MA39568A1 - Dérivé de macrolide de polyène - Google Patents

Dérivé de macrolide de polyène

Info

Publication number
MA39568A1
MA39568A1 MA39568A MA39568A MA39568A1 MA 39568 A1 MA39568 A1 MA 39568A1 MA 39568 A MA39568 A MA 39568A MA 39568 A MA39568 A MA 39568A MA 39568 A1 MA39568 A1 MA 39568A1
Authority
MA
Morocco
Prior art keywords
polyene macrolide
macrolide derivative
formula
derivative
polyene
Prior art date
Application number
MA39568A
Other languages
English (en)
Inventor
Keisuke Miyazaki
Kenji Takaya
Takafumi Ohara
Hideki Sugimoto
Manabu Fujitani
Yuki Ogata
Naoyuki Suzuki
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of MA39568A1 publication Critical patent/MA39568A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention concerne un dérivé d'amphotéricine b représenté par la formule (i). Dans ladite formule, chaque symbole est tel que défini dans la description.Le composé de l'invention, qui se caractérise en ce qu'il présente une structure d'urée, une structure cyclique, hydroxyalkyle ou monoalkylcarbamoyle substitué à la position 16 (x), présente une activité antifongique.
MA39568A 2014-06-12 2015-06-12 Dérivé de macrolide de polyène MA39568A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014121341 2014-06-12
PCT/JP2015/066976 WO2015190587A1 (fr) 2014-06-12 2015-06-12 Dérivé de macrolide de polyène

Publications (1)

Publication Number Publication Date
MA39568A1 true MA39568A1 (fr) 2017-09-29

Family

ID=54833670

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39568A MA39568A1 (fr) 2014-06-12 2015-06-12 Dérivé de macrolide de polyène

Country Status (16)

