KR840005340A - 국소용 소염조성물의 제조방법 - Google Patents

국소용 소염조성물의 제조방법 Download PDF

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Publication number
KR840005340A
KR840005340A KR1019830003173A KR830003173A KR840005340A KR 840005340 A KR840005340 A KR 840005340A KR 1019830003173 A KR1019830003173 A KR 1019830003173A KR 830003173 A KR830003173 A KR 830003173A KR 840005340 A KR840005340 A KR 840005340A
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South Korea
Prior art keywords
weight
concentration
carbon atoms
film
amount
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KR1019830003173A
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English (en)
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KR860001801B1 (ko
Inventor
가쭈미 오오야 (외 2)
Original Assignee
다니엘 파·크로닌
화이자 코포레이션
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=14821545&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR840005340(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 다니엘 파·크로닌, 화이자 코포레이션 filed Critical 다니엘 파·크로닌
Publication of KR840005340A publication Critical patent/KR840005340A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

내용 없음

Description

국소용 소염조성물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. (a) 카복시비닐폴리머 및 필요하면 피막-생성제를 물에 분산시키고; (b) 생성된 수성 분산액을 저급알칸을 및 다가알콜과 혼합하고; (c) 이와 별도로 피록시캄을 알콜성 혼합물을 합해 생성된 최종 혼합물을 일정하게 진랑시켜 젤연고를 행성함을 특징으로 하여,소염 유효량의 피록시킴; , 탄소수 1 내지 4의 저급알잔을 약 10내지 50중량%;젤-생성량의 카복시비닐폴리머; 탄소수 2 내지 6의 저급알킬렌글리콜,글리세린 및 평균분자량 200 내지 2000의 폴리에틸렌글리콜 중에서 선택된 적어도 한가지의 다가알콜 약 5 내지약 40중략%;탄소수 1 내지 4의 모노알칸올아민, 탄소수 2 내지 8의 디알칸올라민 및 탄소수 3 내지 12의 트리알칸올아민 중에서 선택된 적어도 한가지의 알칸올아민의 피록시킴-가용화량; 및 임의로는,카복시메틸 셀루로즈,하이드록시에틸 셀루로즈 및 폴리비닐 피톨리돈 중에서 선택된 적어도 한가지의 피막-생성제의 피막-생성량 및 총 100%로 하기에 충분한 양의 룰로 구성되는 수성계로 이루어지며,pH가 약6.5 내지 약 9.0인 젤연고형태의 국소용 소염 조성물ㅇ르 제조하는 방법.
  2. 제1항에 있어서, 피록시캄의 농도가 총중량을 기준해서 약 0.3 내지 약 2.0% 임을 특징으로 하는 방법.
  3. 제1항에 있어서, 카복시비닐 폴리머의 농도가 총중량을 기준하여 약 0.2 내지 약 2.0% 임을 특징으로 하는 방법.
  4. 제1항에 있어서, 알칸올 아민의 농도가 총중량을 기준하여 약 3.0% 이하임을 특징으로 하는 방법.
  5. 제1항에 있어서, 물의 함량이 총중량을 기준하여 약 30 내지 약 60%임을 특징으로 하는 방법.
  6. 제1항에 있어서, 피막-생성제의 농도가 총중량을 기준하여 약 0.2 내지 약 2.0%임을 특징으로 하는 방법.
  7. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830003173A 1982-07-13 1983-07-12 국소용 소염조성물의 제조방법 KR860001801B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP57121853A JPS5913714A (ja) 1982-07-13 1982-07-13 外用消炎鎮痛剤
JP121853 1982-07-13

Publications (2)

Publication Number Publication Date
KR840005340A true KR840005340A (ko) 1984-11-12
KR860001801B1 KR860001801B1 (ko) 1986-10-23

Family

ID=14821545

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830003173A KR860001801B1 (ko) 1982-07-13 1983-07-12 국소용 소염조성물의 제조방법

Country Status (27)

