KR880013881A - 하이드라진 유도체, 그들의 제조방법 및 그들이 함유된 약제학적 조성물 - Google Patents

하이드라진 유도체, 그들의 제조방법 및 그들이 함유된 약제학적 조성물

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KR880013881A
KR880013881A KR1019880005571A KR880005571A KR880013881A KR 880013881 A KR880013881 A KR 880013881A KR 1019880005571 A KR1019880005571 A KR 1019880005571A KR 880005571 A KR880005571 A KR 880005571A KR 880013881 A KR880013881 A KR 880013881A
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hydrazine
ethylidene
orthochlorophenyl
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hydroxyisobutyroyl
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KR1019880005571A
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미오끄 마르셀
비네 삐에르
갈롱 헤르베
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원본미기재
레 라보라뚜와르 메람 쏘씨에떼 아노님
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Publication of KR880013881A publication Critical patent/KR880013881A/ko

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    • C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/16—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

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Abstract

내용 없음

Description

하이드라진 유도체, 그들의 제조방법 및 그들이 함유된 약제학적 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 하기 일반식의 하이드라진 유도체 :
    상기 식에서, X는 C₁ 내지 C₄의 알킬 또는 트리플루오로메틸그룹이거나, 클로로(오르토 또는 메타위치), 플루오로 및 브로모중에서 선택되는 할로겐이고 ; R₁은 C₁ 내지 C₄의 알킬그룹이고 ; R₂는 수소, 측쇄상 C₃ 내지 C₄알킬, 일반식-CR₃R₄R5[여기에서, R₃은 그룹 OR6또는 NR7R8(여기에서, R6은 수소 또는 C₁ 내지 C₄의 알킬이고 ; R7및 R8은 각각 수소, C₁ 내지 C₄의 알킬그룹 또는 C₂ 내지 C₄의 아실그룹이거나, 벤조일그룹이거나, 또는 R7및 R8이 그들이 결합되어 있는 질소원자와 함께 5원- 도는 6원-헤테로사이클릭그룹을 형성한다)이고 ; R₄ 및 R5는 서로 동일하며, 수소 또는 C₁ 내지 C₄의 알킬그룹을 나타내거나, 또는 R₄는 수소이고, R5는 하이드록실그룹에 의해 임의치환된 C₁ 내지 C₄의 알킬그룹 또는 페닐그룹이거나 ; 또는 R₃, R₄ 및 R5가 그들의 결합되어 있는 탄소원자와 함께 아니도그룹을 형성한다]의 그룹, 하이드록실그룹에 의해 임의 치환된 페닐그룹, 5원- 또는 6원-헤테로사이클릭그룹, 또는 C₁ 내지 C₄의 알콕시그룹(바람직하게는, 에톡시그룹)이다.
  2. 제1항에 있어서, 1-(2-하이드록시이소부티로일)-2-(1-오르토클로로페닐-1-에틸리덴)하이드라진 ; 1-(2,2,2-트리메틸아세틸)-2-(1-오르토클로로페닐-1-에틸리덴)하이드라진 ; 1-(2-하이드록시프로파노일)-2-(1-오르토클로로페닐-1-에틸리덴)하이드라진 ; 1-(2-하이드록시아세틸)-2-(1-오르토클로로페닐-1-에틸리덴)하이드라진 ; 1-(2-하이드록시-2-페닐아세틸)-2-(1-오르토클로로페닐-1-에틸리덴)하이드라진 ; 1-(2-메톡시아세틸)-2-(1-오르토클로로페닐-1-에틸리덴)하이드라진 ; 1-(2-아미노아세틸)-2-(1-오르토클로로페닐-1-에틸리덴)하이드라진 ; 1-(2-메틸티오아세틸)-2-(1-오르토클로로페닐-1-에틸리덴)하이드라진 ; 1-옥사모일-2-(1-오르토클로로페닐-1-에틸리덴)하이드라진 ; 1-(2-옥소피롤리딘-5-일)-2-(1-오르토클로로페닐-1-에틸리덴)하이드라진 ; 1-니코티노일-2-(1-오르토클로로페닐-1-에틸리덴)하이드라진 ; 1-포르밀-2-(1-오르토클로로페닐-1-에틸리덴)하이드라진 ; 1-(2-아미노아세틸)-2-(1-파라플루오로페닐-1-에틸리덴)하이드라진 ; 1-(2-하이드록시이소부티로일)-2-(1-메타트리플루오로메틸페닐-1-에틸리덴)하이드라진 ; 1-모노폴리로아세틸-2-(1-오르토클로로페닐-1-에틸리덴)하이드라진 ; 1-(2-하이드록시이소부티로일)-2-(1-오르토클로로페닐-1-프로필리덴)하이드라진 ; 1-(2-하이드록시이소부티로일)-2-(1-파라클로로페닐-1-프로필리덴)하이드라진; 1-(2-하이드록시아세틸)-2-(1오르토플루오로페닐-1-에틸리덴)하이드라진 ; 1-(2-하이드록시이소부티로일)-2-(1-메타글로로페닐-1-프로필리덴)하이드라진 ; 1-N-아세틸글리실-2-(1-오르토클로로페닐-1-에틸리덴)하이드라진;1-(2-하이드록시이소부티로일)--2-(1-오르토클로로페닐-1-에틸리덴)하이드라진 ; 1-(2-하이드록시이소부티로일)-2-(1-파라플루오로페닐-1-에틸리덴)하이드라진 ; 1-(2-하이드록시이소부티로일)-2-(1-오르토브로모페닐-1-에틸리덴)하이드라진 ; 1-(2-하이드록시프로파노일)-2-(1-오르토클로로페닐-1-에틸리덴)하이드라진 ; 1-(2-하이드록시아세틸)-2-(1-오르토브로모페닐-1-에틸리덴)하이드라진 ; 1-(2-하이드록시이소부티로일)-2-(1-파라플루오로메틸페닐-1-에틸리덴)하이드라진 ; 1-(2-하이드록시이소부티로일)-2-(1-(2-클로로페닐)-1펜틸리덴) 하이드라진; 1-(2-하이드록시프로파노일)-2-(1-오르토플루오로페닐-1-에틸리덴)하이드라진; 1-(2-하이드록시이소부티로일)-2-(1-(2-클로로페닐)-1-펜틸리덴)하이드라진: 1-(2-하이드록시프로파노일)--2-(1-메타클로로페닐-1-에틸리덴) 하이드라진 ; 1-(2-하이드록시이소부티로일)-2-(1-오르토메틸페닐-1-에틸리덴)하이드라진 ; S-1-(3-하이드록시-2-아미노프로파노일)-2-(1-(2-클로로페닐)-1-에틸리덴)하이드라진 ; 1-아미노아세틸-2-(1-메타메톡시페닐-1-에틸리덴)하이드라진 염산염 ; 1-아미노아세틸-2-(1-파라메틸페닐-1-에틸리덴)하이드라진 염산염 ; 1-살리실로일-2-(1-오르토클로로페닐-1-에틸리덴)하이드라진 ; 1-(2-하이드록시이소부티로일)-2-(1-메타메틸페닐-1-에틸리덴)하이드라진 ; 1-(피페리디노글리옥실)-2-오르토클로로벤질리덴하이드라진 ; 및 S-1(N-벤조일세릴)-2-(1-(2-클로로페닐)-1-에틸리덴)하이드라진 중이 어느 하나인 하이드라진 유도체.
  3. 하이드라진 수화물과 일반식(2)의 에스테르로부터 일반식(1)의 아실하이드라진을 제조한 다음, 생성물(1)을 일반식(3)의 아릴 알킬케톤과 반응시켜 일반식(Ⅲ)의 하이드라진 유도체를 수득함을 특징으로 하여 제1항의 유도체를 합성하는 방법.
    상기 식에서, R₁ 및 R₂는 제1항에서 정의한 바와 같다.
  4. 제1항 또는 제2항에 청구된 하이드라진 유도체가 활성성분으로서 약제학적으로 허용되는 부형제와 함께 존재하는 약제학적 조성물.
  5. 제1항에 있어서, R₂가 제1항에서 정의한 바와 같은 그룹 CR₃R₄R5인 유도체.
  6. 제5항에 있어서, X가 오르토-클로로, 메타-브로모, 플루오르 및 브로모중에서 선택되는 할로겐인 유도체.
  7. 제6항에 있어서, R₁이 메틸그룹인 유도체.
  8. 제1항에 있어서, R₁ 이 메틸구릅이고, X가 오르토-클로로이며, R₂가 그룹인 유도체.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880005571A 1987-05-14 1988-05-13 하이드라진 유도체, 그들의 제조방법 및 그들이 함유된 약제학적 조성물 KR880013881A (ko)