Country Link
US (2) US10246478B2 (fr)
EP (1) EP3156410A4 (fr)
JP (1) JP6601818B2 (fr)
KR (1) KR102106765B1 (fr)
CN (1) CN106414473B (fr)
AU (1) AU2015272398B2 (fr)
BR (1) BR112016028890A8 (fr)
CA (1) CA2951516C (fr)
EA (1) EA037093B1 (fr)
IL (1) IL249430B (fr)
MA (1) MA39568A1 (fr)
MX (1) MX2016015455A (fr)
PH (1) PH12016502357A1 (fr)
SG (1) SG11201610162XA (fr)
TW (1) TWI702223B (fr)
WO (1) WO2015190587A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016061437A1 (fr) 2014-10-17 2016-04-21 The Board Of Trustees Of The University Of Illinois Synthèse modulable de dérivés d'amphotéricine b à toxicité réduite
EP3242554A4 (fr) * 2015-01-08 2018-06-06 The Board of Trustees of the University of Illionis Synthèse concise de dérivés d'urée d'amphotéricine b
JP7240811B2 (ja) 2015-04-15 2023-03-16 スファンガ セラピューティクス インコーポレイテッド アムホテリシンｂの誘導体
WO2017100171A1 (fr) * 2015-12-08 2017-06-15 Kalyra Pharmaceuticals, Inc. Composés antifongiques et procédés s'y rapportant
WO2018106571A1 (fr) * 2016-12-06 2018-06-14 Kalyra Pharmaceuticals, Inc. Composés antifongiques et procédés
KR20210064247A (ko) * 2018-09-07 2021-06-02 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 독성이 감소된 혼성 암포테리신 b 유도체
EP4192248A1 (fr) * 2020-08-10 2023-06-14 The Board Of Trustees Of The University Of Illinois Dérivés amides hybrides d'amphotéricine b
CN111909226A (zh) * 2020-08-11 2020-11-10 深圳市儿童医院 一种葡萄糖酸修饰的两性霉素b衍生物及其用途
CN115536716A (zh) * 2021-06-29 2022-12-30 中国科学院上海药物研究所 两性霉素b半合成衍生物及其制备方法和用途
CN113773355B (zh) * 2021-08-23 2023-03-10 湖南省微生物研究院 一种多烯大环内酯类化合物及其制备方法和应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL122086B1 (en) 1979-04-09 1982-06-30 Politechnika Gdanska Process for preparing amides of antibiotics from the group of polyene macrolides and their derivativesvykh makrolidov i ikh proizvodnykh
ZA807892B (en) * 1979-12-24 1981-12-30 Dumex Ltd As Water soluble guanidine derivatives of polyene marcrolides and the esters thereof
JPS56123794A (en) * 1980-02-29 1981-09-29 Nippon Denso Co Ltd Load driving unit for vehicle
JPH024295A (ja) * 1988-06-22 1990-01-09 Toshiba Corp 医用画像診断装置
GB8829593D0 (en) * 1988-12-19 1989-02-08 Beecham Group Plc Novel compounds
FR2654339B1 (fr) 1989-11-14 1994-10-28 Mayoly Spindler Laboratoires Nouveaux derives solubles et non toxiques des macrolides polyeniques basiques, leur preparation et leurs applications.
FR2683723B1 (fr) * 1991-11-14 1995-05-19 Mayoly Spindler Laboratoires Nouveaux medicaments antiviraux actifs sur le virus vih.
AU3460693A (en) * 1992-02-12 1993-09-03 Smithkline Beecham Plc Amphotericin B derivative
GB9203476D0 (en) * 1992-02-19 1992-04-08 Smithkline Beecham Plc Novel compounds
US5606038A (en) 1995-04-10 1997-02-25 Competitive Technologies, Inc. Amphiphilic polyene macrolide antibiotic compounds
PL180253B1 (pl) 1995-05-13 2001-01-31 Politechnika Gdanska Pochodne N-metylo-N-glikozylowe estrów metylowych antybiotyków z grupy makrolidów polienowych i ich sole oraz sposób ich otrzymywania PL PL PL PL PL PL
FR2776927B1 (fr) 1998-04-07 2002-07-05 Univ Paris Curie Compositions pour la vectorisation de molecules
JP2003522994A (ja) 1999-08-02 2003-07-29 グラクソ グループ リミテッド 疾病管理に伴い発生する費用と利益を見積るコンピュータの実行方法およびシステム
WO2001051061A1 (fr) 2000-01-14 2001-07-19 Intrabiotics Pharmaceuticals, Inc. Derives de macrolides de polyene, preparation et utilisations correspondantes
WO2007096137A1 (fr) * 2006-02-23 2007-08-30 Eth Zurich Dérivés d'amphotéricine
JP2010534688A (ja) 2007-07-30 2010-11-11 上海医薬工業研究院 ポリエン類抗生物質ジエステル化合物
MX365184B (es) 2010-12-21 2019-05-21 Centro De Investig Y De Estudios Avanzados Del I P N Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen.
WO2013186384A1 (fr) 2012-06-15 2013-12-19 Blirt S.A. Dérivés de seconde génération n-substitués de l'amphotéricine b antibiotique antifongique et leurs procédés de préparation et d'utilisation
CA2925904C (fr) 2013-10-07 2021-11-23 The Board Of Trustees Of The University Of Illinois Derives d'amphotericine b ayant un indice therapeutique ameliore
WO2016112243A1 (fr) 2015-01-08 2016-07-14 The Board Of Trustees Of The University Of Illinois Dérivés d'urée de l'amphotéricine b dérivée d'amines secondaires
JP7240811B2 (ja) 2015-04-15 2023-03-16 スファンガ セラピューティクス インコーポレイテッド アムホテリシンｂの誘導体

Also Published As

Publication number Publication date
US10696707B2 (en) 2020-06-30
IL249430A0 (en) 2017-02-28
KR102106765B1 (ko) 2020-05-06
KR20170016957A (ko) 2017-02-14
CN106414473B (zh) 2020-03-13
TWI702223B (zh) 2020-08-21
PH12016502357A1 (en) 2017-02-13
CA2951516C (fr) 2019-04-02
AU2015272398A1 (en) 2016-12-08
US20190135847A1 (en) 2019-05-09
EP3156410A1 (fr) 2017-04-19
CN106414473A (zh) 2017-02-15
EP3156410A4 (fr) 2018-01-03
AU2015272398B2 (en) 2018-04-26
TW201625655A (zh) 2016-07-16
EA037093B1 (ru) 2021-02-04
SG11201610162XA (en) 2017-01-27
IL249430B (en) 2020-05-31
BR112016028890A2 (pt) 2017-08-22
MX2016015455A (es) 2017-03-23
US20170190729A1 (en) 2017-07-06
WO2015190587A1 (fr) 2015-12-17
CA2951516A1 (fr) 2015-12-17
JP6601818B2 (ja) 2019-11-06
BR112016028890A8 (pt) 2021-03-23
US10246478B2 (en) 2019-04-02
EA201692508A1 (ru) 2017-04-28
JPWO2015190587A1 (ja) 2017-04-20

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