JP5284290B2 - ウイルス様粒子の精製 - Google Patents

ウイルス様粒子の精製 Download PDF

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Publication number
JP5284290B2
JP5284290B2 JP2009553820A JP2009553820A JP5284290B2 JP 5284290 B2 JP5284290 B2 JP 5284290B2 JP 2009553820 A JP2009553820 A JP 2009553820A JP 2009553820 A JP2009553820 A JP 2009553820A JP 5284290 B2 JP5284290 B2 JP 5284290B2
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Prior art keywords
vlp
chromatography
vlps
chromatographic
purification
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Japanese (ja)
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JP2010530734A (ja
Inventor
ヴェドヴィック，トーマス，エス．
シュテットマン，ブライアン
リチャードソン，チャールズ
フォーベルト，トーマス，アール．
アール． ピートリー，チャールス
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リゴサイト ファーマスーティカルズ，インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02—Recovery or purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16051—Methods of production or purification of viral material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2009553820A 2007-03-14 2008-03-14 ウイルス様粒子の精製 Active JP5284290B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90682107P 2007-03-14 2007-03-14
US60/906,821 2007-03-14
PCT/US2008/057072 WO2008113011A2 (en) 2007-03-14 2008-03-14 Virus like particle purification

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013112580A Division JP2013176392A (ja) 2007-03-14 2013-05-29 ウイルス様粒子の精製

Publications (2)

Publication Number Publication Date
JP2010530734A JP2010530734A (ja) 2010-09-16
JP5284290B2 true JP5284290B2 (ja) 2013-09-11

Family

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Family Applications (4)

Application Number Title Priority Date Filing Date
JP2009553820A Active JP5284290B2 (ja) 2007-03-14 2008-03-14 ウイルス様粒子の精製
JP2013112580A Pending JP2013176392A (ja) 2007-03-14 2013-05-29 ウイルス様粒子の精製
JP2017032171A Pending JP2017086090A (ja) 2007-03-14 2017-02-23 ウイルス様粒子の精製
JP2019000688A Pending JP2019068846A (ja) 2007-03-14 2019-01-07 ウイルス様粒子の精製

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2013112580A Pending JP2013176392A (ja) 2007-03-14 2013-05-29 ウイルス様粒子の精製
JP2017032171A Pending JP2017086090A (ja) 2007-03-14 2017-02-23 ウイルス様粒子の精製
JP2019000688A Pending JP2019068846A (ja) 2007-03-14 2019-01-07 ウイルス様粒子の精製

Country Status (12)

Country Link
US (4) US8481693B2 (enExample)
EP (1) EP2134360B1 (enExample)
JP (4) JP5284290B2 (enExample)
KR (3) KR20150098681A (enExample)
AU (1) AU2008224877B2 (enExample)
CA (1) CA2683977C (enExample)
DK (1) DK2134360T3 (enExample)
ES (1) ES2559421T3 (enExample)
HU (1) HUE028605T2 (enExample)
PL (1) PL2134360T3 (enExample)
SG (2) SG10201701988TA (enExample)
WO (1) WO2008113011A2 (enExample)

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JP2025022899A (ja) * 2017-12-07 2025-02-14 エーエムペー・バイオテック・ゲーエムベーハー 応用ラジアル技術クロマトグラフィのシステム及び方法

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JP6479305B2 (ja) 2013-07-12 2019-03-06 株式会社Ｕｍｎファーマ ウイルス様粒子の精製方法
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025022899A (ja) * 2017-12-07 2025-02-14 エーエムペー・バイオテック・ゲーエムベーハー 応用ラジアル技術クロマトグラフィのシステム及び方法

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US20160317645A1 (en) 2016-11-03
EP2134360B1 (en) 2015-11-18
US10172930B2 (en) 2019-01-08
EP2134360A4 (en) 2011-08-24
US9359410B2 (en) 2016-06-07
WO2008113011A3 (en) 2008-12-24
US8481693B2 (en) 2013-07-09
EP2134360A2 (en) 2009-12-23
CA2683977C (en) 2017-04-25
KR20150098681A (ko) 2015-08-28
US20190282686A1 (en) 2019-09-19
WO2008113011A2 (en) 2008-09-18
JP2017086090A (ja) 2017-05-25
KR20100015562A (ko) 2010-02-12
DK2134360T3 (en) 2016-02-22
SG10201701988TA (en) 2017-04-27
JP2019068846A (ja) 2019-05-09
US20100150961A1 (en) 2010-06-17
AU2008224877A1 (en) 2008-09-18
HK1138795A1 (zh) 2010-09-03
HUE028605T2 (en) 2016-12-28
ES2559421T3 (es) 2016-02-12
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US20130344107A1 (en) 2013-12-26
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