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FR8706801 1987-05-14
FR8706801A FR2615188B1 (fr) 1987-05-14 1987-05-14 Derives d'hydrazine, procede d'obtention et compositions pharmaceutiques les contenant

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JPS5459326A (en) * 1977-10-18 1979-05-12 Nissan Chem Ind Ltd Insecticide
FR2457288A2 (fr) * 1978-09-12 1980-12-19 Rhone Poulenc Agrochimie Nouveaux derives de l'oxadiazoline-1,3,4-one-5, leur preparation et compositions insecticides les contenant
HU190795B (en) * 1982-05-04 1986-11-28 Egyt Gyogyszervegyeszeti Gyar,Hu Process for producing carbazinic derivatives and compositions containing them for increasing weight yield
DE3624349A1 (de) * 1986-07-17 1988-01-28 Schering Ag Substituierte hydrazone, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel

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AU1613488A (en) 1988-11-17
DK265788A (da) 1988-11-15
JPS6463561A (en) 1989-03-09
FR2615188A1 (fr) 1988-11-18
FI882267A0 (fi) 1988-05-13
OA08734A (fr) 1989-03-31
DK265788D0 (da) 1988-05-13
CN88102858A (zh) 1988-12-14
NZ224617A (en) 1991-02-26
NO882030L (no) 1988-11-15
FI882267A (fi) 1988-11-15
TNSN88045A1 (fr) 1990-07-10
FR2615188B1 (fr) 1989-11-17
EP0294258A1 (fr) 1988-12-07
MA21273A1 (fr) 1988-12-31
SU1672929A3 (ru) 1991-08-23
ZA883301B (en) 1988-11-14
NO882030D0 (no) 1988-05-10

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