KR20150027217A - 항진균성 항생 암포테리신 b의 n-치환된 제2 세대 유도체, 및 이의 제조 및 응용 방법 - Google Patents

항진균성 항생 암포테리신 b의 n-치환된 제2 세대 유도체, 및 이의 제조 및 응용 방법 Download PDF

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Publication number
KR20150027217A
KR20150027217A KR20157000820A KR20157000820A KR20150027217A KR 20150027217 A KR20150027217 A KR 20150027217A KR 20157000820 A KR20157000820 A KR 20157000820A KR 20157000820 A KR20157000820 A KR 20157000820A KR 20150027217 A KR20150027217 A KR 20150027217A
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South Korea
Prior art keywords
amphotericin
optionally substituted
alkyl
compound
derivative
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Ceased
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KR20157000820A
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Korean (ko)
Inventor
에드워드 보로프스키
나탈리아 잘레프스카
조안나 보로스-마제프스카
마리아 밀레프스카
말고르자타 위소카
슬라보미르 밀레프스키
이자벨라 차보프스카
미할 사비츠
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블러트 에스.에이.
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Publication of KR20150027217A publication Critical patent/KR20150027217A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
KR20157000820A 2012-06-15 2013-06-14 항진균성 항생 암포테리신 b의 n-치환된 제2 세대 유도체, 및 이의 제조 및 응용 방법 Ceased KR20150027217A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PLP.399545 2012-06-15
PL39954512 2012-06-15
PCT/EP2013/062436 WO2013186384A1 (en) 2012-06-15 2013-06-14 N-substituted second generation derivatives of antifungal antibiotic amphotericin b and methods of their preparation and application

Publications (1)

Publication Number Publication Date
KR20150027217A true KR20150027217A (ko) 2015-03-11

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Family Applications (1)

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KR20157000820A Ceased KR20150027217A (ko) 2012-06-15 2013-06-14 항진균성 항생 암포테리신 b의 n-치환된 제2 세대 유도체, 및 이의 제조 및 응용 방법

Country Status (12)

Country Link
US (1) US9745335B2 (https=)
EP (1) EP2861610A1 (https=)
JP (1) JP2015519389A (https=)
KR (1) KR20150027217A (https=)
CN (1) CN104520309B (https=)
AU (1) AU2013276480B2 (https=)
BR (1) BR112014031060A2 (https=)
CA (1) CA2876074A1 (https=)
IN (1) IN2014DN10551A (https=)
MX (1) MX2014015249A (https=)
RU (1) RU2014152459A (https=)
WO (1) WO2013186384A1 (https=)

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TWI702223B (zh) 2014-06-12 2020-08-21 日商塩野義製藥股份有限公司 多烯巨環內酯衍生物
CA3021061C (en) 2015-04-15 2023-10-24 Martin D. Burke Derivatives of amphotericin b
CA3076336A1 (en) * 2017-09-20 2019-03-28 Atopic Medical, LLC Compositions and methods for treating and ameliorating respiratory conditions and inflammation of mucosa
RU2688658C1 (ru) * 2018-04-10 2019-05-22 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Противогрибковый полусинтетический полиеновый антибиотик, его водорастворимые соли и фармацевтические композиции на их основе
CN110669087B (zh) * 2018-07-02 2023-03-31 上海医药工业研究院 两性霉素b肽衍生物及其制备方法
CN113166188B (zh) * 2018-12-13 2023-06-20 正大天晴药业集团股份有限公司 两性霉素b肽衍生物
EP4009985A4 (en) * 2019-08-08 2023-09-06 The Board Of Trustees Of The University Of Illinois HYBRID AMIDE DERIVATIVES OF AMPHOTERICIN B
FR3112145A1 (fr) * 2020-07-03 2022-01-07 Nanotracks Diagnostics Derives uree de macrolides polyeniques, composes chimiques particuliers susceptibles d’etre utilises pour obtenir ces derives uree, compositions les contenant et utilisations
WO2022003181A1 (fr) * 2020-07-03 2022-01-06 Nanotracks Diagnostics Derivés urée de l'amphotéricine amb, compositions les contenant et leurs utilisations, dérivés isocyanate d'alkyle omega-aminés et leur utilisation pour obtenir lesdits dérivés urée
CN111875653A (zh) * 2020-08-11 2020-11-03 深圳市儿童医院 一种含二硫键的两性霉素b衍生物及其用途
RU2751333C1 (ru) * 2020-12-16 2021-07-13 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Способ получения противогрибкового полусинтетического полиенового антибиотика
CN115536716B (zh) * 2021-06-29 2025-08-08 中国科学院上海药物研究所 两性霉素b半合成衍生物及其制备方法和用途
CN113603738B (zh) * 2021-07-23 2023-05-23 西南大学 一种pH响应性两性霉素B衍生物及其制备方法和应用
CN114133428B (zh) * 2021-12-09 2023-10-27 华东理工大学 两性霉素b亲水性多肽衍生物及其应用
WO2025176869A1 (fr) 2024-02-21 2025-08-28 Mayan Pharma Nouveaux dérivés urées de macrolides amphotères et solubilisation d'antibiotiques amphotères par des dérivés urées de glucides

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DE2706156C3 (de) 1977-02-14 1981-08-20 Vsesojuznyj naučno-issledovatel'skij technologičeskij institut antibiotikov i fermentov medicinskogo naznačenija, Leningrad N,N,N-Trimethylderivate amphoterer, antimykotischer Polyenantibiotika und Verfahren zu deren Herstellung
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JP2002096091A (ja) * 2000-09-21 2002-04-02 Hitachi Ltd 油脂分解組成物及び油脂分解方法
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Also Published As

Publication number Publication date
CA2876074A1 (en) 2013-12-19
US20150291648A1 (en) 2015-10-15
EP2861610A1 (en) 2015-04-22
IN2014DN10551A (https=) 2015-08-21
WO2013186384A1 (en) 2013-12-19
US9745335B2 (en) 2017-08-29
CN104520309B (zh) 2018-05-04
AU2013276480B2 (en) 2018-01-04
MX2014015249A (es) 2015-08-20
AU2013276480A1 (en) 2015-01-15
BR112014031060A2 (pt) 2017-06-27
RU2014152459A (ru) 2016-08-10
CN104520309A (zh) 2015-04-15
JP2015519389A (ja) 2015-07-09

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