI 880716A0 FI 880716 A FI880716 A FI 880716A FI 880716 A FI880716 A FI 880716A FI 880716 A0 FI880716 A0 FI 880716A0
Authority
FI
Finland
Prior art keywords
arylpiperazinylalkylene
preparation
phenyl substituted
substituted heterocyclic
heterocyclic compounds
Prior art date
Application number
FI880716A
Other languages
English (en)
Swedish (sv)
Other versions
FI91752C (fi
FI880716A (fi
FI91752B (fi
Inventor
Iii John Adams Lowe
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI880716A0 publication Critical patent/FI880716A0/fi
Publication of FI880716A publication Critical patent/FI880716A/fi
Application granted granted Critical
Publication of FI91752B publication Critical patent/FI91752B/fi
Publication of FI91752C publication Critical patent/FI91752C/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28Radicals substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/40Unsubstituted amino or imino radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01Five-membered rings
    • C07D285/02Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/061,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
FI880716A 1987-02-17 1988-02-16 Menetelmä terapeuttisesti käyttökelpoisten aryylipiperatsinyylialkyleenifenyylisubstituoitujen heterosyklisten yhdisteiden valmistamiseksi FI91752C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8700340 1987-02-17
US8700340 1987-02-17

Publications (4)

Publication Number Publication Date
FI880716A0 true FI880716A0 (fi) 1988-02-16
FI880716A FI880716A (fi) 1988-08-18
FI91752B FI91752B (fi) 1994-04-29
FI91752C FI91752C (fi) 1994-08-10

Family

ID=22202287

Family Applications (1)

Application Number Title Priority Date Filing Date
FI880716A FI91752C (fi) 1987-02-17 1988-02-16 Menetelmä terapeuttisesti käyttökelpoisten aryylipiperatsinyylialkyleenifenyylisubstituoitujen heterosyklisten yhdisteiden valmistamiseksi

Country Status (30)

Country Link
EP (1) EP0279598B1 (fi)
JP (1) JPH0699405B2 (fi)
KR (1) KR900004126B1 (fi)
CN (1) CN1015627B (fi)
AP (1) AP88A (fi)
AR (1) AR245125A1 (fi)
AT (1) ATE94537T1 (fi)
AU (1) AU583761B2 (fi)
CA (1) CA1312080C (fi)
CS (1) CS272783B2 (fi)
DD (1) DD272080A5 (fi)
DE (1) DE3884007T2 (fi)
DK (1) DK170878B1 (fi)
EG (1) EG18635A (fi)
ES (1) ES2058249T3 (fi)
FI (1) FI91752C (fi)
HU (1) HU207731B (fi)
IE (1) IE61258B1 (fi)
IL (1) IL85368A0 (fi)
IN (1) IN171858B (fi)
MA (1) MA21183A1 (fi)
MX (1) MX174210B (fi)
MY (1) MY103210A (fi)
NO (1) NO170582C (fi)
NZ (1) NZ223530A (fi)
PL (1) PL157118B1 (fi)
PT (1) PT86766B (fi)
SU (1) SU1634136A3 (fi)
YU (1) YU46624B (fi)
ZA (1) ZA881064B (fi)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
SE8803429D0 (sv) * 1988-09-28 1988-09-28 Pharmacia Ab Novel pyridyl- and pyrimidyl derivatives
FR2655988B1 (fr) * 1989-12-20 1994-05-20 Adir Cie Nouveaux derives de la napht-1-yl piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5166156A (en) * 1989-12-20 1992-11-24 Adir Et Compagnie Naphthyl piperazines useful as 5-HT1A receptor ligands
US5162324A (en) * 1989-12-20 1992-11-10 Adir Et Compagnie Naphyl piperazines useful as 5-HT1A receptor ligands
US5162321A (en) * 1989-12-20 1992-11-10 Adir Et Compagnie 1-naphthyl piperazines useful as 5-HT1A receptor ligands
US5166157A (en) * 1989-12-20 1992-11-24 Adir Et Compagnie Naphthyl piperazines useful as 5-HT1A receptor ligands
DE69611783T2 (de) * 1995-06-06 2001-09-20 Aventis Pharma Inc Benzisoxazol- und indazol- derivate als antipsychotika
GB9517381D0 (en) * 1995-08-24 1995-10-25 Pharmacia Spa Aryl and heteroaryl piperazine derivatives
US6288091B1 (en) 1995-12-29 2001-09-11 Boehringer Ingelheim Ltd. Antiherpes virus compounds and methods for their preparation and use
WO1997024343A1 (en) * 1995-12-29 1997-07-10 Boehringer Ingelheim Pharmaceuticals, Inc. Phenyl thiazole derivatives with anti herpes virus properties
WO1999001420A1 (fr) * 1997-07-03 1999-01-14 Taito Co., Ltd. Procede de preparation de derives d'acide 2-aminomalonique, et intermediaires utilises dans ce procede
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2927924A (en) * 1958-04-03 1960-03-08 Lilly Co Eli Novel phenethyl-substituted piperazines
FR1300728A (fi) * 1959-10-20 1962-07-02
DE1695410A1 (de) * 1967-04-20 1971-04-08 Merck Patent Gmbh Verfahren zur Herstellung von 1-(Thiazolyl-5-alkyl)-4-(pyridyl-2)-piperazinen
JPS5910675B2 (ja) * 1976-03-22 1984-03-10 ウェルファイド株式会社 アラルキルアミン誘導体
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4619930A (en) * 1985-01-16 1986-10-28 Bristol-Myers Company Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use
JPH075579B2 (ja) * 1986-09-01 1995-01-25 吉富製薬株式会社 アミノチアゾ−ル化合物

