ES8304567A1 - "un procedimiento para preparar nuevos derivados de la n-dihidrotiazolil-3-quinolein-carboxamida". - Google Patents

"un procedimiento para preparar nuevos derivados de la n-dihidrotiazolil-3-quinolein-carboxamida".

Info

Publication number
ES8304567A1
ES8304567A1 ES512852A ES512852A ES8304567A1 ES 8304567 A1 ES8304567 A1 ES 8304567A1 ES 512852 A ES512852 A ES 512852A ES 512852 A ES512852 A ES 512852A ES 8304567 A1 ES8304567 A1 ES 8304567A1
Authority
ES
Spain
Prior art keywords
pharmaceutical preparations
preparation
carbon atoms
salts
quinoleine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES512852A
Other languages
English (en)
Other versions
ES512852A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8111607A external-priority patent/FR2507602A1/fr
Priority claimed from FR8204331A external-priority patent/FR2523130A1/fr
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES8304567A1 publication Critical patent/ES8304567A1/es
Publication of ES512852A0 publication Critical patent/ES512852A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE LA N-DIHIDROTIAZOLIL-3-QUINOLEIN-CARBOXAMIDA Y DE SUS SALES DE ADICION DE ACIDOS, DE FORMULA (I), EN LA QUE R ES HIDROGENO O ALCOHILO C <- ; Y R PUEDE SER UNO DE VARIOS RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R Y R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I); Y X ES CLORO, BROMO, HIDROXI O ALCOXI C <- , CON LA 2-AMINOTIAZOLINA. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE Y DE UN AGENTE DE CONDENSACION, A LA TEMPERATURA DE REFLUJO DEL MEDIO DE REACCION. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANALGESICA.
ES512852A 1981-06-12 1982-06-04 "un procedimiento para preparar nuevos derivados de la n-dihidrotiazolil-3-quinolein-carboxamida". Granted ES512852A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8111607A FR2507602A1 (fr) 1981-06-12 1981-06-12 Nouveau derive dihydrothiazole de la quinoleine, ses sels, procede de preparation, application a titre de medicaments et compositions les renfermant
FR8204331A FR2523130A1 (fr) 1982-03-15 1982-03-15 Nouveaux derives de la n-dihydrothiazolyl-3-quinoleine carboxamide, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant

Publications (2)

Publication Number Publication Date
ES8304567A1 true ES8304567A1 (es) 1983-03-01
ES512852A0 ES512852A0 (es) 1983-03-01

Family

ID=26222434

Family Applications (1)

Application Number Title Priority Date Filing Date
ES512852A Granted ES512852A0 (es) 1981-06-12 1982-06-04 "un procedimiento para preparar nuevos derivados de la n-dihidrotiazolil-3-quinolein-carboxamida".

Country Status (16)

Country Link
US (1) US4450166A (es)
EP (1) EP0067772B1 (es)
KR (1) KR880000808B1 (es)
AU (1) AU552029B2 (es)
CA (1) CA1216795A (es)
DE (1) DE3262536D1 (es)
DK (1) DK150070C (es)
ES (1) ES512852A0 (es)
FI (1) FI78087C (es)
GR (1) GR77201B (es)
HU (1) HU190796B (es)
IE (1) IE53520B1 (es)
IL (1) IL65943A (es)
MA (1) MA19488A1 (es)
NZ (1) NZ200931A (es)
PT (1) PT75023B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2557570B1 (fr) * 1984-01-04 1986-04-18 Adir Nouveaux derives de la quinoleine, leur procede de preparation et les compositions pharmaceutiques les renfermant
FR2566405B1 (fr) * 1984-06-25 1986-09-26 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus
US4602014A (en) * 1984-07-09 1986-07-22 Ciba-Geigy Corporation Ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives as benzodiazepine receptor modulators
US4560692A (en) * 1984-07-18 1985-12-24 Hoffmann-La Roche Inc. 4-Piperidino-2-phenylquinolines
US4786644A (en) * 1987-11-27 1988-11-22 Hoechst-Roussel Pharmaceuticals Inc. 1-aryl-3-quinolinecarboxamide
ES2243046T3 (es) 1998-02-26 2005-11-16 Neurogen Corporation Carboxamidas cicloalquil-4-oxonicotinicas sustituidas; ligandos de receptores gaba del cerebro.
MXPA01011173A (es) * 1999-05-06 2002-04-24 Neurogen Corp 4-0x0-quinolin-3-carboxamidas sustituidas: ligandos del receptor cerebro de gaba.
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
NZ587547A (en) * 2004-06-24 2012-09-28 Vertex Pharma Modulators of ATP-Binding Cassette Transporters
US20090105272A1 (en) * 2005-12-24 2009-04-23 Grootenhuis Peter D J Prodrugs of modulators of ABC transporters
PL3219705T3 (pl) 2005-12-28 2020-08-10 Vertex Pharmaceuticals Incorporated Kompozycje farmaceutyczne amorficznych postaci n-[2,4-bis(1,1-dimetyloetylo)-5-hydroksyfenylo]-1,4-dihydro-4-oksochinolino-3-karboksyamidu
NZ624460A (en) 2009-03-20 2015-12-24 Vertex Pharma Process for making modulators of cystic fibrosis transmembrane conductance regulator
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
IL265430B1 (en) 2012-02-27 2024-04-01 Vertex Pharma Pharmaceutical preparations containing a solid dispersion of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide and uses thereof
CN107250113B (zh) 2014-10-07 2019-03-29 弗特克斯药品有限公司 囊性纤维化跨膜传导调节蛋白的调节剂的共晶

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1364605A (fr) * 1962-03-01 1964-06-26 Procédé de préparation d'amides des acides carboxyliques
FR2281761A1 (fr) * 1974-08-13 1976-03-12 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2324304A2 (fr) * 1975-09-22 1977-04-15 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2340735A1 (fr) * 1976-02-11 1977-09-09 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2377400A2 (fr) * 1977-01-18 1978-08-11 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2443467A1 (fr) * 1978-12-08 1980-07-04 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2482596A1 (fr) * 1980-05-19 1981-11-20 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur procede de preparation et leur application comme medicament

Also Published As

Publication number Publication date
FI78087B (fi) 1989-02-28
IL65943A0 (en) 1982-09-30
AU8482782A (en) 1982-12-16
IE53520B1 (en) 1988-12-07
NZ200931A (en) 1984-12-14
US4450166A (en) 1984-05-22
FI822067A0 (fi) 1982-06-10
KR840000541A (ko) 1984-02-25
ES512852A0 (es) 1983-03-01
IE821394L (en) 1982-12-12
FI78087C (fi) 1989-06-12
DK150070B (da) 1986-12-01
DK262782A (da) 1982-12-13
HU190796B (en) 1986-11-28
PT75023B (fr) 1985-05-17
GR77201B (es) 1984-09-11
EP0067772B1 (fr) 1985-03-13
DK150070C (da) 1987-11-09
EP0067772A1 (fr) 1982-12-22
KR880000808B1 (ko) 1988-05-11
AU552029B2 (en) 1986-05-22
DE3262536D1 (en) 1985-04-18
MA19488A1 (fr) 1982-12-31
IL65943A (en) 1985-12-31
CA1216795A (fr) 1987-01-20
PT75023A (fr) 1982-07-01

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