Country Link
US (1) US4678666A (ko)
EP (1) EP0101178B2 (ko)
JP (1) JPS5913714A (ko)
KR (1) KR860001801B1 (ko)
AR (1) AR230375A1 (ko)
AU (1) AU543654B2 (ko)
CA (1) CA1206418A (ko)
CS (1) CS241062B2 (ko)
DD (1) DD209972A5 (ko)
DE (1) DE3373270D1 (ko)
DK (1) DK159640C (ko)
EG (1) EG17670A (ko)
ES (1) ES524094A0 (ko)
FI (1) FI78235C (ko)
GR (1) GR78874B (ko)
HK (1) HK85289A (ko)
HU (1) HU187110B (ko)
IE (1) IE54844B1 (ko)
IL (1) IL69207A0 (ko)
IN (1) IN159679B (ko)
NO (1) NO162494C (ko)
NZ (1) NZ204870A (ko)
PH (1) PH18117A (ko)
PL (1) PL147503B1 (ko)
PT (1) PT77016B (ko)
SG (1) SG30489G (ko)
ZA (1) ZA835058B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100288190B1 (ko) * 1998-02-09 2001-04-16 김용규 피록시캄 함유 알콜성 하이드로겔 조성물

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6168413A (ja) * 1984-09-10 1986-04-08 Lion Corp 外用ゲル組成物
IT1196307B (it) * 1984-10-22 1988-11-16 Chiesi Farma Spa Formulazioni farmaceutiche acquose di piroxicam monoidrato
US4654169A (en) * 1985-02-06 1987-03-31 Givaudan Corporation Phenyl-aliphatic oximes as odorants
JPS61212516A (ja) * 1985-03-18 1986-09-20 Toyobo Co Ltd ピロキシカム軟膏剤
JPH0794394B2 (ja) * 1986-12-24 1995-10-11 前田薬品工業株式会社 消炎鎮痛外用貼付剤
US5332577A (en) * 1988-12-27 1994-07-26 Dermamed Transdermal administration to humans and animals
US5241925A (en) * 1988-12-27 1993-09-07 Dermamed Apparatus and techniques for administering veterinary medicaments
US5599768A (en) * 1989-09-21 1997-02-04 E. I. Du Pont De Nemours And Company Stabilization of non-aqueous suspensions
US4988500A (en) * 1989-09-29 1991-01-29 The Procter & Gamble Company Oral compositions
US5324521A (en) * 1989-12-18 1994-06-28 Dermamed Systems for transdermal administration of medicaments
DE59003020D1 (de) * 1990-04-26 1993-11-11 Sagitta Arzneimittel Gmbh Piroxicam enthaltende pharmazeutische Zusammensetzung zur topischen Anwendung.
FR2679135B1 (fr) * 1991-07-18 1995-05-19 Europhta Sa Laboratoire Nouvelles compositions ophtalmiques a adhesivite amelioree et leurs procedes de preparation.
US5362758A (en) * 1992-09-18 1994-11-08 Pfizer Inc. Ophthalmic piroxicam solution
HU209518B (en) * 1992-12-23 1994-06-28 Egyt Gyogyszervegyeszeti Gyar Process for production of free of skin damaging effect unguent preparation containing piroxicam
US5436241A (en) * 1994-01-14 1995-07-25 Bristol-Myers Squibb Company Topical anti-inflammatory compositions containing piroxicam
ES2074030B1 (es) * 1994-01-31 1996-02-01 S A L V A T Lab Sa Composiciones portadoras, autocalentadoras y aplicables en terapeutica por via topica.
US5905092A (en) * 1994-09-27 1999-05-18 Virotex Corporation Reel/Frame Topical antibiotic composition providing optimal moisture environment for rapid wound healing that reduces skin contraction
US5807568A (en) * 1994-12-27 1998-09-15 Mcneil-Ppc, Inc. Enhanced delivery of topical compositions containing flurbiprofen
GB2305603A (en) * 1995-09-26 1997-04-16 Allied Medical Group Topical cooling gels for reducing excess body fat
KR100342945B1 (ko) * 1999-03-09 2002-07-02 민경윤 항진균제의 외용 약제 조성물 및 이의 제조방법
IL142037A0 (en) 2001-03-15 2002-03-10 Agis Ind 1983 Ltd Pharmaceutical compositions containing a non-steroidal anti-inflammatory drug
KR100406576B1 (ko) * 2001-06-23 2003-11-20 최후균 경피투여용 패취제
US20060067958A1 (en) * 2004-09-24 2006-03-30 Unilab Pharmatech, Ltd. Pharmaceutical topical gel compositions
JP2006188500A (ja) * 2004-12-08 2006-07-20 Toyama Chem Co Ltd ピロキシカムを含有する外用液剤
JOP20200109A1 (ar) 2012-04-23 2017-06-16 Otsuka Pharma Co Ltd مستحضر قابل للحقن
KR102319497B1 (ko) 2016-03-02 2021-11-01 노반, 인크. 염증 치료용 조성물 및 염증 치료 방법
KR20210133821A (ko) 2020-04-29 2021-11-08 신신제약 주식회사 피록시캄을 함유하는 경피 흡수 제제
KR20240015682A (ko) * 2021-05-28 2024-02-05 베테리너리 파마시 코퍼레이션 수용성 복합체 조성물 및 이의 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3541584A (en) 1968-08-14 1970-11-17 Bendix Corp Control for fog simulator effects
US3591584A (en) * 1968-08-27 1971-07-06 Pfizer Benzothiazine dioxides
JPS52156913A (en) * 1976-06-21 1977-12-27 Toko Yakuhin Kogyo Kk Production of injectionable medicine
JPS5381616A (en) * 1976-12-27 1978-07-19 Kowa Co Production of antiinflammatory and anodyne ointment
JPS5540604A (en) 1978-09-14 1980-03-22 Mitsui Toatsu Chem Inc Improved local topicum
US4434164A (en) * 1981-06-01 1984-02-28 Pfizer Inc. Crystalline benzothiazine dioxide salts

