KR20220139448A - 미세바늘 어레이 및 제조 및 사용 방법 - Google Patents

미세바늘 어레이 및 제조 및 사용 방법 Download PDF

Info

Publication number
KR20220139448A
KR20220139448A KR1020227034384A KR20227034384A KR20220139448A KR 20220139448 A KR20220139448 A KR 20220139448A KR 1020227034384 A KR1020227034384 A KR 1020227034384A KR 20227034384 A KR20227034384 A KR 20227034384A KR 20220139448 A KR20220139448 A KR 20220139448A
Authority
KR
South Korea
Prior art keywords
microneedles
microneedle
skin
microneedle array
benefit agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020227034384A
Other languages
English (en)
Korean (ko)
Inventor
마크 앨러리
페이톤 홉슨
잔-쥬 리우
에릭 룬드
바라트 파텔
엠마뉴엘 모라노
Original Assignee
존슨 앤드 존슨 컨수머 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 존슨 앤드 존슨 컨수머 인코포레이티드 filed Critical 존슨 앤드 존슨 컨수머 인코포레이티드
Publication of KR20220139448A publication Critical patent/KR20220139448A/ko
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020227034384A 2016-12-22 2017-12-21 미세바늘 어레이 및 제조 및 사용 방법 Pending KR20220139448A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662437800P 2016-12-22 2016-12-22
US62/437,800 2016-12-22
KR1020197021175A KR20190099267A (ko) 2016-12-22 2017-12-21 미세바늘 어레이 및 제조 및 사용 방법
PCT/US2017/067790 WO2018119174A1 (en) 2016-12-22 2017-12-21 Microneedle arrays and methods for making and using

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020197021175A Division KR20190099267A (ko) 2016-12-22 2017-12-21 미세바늘 어레이 및 제조 및 사용 방법

Publications (1)

Publication Number Publication Date
KR20220139448A true KR20220139448A (ko) 2022-10-14

Family

ID=61628455

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020227034384A Pending KR20220139448A (ko) 2016-12-22 2017-12-21 미세바늘 어레이 및 제조 및 사용 방법
KR1020197021175A Ceased KR20190099267A (ko) 2016-12-22 2017-12-21 미세바늘 어레이 및 제조 및 사용 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020197021175A Ceased KR20190099267A (ko) 2016-12-22 2017-12-21 미세바늘 어레이 및 제조 및 사용 방법

Country Status (11)

