KR20170001720A - 바이러스 유사 입자 정제 - Google Patents

바이러스 유사 입자 정제 Download PDF

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Publication number
KR20170001720A
KR20170001720A KR1020167036031A KR20167036031A KR20170001720A KR 20170001720 A KR20170001720 A KR 20170001720A KR 1020167036031 A KR1020167036031 A KR 1020167036031A KR 20167036031 A KR20167036031 A KR 20167036031A KR 20170001720 A KR20170001720 A KR 20170001720A
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KR
South Korea
Prior art keywords
vlps
chromatography
chromatographic
vlp
hydroxyapatite
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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KR1020167036031A
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English (en)
Korean (ko)
Inventor
토마스 에스 베드빅
브라이언 스테드먼
찰스 리차드슨
토마스 알 포버트
찰스 알 페트리
Original Assignee
다케다 백신즈 인코포레이티드
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Publication of KR20170001720A publication Critical patent/KR20170001720A/ko
Ceased legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/18Ion-exchange chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02Recovery or purification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/16011Caliciviridae
    • C12N2770/16023Virus like particles [VLP]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/16011Caliciviridae
    • C12N2770/16034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/16011Caliciviridae
    • C12N2770/16051Methods of production or purification of viral material

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020167036031A 2007-03-14 2008-03-14 바이러스 유사 입자 정제 Ceased KR20170001720A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90682107P 2007-03-14 2007-03-14
US60/906,821 2007-03-14
PCT/US2008/057072 WO2008113011A2 (en) 2007-03-14 2008-03-14 Virus like particle purification

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020157020558A Division KR20150098681A (ko) 2007-03-14 2008-03-14 바이러스 유사 입자 정제

Publications (1)

Publication Number Publication Date
KR20170001720A true KR20170001720A (ko) 2017-01-04

Family

ID=39760420

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020167036031A Ceased KR20170001720A (ko) 2007-03-14 2008-03-14 바이러스 유사 입자 정제
KR1020157020558A Ceased KR20150098681A (ko) 2007-03-14 2008-03-14 바이러스 유사 입자 정제
KR1020097021421A Active KR101576219B1 (ko) 2007-03-14 2008-03-14 바이러스 유사 입자 정제

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020157020558A Ceased KR20150098681A (ko) 2007-03-14 2008-03-14 바이러스 유사 입자 정제
KR1020097021421A Active KR101576219B1 (ko) 2007-03-14 2008-03-14 바이러스 유사 입자 정제

Country Status (12)

Country Link
US (4) US8481693B2 (enExample)
EP (1) EP2134360B1 (enExample)
JP (4) JP5284290B2 (enExample)
KR (3) KR20170001720A (enExample)
AU (1) AU2008224877B2 (enExample)
CA (1) CA2683977C (enExample)
DK (1) DK2134360T3 (enExample)
ES (1) ES2559421T3 (enExample)
HU (1) HUE028605T2 (enExample)
PL (1) PL2134360T3 (enExample)
SG (2) SG179488A1 (enExample)
WO (1) WO2008113011A2 (enExample)

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JP2019068846A (ja) 2019-05-09
CA2683977A1 (en) 2008-09-18
JP2013176392A (ja) 2013-09-09
JP2010530734A (ja) 2010-09-16
JP5284290B2 (ja) 2013-09-11
KR20100015562A (ko) 2010-02-12
SG179488A1 (en) 2012-04-27
US20130344107A1 (en) 2013-12-26
US20100150961A1 (en) 2010-06-17
US20190282686A1 (en) 2019-09-19
PL2134360T3 (pl) 2016-05-31
EP2134360A4 (en) 2011-08-24
HUE028605T2 (en) 2016-12-28
AU2008224877A1 (en) 2008-09-18
ES2559421T3 (es) 2016-02-12
KR101576219B1 (ko) 2015-12-10
US10792353B2 (en) 2020-10-06
US20160317645A1 (en) 2016-11-03
EP2134360A2 (en) 2009-12-23
JP2017086090A (ja) 2017-05-25
KR20150098681A (ko) 2015-08-28
DK2134360T3 (en) 2016-02-22
WO2008113011A3 (en) 2008-12-24
CA2683977C (en) 2017-04-25
WO2008113011A2 (en) 2008-09-18
SG10201701988TA (en) 2017-04-27
EP2134360B1 (en) 2015-11-18
AU2008224877B2 (en) 2013-07-11
HK1138795A1 (zh) 2010-09-03
US10172930B2 (en) 2019-01-08
US9359410B2 (en) 2016-06-07
US8481693B2 (en) 2013-07-09

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