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100288190B1 (ko) * 1998-02-09 2001-04-16 김용규 피록시캄 함유 알콜성 하이드로겔 조성물

Also Published As

Publication number Publication date
IE831611L (en) 1984-01-13
HU187110B (en) 1985-11-28
FI832536L (fi) 1984-01-14
FI78235C (fi) 1989-07-10
EP0101178B2 (en) 1992-08-12
EP0101178B1 (en) 1987-09-02
CS241062B2 (en) 1986-03-13
JPS5913714A (ja) 1984-01-24
JPH0338250B2 (ko) 1991-06-10
PT77016B (en) 1986-05-05
IN159679B (ko) 1987-05-30
DK320583D0 (da) 1983-07-12
PL242971A1 (en) 1985-05-21
ES8500738A1 (es) 1984-11-01
US4678666A (en) 1987-07-07
AU543654B2 (en) 1985-04-26
ES524094A0 (es) 1984-11-01
ZA835058B (en) 1984-03-28
EG17670A (en) 1991-03-30
FI78235B (fi) 1989-03-31
DE3373270D1 (en) 1987-10-08
NO832529L (no) 1984-01-16
NZ204870A (en) 1986-06-11
DK159640C (da) 1991-04-08
NO162494C (no) 1990-01-10
DK320583A (da) 1984-01-14
HK85289A (en) 1989-11-03
IE54844B1 (en) 1990-02-28
AR230375A1 (es) 1984-04-30
KR860001801B1 (ko) 1986-10-23
AU1676783A (en) 1984-01-19
NO162494B (no) 1989-10-02
GR78874B (ko) 1984-10-02
CS528283A2 (en) 1985-07-16
EP0101178A2 (en) 1984-02-22
DK159640B (da) 1990-11-12
PT77016A (en) 1983-08-01
EP0101178A3 (en) 1985-05-22
PH18117A (en) 1985-03-22
FI832536A0 (fi) 1983-07-12
SG30489G (en) 1989-08-11
CA1206418A (en) 1986-06-24
DD209972A5 (de) 1984-05-30
IL69207A0 (en) 1983-11-30
PL147503B1 (en) 1989-06-30

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