KR840005433A - 비사이클릭 화합물의 n-이미다졸릴 유도체의 제조방법 - Google Patents

비사이클릭 화합물의 n-이미다졸릴 유도체의 제조방법 Download PDF

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KR840005433A
KR840005433A KR1019830003067A KR830003067A KR840005433A KR 840005433 A KR840005433 A KR 840005433A KR 1019830003067 A KR1019830003067 A KR 1019830003067A KR 830003067 A KR830003067 A KR 830003067A KR 840005433 A KR840005433 A KR 840005433A
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코찌 파올로 (외 3)
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비토리노 페라리오
파르이탈리아 카를로 에르바 에스·피·에이
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Abstract

내용 없음

Description

비싸이클릭 화합물의 N-이미다졸릴 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (22)

  1. a) 일반식(Ⅱ)의 화합물을가 이중결합을 표시하는 일반식(I)의 화합물로 전환시키거나
  2. b) 일반식(Ⅱ)의 화합물을 환원하여이 단일결합을 표시하는 일반식(I)의 화합물을 수득하거나
  3. c) 일반식(Ⅲ)의 화합물을 환원하여이 단일결합을 표시하는 일반식(I)의 화합물을 수득하거나
  4. d) 하기 일반식(Ⅳ)의 화합물을 환원하여가 단일결합을 표시하는 일반식(I)의 화합물로 전환시키고, 필요하면 일반식(I)의 화합물을 다른 일반식(I)의 화합물로 전환시키고/시키거나, 필요하면, 일반식(I)의 화합물을 약제학적으로 무독한 그의 염으로 전환시키고/전환시키거나, 필요하면 염을 유리화합물로 전환시키고/전환시키거나, 필요하면, 일반식(I)의 이성체 혼합물을 단일이성체로 분리함을 특징으로 하여 하기 일반식(I)의 화합물 및 그의 약제학적으로 허용되는 염을 제조하는 방법.
  6. 상기 식에서,
  7. 는 단일 또는 이중결합을 나타내고,
  8. Z는 단일결합을 이루거나 산소원자 또는 -CH2- 그룹이며,
  9. R1, R2, R3및 R4는 각각 같거나 다를 수 있으며,
  10. (a) 수소, 하이드록시, 할로겐, 시아노, C1내지 C6의 알킬, C1내지 C6의 알콕시, C2내지 C4의 아실 또는 C2내지 C4의 아실아미노그룹, -SR',, -CH2OR', -COR 또는 -CH2COR(여기에서, R은 OR' 또는이고, R' 및 R"는 각각 같거나 다를 수 있으며, 수소 또는 C1내지 C6의 알킬임) 또는
  11. (b) R1, R2, R3및 R4중 하나는 5-테트라졸릴 또는 -COCH2OR',중에서 선택된 그룹이고(여기에서 R, R' 및 R"는 전술한 바와 같고, X는 -O-, -S- 또는 -NH-이며) 나머지는 (a)항에서 정의한 바와 같으며, R5및 R6중 하나는 수소이고 나머지 하나는 수소, C1내지 C6의 알킬, C3내지 C6의 시클로알킬, 또는 페닐 또는 피리딜환이며(여기에서 페닐 또는 피리딜환은 비치환 또는 하이드록시 및 C1내지 C4의 알콕시로부터 선택된 1 내지 3개의 치환기로 치환된 환이다), M은 수소 또는 산의 활성유도체 잔기이다.
  12. 제1항에 있어서,이 이중결합을 표시하고 Z가 1항에서 정의한 바와 같으며 각각의 R1, R2, R3및 R4는 같거나 다를 수 있으며,
  13. (a') 수소, 하이드록시, 할로겐, C1내지 C4의 알킬, C1내지 C4의 알콕시, -CH2OH, -COORa또는이거나(여기에서 각각의 Ra및 Rb는 독립적으로 수소 또는 C1내지 C4의 알킬이다),
  14. (b') R1, R2, R3및 R4중의 하나는 C2내지 C4의 아실, -CH2COORa,
  15. 이고(여기서 Rb및 Rb는 전술된 바와 같고) 나머지는 (a')항에서 정의한 바와 같으며,
  16. R5및 R6중 하나는 수소이고 나머지 하나는 수소, C1내지 C3의 알킬, 시클로프로필 또는 비치환 또는 하이드록시 및 C1내지 C2의 알콕시로부터 선택된 1 내지 3개의 치환기로 치환된 페닐 또는 피리딜환인 일반식(I)의 화합물 및 약제학적으로 무독한 그의 염을 제조하는 방법.
  17. 제1항에 있어서이 이중결합을 표시하고, Z가 산소원자 또는 -CH2-그룹이며, R1, R2, R3및 R4중 하나가 -COORa이고(여기서 Ra는 제2항에서 정의한 바와 같고, 나머지는 독립적으로 수소 및 하이드록시로부터 선택되거나, R1, R2, R3및 R4중 하나는 -CONH2, -CH2OH, -COCH3, -CH2COORa,Ra및 Rb는 제2항에서 정의된 바와 같고, 나머지는 수소이다.)
  18. R5및 R6가 모두 수소인 일반식(I)의 화합물 및 약제학적으로 무독한 그의 염을 제조하는 방법.
  19. 제1항에 있어서,이 이중결합을 표시하고, Z가 산소 또는 -CH2-그룹이며, R1, R2, R3및 R4중 하나가(여기서 Rg는 -NH2이거나 -ORa이고 Ra및 Rb는 제2항에서 정의한 바와 같고) 나머지는 수소이며, R5및 R6는 수소인 일반식(I)의 화합물 및 약제학적으로 무독한 그의 염을 제조하는 방법.
  20. 제1항에 있어서,이 이중결합을 나타내고, Z가 -CH2- 그룹이며, R1, R2, R3및 R4중 하나가 -CORg, -CH2COORa또는(여기서 Ra는 제2항에서 정의한 바와 같고, Rg는 제4항에서 정의한 바와 같으며) 나머지는 독립적으로 수소 및 하이드록시부터 선택되며, R5및 R6는 수소인 일반식(I)의 화합물 및 약제학적으로 무독한 그의 염을 제조하는 방법.
  21. 제1항에 있어서, Z가 -CH2- 그룹이고, R1, R2, R3및 R4중 하나가 -CORg이며(여기서 Rg는 제4항에서 정의한 바와 같고) 나머지는 수소이고, R5및 R6는 수소인 일반식(I)의 화합물 및 약제학적으로 무독한 그의 염을 제조하는 방법.
  22. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830003067A 1982-07-05 1983-07-05 비사이클릭 화합물의 n-이미다졸릴 유도체의 제조방법 KR910000414B1 (ko)