Country Link
US (2) US11241563B2 (enExample)
EP (1) EP3558441A1 (enExample)
JP (2) JP2020513899A (enExample)
KR (2) KR20220139448A (enExample)
CN (1) CN110099714A (enExample)
AU (1) AU2017379065B2 (enExample)
CA (1) CA3048102A1 (enExample)
MX (2) MX2019007549A (enExample)
RU (1) RU2750904C2 (enExample)
WO (1) WO2018119174A1 (enExample)
ZA (1) ZA201904779B (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
EP2765927B1 (en) 2011-10-12 2021-02-24 Vaxxas Pty Limited Delivery device
EP4218892A1 (en) 2015-02-02 2023-08-02 Vaxxas Pty Limited Microprojection array applicator
US11103259B2 (en) 2015-09-18 2021-08-31 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
AU2016333148B2 (en) 2015-09-28 2021-10-14 Vaxxas Pty Limited Microprojection arrays with enhanced skin penetrating properties and methods thereof
CN115923337A (zh) 2017-03-31 2023-04-07 瓦克萨斯私人有限公司 用于涂覆表面的设备和方法
WO2018227246A1 (en) 2017-06-13 2018-12-20 Vaxxas Pty Limited Quality control of substrate coatings
US11464957B2 (en) 2017-08-04 2022-10-11 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP)
AU2018315629B2 (en) * 2017-08-10 2025-06-26 Vaxxas Pty Limited Differential coating of microprojections and microneedles on arrays
JP2019103627A (ja) * 2017-12-13 2019-06-27 株式会社三洋物産 遊技機
JP7235153B2 (ja) * 2017-12-29 2023-03-08 株式会社三洋物産 遊技機
JP7235154B2 (ja) * 2018-02-15 2023-03-08 株式会社三洋物産 遊技機
JP7231076B2 (ja) * 2018-03-08 2023-03-01 株式会社三洋物産 遊技機
JP7476119B2 (ja) 2018-06-29 2024-04-30 ジョンソン アンド ジョンソン コンシューマー インコーポレイテッド 活性物質の送達のための三次元マイクロ流体デバイス
TWI698263B (zh) * 2018-07-19 2020-07-11 淡江大學 微針元件的製造方法與微針模具的製造方法
US20200147359A1 (en) * 2018-11-11 2020-05-14 Esthetic Education LLC Microneedle Array
JP2020130466A (ja) * 2019-02-15 2020-08-31 株式会社三洋物産 遊技機
KR102194089B1 (ko) * 2019-03-18 2020-12-22 랩앤피플주식회사 항산화 활성 및 미백 효과를 갖는 플렉시블 금속 패치 및 그 사용방법
JP7234740B2 (ja) * 2019-03-28 2023-03-08 株式会社三洋物産 遊技機
JP7234741B2 (ja) * 2019-03-28 2023-03-08 株式会社三洋物産 遊技機
JP7234761B2 (ja) * 2019-04-11 2023-03-08 株式会社三洋物産 遊技機
JP7234760B2 (ja) * 2019-04-11 2023-03-08 株式会社三洋物産 遊技機
CN110435139A (zh) * 2019-09-09 2019-11-12 武汉大学 一种3d打印空心微针的制作方法及其应用
EP3795358A1 (de) * 2019-09-20 2021-03-24 Axenoll Life Sciences AG Mikronadel und verfahren zur herstellung einer mikronadel
US12005220B2 (en) * 2019-11-22 2024-06-11 Veradermics Incorporated Microneedle patch for immunostimulatory drug delivery
CN111184942A (zh) * 2020-03-18 2020-05-22 四川大学华西医院 一种治疗黄褐斑的可溶性微针
CN111544759B (zh) * 2020-04-26 2022-02-25 优微（珠海）生物科技有限公司 一种祛除黑眼圈的微针贴片及其制备方法
US20240382412A1 (en) * 2020-05-06 2024-11-21 The Regents The University Of California Bioorthogonal catalytic patch and methods of using the same
AU2021390587A1 (en) * 2020-12-04 2023-03-30 Dermr Health Solutions Pty Ltd Minimally invasive skin sample collection apparatus
EP4301448A4 (en) * 2021-03-03 2025-01-15 Washington State University MICRO-NEEDLE ARRAY WITH LOCKING ELEMENT
US20220354998A1 (en) * 2021-05-07 2022-11-10 University Of Connecticut Hydrogel-filled microneedle arrays and uses thereof
US20240261552A1 (en) * 2021-05-21 2024-08-08 Veradermics Incorporated Microneedle patch for immunostimulatory drug delivery
GB2607115B (en) * 2021-06-25 2023-10-04 Cipherx Tech Ltd Method of producing a microneedle array
DE102021118997A1 (de) * 2021-07-22 2023-01-26 Lts Lohmann Therapie-Systeme Ag. Mikronadelarray mit Antiseptika
CN114177513A (zh) * 2021-12-27 2022-03-15 广州纳丽生物科技有限公司 一种增强针杆利用率的超微针片
JP2023063369A (ja) * 2022-01-07 2023-05-09 株式会社三洋物産 遊技機
JP2023053387A (ja) * 2022-02-04 2023-04-12 株式会社三洋物産 遊技機
JP2023060270A (ja) * 2022-04-01 2023-04-27 株式会社三洋物産 遊技機
JP2023060269A (ja) * 2022-04-01 2023-04-27 株式会社三洋物産 遊技機
CN120091847A (zh) * 2022-08-22 2025-06-03 国科温州研究院(温州生物材料与工程研究所) 微针阵列和制造方法
TWI824724B (zh) * 2022-09-16 2023-12-01 達運精密工業股份有限公司 微針貼片、其製造模具、以及其製造方法
KR20240059023A (ko) * 2022-10-26 2024-05-07 재단법인대구경북과학기술원 폴리머 기반 마이크로니들 패치 제조 방법 및 이를 통해 제조된 마이크로니들 패치
WO2024129424A1 (en) * 2022-12-16 2024-06-20 Kindeva Drug Delivery L.P. Drug delivery device

