JP2020513899A - マイクロニードルアレイ及び製造方法及び使用方法 - Google Patents
マイクロニードルアレイ及び製造方法及び使用方法 Download PDFInfo
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
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Abstract
Description
(1) 第1及び第2の外側向きの主表面を有するフィルムを含む、マイクロニードルアレイであって、前記第1の外側向きの主表面は、前記第1の外側向きの主表面から延びる複数の角質層穿刺マイクロニードルを有しており、前記複数のマイクロニードルは、第1の有益剤を有する複数の第1のマイクロニードル、及び第2の有益剤を有する複数の第2のマイクロニードルを含む、マイクロニードルアレイ。
(2) 前記第1の外側向きの主表面に配置された接着剤を更に含む、実施態様1に記載のマイクロニードルアレイ。
(3) 複数のマイクロニードルは、各々、前記第1の外側向きの主表面から延びる高さが約1μm〜約5000μmである、実施態様1に記載のマイクロニードルアレイ。
(4) 前記複数のマイクロニードルは全て、実質的に均一な高さを有する、実施態様3に記載のマイクロニードルアレイ。
(5) 前記複数のマイクロニードルが、変更可能な高さを有する、実施態様3に記載のマイクロニードルアレイ。
(7) 個々のマイクロニードルが、少なくとも1種類の有益剤を含む、実施態様1に記載のマイクロニードルアレイ。
(8) 個々のマイクロニードルが、少なくとも2種類の別個の有益剤を含む、実施態様7に記載のマイクロニードルアレイ。
(9) 少なくとも1つの個々のマイクロニードルが、コア部分とシース部分とを含む、実施態様8に記載のマイクロニードルアレイ。
(10) 前記少なくとも1つの個々のマイクロニードルの前記コア部分が、剛性組成物を含む、実施態様9に記載のマイクロニードルアレイ。
(12) 前記第1の有益剤及び前記第2の有益剤の少なくとも1つが、マイクロニードル材料に溶解している、実施態様1に記載のマイクロニードルアレイ。
(13) 前記第1の有益剤及び前記第2の有益剤の少なくとも1つが、容器内に保存されており、少なくとも1つのマイクロニードル内のマイクロ流体路を通して送達される、実施態様1に記載のマイクロニードルアレイ。
Claims (13)
- 第1及び第2の外側向きの主表面を有するフィルムを含む、マイクロニードルアレイであって、前記第1の外側向きの主表面は、前記第1の外側向きの主表面から延びる複数の角質層穿刺マイクロニードルを有しており、前記複数のマイクロニードルは、第1の有益剤を有する複数の第1のマイクロニードル、及び第2の有益剤を有する複数の第2のマイクロニードルを含む、マイクロニードルアレイ。
- 前記第1の外側向きの主表面に配置された接着剤を更に含む、請求項1に記載のマイクロニードルアレイ。
- 複数のマイクロニードルは、各々、前記第1の外側向きの主表面から延びる高さが約1μm〜約5000μmである、請求項1に記載のマイクロニードルアレイ。
- 前記複数のマイクロニードルは全て、実質的に均一な高さを有する、請求項3に記載のマイクロニードルアレイ。
- 前記複数のマイクロニードルが、変更可能な高さを有する、請求項3に記載のマイクロニードルアレイ。
- 個々のマイクロニードルが、前記第1の外側向きの主表面から、そこから遠位の点まで先細形状になっている、請求項1に記載のマイクロニードルアレイ。
- 個々のマイクロニードルが、少なくとも1種類の有益剤を含む、請求項1に記載のマイクロニードルアレイ。
- 個々のマイクロニードルが、少なくとも2種類の別個の有益剤を含む、請求項7に記載のマイクロニードルアレイ。
- 少なくとも1つの個々のマイクロニードルが、コア部分とシース部分とを含む、請求項8に記載のマイクロニードルアレイ。
- 前記少なくとも1つの個々のマイクロニードルの前記コア部分が、剛性組成物を含む、請求項9に記載のマイクロニードルアレイ。
- 少なくとも1つのマイクロニードルは、前記第1の外側向きの主表面に対して実質的に垂直に延びる初期の実質的に線形の形態と、遠位端がフック様形態に湾曲する第2の展開形態とを有する、請求項1に記載のマイクロニードルアレイ。
- 前記第1の有益剤及び前記第2の有益剤の少なくとも1つが、マイクロニードル材料に溶解している、請求項1に記載のマイクロニードルアレイ。
- 前記第1の有益剤及び前記第2の有益剤の少なくとも1つが、容器内に保存されており、少なくとも1つのマイクロニードル内のマイクロ流体路を通して送達される、請求項1に記載のマイクロニードルアレイ。
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PCT/US2017/067790 WO2018119174A1 (en) | 2016-12-22 | 2017-12-21 | Microneedle arrays and methods for making and using |
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JP2023086967A (ja) | 2023-06-22 |
BR112019012728A8 (pt) | 2022-08-09 |
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RU2750904C2 (ru) | 2021-07-06 |
AU2017379065A1 (en) | 2019-06-27 |
CA3048102A1 (en) | 2018-06-28 |
US11241563B2 (en) | 2022-02-08 |
BR112019012728A2 (pt) | 2019-11-26 |
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CN110099714A (zh) | 2019-08-06 |
US20220111189A1 (en) | 2022-04-14 |
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EP3558441A1 (en) | 2019-10-30 |
WO2018119174A1 (en) | 2018-06-28 |
KR20190099267A (ko) | 2019-08-26 |
US20180177990A1 (en) | 2018-06-28 |
MX2019007549A (es) | 2019-11-18 |
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