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JPS6081566A (ja) * 1983-10-07 1985-05-09 Nissan Motor Co Ltd ロツクアツプトルクコンバ−タのスリツプ制御装置

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AU557304B2 (en) 1986-12-18
FI74466C (fi) 1988-02-08
NO161439C (no) 1989-08-16
DE3324069A1 (de) 1984-01-26
IT8321886A0 (it) 1983-07-01
DK163359B (da) 1992-02-24
DE3324069C2 (de) 1994-08-25
YU144283A (en) 1986-10-31
IE831564L (en) 1984-01-05
US4510149A (en) 1985-04-09
NO832437L (no) 1984-01-06
CS273310B2 (en) 1991-03-12
SE8303824D0 (sv) 1983-07-04
IE55894B1 (en) 1991-02-14
IT1163641B (it) 1987-04-08
FR2529547A1 (fr) 1984-01-06
SG73487G (en) 1988-03-04
KR910000414B1 (ko) 1991-01-25
DK163359C (da) 1992-07-13
YU43545B (en) 1989-08-31
FI74466B (fi) 1987-10-30
PT76979A (en) 1983-08-01
DK307983A (da) 1984-01-06
AT386201B (de) 1988-07-25
NO161439B (no) 1989-05-08
LU84895A1 (fr) 1983-11-23
GR77577B (ko) 1984-09-24
JPH0454662B2 (ko) 1992-08-31
US4602022A (en) 1986-07-22
AU1654083A (en) 1984-01-12
ES523609A0 (es) 1985-03-01
FI832420L (fi) 1984-01-06
SU1342414A3 (ru) 1987-09-30
NL8302347A (nl) 1984-02-01
NZ204802A (en) 1986-04-11
PH21115A (en) 1987-07-16
MY104376A (en) 1994-03-31
HK101187A (en) 1988-01-08
ATA247383A (de) 1987-12-15
IL69152A0 (en) 1983-11-30
HU193529B (en) 1987-10-28
ES8503669A1 (es) 1985-03-01
JPS5927874A (ja) 1984-02-14
SE8303824L (sv) 1984-01-06
SE461791B (sv) 1990-03-26
ZA834865B (en) 1984-03-28
CH655102A5 (de) 1986-03-27
CA1202030A (en) 1986-03-18
CS509483A2 (en) 1990-08-14
BE897207A (fr) 1984-01-04
CZ413491A3 (en) 1993-10-13
DK307983D0 (da) 1983-07-04
FI832420A0 (fi) 1983-07-01
FR2529547B1 (fr) 1986-09-05
PT76979B (en) 1986-01-09

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