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6623457B1 (en) * 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
SE0102736D0 (sv) 2001-08-14 2001-08-14 Patrick Griss Side opened out-of-plane microneedles for microfluidic transdermal interfacing and fabrication process of side opened out-of-plane microneedles
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
EP1478428B1 (en) * 2002-02-04 2009-07-15 Becton, Dickinson and Company Device and method for delivering or withdrawing a substance through the skin
US6878643B2 (en) 2002-12-18 2005-04-12 The Regents Of The University Of California Electronic unit integrated into a flexible polymer body
US7972616B2 (en) 2003-04-17 2011-07-05 Nanosys, Inc. Medical device applications of nanostructured surfaces
US7811272B2 (en) 2003-12-29 2010-10-12 Kimberly-Clark Worldwide, Inc. Nanofabricated gecko-like fasteners with adhesive hairs for disposable absorbent articles
CN101120101A (zh) 2004-04-13 2008-02-06 阿尔扎公司 多联疫苗透皮释放的装置和方法
US7540717B2 (en) 2005-06-03 2009-06-02 The Hong Kong University Of Science And Technology Membrane nanopumps based on porous alumina thin films, membranes therefor and a method of fabricating such membranes
US20070078414A1 (en) * 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
JP2007089792A (ja) 2005-09-28 2007-04-12 Nano Device & System Research Inc 経皮投与装置
US9095639B2 (en) 2006-06-30 2015-08-04 The University Of Akron Aligned carbon nanotube-polymer materials, systems and methods
US20090182306A1 (en) * 2006-07-21 2009-07-16 Georgia Tech Research Corporation Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal
AU2008209537B2 (en) * 2007-01-22 2013-01-31 Corium Pharma Solutions, Inc. Applicators for microneedle arrays
JP2008284318A (ja) 2007-05-15 2008-11-27 Kosumedei Seiyaku Kk 生体由来物質からなる投薬用微細針
WO2009051147A1 (ja) * 2007-10-18 2009-04-23 Hisamitsu Pharmaceutical Co., Inc. マイクロニードルデバイス
CA2706341C (en) 2007-11-19 2018-08-14 Massachusetts Institute Of Technology Adhesive articles
EP2213284B1 (en) * 2007-11-21 2017-11-15 BioSerenTach Co., Ltd. Preparation for application to body surface and preparation holding sheet for application to body surface
GB0725018D0 (en) 2007-12-21 2008-01-30 Univ Cardiff Monitoring system for microneedle delivery
US8343425B1 (en) 2008-02-29 2013-01-01 Uchicago Argonne, Llc Multi-layer micro/nanofluid devices with bio-nanovalves
US10080876B2 (en) 2008-08-21 2018-09-25 Kibur Medical, Inc. Device and method for drug evaluation and local treatment
JP2010069242A (ja) 2008-09-22 2010-04-02 Fujifilm Corp マイクロニードルシート及びその製造方法
JP5063544B2 (ja) 2008-09-22 2012-10-31 富士フイルム株式会社 経皮吸収シート及びその製造方法
JP2010233673A (ja) 2009-03-30 2010-10-21 Fujifilm Corp 経皮吸収シート及びその製造方法
US9017310B2 (en) 2009-10-08 2015-04-28 Palo Alto Research Center Incorporated Transmucosal drug delivery device and method including microneedles
US20140363610A1 (en) 2009-10-14 2014-12-11 Daniel Elliot Sameoto Compression, extrusion and injection molding of interlocking dry adhesive microstructures with flexible mold technology
EP2338557A1 (en) * 2009-12-23 2011-06-29 Debiotech S.A. Soluble microneedle
MX2012010681A (es) 2010-03-19 2012-10-09 Otsuka Pharma Co Ltd Conjunto de microagujas que comprenden proteoglicano.
ES2634551T3 (es) 2010-04-03 2017-09-28 Praful Doshi Métodos para revestir una lente de contacto
KR101180032B1 (ko) 2010-07-12 2012-09-05 인싸이토(주) 외형 조절이 가능한 중공형 마이크로니들의 제조방법
US20120052234A1 (en) 2010-08-30 2012-03-01 Sriram Natarajan Adhesive structure with stiff protrusions on adhesive surface
US9089677B2 (en) * 2011-01-25 2015-07-28 The Regents Of The University Of California Transcutaneous multimodal delivery system (TMDS)
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
CN103301092B (zh) 2012-03-06 2014-12-03 中国科学院理化技术研究所 聚合物微针阵列芯片及其制备方法和应用
EP2858614A4 (en) 2012-06-07 2016-03-30 Brigham & Womens Hospital QUICK RELEASE ADHESIVE TAPES
DE102012011422A1 (de) 2012-06-08 2013-12-12 Gottlieb Binder Gmbh & Co. Kg Medizinprodukt zur Versorgung eines Individuums
TWI554289B (zh) 2012-06-29 2016-10-21 國立成功大學 鑲嵌式經皮藥物釋放貼片及其製造方法
US20140081295A1 (en) 2012-09-14 2014-03-20 Novo Contour, Inc. Microadhesive Mesh And Sutures
US20150352777A1 (en) * 2013-01-18 2015-12-10 The University Of North Carolina At Chapel Hill High-throughput manufacturing of microneedles
US10420922B2 (en) * 2013-02-01 2019-09-24 The Brigham And Women's Hospital, Inc. Swellable adhesive needles
JPWO2014142135A1 (ja) * 2013-03-12 2017-02-16 武田薬品工業株式会社 マイクロニードルパッチ
JP2015157072A (ja) * 2014-01-27 2015-09-03 コスメディ製薬株式会社 ３ｄプリンターによるマイクロニードルの製造
WO2015167991A1 (en) 2014-04-28 2015-11-05 The Board Of Trustees Of The Leland Stanford Junior University Climbing device with dry adhesives
US9605181B2 (en) 2014-05-13 2017-03-28 Metna Co Micropatterned structures for forming a seal with the face skin and other surfaces and method of make
JP6249885B2 (ja) 2014-05-30 2017-12-20 株式会社ワークス マイクロニードル構造体及びマイクロニードル構造体の製造方法
US10722174B2 (en) 2014-07-11 2020-07-28 The Board Of Trustees Of The Leland Stanford Junior University Skin-conformal sensors
US11040182B2 (en) * 2014-08-18 2021-06-22 Noven Pharmaceuticals, Inc. Microneedle device and methods
KR102338552B1 (ko) 2014-09-30 2021-12-13 엘지전자 주식회사 피부패치 및 이를 이용한 피부재생방법
JP2016171888A (ja) 2015-03-17 2016-09-29 日本写真印刷株式会社 マイクロニードルシートとその製造方法
US20160296149A1 (en) * 2015-04-08 2016-10-13 Sandia Corporation In Vivo Extraction of Interstitial Fluid Using Hollow Microneedles
KR101676861B1 (ko) 2015-04-10 2016-11-17 씨앤텍 주식회사 마이크로 니들 패치 제조장치와 방법, 및 이에 의해 제조되는 마이크로 니들 패치
US20160346466A1 (en) 2015-05-25 2016-12-01 National University Of Singapore Microfluidic device
CN204890945U (zh) 2015-08-24 2015-12-23 苏州先蚕丝绸生物科技有限公司 一种丝素蛋白缓释微针
CN105126243B (zh) 2015-09-06 2018-08-07 台州薇凯生物科技有限公司 微针注射弹及其制备方法和微针注射设备
CN105797266A (zh) * 2016-03-07 2016-07-27 李媚 一种微结构体及其制备方法
US20170341075A1 (en) 2016-05-27 2017-11-30 Idex Health & Science Llc Methods and Apparatus for Coated Flowcells
JP7476119B2 (ja) 2018-06-29 2024-04-30 ジョンソン アンド ジョンソン コンシューマー インコーポレイテッド 活性物質の送達のための三次元マイクロ流体デバイス