Also Published As

Publication number Publication date
DE3884007D1 (de) 1993-10-21
ES2058249T3 (es) 1994-11-01
KR900004126B1 (ko) 1990-06-16
DK78888A (da) 1988-08-18
AU1174088A (en) 1988-08-18
YU30388A (en) 1989-10-31
PL157118B1 (pl) 1992-04-30
AP88A (en) 1990-06-06
PT86766A (pt) 1988-03-01
CA1312080C (en) 1992-12-29
DD272080A5 (de) 1989-09-27
CS96488A2 (en) 1990-04-11
AU583761B2 (en) 1989-05-04
IL85368A0 (en) 1988-07-31
ZA881064B (en) 1989-09-27
MX174210B (es) 1994-04-28
CN88100986A (zh) 1988-09-21
NO170582B (no) 1992-07-27
MY103210A (en) 1993-05-29
JPS63216875A (ja) 1988-09-09
CS272783B2 (en) 1991-02-12
IE880420L (en) 1988-08-17
PL270653A1 (en) 1988-12-08
FI91752C (fi) 1994-08-10
SU1634136A3 (ru) 1991-03-07
NO880667L (no) 1988-08-18
IN171858B (fi) 1993-01-23
NO170582C (no) 1992-11-04
CN1015627B (zh) 1992-02-26
DK78888D0 (da) 1988-02-16
HU207731B (en) 1993-05-28
HUT50334A (en) 1990-01-29
KR880009964A (ko) 1988-10-06
AP8800082A0 (en) 1988-02-01
MX10428A (es) 1993-09-01
FI880716A (fi) 1988-08-18
EP0279598A3 (en) 1989-07-26
MA21183A1 (fr) 1988-10-01
IE61258B1 (en) 1994-10-19
EG18635A (en) 1994-04-30
JPH0699405B2 (ja) 1994-12-07
EP0279598A2 (en) 1988-08-24
ATE94537T1 (de) 1993-10-15
AR245125A1 (es) 1993-12-30
PT86766B (pt) 1992-05-29
NO880667D0 (no) 1988-02-16
DE3884007T2 (de) 1994-01-20
NZ223530A (en) 1990-07-26
YU46624B (sh) 1994-01-20
DK170878B1 (da) 1996-02-26
EP0279598B1 (en) 1993-09-15
FI91752B (fi) 1994-04-29

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FG Patent granted

Owner name: PFIZER INC.