KR20250040753A - 5-ht2b 작용물질의 형성을 억제하기 위한 제제 및 그것의 사용 방법 - Google Patents

5-ht2b 작용물질의 형성을 억제하기 위한 제제 및 그것의 사용 방법 Download PDF

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Publication number
KR20250040753A
KR20250040753A KR1020257007992A KR20257007992A KR20250040753A KR 20250040753 A KR20250040753 A KR 20250040753A KR 1020257007992 A KR1020257007992 A KR 1020257007992A KR 20257007992 A KR20257007992 A KR 20257007992A KR 20250040753 A KR20250040753 A KR 20250040753A
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South Korea
Prior art keywords
fenfluramine
drug
inhibitor
day
syndrome
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Pending
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KR1020257007992A
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English (en)
Korean (ko)
Inventor
스티븐 제이. 파르
브룩스 보이드
Original Assignee
조게닉스 인터내셔널 리미티드
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Application filed by 조게닉스 인터내셔널 리미티드 filed Critical 조게닉스 인터내셔널 리미티드
Publication of KR20250040753A publication Critical patent/KR20250040753A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/105—Persulfides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020257007992A 2016-08-24 2017-08-02 5-ht2b 작용물질의 형성을 억제하기 위한 제제 및 그것의 사용 방법 Pending KR20250040753A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662379183P 2016-08-24 2016-08-24
US62/379,183 2016-08-24
US201762515383P 2017-06-05 2017-06-05
US62/515,383 2017-06-05
PCT/IB2017/054740 WO2018037306A1 (en) 2016-08-24 2017-08-02 Formulation for inhibiting formation of 5-ht 2b agonists and methods of using same
KR1020237003353A KR20230021172A (ko) 2016-08-24 2017-08-02 5-ht2b 작용물질의 형성을 억제하기 위한 제제 및 그것의 사용 방법

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020237003353A Division KR20230021172A (ko) 2016-08-24 2017-08-02 5-ht2b 작용물질의 형성을 억제하기 위한 제제 및 그것의 사용 방법

Publications (1)

Publication Number Publication Date
KR20250040753A true KR20250040753A (ko) 2025-03-24

Family

ID=59955585

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020197006888A Abandoned KR20190040237A (ko) 2016-08-24 2017-08-02 5-ht2b 작용물질의 형성을 억제하기 위한 제제 및 그것의 사용 방법
KR1020257007992A Pending KR20250040753A (ko) 2016-08-24 2017-08-02 5-ht2b 작용물질의 형성을 억제하기 위한 제제 및 그것의 사용 방법
KR1020237003353A Ceased KR20230021172A (ko) 2016-08-24 2017-08-02 5-ht2b 작용물질의 형성을 억제하기 위한 제제 및 그것의 사용 방법

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020197006888A Abandoned KR20190040237A (ko) 2016-08-24 2017-08-02 5-ht2b 작용물질의 형성을 억제하기 위한 제제 및 그것의 사용 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020237003353A Ceased KR20230021172A (ko) 2016-08-24 2017-08-02 5-ht2b 작용물질의 형성을 억제하기 위한 제제 및 그것의 사용 방법

Country Status (15)

Country Link
US (6) US20180055789A1 (enExample)
EP (2) EP3518975B1 (enExample)
JP (3) JP2019526544A (enExample)
KR (3) KR20190040237A (enExample)
CN (2) CN120241681A (enExample)
AU (3) AU2017315273B2 (enExample)
CA (1) CA3032996C (enExample)
ES (1) ES3029536T3 (enExample)
IL (2) IL290727B2 (enExample)
MX (2) MX2019001799A (enExample)
RU (2) RU2746000C2 (enExample)
SG (1) SG11201900975XA (enExample)
TW (3) TWI722233B (enExample)
WO (1) WO2018037306A1 (enExample)
ZA (1) ZA201900766B (enExample)

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US20210401776A1 (en) * 2018-11-30 2021-12-30 Zogenix International Limited Method of treating refractory epilepsy syndromes using fenfluramine enantiomers
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