Also Published As

Publication number Publication date
MX2019007549A (es) 2019-11-18
ZA201904779B (en) 2024-07-31
US20220111189A1 (en) 2022-04-14
EP3558441A1 (en) 2019-10-30
RU2750904C2 (ru) 2021-07-06
WO2018119174A1 (en) 2018-06-28
AU2017379065A1 (en) 2019-06-27
US11241563B2 (en) 2022-02-08
RU2019122836A3 (enExample) 2021-01-22
JP2020513899A (ja) 2020-05-21
KR20190099267A (ko) 2019-08-26
JP2023086967A (ja) 2023-06-22
BR112019012728A2 (pt) 2019-11-26
US20180177990A1 (en) 2018-06-28
CA3048102A1 (en) 2018-06-28
BR112019012728A8 (pt) 2022-08-09
MX2023012900A (es) 2023-11-08
AU2017379065B2 (en) 2023-05-18
CN110099714A (zh) 2019-08-06
RU2019122836A (ru) 2021-01-22

Similar Documents

Publication Publication Date Title
US20220111189A1 (en) Microneedle arrays and methods for making and using
US20220347449A1 (en) Three-dimensional microfluidics devices for the delivery of actives
Alkilani et al. Beneath the skin: a review of current trends and future prospects of transdermal drug delivery systems
KR101708966B1 (ko) 어플리케이터들에 일체화될 수 있는 내장형 비-경구 지시 장치
KR20180121537A (ko) 푸코이단 육모제
EP4626532A1 (en) Microneedle particles for enhanced topical transdermal drug delivery
BR112019012728B1 (pt) Matriz de microagulhas
JP2002060349A (ja) 皮膚外用剤
Pitzanti Lipid nanocarriers and 3D printed hollow microneedles as strategies to promote drug delivery via the skin
Upasani et al. 14 Innovations Future Prospects and

Legal Events

Date Code Title Description
A107 Divisional application of patent
PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A18-div-PA0104

St.27 status event code: A-0-1-A10-A16-div-PA0104

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

E90F Notification of reason for final refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000