KR870700344A - 유효 화합물을 서서히 방출하는 신규 약제, 그의 제조방법 및 이신규 제제물의 용도 - Google Patents

유효 화합물을 서서히 방출하는 신규 약제, 그의 제조방법 및 이신규 제제물의 용도

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Publication number
KR870700344A
KR870700344A KR870700494A KR870700494A KR870700344A KR 870700344 A KR870700344 A KR 870700344A KR 870700494 A KR870700494 A KR 870700494A KR 870700494 A KR870700494 A KR 870700494A KR 870700344 A KR870700344 A KR 870700344A
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KR
South Korea
Prior art keywords
columnar
effective compound
pharmaceutically effective
sustained release
particle size
Prior art date
Application number
KR870700494A
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English (en)
Other versions
KR940000098B1 (ko
Inventor
라르스-에릭 다비드 달린더
마트스 오베 요한손
존 안데르스 산드베르크
존 알베르트 스죄그렌
Original Assignee
안데르스 베딘
악티에볼라게트 헤슬레
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 안데르스 베딘, 악티에볼라게트 헤슬레 filed Critical 안데르스 베딘
Publication of KR870700344A publication Critical patent/KR870700344A/ko
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Publication of KR940000098B1 publication Critical patent/KR940000098B1/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Abstract

내용 없음

Description

유효 화합물을 서서히 방출하는 신규 약제, 그의 제조방법 및 이신규 제제물의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. 조밀한 불용성 코어 물질상에 도포된 1개 이상의 계약상 유효한 화합물을 함유시킴으로써 불용성 코어상에 유효 화합물의 조밀층을 형성시키고, 이 조밀층을 추가로 서방형 중합체막으로 피복시킨 것을 특정으로 하는, 약품을 서서히 방출하는 막으로 피복된 서방형 주상물.
  2. 제 1 항에 있어서,
    코어 물질의 입도가 0.1-2㎜이고, 제약상 유효한 화합물로 피복된 코어의 입도가 0.2-3.0㎜임을 특징으로 하는 주상물.
  3. 제 2 항에 있어서,
    코어 물질이 0.1-0.5㎜의 입도를 갖고, 상기 제약상 유효한 화합물로 피복된 코어 물질이 3.0-1.0㎜의 입도를 갖음을 특징으로 하는 주상물.
  4. 제 1 항에 있어서,
    코어 물질이 이산화 실리콘입을 특징으로 하는 주상물.
  5. 제 1 항에 있어서,
    코어 물질이 소입자의 유리임을 특징으로 하는 주상물.
  6. 제 1 항에 있어서,
    약품이 서서히 방출되는 것을 원하는 제약상 유효한 화합물을 함유함을 특징으로 하는 주상물.
  7. 제 1 항에 있어서,
    제약상 유효한 화합물이 경구 또는 비경구 투여용임을 특징으로 하는 주상물.
  8. 제 1 항에 있어서,
    제약상 유효한 화합물이 심장혈관, 위장 또는 화학요법 분야에서 사용됨을 특징으로 하는 주상물.
  9. 제 1 항에 있어서,
    제약상 유효한 화합물이 아드레날린 베타-차폐제의 염임을 특징으로 하는 주상물.
  10. 제 1 항에 있어서,
    제약상 유효한 화합물이 항생물질임을 특징으로 하는 주상물.
  11. 용매 중에 용해시킨 제약상 유효한 화합물을 0.1-2㎜의 입도를 갖는 불용성 코어 물질 상에 도포시키고, 용매를 증발시켜서, 유효 화합물의 조밀층으로 도포된, 0.2-3.0㎜의 크기를 갖는 주상물을 얻은후, 얻느 주상물을 추가로 서방형 중합체 막으로 도포시킴을 특징으로 하는 서방형 제품 제조용 주상물의 제조 방법.
  12. 제 1 항에 의한 조성물을, 상기 치료적으로 유효한 화합물을 서서히 방출할 필요가 있는 숙주에 투여함을 특징으로 하는 치료학적으로 유효한 화합물의 서방을 획득하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870700494A 1985-10-11 1986-09-10 유효 화합물을 서서히 방출하는 신규 제제의 제조방법 KR940000098B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE8504720-7 1985-10-11
SE8504720A SE450087B (sv) 1985-10-11 1985-10-11 Korn med kontrollerad frisettning av farmaceutiskt aktiva emnen som anbringats teckande pa ett kompakt olosligt kernmaterial
SE8504720 1985-10-11
PCT/SE1986/000400 WO1987002240A1 (en) 1985-10-11 1986-09-10 New drug preparation with controlled release of the active compound, a method for the manufacture thereof and the use of the new preparation

