KR840005169A - 새로운 생리활성 물질 아르파메닌(Arphamenine)의 제조방법 - Google Patents

새로운 생리활성 물질 아르파메닌(Arphamenine)의 제조방법 Download PDF

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KR840005169A
KR840005169A KR1019830002470A KR830002470A KR840005169A KR 840005169 A KR840005169 A KR 840005169A KR 1019830002470 A KR1019830002470 A KR 1019830002470A KR 830002470 A KR830002470 A KR 830002470A KR 840005169 A KR840005169 A KR 840005169A
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arpamenin
chromobacterium
bioactive substance
producing
new
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KR1019830002470A
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KR900008247B1 (ko
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하마오(외 4) 우메쟈와
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이키카와 토쿠지
자이단호진 비세이부쓰 가가구 겐규카이
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
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    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • C—CHEMISTRY; METALLURGY
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    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
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    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales

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Abstract

내용 없음

Description

새로운 생리활성물질 아르파메닌(Arphamenine)의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명의 아르파메닌 A의 자외선 흡수 스펙트럼.
제2도는 아르파메닌 A의 적외부 흡수 스펙트럼.
제3도는 아르파메닌 A의 핵자기 공명 흡수 스펙트럼.
제4도는 본 발명의 아르파메닌 B의 자외부 흡수 스펙트럼.
제5도는 아르파메닌 B의 적외부 흡수 스펙트럼.
제6도는 아르파메닌 B의 핵자기 공명 흡수 스펙트럼을 나타낸다.

Claims (6)

  1. 크로모박테륨(Chromobacterium)속의 아르파메닌 생산균주를 탄소 및 질소원함유 배양액중에서 충분한 시간동안 배양시켜 아르파메닌(Arphamenine)을 그 배양액중에서 생산, 축적시킴을 특징으로 하는 새로운 생리활성 물질 아르파메닌의 제조방법.
  2. 제1항에 있어서, 상기 배양액에서 아르파메닌을 회수시킴을 특징으로한 새로운 생리활성 물질 아르파메닌의 제조방법.
  3. 제1,2항에 있어서, 아르파페닌 생산균주는 FERM.P-3521 또는 FERM BP-286으로 기탁된크로모박테륨 비오라세움(chromobacterium Violaceurn)임을 특징으로한 새로운 생리활성물질 아르파메닌의 제조방법.
  4. 제1항에 있어서, 크로모박테륨 비오라세움의 아르파틸닌 A-생산균주를 탄소 및 질소원으로 함유한배양액중에서 충분한 시간동안 호기성 조건하에서 배양시켜 그 배양액중에서 아르파메닌 A를 생산, 축적시킴을특징으로한 새로운 생리활성물질 아르파메닌의 제조방법.
  5. 제1항에 있어서, 크로모박테륨 비오라세움의 아르파틸린 B-생산균주를 탄소 및 질소원으로 함유한배양액중에서 충분ㅇ한 시간동안 호기성 조건하에서 배양시켜 그 배양액중에서 아르파메닌 B를 생산, 축적시킴을 특징으로한 새로운 생리활성물질 아프파메닌의 제조방법.
  6. 제4 및 5항에 있어서, 크로모박태륨 비오라세움 BMG361-CF4는 온도 25-35°C에서 8-5시간 배양시킴을 특징으로한 새로운 생리활성물질 아르파메닌의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830002470A 1982-06-07 1983-06-02 새로운 생리활성물질 아르파메닌(Arphamenine)의 제조방법 KR900008247B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP96276 1982-06-07
JP57096276A JPS58212791A (ja) 1982-06-07 1982-06-07 新生理活性物質アルフアメニン及びその製造法
JP57-96276 1982-06-07

Publications (2)

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KR840005169A true KR840005169A (ko) 1984-11-05
KR900008247B1 KR900008247B1 (ko) 1990-11-06

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KR1019830002470A KR900008247B1 (ko) 1982-06-07 1983-06-02 새로운 생리활성물질 아르파메닌(Arphamenine)의 제조방법

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US (2) US4595698A (ko)
EP (1) EP0096356B1 (ko)
JP (1) JPS58212791A (ko)
KR (1) KR900008247B1 (ko)
AT (1) ATE37393T1 (ko)
CA (1) CA1201992A (ko)
DE (1) DE3378058D1 (ko)
DK (1) DK257083A (ko)
ES (1) ES523022A0 (ko)
FI (1) FI71765C (ko)
HU (1) HU191849B (ko)
NO (1) NO165200C (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS606647A (ja) * 1983-06-17 1985-01-14 Microbial Chem Res Found アルフアメニン及びその関連化合物と合成法
JPS6034190A (ja) * 1983-08-05 1985-02-21 Microbial Chem Res Found アルフアメニンの高収率製造法
JPS61204170A (ja) * 1984-09-03 1986-09-10 Microbial Chem Res Found アルフアメニン関連化合物と免疫賦活剤
JPH05279374A (ja) * 1992-03-31 1993-10-26 Sawao Murao スイダトレスチン及びその製造方法
JPH06247964A (ja) * 1993-02-22 1994-09-06 Snow Brand Milk Prod Co Ltd 新規生理活性物質ｈｓ−１及びその製造方法
EP2545181B1 (en) 2010-03-12 2014-11-12 Council Of Scientific & Industrial Research Process for the production of violacein and its derivative deoxyviolacein containing bioactive pigment from chromobacterium sp. (mtcc 5522)
CN112430633B (zh) * 2020-11-02 2023-05-09 新疆阜丰生物科技有限公司 一种利用流加培养液发酵生产精氨酸的工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3824267A (en) * 1971-08-19 1974-07-16 Ono Pharmaceutical Co Thiolesters of guanidino organic acids
DE2359544A1 (de) * 1973-11-29 1975-10-30 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
US3994965A (en) * 1974-08-09 1976-11-30 Pfizer Inc. D-N-(guanylureidoacetyl)-α-aminophenyl acetic acid and D-N-(guanylureidoacetyl)-α-aminophenyl acetyl chloride
US4105789A (en) * 1976-05-10 1978-08-08 E. R. Squibb & Sons, Inc. Carboxyalkylacylamino acids
JPS6026099B2 (ja) * 1977-09-21 1985-06-21 財団法人微生物化学研究会 ペプチド、その酸附加塩およびその製造法
JPS5832592B2 (ja) * 1979-01-31 1983-07-14 財団法人微生物化学研究会 新抗生物質バクトロポンおよびその製造法

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JPH022593B2 (ko) 1990-01-18
JPS58212791A (ja) 1983-12-10
DK257083D0 (da) 1983-06-06
US4859593A (en) 1989-08-22
EP0096356B1 (en) 1988-09-21
EP0096356A2 (en) 1983-12-21
FI832007L (fi) 1983-12-08
ATE37393T1 (de) 1988-10-15
FI71765B (fi) 1986-10-31
DE3378058D1 (en) 1988-10-27
NO165200B (no) 1990-10-01
EP0096356A3 (en) 1985-06-12
DK257083A (da) 1983-12-08
NO832046L (no) 1983-12-08
ES8503029A1 (es) 1985-02-01
HU191849B (en) 1987-04-28
ES523022A0 (es) 1985-02-01
US4595698A (en) 1986-06-17
KR900008247B1 (ko) 1990-11-06
FI832007A0 (fi) 1983-06-03
CA1201992A (en) 1986-03-18
FI71765C (fi) 1987-02-09
NO165200C (no) 1991-01-16

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