Publications (2)

Publication Number Publication Date
KR870700344A true KR870700344A (ko) 1987-12-28
KR940000098B1 KR940000098B1 (ko) 1994-01-05

Family

ID=20361705

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870700494A KR940000098B1 (ko) 1985-10-11 1986-09-10 유효 화합물을 서서히 방출하는 신규 제제의 제조방법

Country Status (24)

Country Link
US (1) US4927640A (ko)
EP (1) EP0277127B1 (ko)
JP (1) JP2560019B2 (ko)
KR (1) KR940000098B1 (ko)
CN (1) CN1025283C (ko)
AU (1) AU593038B2 (ko)
CS (1) CS268819B2 (ko)
CY (1) CY1764A (ko)
DD (1) DD266734A5 (ko)
DK (1) DK175592B1 (ko)
ES (1) ES2003139A6 (ko)
FI (1) FI97686C (ko)
GR (1) GR862526B (ko)
HU (1) HU199677B (ko)
IE (1) IE58967B1 (ko)
IS (1) IS1530B (ko)
NZ (1) NZ217697A (ko)
PH (1) PH24739A (ko)
PL (1) PL148624B1 (ko)
PT (1) PT83508B (ko)
SE (1) SE450087B (ko)
SU (1) SU1706373A3 (ko)
WO (1) WO1987002240A1 (ko)
ZA (1) ZA866861B (ko)

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SE8504720D0 (sv) 1985-10-11
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EP0277127A1 (en) 1988-08-10
ES2003139A6 (es) 1988-10-16
EP0277127B1 (en) 1991-04-10
AU6529686A (en) 1987-05-05
CS268819B2 (en) 1990-04-11
DK287687A (da) 1987-06-04
DK287687D0 (da) 1987-06-04
DK175592B1 (da) 2004-12-13
FI97686B (fi) 1996-10-31
SU1706373A3 (ru) 1992-01-15
ZA866861B (en) 1987-05-27
NZ217697A (en) 1989-04-26
FI881657A0 (fi) 1988-04-08
WO1987002240A1 (en) 1987-04-23
CN1025283C (zh) 1994-07-06
PL261801A1 (en) 1987-08-10
HUT47843A (en) 1989-04-28
CS729486A2 (en) 1989-08-14
SE450087B (sv) 1987-06-09
FI881657A (fi) 1988-04-08
IS1530B (is) 1993-02-23
PL148624B1 (en) 1989-11-30
PT83508A (en) 1986-11-01
GR862526B (en) 1987-02-09
JPS63501080A (ja) 1988-04-21
SE8504720L (sv) 1987-04-12
CY1764A (en) 1994-07-15
HU199677B (en) 1990-03-28
KR940000098B1 (ko) 1994-01-05
AU593038B2 (en) 1990-02-01
PH24739A (en) 1990-10-01
IE862493L (en) 1987-04-11
FI97686C (fi) 1997-02-10
US4927640A (en) 1990-05-22
JP2560019B2 (ja) 1996-12-04
PT83508B (pt) 1989-05-31
IE58967B1 (en) 1993-12-01
CN86106651A (zh) 1987-04-15

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